| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Unknown player | Ankle Injury | 7 Aug 2016 | 9 Sept 2016 | 33 | 4 |
 Unknown player | Ankle Injury | 8 May 2016 | 19 May 2016 | 11 | 2 |
 Unknown player | Injury | 7 Apr 2016 | 5 May 2016 | 28 | 6 |
 Unknown player | Hamstring Injury | 29 Feb 2016 | 22 Mar 2016 | 22 | 0 |
 Unknown player | Groin Injury | 22 Feb 2016 | 9 Sept 2016 | 200 | — |
 Unknown player | Knock | 22 Feb 2016 | 23 Mar 2016 | 30 | 9 |
 Unknown player | Shoulder Injury | 22 Feb 2016 | 7 Mar 2016 | 14 | 5 |
 Unknown player | Hamstring Injury | 22 Feb 2016 | 29 Feb 2016 | 7 | 3 |
 David de Gea | Knee Injury | 18 Feb 2016 | 28 Feb 2016 | 10 | 3 |
| Unknown player | Shoulder Injury | 13 Feb 2016 | 1 Mar 2016 | 17 | 5 |
 Unknown player | Hamstring Injury | 11 Feb 2016 | 3 Mar 2016 | 21 | 5 |
| Unknown player | Hamstring Injury | 9 Feb 2016 | 27 Feb 2016 | 18 | 4 |
 Unknown player | Ankle Injury | 8 Feb 2016 | 4 Apr 2016 | 56 | 11 |
 Unknown player | Knock | 18 Jan 2016 | 14 Mar 2016 | 56 | 12 |
| Unknown player | Ankle Sprain | 4 Jan 2016 | 3 Feb 2016 | 30 | 5 |
| Unknown player | Injury | 8 Dec 2015 | 27 Dec 2015 | 19 | 3 |
 Unknown player | Knock | 8 Dec 2015 | 11 Dec 2015 | 3 | 1 |
 Unknown player | Shoulder Injury | 3 Dec 2015 | 25 Feb 2016 | 84 | 17 |
| Unknown player | Ankle Sprain | 23 Nov 2015 | 10 Dec 2015 | 17 | 4 |
 Unknown player | Knock | 23 Nov 2015 | 14 Dec 2015 | 21 | 5 |
 Paddy McNair | Bruised Ribs | 11 Oct 2015 | 7 Nov 2015 | 27 | 6 |
| Unknown player | Hamstring Strain | 21 Sept 2015 | 15 Oct 2015 | 24 | 4 |
 Luke Shaw | Tibia And Fibula Fracture | 16 Sept 2015 | 30 Jun 2016 | 288 | 51 |
| Unknown player | Injury | 27 Aug 2015 | 1 Sept 2015 | 5 | — |
 Unknown player | Knee Surgery | 15 Aug 2015 | 22 Nov 2015 | 99 | 18 |
| Unknown player | Vein Occlusion | 6 Aug 2015 | 24 Sept 2015 | 49 | 9 |
| Unknown player | Knock | 6 Jul 2015 | 3 Sept 2015 | 59 | 6 |
| David de Gea | Hamstring Injury | 19 May 2015 | 10 Jun 2015 | 22 | 1 |
| Luke Shaw | Facial Injury | 11 May 2015 | 21 May 2015 | 10 | 1 |
 Unknown player | Dead Leg | 7 May 2015 | 14 May 2015 | 7 | 1 |
 Unknown player | Rib Fracture | 20 Apr 2015 | 1 Jun 2015 | 42 | 5 |
| Unknown player | Groin Problems | 13 Apr 2015 | 14 May 2015 | 31 | 4 |
| Unknown player | Ankle Injury | 13 Apr 2015 | 30 Apr 2015 | 17 | 2 |
 Unknown player | Ankle Injury | 12 Apr 2015 | 26 Apr 2015 | 14 | 2 |
| Luke Shaw | Hamstring Injury | 9 Mar 2015 | 16 Apr 2015 | 38 | 5 |
| Unknown player | Hamstring Injury | 1 Jan 2015 | 2 Feb 2015 | 32 | 6 |
| Unknown player | Groin Injury | 24 Dec 2014 | 3 Jan 2015 | 10 | 3 |
| Unknown player | Muscle Injury | 18 Dec 2014 | 29 Dec 2014 | 11 | 3 |
| Unknown player | Dead Leg | 8 Dec 2014 | 1 Jan 2015 | 24 | 5 |
| Unknown player | Groin Injury | 8 Dec 2014 | 25 Dec 2014 | 17 | 3 |
| Unknown player | Hamstring Injury | 1 Dec 2014 | 11 Dec 2014 | 10 | 2 |
| Luke Shaw | Ankle Injury | 24 Nov 2014 | 1 Jan 2015 | 38 | 7 |
| Unknown player | Knee Injury | 19 Nov 2014 | 9 Jan 2015 | 51 | 10 |
| Unknown player | Shoulder Injury | 3 Nov 2014 | 27 Nov 2014 | 24 | 2 |
| Unknown player | Hairline Fracture In The Fibula | 30 Oct 2014 | 8 Dec 2014 | 39 | 5 |
| Unknown player | Shin Injury | 23 Oct 2014 | 11 Dec 2014 | 49 | 7 |
| Paddy McNair | Hamstring Injury | 5 Oct 2014 | 26 Oct 2014 | 21 | 2 |
| Unknown player | Rib Fracture | 29 Sept 2014 | 20 Oct 2014 | 21 | 1 |
| Unknown player | Hamstring Injury | 25 Sept 2014 | 6 Oct 2014 | 11 | 2 |
| Unknown player | Groin Injury | 11 Sept 2014 | 20 Oct 2014 | 39 | 4 |
 Unknown player | Foot Bruise | 8 Sept 2014 | 2 Oct 2014 | 24 | 3 |
| Unknown player | Hamstring Injury | 8 Sept 2014 | 6 Oct 2014 | 28 | 4 |
| Unknown player | Ankle Injury | 21 Aug 2014 | 15 Sept 2014 | 25 | 4 |
| Unknown player | Ankle Injury | 21 Aug 2014 | 29 Sept 2014 | 39 | 6 |
| Unknown player | Knee Injury | 16 Aug 2014 | 8 Dec 2014 | 114 | 15 |
| Luke Shaw | Hamstring Injury | 7 Aug 2014 | 11 Sept 2014 | 35 | 4 |
| Unknown player | Groin Injury | 24 Jul 2014 | 11 Sept 2014 | 49 | 4 |
| Unknown player | Shoulder Injury | 5 May 2014 | 31 May 2014 | 26 | 2 |
| Unknown player | Concussion | 17 Feb 2014 | 6 Mar 2014 | 17 | 2 |
 Unknown player | Calf Injury | 2 Feb 2014 | 15 Apr 2014 | 72 | 13 |
| Unknown player | Knee Injury | 26 Dec 2013 | 6 Jan 2014 | 11 | 4 |
| Unknown player | Wrist Injury | 23 Dec 2013 | 10 Feb 2014 | 49 | 10 |
 Unknown player | Hamstring Injury | 21 Dec 2013 | 25 Feb 2014 | 66 | 14 |
| Unknown player | Back Injury | 5 Dec 2013 | 19 Dec 2013 | 14 | 3 |
| Unknown player | Hamstring Injury | 5 Dec 2013 | 16 Dec 2013 | 11 | 3 |
 Unknown player | Finger Injury | 19 Aug 2013 | 19 Oct 2013 | 61 | 9 |
| Unknown player | Hamstring Injury | 12 Aug 2013 | 9 Sept 2013 | 28 | 3 |
| Unknown player | Groin Injury | 6 Aug 2013 | 30 Aug 2013 | 24 | 3 |
 Unknown player | Hamstring Injury | 5 Aug 2013 | 29 Aug 2013 | 24 | 3 |
| Unknown player | Ankle Injury | 8 Apr 2013 | 19 Aug 2013 | 133 | 10 |
| Unknown player | Hamstring Injury | 10 Mar 2013 | 30 Mar 2013 | 20 | 2 |
| Unknown player | Ankle Injury | 18 Feb 2013 | 1 Apr 2013 | 42 | 7 |
| Unknown player | Knee Injury | 14 Jan 2013 | 11 Feb 2013 | 28 | 5 |
| Unknown player | Hamstring Injury | 12 Jan 2013 | 1 Feb 2013 | 20 | 5 |
| Unknown player | Hamstring Injury | 13 Dec 2012 | 31 Dec 2012 | 18 | 4 |
| Unknown player | Groin Problems | 7 Nov 2012 | 20 Nov 2012 | 13 | 3 |
| Unknown player | Hamstring Injury | 7 Nov 2012 | 15 Jan 2013 | 69 | 16 |
 Unknown player | Knee Injury | 25 Oct 2012 | 27 Dec 2012 | 63 | 15 |
| Unknown player | Knee Injury | 10 Sept 2012 | 8 Nov 2012 | 59 | 13 |
| Unknown player | Knee Injury | 27 Aug 2012 | 8 Oct 2012 | 42 | 7 |
| Unknown player | Back Injury | 6 Aug 2012 | 6 Sept 2012 | 31 | 5 |
| Unknown player | Metatarsal Fracture | 19 Jul 2012 | 1 Nov 2012 | 105 | 19 |
 Unknown player | Ankle Injury | 17 Apr 2012 | 20 May 2012 | 33 | 4 |
| Unknown player | Head Injury | 1 Mar 2012 | 8 Mar 2012 | 7 | 1 |
 Unknown player | Ankle Injury | 23 Feb 2012 | 10 Mar 2012 | 16 | 4 |
 Unknown player | Ankle Injury | 3 Feb 2012 | 10 Mar 2012 | 36 | 7 |
| Unknown player | Ankle Injury | 22 Dec 2011 | 2 Feb 2012 | 42 | 7 |
| Unknown player | Ankle Injury | 5 Dec 2011 | 15 Dec 2011 | 10 | 2 |
 Unknown player | Achilles Tendon Rupture | 30 Nov 2011 | 1 Jan 2012 | 32 | 7 |
| Unknown player | Ankle Injury | 29 Oct 2011 | 1 Feb 2012 | 95 | 18 |
 Danny Welbeck | Torn Muscle Fiber | 29 Aug 2011 | 19 Sept 2011 | 21 | 2 |
| Unknown player | Hamstring Injury | 17 Mar 2011 | 7 Apr 2011 | 21 | 3 |
| Unknown player | Knee Surgery | 15 Mar 2011 | 1 May 2011 | 47 | 10 |
 Unknown player | Thigh Problems | 15 Mar 2011 | 18 Apr 2011 | 34 | 7 |
| Unknown player | Shin Injury | 6 Mar 2011 | 15 Mar 2011 | 9 | 2 |
| Unknown player | Ankle Injury | 5 Feb 2011 | 19 Mar 2011 | 42 | 9 |
| Unknown player | Concussion | 24 Jan 2011 | 31 Jan 2011 | 7 | 2 |
| Unknown player | Calf Problems | 18 Dec 2010 | 17 Jan 2011 | 30 | 5 |
| Unknown player | Hip Problems | 15 Dec 2010 | 3 Jan 2011 | 19 | 3 |
| Unknown player | Dead Leg | 11 Nov 2010 | 18 Nov 2010 | 7 | 1 |
