| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Moisés Caicedo | Injury | 30 Aug 2026 | Current | — | 4 |
| Moisés Caicedo | Knock | 22 Aug 2026 | 29 Aug 2026 | 7 | 2 |
 Marco Palestra | Injury | 22 Aug 2026 | Current | — | 6 |
 Aarón Anselmino | Hamstring Injury | 9 Aug 2026 | 10 Aug 2026 | 1 | — |
 Emmanuel Emegha | Hamstring Injury | 24 Jul 2026 | 10 Aug 2026 | 17 | — |
 Jordan Henderson | Forearm Fracture | 6 Jul 2026 | — | — | 0 |
 Roméo Lavia | Muscle Injury | 12 May 2026 | 1 Jun 2026 | 20 | 3 |
 Robert Sánchez | Head Injury | 4 May 2026 | 12 May 2026 | 8 | 2 |
 Unknown player | Concussion | 4 May 2026 | 31 May 2026 | 27 | 0 |
 Alejandro Garnacho | Muscle Injury | 3 May 2026 | 15 May 2026 | 12 | 2 |
 Pedro Neto | Muscle Injury | 3 May 2026 | 15 May 2026 | 12 | 2 |
 Cole Palmer | Hamstring Injury | 19 Apr 2026 | 25 Apr 2026 | 6 | 1 |
 Estêvão | Hamstring Injury | 18 Apr 2026 | 8 Jul 2026 | 81 | 8 |
 João Pedro | Thigh Problems | 17 Apr 2026 | 24 Apr 2026 | 7 | 2 |
 Jamie Gittens | Hamstring Injury | 3 Apr 2026 | 29 Jun 2026 | 87 | 9 |
 Trevoh Chalobah | Ankle Injury | 17 Mar 2026 | 17 Apr 2026 | 31 | 4 |
 Filip Jørgensen | Groin Surgery | 16 Mar 2026 | 1 May 2026 | 46 | 7 |
 Benoît Badiashile | ILL | 16 Mar 2026 | 20 Mar 2026 | 4 | 1 |
 Reece James | Hamstring Injury | 15 Mar 2026 | 3 May 2026 | 49 | 7 |
 Malo Gusto | ILL | 15 Mar 2026 | 19 Mar 2026 | 4 | 1 |
| Filip Jørgensen | Groin Problems | 13 Mar 2026 | 15 Mar 2026 | 2 | 1 |
| Estêvão | Hamstring Injury | 20 Feb 2026 | 16 Mar 2026 | 24 | 5 |
 Marc Cucurella | Hamstring Injury | 10 Feb 2026 | 3 Mar 2026 | 21 | 4 |
| Reece James | Knock | 1 Feb 2026 | 11 Feb 2026 | 10 | 1 |
| Jamie Gittens | Hamstring Injury | 1 Feb 2026 | 31 Mar 2026 | 58 | 11 |
| Pedro Neto | Knock | 1 Feb 2026 | 6 Feb 2026 | 5 | 1 |
| Aarón Anselmino | Dead Leg | 25 Jan 2026 | 11 Feb 2026 | 17 | 5 |
| Filip Jørgensen | Injury | 21 Jan 2026 | 22 Feb 2026 | 32 | 1 |
| Cole Palmer | Knock | 20 Jan 2026 | 26 Jan 2026 | 6 | 2 |
 Tosin Adarabioyo | Hamstring Injury | 17 Jan 2026 | 13 Feb 2026 | 27 | 8 |
| Roméo Lavia | Fitness | 16 Jan 2026 | 9 Feb 2026 | 24 | 7 |
 Dário Essugo | Injury | 16 Jan 2026 | 1 Mar 2026 | 44 | 7 |
| Estêvão | ILL | 15 Jan 2026 | 20 Jan 2026 | 5 | 1 |
 Liam Delap | ILL | 13 Jan 2026 | 16 Jan 2026 | 3 | 1 |
| Jamie Gittens | ILL | 13 Jan 2026 | 18 Jan 2026 | 5 | 1 |
| Reece James | Hip Problems | 9 Jan 2026 | 16 Jan 2026 | 7 | 2 |
| Malo Gusto | ILL | 9 Jan 2026 | 18 Jan 2026 | 9 | 3 |
| Cole Palmer | Thigh Problems | 9 Jan 2026 | 16 Jan 2026 | 7 | 2 |
| Robert Sánchez | Muscle Injury | 3 Jan 2026 | 6 Jan 2026 | 3 | 1 |
 Wesley Fofana | Fever | 31 Dec 2025 | 6 Jan 2026 | 6 | 3 |
| Marc Cucurella | Hamstring Injury | 27 Dec 2025 | 5 Jan 2026 | 9 | 2 |
 Jorrel Hato | Injury | 20 Dec 2025 | 31 Dec 2025 | 11 | 2 |
| Jamie Gittens | Shoulder Injury | 19 Dec 2025 | 24 Dec 2025 | 5 | 1 |
| Estêvão | Muscle Injury | 14 Dec 2025 | 25 Dec 2025 | 11 | 2 |
| Liam Delap | Shoulder Injury | 6 Dec 2025 | 25 Dec 2025 | 19 | 5 |
| Wesley Fofana | Rest | 2 Dec 2025 | 4 Dec 2025 | 2 | 1 |
| Dário Essugo | Fitness | 28 Nov 2025 | — | — | 52 |
| Wesley Fofana | Rest | 21 Nov 2025 | 23 Nov 2025 | 2 | 1 |
| Cole Palmer | Broken Toe | 19 Nov 2025 | 28 Nov 2025 | 9 | 2 |
| Roméo Lavia | Muscle Strain | 5 Nov 2025 | 16 Jan 2026 | 72 | 17 |
| Pedro Neto | Muscle Injury | 1 Nov 2025 | 7 Nov 2025 | 6 | 2 |
 Caleb Wiley | Adductor Injury | 20 Oct 2025 | 10 Aug 2026 | 294 | 53 |
| Benoît Badiashile | Muscle Injury | 17 Oct 2025 | 21 Nov 2025 | 35 | 7 |
 Enzo Fernández | Knee Problems | 14 Oct 2025 | 20 Oct 2025 | 6 | 1 |
 Andrey Santos | Injury | 28 Sept 2025 | 13 Oct 2025 | 15 | 2 |
| Wesley Fofana | Concussion | 24 Sept 2025 | 20 Oct 2025 | 26 | 4 |
| Tosin Adarabioyo | Calf Problems | 21 Sept 2025 | 12 Oct 2025 | 21 | 4 |
| Cole Palmer | Groin Injury | 20 Sept 2025 | 18 Nov 2025 | 59 | 15 |
 Josh Acheampong | ILL | 19 Sept 2025 | 24 Sept 2025 | 5 | 1 |
| Estêvão | ILL | 12 Sept 2025 | 15 Sept 2025 | 3 | 1 |
| Dário Essugo | Surgery | 8 Sept 2025 | 8 Jan 2026 | 122 | 16 |
| Liam Delap | Hamstring Injury | 31 Aug 2025 | 28 Oct 2025 | 58 | 10 |
| Cole Palmer | Groin Problems | 21 Aug 2025 | 11 Sept 2025 | 21 | 2 |
| Tosin Adarabioyo | Injury | 16 Aug 2025 | 18 Aug 2025 | 2 | 0 |
| Benoît Badiashile | Muscle Injury | 1 Jul 2025 | 24 Sept 2025 | 85 | 8 |
| Benoît Badiashile | Muscle Strain | 29 Jun 2025 | 15 Jul 2025 | 16 | 3 |
| Roméo Lavia | Muscle Strain | 29 Jun 2025 | 24 Sept 2025 | 87 | 2 |
 Unknown player | Fitness | 11 Jun 2025 | 1 Sept 2025 | 82 | — |
 Christopher Nkunku | Knock | 30 Apr 2025 | 26 May 2025 | 26 | 5 |
| Malo Gusto | Muscle Injury | 20 Apr 2025 | 28 Apr 2025 | 8 | 2 |
| Wesley Fofana | Surgery | 1 Apr 2025 | 1 Jul 2025 | 91 | 18 |
| Roméo Lavia | Thigh Problems | 17 Mar 2025 | 18 Apr 2025 | 32 | 4 |
| Cole Palmer | Hamstring Injury | 15 Mar 2025 | 3 Apr 2025 | 19 | 1 |
 Omari Kellyman | Fitness | 10 Mar 2025 | — | — | 96 |
| Reece James | ILL | 8 Mar 2025 | 12 Mar 2025 | 4 | 1 |
| Malo Gusto | Ankle Injury | 7 Mar 2025 | 15 Mar 2025 | 8 | 2 |
| Trevoh Chalobah | Injury | 23 Feb 2025 | 4 Mar 2025 | 9 | 1 |
| Trevoh Chalobah | Back Injury | 22 Feb 2025 | 6 Mar 2025 | 12 | 2 |
| Aarón Anselmino | Hamstring Injury | 20 Feb 2025 | 12 May 2025 | 81 | 16 |
 Noni Madueke | Hamstring Injury | 14 Feb 2025 | 2 Apr 2025 | 47 | 7 |
 Marc Guiu | Hamstring Injury | 3 Feb 2025 | 12 May 2025 | 98 | 9 |
 Nicolas Jackson | Hamstring Injury | 3 Feb 2025 | 1 Apr 2025 | 57 | 2 |
 Unknown player | Injury | 25 Jan 2025 | — | — | 104 |
 Levi Colwill | Knock | 16 Jan 2025 | 23 Jan 2025 | 7 | 1 |
| Roméo Lavia | Hamstring Injury | 16 Jan 2025 | 7 Mar 2025 | 50 | 7 |
| Enzo Fernández | Knock | 16 Jan 2025 | 23 Jan 2025 | 7 | 1 |
| Noni Madueke | ILL | 10 Jan 2025 | 13 Jan 2025 | 3 | 1 |
 Kiernan Dewsbury-Hall | Knock | 25 Dec 2024 | 16 Jan 2025 | 22 | 5 |
 Carney Chukwuemeka | ILL | 20 Dec 2024 | 31 Dec 2024 | 11 | 4 |
| Benoît Badiashile | Hamstring Injury | 14 Dec 2024 | 3 Mar 2025 | 79 | 16 |
 Ben Chilwell | ILL | 13 Dec 2024 | 20 Dec 2024 | 7 | 1 |
| Unknown player | Injury | 11 Dec 2024 | 18 Dec 2024 | 7 | 2 |
| Roméo Lavia | Hamstring Injury | 9 Dec 2024 | 7 Jan 2025 | 29 | 2 |
 Unknown player | Knee Injury | 7 Dec 2024 | 29 May 2025 | 173 | 9 |
 Mykhaylo Mudryk | ILL | 3 Dec 2024 | 16 Dec 2024 | 13 | 2 |
| Wesley Fofana | Hamstring Injury | 1 Dec 2024 | 24 Feb 2025 | 85 | 18 |
| Malo Gusto | ILL | 22 Nov 2024 | 29 Nov 2024 | 7 | 1 |
| Reece James | Hamstring Injury | 19 Nov 2024 | 27 Dec 2024 | 38 | 10 |
| Pedro Neto | Injury | 17 Nov 2024 | 29 Nov 2024 | 12 | 1 |
 Gabriel Slonina | Finger Injury | 8 Nov 2024 | 3 Feb 2025 | 87 | 17 |
