| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Antonio Rüdiger | Groin Injury | 24 Sept 2018 | 1 Oct 2018 | 7 | 2 |
Unknown player | Achilles Heel Problems | 23 Sept 2018 | 3 Oct 2018 | 10 | 3 |
 Ruben Loftus-Cheek | Knock | 21 Sept 2018 | 3 Oct 2018 | 12 | 3 |
 Emerson | Knock | 13 Sept 2018 | 25 Sept 2018 | 12 | 3 |
| Ruben Loftus-Cheek | Foot Injury | 13 Sept 2018 | 19 Sept 2018 | 6 | 1 |
Cesc Fàbregas | Knee Problems | 10 Aug 2018 | 15 Sept 2018 | 36 | 4 |
Unknown player | Knock | 9 Aug 2018 | 19 Sept 2018 | 41 | 5 |
 Mateo Kovacic | Knock | 9 Aug 2018 | 17 Aug 2018 | 8 | 1 |
Unknown player | Knee Injury | 1 Jun 2018 | 12 Jan 2021 | 956 | 128 |
Unknown player | Calf Injury | 11 Apr 2018 | 1 Jun 2018 | 51 | 8 |
Unknown player | Knee Injury | 1 Apr 2018 | 13 May 2018 | 42 | 8 |
 Thibaut Courtois | Muscular Problems | 15 Mar 2018 | 5 Apr 2018 | 21 | 2 |
 Ethan Ampadu | Broken Ankle | 14 Mar 2018 | 1 Jul 2018 | 109 | 12 |
Unknown player | Circulation Problems | 1 Mar 2018 | 5 Mar 2018 | 4 | 1 |
| Ethan Ampadu | Hamstring Injury | 23 Feb 2018 | 9 Mar 2018 | 14 | 2 |
Unknown player | Ankle Injury | 10 Feb 2018 | 31 Mar 2018 | 49 | 8 |
 Ross Barkley | Hamstring Injury | 2 Feb 2018 | 30 Mar 2018 | 56 | 9 |
 Andreas Christensen | Hamstring Injury | 28 Jan 2018 | 9 Feb 2018 | 12 | 3 |
Unknown player | Ankle Problems | 25 Jan 2018 | 2 Feb 2018 | 8 | 2 |
Unknown player | Achilles Tendon Problems | 24 Jan 2018 | 2 Feb 2018 | 9 | 3 |
 Álvaro Morata | Back Injury | 19 Jan 2018 | 9 Feb 2018 | 21 | 5 |
| Thibaut Courtois | Ankle Problems | 18 Jan 2018 | 29 Jan 2018 | 11 | 2 |
Cesc Fàbregas | Hamstring Injury | 14 Jan 2018 | 29 Jan 2018 | 15 | 3 |
| Álvaro Morata | Back Problems | 10 Dec 2017 | 13 Dec 2017 | 3 | 1 |
Unknown player | Knee Injury | 26 Nov 2017 | 5 Jan 2018 | 40 | 11 |
Unknown player | Ankle Injury | 9 Nov 2017 | 30 Nov 2017 | 21 | 3 |
Unknown player | Hamstring Injury | 14 Oct 2017 | 25 Nov 2017 | 42 | 9 |
Unknown player | Hamstring Injury | 5 Oct 2017 | 6 Nov 2017 | 32 | 7 |
| Álvaro Morata | Hamstring Injury | 30 Sept 2017 | 18 Oct 2017 | 18 | 2 |
Unknown player | Calf Injury | 11 Sept 2017 | 25 Oct 2017 | 44 | 9 |
Unknown player | Ankle Injury | 7 Aug 2017 | 18 Aug 2017 | 11 | 1 |
Unknown player | Ankle Surgery | 5 Jun 2017 | 24 Aug 2017 | 80 | 6 |
Unknown player | Knee Surgery | 25 May 2017 | 20 Aug 2017 | 87 | 10 |
| Thibaut Courtois | Ankle Injury | 13 Apr 2017 | 20 Apr 2017 | 7 | 1 |
Unknown player | Calf Injury | 18 Mar 2017 | 7 Apr 2017 | 20 | 3 |
Unknown player | Calf Injury | 16 Mar 2017 | 30 Mar 2017 | 14 | 1 |
Unknown player | Knock | 12 Dec 2016 | 15 Dec 2016 | 3 | 1 |
Unknown player | ILL | 8 Dec 2016 | 17 Dec 2016 | 9 | 2 |
 Nemanja Matić | Knock | 27 Nov 2016 | 10 Dec 2016 | 13 | 1 |
Cesc Fàbregas | Thigh Problems | 14 Oct 2016 | 18 Nov 2016 | 35 | 5 |
Unknown player | Knee Injury | 5 Aug 2016 | 29 Oct 2016 | 85 | 13 |
| Nemanja Matić | Calf Injury | 7 Apr 2016 | 12 Apr 2016 | 5 | 1 |
Unknown player | Hip Problems | 10 Mar 2016 | 21 Apr 2016 | 42 | 5 |
Unknown player | Injury | 3 Mar 2016 | 7 Mar 2016 | 4 | 1 |
Unknown player | Hamstring Injury | 29 Feb 2016 | 7 Mar 2016 | 7 | 2 |
Unknown player | Cruciate Ligament Tear | 8 Feb 2016 | 21 Nov 2016 | 287 | 37 |
Unknown player | Fitness | 30 Jan 2016 | 13 Mar 2016 | 43 | 10 |
Unknown player | Minor Knock | 4 Jan 2016 | 18 Jan 2016 | 14 | 3 |
Unknown player | Ankle Injury | 30 Dec 2015 | 4 Jan 2016 | 5 | 0 |
Cesc Fàbregas | ILL | 27 Dec 2015 | 29 Dec 2015 | 2 | 0 |
Unknown player | Minor Knock | 14 Dec 2015 | 21 Dec 2015 | 7 | 2 |
Unknown player | Groin Injury | 2 Nov 2015 | 31 Mar 2016 | 150 | 28 |
Unknown player | Bruise | 19 Oct 2015 | 5 Nov 2015 | 17 | 5 |
| Thibaut Courtois | Meniscus Tear | 10 Sept 2015 | 3 Dec 2015 | 84 | 17 |
Unknown player | Hip Injury | 5 Sept 2015 | 19 Sept 2015 | 14 | 2 |
Unknown player | Knee Bruise | 14 Aug 2015 | 16 Sept 2015 | 33 | 4 |
Unknown player | Thigh Problems | 30 Jul 2015 | 6 Aug 2015 | 7 | 1 |
Unknown player | Knee Injury | 11 May 2015 | 2 Jul 2015 | 52 | 2 |
Unknown player | Hamstring Injury | 1 May 2015 | 30 Jun 2015 | 60 | 4 |
Unknown player | Calf Problems | 11 Apr 2015 | 3 May 2015 | 22 | 4 |
Unknown player | Hamstring Injury | 6 Apr 2015 | 18 May 2015 | 42 | 6 |
| Nemanja Matić | Ankle Injury | 26 Feb 2015 | 9 Mar 2015 | 11 | 2 |
| Thibaut Courtois | Muscular Problems | 8 Dec 2014 | 18 Dec 2014 | 10 | 3 |
Unknown player | Groin Injury | 21 Oct 2014 | 22 Nov 2014 | 32 | 6 |
Unknown player | Hamstring Injury | 13 Oct 2014 | 30 Oct 2014 | 17 | 4 |
Unknown player | Hip Problems | 6 Mar 2014 | 17 Mar 2014 | 11 | 2 |
Unknown player | Hip Problems | 18 Feb 2014 | 27 Feb 2014 | 9 | 2 |
Unknown player | Knee Injury | 22 Nov 2013 | 10 Dec 2013 | 18 | 5 |
Unknown player | Cruciate Ligament Tear | 24 Sept 2013 | 20 Mar 2014 | 177 | 38 |
Unknown player | Broken Fibula | 30 Jul 2013 | 1 Oct 2013 | 63 | 9 |
Unknown player | Hamstring Injury | 13 May 2013 | 30 May 2013 | 17 | 2 |
Unknown player | Knee Injury | 2 May 2013 | 1 Jul 2013 | 60 | 6 |
Unknown player | Knee Surgery | 18 Mar 2013 | 24 Apr 2013 | 37 | 8 |
Unknown player | Calf Problems | 25 Jan 2013 | 4 Feb 2013 | 10 | 3 |
Unknown player | Groin Injury | 19 Dec 2012 | 2 Jan 2013 | 14 | 4 |
Unknown player | Knee Injury | 8 Dec 2012 | 1 May 2013 | 144 | 38 |
Unknown player | Hamstring Injury | 20 Nov 2012 | 27 Dec 2012 | 37 | 11 |
Unknown player | Torn Thigh Muscle | 15 Apr 2012 | 15 May 2012 | 30 | 9 |
Unknown player | Shoulder Injury | 1 Dec 2010 | 16 Feb 2011 | 77 | 14 |
Unknown player | Calf Problems | 18 Nov 2010 | 14 Feb 2011 | 88 | 16 |
Unknown player | Knee Injury | 15 Aug 2009 | 21 Sept 2009 | 37 | 6 |
Unknown player | Torn Muscle Fiber | 13 Nov 2008 | 22 Dec 2008 | 39 | 7 |
