| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Jean-Philippe Mateta | Hamstring Injury | 23 Aug 2026 | Current | — | 4 |
 Chadi Riad | Knee Surgery | 22 Aug 2026 | Current | — | 5 |
 Ismaïla Sarr | Groin Injury | 20 Aug 2026 | Current | — | 5 |
 Adam Wharton | Groin Problems | 17 Apr 2026 | 24 Apr 2026 | 7 | 1 |
 Evann Guessand | Knee Injury | 9 Apr 2026 | 17 May 2026 | 38 | 10 |
 Eddie Nketiah | Hamstring Injury | 8 Apr 2026 | 15 Jun 2026 | 68 | 13 |
 Cheick Doucouré | Muscle Injury | 2 Apr 2026 | 16 Apr 2026 | 14 | 2 |
 Dean Henderson | ILL | 13 Mar 2026 | 20 Mar 2026 | 7 | 1 |
 Daniel Muñoz | Shoulder Injury | 5 Mar 2026 | 16 Mar 2026 | 11 | 3 |
| Jean-Philippe Mateta | Knee Problems | 31 Jan 2026 | 9 Mar 2026 | 37 | 5 |
 Unknown player | Ankle Injury | 30 Jan 2026 | 10 Feb 2026 | 11 | 2 |
 Unknown player | Adductor Injury | 6 Jan 2026 | 26 Jan 2026 | 20 | 4 |
 Jefferson Lerma | Head Injury | 6 Jan 2026 | 12 Jan 2026 | 6 | 2 |
| Eddie Nketiah | Thigh Problems | 31 Dec 2025 | 31 Mar 2026 | 90 | 12 |
 Chris Richards | Foot Injury | 23 Dec 2025 | 5 Jan 2026 | 13 | 2 |
 Unknown player | Muscle Injury | 17 Dec 2025 | 1 Feb 2026 | 46 | 8 |
| Chadi Riad | Fitness | 15 Dec 2025 | 10 Jan 2026 | 26 | 7 |
 Daichi Kamada | Hamstring Injury | 14 Dec 2025 | 2 Feb 2026 | 50 | 15 |
| Daniel Muñoz | Knee Injury | 6 Dec 2025 | 19 Jan 2026 | 44 | 11 |
| Ismaïla Sarr | Ankle Problems | 1 Dec 2025 | 12 Dec 2025 | 11 | 3 |
 Borna Sosa | Knock | 25 Nov 2025 | 5 Dec 2025 | 10 | 3 |
 Marc Guéhi | Ankle Injury | 6 Nov 2025 | 21 Nov 2025 | 15 | 2 |
| Unknown player | Adductor Pain | 3 Nov 2025 | 1 Dec 2025 | 28 | 2 |
| Eddie Nketiah | Thigh Problems | 30 Oct 2025 | 21 Nov 2025 | 22 | 3 |
| Adam Wharton | ILL | 27 Oct 2025 | 3 Nov 2025 | 7 | 2 |
 Walter Benítez | Finger Injury | 19 Sept 2025 | 29 Sept 2025 | 10 | 2 |
| Ismaïla Sarr | Injury | 3 Sept 2025 | 23 Sept 2025 | 20 | 3 |
 Odsonne Édouard | Achilles Tendon Contusion | 27 Aug 2025 | 11 Sept 2025 | 15 | 2 |
| Daichi Kamada | Knee Problems | 11 Aug 2025 | 25 Aug 2025 | 14 | 2 |
| Eddie Nketiah | Hamstring Injury | 2 Aug 2025 | 18 Sept 2025 | 47 | 8 |
 Unknown player | Adductor Tear | 13 Jul 2025 | 29 Aug 2025 | 47 | 4 |
| Marc Guéhi | Concussion | 12 May 2025 | 7 Jun 2025 | 26 | 3 |
| Adam Wharton | Ankle Injury | 6 May 2025 | 12 May 2025 | 6 | 0 |
 Unknown player | ILL | 11 Apr 2025 | 15 Apr 2025 | 4 | 1 |
 Unknown player | ILL | 11 Apr 2025 | 15 Apr 2025 | 4 | 1 |
| Chris Richards | Calf Problems | 1 Apr 2025 | 11 Apr 2025 | 10 | 2 |
| Jean-Philippe Mateta | Head Injury | 8 Mar 2025 | 29 Mar 2025 | 21 | 2 |
| Ismaïla Sarr | ILL | 7 Feb 2025 | 12 Feb 2025 | 5 | 1 |
| Eddie Nketiah | Ankle Injury | 6 Feb 2025 | 11 Feb 2025 | 5 | 0 |
 Eberechi Eze | Foot Injury | 3 Feb 2025 | 11 Feb 2025 | 8 | 0 |
| Jefferson Lerma | Doubtful | 26 Jan 2025 | 26 Jan 2025 | 0 | 1 |
 Unknown player | Calf Injury | 24 Jan 2025 | 9 Mar 2025 | 44 | 7 |
| Chadi Riad | Cruciate Ligament Tear | 24 Jan 2025 | 15 Dec 2025 | 325 | 41 |
| Cheick Doucouré | Knee Surgery | 24 Jan 2025 | 1 Mar 2026 | 401 | 22 |
| Dean Henderson | ILL | 12 Jan 2025 | 15 Jan 2025 | 3 | 1 |
 Will Hughes | Leg Injury | 30 Dec 2024 | 6 Jan 2025 | 7 | 1 |
| Unknown player | Calf Injury | 8 Dec 2024 | 18 Dec 2024 | 10 | 1 |
| Adam Wharton | Groin Surgery | 1 Nov 2024 | 1 Feb 2025 | 92 | 6 |
| Eberechi Eze | Hamstring Injury | 30 Oct 2024 | 25 Nov 2024 | 26 | 4 |
| Chris Richards | Hamstring Injury | 27 Sept 2024 | 3 Nov 2024 | 37 | 5 |
| Cheick Doucouré | Toe Injury | 15 Sept 2024 | 28 Oct 2024 | 43 | 5 |
| Chadi Riad | Doubtful | 1 Sept 2024 | 1 Sept 2024 | 0 | 1 |
| Chadi Riad | Knee Injury | 28 Aug 2024 | 9 Dec 2024 | 103 | 5 |
 Unknown player | Hamstring Injury | 23 Apr 2024 | 1 May 2024 | 8 | 2 |
| Jefferson Lerma | Hamstring Injury | 15 Apr 2024 | 15 May 2024 | 30 | 5 |
| Chris Richards | Knee Problems | 1 Apr 2024 | 19 Apr 2024 | 18 | 3 |
 Unknown player | Elbow Injury | 24 Mar 2024 | 14 Jul 2024 | 112 | 10 |
| Odsonne Édouard | Knee Injury | 13 Mar 2024 | 15 Apr 2024 | 33 | 5 |
| Unknown player | Rib Fracture | 9 Mar 2024 | 26 Feb 2025 | 354 | 25 |
| Unknown player | Ankle Surgery | 29 Feb 2024 | 21 Aug 2024 | 174 | 69 |
 Unknown player | Injury | 20 Feb 2024 | 10 Apr 2024 | 50 | 7 |
| Marc Guéhi | Knee Problems | 3 Feb 2024 | 1 May 2024 | 88 | 14 |
 Michael Olise | Hamstring Injury | 3 Feb 2024 | 3 Apr 2024 | 60 | 8 |
| Eberechi Eze | Muscle Injury | 30 Jan 2024 | 1 Mar 2024 | 31 | 5 |
| Unknown player | Hamstring Injury | 17 Dec 2023 | 6 Feb 2024 | 51 | 8 |
| Odsonne Édouard | Knee Injury | 10 Dec 2023 | 29 Dec 2023 | 19 | 3 |
| Unknown player | Calf Injury | 10 Dec 2023 | 16 Jan 2024 | 37 | 5 |
| Unknown player | Injury | 1 Dec 2023 | 10 Jan 2024 | 40 | 8 |
| Cheick Doucouré | Achilles Tendon Rupture | 26 Nov 2023 | 30 May 2024 | 186 | 28 |
| Eberechi Eze | Ankle Injury | 25 Nov 2023 | 14 Dec 2023 | 19 | 4 |
 Unknown player | Hamstring Injury | 2 Nov 2023 | 15 Apr 2024 | 165 | 27 |
| Cheick Doucouré | Dead Leg | 6 Oct 2023 | 18 Oct 2023 | 12 | 1 |
| Eberechi Eze | Hamstring Injury | 3 Oct 2023 | 1 Nov 2023 | 29 | 3 |
| Dean Henderson | Hamstring Injury | 27 Sept 2023 | 15 Dec 2023 | 79 | 10 |
| Odsonne Édouard | Hamstring Injury | 24 Sept 2023 | 8 Oct 2023 | 14 | 3 |
| Jefferson Lerma | Injury | 15 Sept 2023 | 19 Oct 2023 | 34 | 5 |
| Marc Guéhi | Hip Injury | 13 Sept 2023 | 20 Sept 2023 | 7 | 1 |
 Unknown player | Injury | 18 Aug 2023 | 16 Sept 2023 | 29 | 4 |
| Unknown player | Back Injury | 5 Aug 2023 | 20 Oct 2023 | 76 | 11 |
| Michael Olise | Muscle Tear | 26 Jun 2023 | 8 Nov 2023 | 135 | 20 |
 Unknown player | Injury | 26 May 2023 | 4 Jul 2023 | 39 | 1 |
 Unknown player | Injury | 26 May 2023 | 4 Jul 2023 | 39 | 1 |
 Unknown player | Injury | 13 May 2023 | 5 Aug 2023 | 84 | 9 |
| Unknown player | Injury | 1 Apr 2023 | 26 Apr 2023 | 25 | 4 |
 Naouirou Ahamada | Ankle Injury | 20 Mar 2023 | 12 May 2023 | 53 | 7 |
| Unknown player | Injury | 21 Jan 2023 | 26 Feb 2023 | 36 | 4 |
 Joachim Andersen | Calf Injury | 15 Jan 2023 | 15 Feb 2023 | 31 | 5 |
| Odsonne Édouard | Dead Leg | 4 Nov 2022 | 11 Nov 2022 | 7 | 2 |
| Chris Richards | Leg Injury | 18 Sept 2022 | 14 Nov 2022 | 57 | 9 |
| Unknown player | Injury | 20 Aug 2022 | 28 Aug 2022 | 8 | 2 |
 Jack Butland | Broken Finger | 19 Jul 2022 | 13 Nov 2022 | 117 | 20 |
| Michael Olise | Inflammation Of The Sole Of The Foot | 1 Apr 2022 | 13 Apr 2022 | 12 | 2 |
| Unknown player | Doubtful | 5 Mar 2022 | 6 Aug 2024 | 885 | — |
 Unknown player | Achilles Tendon Problems | 30 Jan 2022 | 31 Oct 2022 | 274 | 42 |
| Joachim Andersen | Doubtful | 30 Nov 2021 | 5 Jul 2023 | 582 | — |
| Joachim Andersen | Hamstring Injury | 23 Nov 2021 | 13 Dec 2021 | 20 | 3 |
| Unknown player | Injury | 11 Oct 2021 | 19 Oct 2021 | 8 | 0 |
| Unknown player | Achilles Tendon Problems | 24 May 2021 | 27 Nov 2021 | 187 | 18 |
 Unknown player | Doubtful | 19 May 2021 | 5 Jul 2023 | 777 | — |
 Unknown player | Doubtful | 19 May 2021 | 5 Jul 2023 | 777 | — |
