| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Amad Diallo | Knock | 20 Aug 2026 | Current | — | 5 |
 Mason Mount | Foot Injury | 16 Aug 2026 | 28 Aug 2026 | 12 | 1 |
 Carlos Baleba | Ankle Injury | 6 Aug 2026 | Current | 42 | 8 |
 Manuel Ugarte | Cruciate Ligament Tear | 28 Jun 2026 | Current | — | 11 |
 Benjamin Sesko | Shin Injury | 15 May 2026 | 1 Aug 2026 | 78 | 1 |
| Manuel Ugarte | Back Problems | 7 May 2026 | 13 May 2026 | 6 | 1 |
 Unknown player | Injury | 6 May 2026 | 12 May 2026 | 6 | 1 |
 Matheus Cunha | Hip Flexor Problems | 19 Apr 2026 | 30 Apr 2026 | 11 | 1 |
 Leny Yoro | Knock | 17 Apr 2026 | 30 Apr 2026 | 13 | 2 |
 Kobbie Mainoo | Knock | 10 Apr 2026 | 15 Apr 2026 | 5 | 1 |
 Unknown player | Knock | 1 Apr 2026 | 15 Apr 2026 | 14 | 1 |
 Noussair Mazraoui | ILL | 19 Mar 2026 | 23 Mar 2026 | 4 | 1 |
 Lisandro Martínez | Calf Injury | 23 Feb 2026 | 8 Apr 2026 | 44 | 3 |
 Shea Lacey | Calf Injury | 3 Feb 2026 | 6 Mar 2026 | 31 | 5 |
| Mason Mount | Knock | 1 Feb 2026 | 15 Mar 2026 | 42 | 6 |
 Patrick Dorgu | Hamstring Injury | 25 Jan 2026 | 26 Apr 2026 | 91 | 8 |
 Joshua Zirkzee | Knock | 16 Jan 2026 | 30 Jan 2026 | 14 | 2 |
| Mason Mount | Knock | 27 Dec 2025 | 5 Jan 2026 | 9 | 2 |
 Bruno Fernandes | Hamstring Injury | 21 Dec 2025 | 5 Jan 2026 | 15 | 6 |
| Kobbie Mainoo | Calf Injury | 16 Dec 2025 | 6 Jan 2026 | 21 | 4 |
 Matthijs de Ligt | Back Injury | 30 Nov 2025 | 1 Sept 2026 | 275 | 27 |
 Unknown player | Calf Injury | 26 Nov 2025 | 26 Jan 2026 | 61 | 11 |
| Matheus Cunha | Knock | 21 Nov 2025 | 4 Dec 2025 | 13 | 2 |
 Harry Maguire | Thigh Problems | 21 Nov 2025 | 12 Jan 2026 | 52 | 3 |
| Benjamin Sesko | Knee Injury | 8 Nov 2025 | 10 Dec 2025 | 32 | 3 |
| Kobbie Mainoo | Knock | 7 Nov 2025 | 10 Nov 2025 | 3 | 1 |
| Harry Maguire | Knock | 24 Oct 2025 | 27 Oct 2025 | 3 | 1 |
| Noussair Mazraoui | Muscle Injury | 22 Sept 2025 | 17 Oct 2025 | 25 | 2 |
 Diogo Dalot | Muscle Injury | 4 Sept 2025 | 22 Sept 2025 | 18 | 2 |
| Matheus Cunha | Hamstring Injury | 30 Aug 2025 | 18 Sept 2025 | 19 | 2 |
| Mason Mount | Knock | 30 Aug 2025 | 18 Sept 2025 | 19 | 2 |
| Noussair Mazraoui | Knock | 21 Jul 2025 | 29 Aug 2025 | 39 | 7 |
 Unknown player | Hamstring Injury | 12 Jul 2025 | 18 Aug 2025 | 37 | 5 |
 Luke Shaw | Foot Injury | 22 May 2025 | 1 Jun 2025 | 10 | 3 |
| Leny Yoro | Foot Injury | 11 May 2025 | 19 May 2025 | 8 | 2 |
| Matthijs de Ligt | Knee Injury | 5 May 2025 | 23 May 2025 | 18 | 4 |
| Diogo Dalot | Calf Injury | 21 Apr 2025 | 15 May 2025 | 24 | 5 |
| Luke Shaw | Rest | 18 Apr 2025 | 22 Apr 2025 | 4 | 1 |
| Joshua Zirkzee | Thigh Problems | 14 Apr 2025 | 1 Jun 2025 | 48 | 12 |
| Unknown player | Leg Injury | 4 Apr 2025 | 16 May 2025 | 42 | 5 |
| Matthijs de Ligt | Foot Injury | 1 Apr 2025 | 18 Apr 2025 | 17 | 4 |
 Ayden Heaven | Foot Injury | 16 Mar 2025 | 16 May 2025 | 61 | 8 |
| Leny Yoro | Foot Injury | 9 Mar 2025 | 1 Apr 2025 | 23 | 3 |
| Manuel Ugarte | Injury | 4 Mar 2025 | 12 Mar 2025 | 8 | 2 |
| Harry Maguire | Calf Injury | 2 Mar 2025 | 24 Mar 2025 | 22 | 5 |
 Unknown player | ILL | 15 Feb 2025 | 17 Feb 2025 | 2 | 0 |
| Leny Yoro | ILL | 14 Feb 2025 | 17 Feb 2025 | 3 | 0 |
| Amad Diallo | Ankle Injury | 14 Feb 2025 | 28 Apr 2025 | 73 | 21 |
| Kobbie Mainoo | Muscle Injury | 10 Feb 2025 | 7 Apr 2025 | 56 | 7 |
| Unknown player | Knock | 10 Feb 2025 | 3 Mar 2025 | 21 | 5 |
| Manuel Ugarte | Knock | 8 Feb 2025 | 17 Feb 2025 | 9 | 0 |
| Lisandro Martínez | Cruciate Ligament Injury | 3 Feb 2025 | 21 Nov 2025 | 291 | 42 |
 Altay Bayındır | Injury | 3 Feb 2025 | 31 Mar 2025 | 56 | 9 |
 Unknown player | Muscle Injury | 11 Jan 2025 | 18 Apr 2025 | 97 | 20 |
 Marcus Rashford | ILL | 4 Jan 2025 | 15 Jan 2025 | 11 | 2 |
 Victor Lindelöf | Injury | 20 Dec 2024 | 25 Jan 2025 | 36 | 8 |
| Matthijs de Ligt | ILL | 20 Dec 2024 | 23 Dec 2024 | 3 | 0 |
| Mason Mount | Hamstring Injury | 16 Dec 2024 | 14 Mar 2025 | 88 | 19 |
| Luke Shaw | Muscle Injury | 3 Dec 2024 | 4 Apr 2025 | 122 | 14 |
| Lisandro Martínez | Back Problems | 23 Nov 2024 | 25 Nov 2024 | 2 | 0 |
| Victor Lindelöf | Injury | 17 Nov 2024 | 9 Dec 2024 | 22 | 5 |
| Harry Maguire | Injury | 6 Nov 2024 | 29 Nov 2024 | 23 | 3 |
| Kobbie Mainoo | Muscle Injury | 17 Oct 2024 | 11 Nov 2024 | 25 | 6 |
| Harry Maguire | Knee Injury | 7 Oct 2024 | 6 Nov 2024 | 30 | 5 |
| Mason Mount | Head Injury | 30 Sept 2024 | 4 Nov 2024 | 35 | 7 |
| Harry Maguire | Knock | 27 Sept 2024 | 1 Oct 2024 | 4 | 1 |
| Mason Mount | Hamstring Injury | 28 Aug 2024 | 19 Sept 2024 | 22 | 3 |
| Luke Shaw | Calf Injury | 11 Aug 2024 | 8 Nov 2024 | 89 | 6 |
| Victor Lindelöf | Toe Injury | 4 Aug 2024 | 14 Sept 2024 | 41 | 4 |
| Luke Shaw | Knee Injury | 1 Aug 2024 | 20 Oct 2024 | 80 | 13 |
| Leny Yoro | Ankle Injury | 29 Jul 2024 | 1 Dec 2024 | 125 | 4 |
 Rasmus Højlund | Hamstring Injury | 28 Jul 2024 | 16 Sept 2024 | 50 | 5 |
 Unknown player | Shoulder Injury | 5 Jun 2024 | 28 Nov 2024 | 176 | 24 |
| Mason Mount | Injury | 10 May 2024 | 22 May 2024 | 12 | 3 |
| Harry Maguire | Muscle Injury | 5 May 2024 | 30 Jun 2024 | 56 | 5 |
| Bruno Fernandes | Knee Injury | 1 May 2024 | 13 May 2024 | 12 | 1 |
| Marcus Rashford | Injury | 22 Apr 2024 | 13 May 2024 | 21 | 4 |
 Willy Kambwala | Injury | 20 Apr 2024 | 20 Jul 2024 | 91 | 7 |
| Mason Mount | Muscle Injury | 15 Apr 2024 | 25 Apr 2024 | 10 | 2 |
| Unknown player | Muscle Injury | 5 Apr 2024 | 1 May 2024 | 26 | 5 |
 Scott McTominay | Knee Injury | 5 Apr 2024 | 13 Jun 2024 | 69 | 2 |
 Unknown player | Muscle Injury | 4 Apr 2024 | 16 May 2024 | 42 | 8 |
| Lisandro Martínez | Calf Injury | 2 Apr 2024 | 1 May 2024 | 29 | 6 |
| Victor Lindelöf | Hamstring Injury | 30 Mar 2024 | 22 May 2024 | 53 | 7 |
| Altay Bayındır | Groin Problems | 15 Mar 2024 | 5 Apr 2024 | 21 | 1 |
| Harry Maguire | Groin Injury | 26 Feb 2024 | 14 Mar 2024 | 17 | 3 |
| Rasmus Højlund | Muscle Injury | 23 Feb 2024 | 8 Mar 2024 | 14 | 3 |
| Luke Shaw | Muscle Injury | 18 Feb 2024 | 10 Jun 2024 | 113 | 18 |
| Lisandro Martínez | Knee Injury | 4 Feb 2024 | 29 Mar 2024 | 54 | 8 |
 Unknown player | Groin Surgery | 24 Jan 2024 | 6 Mar 2024 | 42 | 8 |
 Aaron Wan-Bissaka | Injury | 1 Jan 2024 | 13 Mar 2024 | 72 | 11 |
| Rasmus Højlund | ILL | 29 Dec 2023 | 1 Jan 2024 | 3 | 1 |
| Luke Shaw | Thigh Problems | 24 Dec 2023 | 24 Jan 2024 | 31 | 4 |
| Unknown player | ILL | 22 Dec 2023 | 25 Dec 2023 | 3 | 0 |
| Harry Maguire | Groin Injury | 13 Dec 2023 | 24 Jan 2024 | 42 | 6 |
| Unknown player | ILL | 11 Dec 2023 | 29 Dec 2023 | 18 | 1 |
| Marcus Rashford | ILL | 11 Dec 2023 | 13 Dec 2023 | 2 | 0 |
| Amad Diallo | Fitness | 8 Dec 2023 | 29 Dec 2023 | 21 | 5 |
| Victor Lindelöf | Groin Injury | 7 Dec 2023 | 2 Feb 2024 | 57 | 9 |
| Mason Mount | Calf Injury | 24 Nov 2023 | 13 Mar 2024 | 110 | 21 |
