| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Christian Pulisic | Doubtful | 29 Nov 2020 | 29 Nov 2020 | 0 | 1 |
 Andreas Christensen | Injury | 25 Nov 2020 | 18 Dec 2020 | 23 | 6 |
 Kai Havertz | Doubtful | 24 Nov 2020 | 24 Nov 2020 | 0 | 1 |
Unknown player | Doubtful | 21 Nov 2020 | 21 Nov 2020 | 0 | 1 |
| Kai Havertz | COVID 19 | 3 Nov 2020 | 22 Nov 2020 | 19 | 2 |
| Christian Pulisic | Muscle Injury | 3 Nov 2020 | 27 Nov 2020 | 24 | 4 |
| Christian Pulisic | Quarantine | 31 Oct 2020 | 3 Nov 2020 | 3 | 1 |
 Kepa Arrizabalaga | Shoulder Injury | 22 Oct 2020 | 8 Nov 2020 | 17 | 5 |
Unknown player | Doubtful | 20 Oct 2020 | 20 Oct 2020 | 0 | 1 |
Unknown player | Doubtful | 20 Oct 2020 | 20 Oct 2020 | 0 | 1 |
 Ben Chilwell | Doubtful | 17 Oct 2020 | 17 Oct 2020 | 0 | 1 |
Unknown player | Doubtful | 17 Oct 2020 | 17 Oct 2020 | 0 | 1 |
Unknown player | Muscle Strain | 16 Oct 2020 | 19 Oct 2020 | 3 | 1 |
Unknown player | Rest | 21 Sept 2020 | 24 Sept 2020 | 3 | 0 |
Unknown player | Knock | 10 Sept 2020 | 22 Sept 2020 | 12 | 2 |
Unknown player | Knee Injury | 30 Aug 2020 | 16 Oct 2020 | 47 | 6 |
| Christian Pulisic | Hamstring Injury | 2 Aug 2020 | 4 Oct 2020 | 63 | 7 |
Unknown player | Hamstring Injury | 1 Aug 2020 | 13 Sept 2020 | 43 | 3 |
| Christian Pulisic | Calf Injury | 1 Aug 2020 | 22 Aug 2020 | 21 | 2 |
Unknown player | Shoulder Injury | 1 Aug 2020 | 26 Sept 2020 | 56 | 6 |
 Ruben Loftus-Cheek | Knock | 31 Jul 2020 | 13 Sept 2020 | 44 | 3 |
Unknown player | Ankle Injury | 31 Jul 2020 | 13 Aug 2020 | 13 | 2 |
 Ross Barkley | ILL | 15 Jul 2020 | 23 Jul 2020 | 8 | 1 |
 Billy Gilmour | Knee Injury | 9 Jul 2020 | 17 Nov 2020 | 131 | 21 |
Unknown player | Calf Injury | 9 Jul 2020 | 9 Dec 2020 | 153 | 24 |
 Mateo Kovacic | Calf Injury | 2 Jul 2020 | 10 Jul 2020 | 8 | 2 |
Unknown player | Hamstring Injury | 2 Jul 2020 | 30 Jul 2020 | 28 | 7 |
| Andreas Christensen | Groin Injury | 26 Jun 2020 | 30 Jun 2020 | 4 | 1 |
 Fikayo Tomori | Knock | 19 Jun 2020 | 13 Jul 2020 | 24 | 7 |
 Callum Hudson-Odoi | Ankle Injury | 15 Jun 2020 | 29 Jun 2020 | 14 | 2 |
| Mateo Kovacic | Achilles Tendon Problems | 4 Mar 2020 | 6 Jun 2020 | 94 | 1 |
 Tammy Abraham | Ankle Injury | 26 Feb 2020 | 6 Jun 2020 | 101 | 3 |
Unknown player | Muscle Injury | 17 Feb 2020 | 8 Jun 2020 | 112 | 6 |
| Callum Hudson-Odoi | Hamstring Injury | 3 Feb 2020 | 6 Apr 2020 | 63 | 6 |
| Tammy Abraham | Knock | 2 Feb 2020 | 21 Feb 2020 | 19 | 1 |
 Reece James | Bruise | 20 Jan 2020 | 3 Feb 2020 | 14 | 3 |
 Olivier Giroud | Groin Injury | 6 Jan 2020 | 16 Feb 2020 | 41 | 5 |
| Christian Pulisic | Adductor Injury | 2 Jan 2020 | 6 Jun 2020 | 156 | 12 |
Unknown player | Hamstring Injury | 2 Jan 2020 | 16 Jan 2020 | 14 | 2 |
Unknown player | Flu | 29 Dec 2019 | 1 Jan 2020 | 3 | 1 |
| Christian Pulisic | Muscle Contusion | 28 Dec 2019 | 31 Dec 2019 | 3 | 1 |
| Reece James | Ankle Injury | 23 Dec 2019 | 30 Dec 2019 | 7 | 1 |
 Marcos Alonso | Knock | 23 Dec 2019 | 20 Jan 2020 | 28 | 6 |
Unknown player | ILL | 21 Dec 2019 | 23 Dec 2019 | 2 | 0 |
| Ross Barkley | Foot Injury | 13 Dec 2019 | 23 Dec 2019 | 10 | 1 |
| Fikayo Tomori | Hip Problems | 9 Dec 2019 | 21 Dec 2019 | 12 | 2 |
| Olivier Giroud | Ankle Injury | 6 Dec 2019 | 4 Jan 2020 | 29 | 7 |
Unknown player | Achilles Tendon Rupture | 4 Dec 2019 | 10 Dec 2019 | 6 | 2 |
| Tammy Abraham | Hip Injury | 28 Nov 2019 | 4 Dec 2019 | 6 | 1 |
| Callum Hudson-Odoi | Minor Knock | 21 Nov 2019 | 28 Nov 2019 | 7 | 1 |
Unknown player | Achilles Tendon Rupture | 2 Nov 2019 | 20 Nov 2019 | 18 | 3 |
| Ross Barkley | Foot Injury | 19 Oct 2019 | 5 Dec 2019 | 47 | 10 |
Unknown player | Groin Injury | 14 Oct 2019 | 4 Nov 2019 | 21 | 5 |
| Andreas Christensen | Groin Injury | 12 Oct 2019 | 8 Nov 2019 | 27 | 6 |
Unknown player | Calf Injury | 6 Oct 2019 | 23 Oct 2019 | 17 | 2 |
| Olivier Giroud | ILL | 27 Sept 2019 | 5 Oct 2019 | 8 | 2 |
Unknown player | Hamstring Injury | 26 Sept 2019 | 30 Sept 2019 | 4 | 1 |
| Andreas Christensen | Knee Injury | 23 Sept 2019 | 27 Sept 2019 | 4 | 1 |
 Antonio Rüdiger | Groin Injury | 12 Sept 2019 | 12 Dec 2019 | 91 | 20 |
 Emerson | Hamstring Injury | 10 Sept 2019 | 20 Oct 2019 | 40 | 7 |
Unknown player | Muscle Contusion | 24 Aug 2019 | 13 Sept 2019 | 20 | 2 |
| Antonio Rüdiger | Knock | 19 Aug 2019 | 16 Sept 2019 | 28 | 3 |
Unknown player | Ankle Sprain | 19 Aug 2019 | 23 Sept 2019 | 35 | 5 |
| Antonio Rüdiger | Knee Injury | 15 Jul 2019 | 12 Aug 2019 | 28 | 4 |
Unknown player | Hamstring Injury | 4 Jul 2019 | 12 Aug 2019 | 39 | 6 |
| Reece James | Ankle Injury | 6 Jun 2019 | 26 Sept 2019 | 112 | 2 |
| Ruben Loftus-Cheek | Achilles Tendon Rupture | 15 May 2019 | 19 Feb 2020 | 280 | 45 |
Unknown player | Bruised Ribs | 6 May 2019 | 30 May 2019 | 24 | 4 |
| Antonio Rüdiger | Knee Surgery | 29 Apr 2019 | 3 Jun 2019 | 35 | 6 |
Unknown player | Achilles Tendon Problems | 24 Apr 2019 | 4 May 2019 | 10 | 2 |
| Callum Hudson-Odoi | Achilles Tendon Rupture | 22 Apr 2019 | 12 Sept 2019 | 143 | 19 |
| Antonio Rüdiger | Minor Knock | 15 Apr 2019 | 29 Apr 2019 | 14 | 2 |
Unknown player | Achilles Heel Problems | 1 Apr 2019 | 7 Apr 2019 | 6 | 1 |
| Marcos Alonso | Hamstring Injury | 1 Apr 2019 | 28 Apr 2019 | 27 | 6 |
 Ethan Ampadu | Back Injury | 28 Mar 2019 | 31 May 2019 | 64 | 14 |
 Davide Zappacosta | Ankle Injury | 15 Mar 2019 | 2 Apr 2019 | 18 | 2 |
Unknown player | ILL | 11 Mar 2019 | 16 Mar 2019 | 5 | 1 |
Unknown player | Knock | 20 Feb 2019 | 23 Feb 2019 | 3 | 1 |
| Kepa Arrizabalaga | Hamstring Injury | 20 Feb 2019 | 23 Feb 2019 | 3 | 1 |
| Davide Zappacosta | Knock | 20 Feb 2019 | 9 Mar 2019 | 17 | 5 |
 Álvaro Morata | Hamstring Injury | 9 Jan 2019 | 20 Jan 2019 | 11 | 1 |
| Ruben Loftus-Cheek | Back Injury | 6 Jan 2019 | 26 Jan 2019 | 20 | 4 |
Unknown player | Knock | 3 Jan 2019 | 11 Jan 2019 | 8 | 2 |
| Olivier Giroud | Ankle Injury | 31 Dec 2018 | 11 Jan 2019 | 11 | 3 |
| Ruben Loftus-Cheek | Back Injury | 29 Dec 2018 | 1 Jan 2019 | 3 | 1 |
Unknown player | Back Injury | 28 Dec 2018 | 9 Mar 2019 | 71 | 18 |
Unknown player | Achilles Tendon Problems | 27 Dec 2018 | 11 Jan 2019 | 15 | 4 |
| Andreas Christensen | Hamstring Injury | 20 Dec 2018 | 29 Dec 2018 | 9 | 2 |
| Álvaro Morata | Knee Injury | 14 Dec 2018 | 29 Dec 2018 | 15 | 4 |
| Mateo Kovacic | Knock | 9 Dec 2018 | 15 Dec 2018 | 6 | 1 |
| Ross Barkley | Ankle Injury | 1 Dec 2018 | 7 Dec 2018 | 6 | 2 |
Unknown player | Knock | 1 Dec 2018 | 21 Dec 2018 | 20 | 6 |
Unknown player | Back Problems | 27 Nov 2018 | 3 Dec 2018 | 6 | 1 |
Unknown player | Ankle Injury | 25 Nov 2018 | 1 Dec 2018 | 6 | 1 |
| Ethan Ampadu | Knock | 17 Nov 2018 | 29 Nov 2018 | 12 | 1 |
Unknown player | Broken Tibia | 16 Nov 2018 | 1 Jun 2019 | 197 | 45 |
Unknown player | Injury | 2 Nov 2018 | 9 Mar 2019 | 127 | 31 |
| Olivier Giroud | Knock | 29 Oct 2018 | 7 Nov 2018 | 9 | 2 |
Unknown player | Thigh Problems | 21 Oct 2018 | 2 Nov 2018 | 12 | 3 |
| Andreas Christensen | Knock | 28 Sept 2018 | 3 Oct 2018 | 5 | 1 |
