| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Daniel James | Back Problems | 7 Oct 2026 | 16 Oct 2026 | 9 | 1 |
 Harry Wilson | Hamstring Injury | 17 Sept 2026 | 30 Sept 2026 | 13 | 1 |
 Joe Rodon | Hamstring Injury | 31 Aug 2026 | 30 Oct 2026 | 60 | 7 |
 Wilfried Gnonto | Thigh Problems | 17 Aug 2026 | 28 Aug 2026 | 11 | 2 |
 Gabriel Gudmundsson | Hamstring Injury | 5 Aug 2026 | 28 Aug 2026 | 23 | 5 |
| Gabriel Gudmundsson | Hamstring Injury | 22 May 2026 | 8 Jun 2026 | 17 | 1 |
 Anton Stach | Ankle Injury | 22 May 2026 | 1 Jun 2026 | 10 | 1 |
 Sean Longstaff | Groin Injury | 22 May 2026 | 27 Jul 2026 | 66 | 2 |
 Ilia Gruev | Knee Injury | 22 May 2026 | 14 Sept 2026 | 115 | 1 |
 Noah Okafor | Calf Injury | 22 May 2026 | 28 May 2026 | 6 | 1 |
| Ilia Gruev | Meniscus Injury | 21 Apr 2026 | 21 May 2026 | 30 | 5 |
 Mateo Joseph | Knee Injury | 8 Apr 2026 | Current | 299 | 25 |
| Joe Rodon | Ankle Injury | 5 Apr 2026 | 17 Apr 2026 | 12 | 2 |
| Anton Stach | Ankle Injury | 5 Apr 2026 | 24 Apr 2026 | 19 | 4 |
| Daniel James | Adductor Injury | 1 Apr 2026 | 21 Apr 2026 | 20 | 3 |
| Noah Okafor | Hamstring Injury | 16 Feb 2026 | 16 Mar 2026 | 28 | 5 |
 Dominic Calvert-Lewin | ILL | 8 Feb 2026 | 11 Feb 2026 | 3 | 1 |
 Pascal Struijk | Hip Problems | 7 Feb 2026 | 20 Feb 2026 | 13 | 2 |
| Anton Stach | Hip Injury | 1 Feb 2026 | 16 Feb 2026 | 15 | 3 |
 Lukas Nmecha | Thigh Problems | 30 Jan 2026 | 2 Feb 2026 | 3 | 1 |
| Gabriel Gudmundsson | Adductor Pain | 18 Jan 2026 | 30 Jan 2026 | 12 | 1 |
| Anton Stach | Muscle Injury | 16 Jan 2026 | 19 Jan 2026 | 3 | 1 |
 Jaka Bijol | Muscle Injury | 12 Jan 2026 | 4 Feb 2026 | 23 | 3 |
| Sean Longstaff | Rest | 5 Jan 2026 | 8 Jan 2026 | 3 | 1 |
 Jayden Bogle | Calf Injury | 2 Jan 2026 | 16 Jan 2026 | 14 | 3 |
| Joe Rodon | Ankle Injury | 29 Dec 2025 | 5 Jan 2026 | 7 | 2 |
| Lukas Nmecha | Hamstring Injury | 4 Dec 2025 | 25 Dec 2025 | 21 | 3 |
| Daniel James | Hamstring Injury | 30 Nov 2025 | 1 Feb 2026 | 63 | 12 |
| Sean Longstaff | Calf Injury | 24 Nov 2025 | 2 Jan 2026 | 39 | 7 |
| Anton Stach | Head Injury | 22 Nov 2025 | 4 Dec 2025 | 12 | 2 |
 Sebastiaan Bornauw | Knee Injury | 7 Nov 2025 | 30 Nov 2025 | 23 | 3 |
| Noah Okafor | Adductor Pain | 16 Oct 2025 | 20 Oct 2025 | 4 | 1 |
| Daniel James | Ankle Injury | 29 Sept 2025 | 13 Oct 2025 | 14 | 1 |
| Wilfried Gnonto | Calf Injury | 19 Sept 2025 | 17 Nov 2025 | 59 | 7 |
| Daniel James | Muscle Injury | 15 Sept 2025 | 22 Sept 2025 | 7 | 1 |
 Lucas Perri | Arm Injury | 12 Sept 2025 | 13 Oct 2025 | 31 | 4 |
Unknown player | Calf Injury | 8 Sept 2025 | 17 Oct 2025 | 39 | 4 |
 Ao Tanaka | Inner Ligament Injury | 24 Aug 2025 | 12 Sept 2025 | 19 | 2 |
 Ethan Ampadu | Inner Ligament Injury | 22 Aug 2025 | 1 Sept 2025 | 10 | 3 |
| Dominic Calvert-Lewin | Fitness | 15 Aug 2025 | 25 Aug 2025 | 10 | 1 |
| Ethan Ampadu | Knee Injury | 24 Feb 2025 | 15 Apr 2025 | 50 | 9 |
 Maximilian Wöber | Knee Surgery | 10 Feb 2025 | 30 Mar 2025 | 48 | 7 |
Unknown player | Muscle Injury | 2 Jan 2025 | 1 Apr 2025 | 89 | 16 |
| Maximilian Wöber | Injury | 20 Dec 2024 | 30 Dec 2024 | 10 | 2 |
Unknown player | Ankle Injury | 22 Oct 2024 | 23 Nov 2024 | 32 | 5 |
| Ilia Gruev | Knee Surgery | 1 Oct 2024 | 12 Jan 2025 | 103 | 19 |
| Ethan Ampadu | Knee Injury | 28 Sept 2024 | 3 Dec 2024 | 66 | 18 |
Unknown player | Hamstring Injury | 18 Sept 2024 | 17 Oct 2024 | 29 | 4 |
| Maximilian Wöber | Knee Surgery | 13 Sept 2024 | 28 Oct 2024 | 45 | 8 |
| Daniel James | Hamstring Injury | 29 Aug 2024 | 16 Oct 2024 | 48 | 6 |
 Darko Gyabi | Groin Surgery | 27 Mar 2024 | 30 Jun 2024 | 95 | 11 |
| Ilia Gruev | Ankle Injury | 25 Mar 2024 | 3 Apr 2024 | 9 | 2 |
Unknown player | Hamstring Injury | 11 Feb 2024 | 25 Feb 2024 | 14 | 3 |
| Pascal Struijk | Groin Injury | 28 Dec 2023 | 14 May 2024 | 138 | 25 |
Unknown player | Strain In The Thigh And Gluteal Muscles | 11 Dec 2023 | 5 Jan 2024 | 25 | — |
Unknown player | Hamstring Injury | 9 Dec 2023 | 23 Dec 2023 | 14 | 3 |
Unknown player | Injury | 21 Nov 2023 | 6 Dec 2023 | 15 | 13 |
| Pascal Struijk | Inguinal Hernia | 10 Nov 2023 | 20 Nov 2023 | 10 | 1 |
Unknown player | Strain In The Thigh And Gluteal Muscles | 1 Nov 2023 | 22 Nov 2023 | 21 | 2 |
| Wilfried Gnonto | Ankle Injury | 20 Sept 2023 | 20 Oct 2023 | 30 | 5 |
 Djed Spence | Outer Ligament Problems | 18 Sept 2023 | 18 Nov 2023 | 61 | 10 |
Unknown player | Foot Injury | 15 Aug 2023 | 18 Sept 2023 | 34 | 4 |
 Junior Firpo | Knee Collateral Ligament Tear | 8 Aug 2023 | 6 Sept 2023 | 29 | 6 |
Unknown player | Groin Injury | 8 Aug 2023 | 30 Aug 2023 | 22 | 4 |
Unknown player | Hamstring Injury | 31 Jul 2023 | 25 Sept 2023 | 56 | 10 |
Unknown player | Injury | 4 Jul 2023 | 5 Jul 2023 | 1 | 0 |
Unknown player | Injury | 26 May 2023 | 5 Jul 2023 | 40 | 1 |
Unknown player | Ankle Injury | 26 Apr 2023 | 1 Jun 2023 | 36 | 5 |
| Wilfried Gnonto | Doubtful | 1 Apr 2023 | 1 Apr 2023 | 0 | 1 |
| Maximilian Wöber | Hamstring Injury | 24 Mar 2023 | 15 Apr 2023 | 22 | 3 |
 Tyler Adams | Hamstring Injury | 15 Mar 2023 | 7 Jun 2023 | 84 | — |
Unknown player | Muscle Injury | 8 Feb 2023 | 10 Mar 2023 | 30 | 6 |
Unknown player | Ankle Injury | 29 Jan 2023 | 10 Mar 2023 | 40 | 7 |
Unknown player | Injury | 13 Jan 2023 | 30 Jan 2023 | 17 | 4 |
Unknown player | Groin Problems | 5 Nov 2022 | 31 Dec 2022 | 56 | 7 |
Unknown player | Foot Injury | 23 Oct 2022 | 19 Dec 2022 | 57 | 7 |
Unknown player | Knock | 1 Sept 2022 | 4 Sept 2022 | 3 | 0 |
| Junior Firpo | Knee Injury | 8 Jul 2022 | 12 Sept 2022 | 66 | 11 |
Unknown player | Femoral Fracture | 30 Apr 2022 | 10 Apr 2024 | 711 | — |
Unknown player | Ankle Injury | 23 Apr 2022 | 30 Jun 2022 | 68 | 6 |
Unknown player | Broken Kneecap | 22 Apr 2022 | 30 Jun 2022 | 69 | 6 |
 Joe Gelhardt | Doubtful | 9 Apr 2022 | 9 Apr 2022 | 0 | 1 |
Unknown player | Doubtful | 9 Apr 2022 | 9 Apr 2022 | 0 | 1 |
Unknown player | Foot Injury | 27 Mar 2022 | 1 Jul 2022 | 96 | 8 |
 Raphinha | COVID 19 | 17 Mar 2022 | 31 Mar 2022 | 14 | 1 |
| Junior Firpo | Collateral Ligament Injury | 11 Mar 2022 | 11 Apr 2022 | 31 | 4 |
Unknown player | Torn Thigh Muscle | 7 Mar 2022 | 27 May 2022 | 81 | 11 |
 Diego Llorente | Doubtful | 5 Mar 2022 | 6 Aug 2024 | 885 | — |
Unknown player | Doubtful | 5 Mar 2022 | 6 Aug 2024 | 885 | — |
| Junior Firpo | Hamstring Strain | 16 Jan 2022 | 14 Feb 2022 | 29 | 4 |
 Charlie Cresswell | Shoulder Injury | 18 Dec 2021 | 18 Feb 2022 | 62 | 0 |
Unknown player | Heel Problems | 9 Dec 2021 | 14 Jan 2022 | 36 | 5 |
Unknown player | Hamstring Injury | 7 Dec 2021 | 28 Feb 2022 | 83 | 12 |
Unknown player | Hamstring Injury | 5 Dec 2021 | 14 Mar 2022 | 99 | 15 |
Unknown player | Hamstring Injury | 2 Dec 2021 | 14 Mar 2022 | 102 | 15 |
| Pascal Struijk | Hip Injury | 1 Dec 2021 | 14 Jan 2022 | 44 | 6 |
 Robin Koch | ILL | 29 Nov 2021 | 17 Dec 2021 | 18 | 4 |
| Raphinha | ILL | 19 Nov 2021 | 22 Nov 2021 | 3 | 1 |
Unknown player | Ankle Injury | 18 Sept 2021 | 28 Nov 2021 | 71 | 9 |
Unknown player | Knee Injury | 17 Sept 2021 | 28 Nov 2021 | 72 | 10 |
