| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
Unknown player | Hamstring Injury | 12 Apr 2023 | 20 May 2023 | 38 | 7 |
 Reece James | ILL | 9 Mar 2023 | 15 Mar 2023 | 6 | 1 |
Unknown player | Hamstring Injury | 9 Mar 2023 | 2 Apr 2023 | 24 | 3 |
| Reece James | Hamstring Injury | 1 Mar 2023 | 5 Mar 2023 | 4 | 0 |
 Mason Mount | Pelvic Contusion | 28 Feb 2023 | 3 Apr 2023 | 34 | 7 |
Unknown player | Cruciate Ligament Injury | 27 Feb 2023 | 10 Apr 2023 | 42 | 7 |
Unknown player | Knee Injury | 26 Feb 2023 | 10 Apr 2023 | 43 | 8 |
 Trevoh Chalobah | Fitness | 25 Feb 2023 | 28 Feb 2023 | 3 | 1 |
Unknown player | Fitness | 20 Feb 2023 | 12 Mar 2023 | 20 | 3 |
 Mateo Kovacic | ILL | 20 Feb 2023 | 27 Feb 2023 | 7 | 0 |
Unknown player | Head Injury | 18 Feb 2023 | 10 Mar 2023 | 20 | 3 |
 Ruben Loftus-Cheek | Knock | 17 Feb 2023 | 19 Feb 2023 | 2 | 0 |
Unknown player | Doubtful | 15 Feb 2023 | 15 Feb 2023 | 0 | 1 |
Unknown player | Doubtful | 15 Feb 2023 | 22 Dec 2023 | 310 | 46 |
Unknown player | Knee Problems | 9 Feb 2023 | 12 Feb 2023 | 3 | 0 |
| Ruben Loftus-Cheek | Knock | 1 Feb 2023 | 5 Feb 2023 | 4 | 1 |
| Mateo Kovacic | Calf Problems | 21 Jan 2023 | 4 Feb 2023 | 14 | 1 |
 Denis Zakaria | Hamstring Injury | 13 Jan 2023 | 13 Feb 2023 | 31 | 4 |
Unknown player | Hamstring Injury | 5 Jan 2023 | 2 Feb 2023 | 28 | 5 |
Unknown player | Shoulder Injury | 5 Jan 2023 | 16 Mar 2023 | 70 | 13 |
 Christian Pulisic | Knee Problems | 5 Jan 2023 | 5 Mar 2023 | 59 | 10 |
| Mason Mount | Knock | 5 Jan 2023 | 7 Jan 2023 | 2 | 1 |
| Reece James | Knee Injury | 27 Dec 2022 | 31 Jan 2023 | 35 | 7 |
 Wesley Fofana | Knee Injury | 20 Dec 2022 | 13 Feb 2023 | 55 | 7 |
| Mateo Kovacic | Rest | 18 Dec 2022 | 28 Dec 2022 | 10 | 0 |
Unknown player | Rest | 18 Dec 2022 | 28 Dec 2022 | 10 | 0 |
Unknown player | Cruciate Ligament Tear | 14 Dec 2022 | 14 Sept 2023 | 274 | 29 |
Unknown player | Knock | 8 Dec 2022 | 4 Jan 2023 | 27 | 3 |
| Ruben Loftus-Cheek | Calf Injury | 12 Nov 2022 | 13 Jan 2023 | 62 | 4 |
 Ben Chilwell | Hamstring Injury | 3 Nov 2022 | 31 Jan 2023 | 89 | 11 |
 Carney Chukwuemeka | Hamstring Injury | 1 Nov 2022 | 15 Dec 2022 | 44 | 5 |
| Reece James | Knee Injury | 13 Oct 2022 | 12 Dec 2022 | 60 | 9 |
| Wesley Fofana | Knee Injury | 6 Oct 2022 | 16 Dec 2022 | 71 | 12 |
| Trevoh Chalobah | Fitness | 29 Aug 2022 | 31 Aug 2022 | 2 | 0 |
Unknown player | Knock | 15 Aug 2022 | 25 Aug 2022 | 10 | 1 |
Unknown player | Hamstring Injury | 15 Aug 2022 | 20 Feb 2023 | 189 | 31 |
| Mateo Kovacic | Knee Problems | 7 Aug 2022 | 24 Aug 2022 | 17 | 2 |
Unknown player | Injury | 1 May 2022 | 8 May 2022 | 7 | 1 |
Unknown player | Knock | 28 Apr 2022 | 12 May 2022 | 14 | 2 |
| Reece James | Hamstring Injury | 21 Apr 2022 | 28 Apr 2022 | 7 | 1 |
| Mateo Kovacic | Ankle Injury | 17 Apr 2022 | 30 Apr 2022 | 13 | 3 |
 Antonio Rüdiger | Groin Injury | 14 Apr 2022 | 28 Apr 2022 | 14 | 3 |
Unknown player | COVID 19 | 8 Apr 2022 | 11 Apr 2022 | 3 | 1 |
 Marcos Alonso | Doubtful | 13 Mar 2022 | 6 Aug 2024 | 877 | — |
Unknown player | ILL | 10 Mar 2022 | 15 Mar 2022 | 5 | 2 |
| Christian Pulisic | ILL | 6 Mar 2022 | 13 Mar 2022 | 7 | 1 |
| Reece James | Muscle Injury | 3 Mar 2022 | 21 Mar 2022 | 18 | 5 |
| Marcos Alonso | COVID 19 | 1 Mar 2022 | 12 Mar 2022 | 11 | 3 |
 Callum Hudson-Odoi | Achilles Heel Problems | 28 Feb 2022 | 2 May 2022 | 63 | 14 |
Unknown player | Knock | 27 Feb 2022 | 6 Mar 2022 | 7 | 2 |
| Trevoh Chalobah | Surgery | 27 Feb 2022 | 3 Mar 2022 | 4 | 1 |
 Andreas Christensen | Achilles Heel Problems | 26 Feb 2022 | 3 Mar 2022 | 5 | 1 |
Unknown player | Achilles Heel Problems | 22 Feb 2022 | 3 Mar 2022 | 9 | 2 |
| Reece James | Fitness | 14 Feb 2022 | 24 Feb 2022 | 10 | 2 |
| Mason Mount | Ankle Injury | 14 Feb 2022 | 21 Feb 2022 | 7 | 1 |
| Andreas Christensen | COVID 19 | 14 Jan 2022 | 1 Feb 2022 | 18 | 3 |
Unknown player | COVID 19 | 7 Jan 2022 | 13 Jan 2022 | 6 | 1 |
Unknown player | COVID 19 | 6 Jan 2022 | 10 Jan 2022 | 4 | 1 |
Unknown player | COVID 19 | 5 Jan 2022 | 11 Jan 2022 | 6 | 2 |
| Trevoh Chalobah | Hamstring Injury | 3 Jan 2022 | 21 Jan 2022 | 18 | 5 |
| Andreas Christensen | Back Injury | 29 Dec 2021 | 7 Jan 2022 | 9 | 3 |
| Reece James | Hamstring Injury | 27 Dec 2021 | 14 Feb 2022 | 49 | 11 |
Unknown player | Knee Problems | 26 Dec 2021 | 31 Dec 2021 | 5 | 2 |
| Ruben Loftus-Cheek | COVID 19 | 23 Dec 2021 | 3 Jan 2022 | 11 | 2 |
| Ruben Loftus-Cheek | Injury | 17 Dec 2021 | 3 Jan 2022 | 17 | 4 |
Unknown player | COVID 19 | 16 Dec 2021 | 25 Dec 2021 | 9 | 3 |
 Kai Havertz | COVID 19 | 15 Dec 2021 | 28 Dec 2021 | 13 | 4 |
Unknown player | COVID 19 | 13 Dec 2021 | 3 Jan 2022 | 21 | 5 |
| Mateo Kovacic | COVID 19 | 3 Dec 2021 | 18 Dec 2021 | 15 | 4 |
| Trevoh Chalobah | Hamstring Injury | 3 Dec 2021 | 13 Dec 2021 | 10 | 3 |
Unknown player | Knee Problems | 25 Nov 2021 | 16 Dec 2021 | 21 | 5 |
| Ben Chilwell | Cruciate Ligament Tear | 22 Nov 2021 | 19 May 2022 | 178 | 42 |
| Mateo Kovacic | Adductor Pain | 29 Oct 2021 | 1 Dec 2021 | 33 | 6 |
| Mason Mount | ILL | 29 Oct 2021 | 3 Nov 2021 | 5 | 2 |
Unknown player | Sprain | 21 Oct 2021 | 21 Nov 2021 | 31 | 5 |
Unknown player | Injury | 21 Oct 2021 | 15 Nov 2021 | 25 | 5 |
| Antonio Rüdiger | Back Problems | 9 Oct 2021 | 20 Oct 2021 | 11 | 1 |
Unknown player | COVID 19 | 27 Sept 2021 | 11 Oct 2021 | 14 | 2 |
| Mason Mount | Minor Knock | 20 Sept 2021 | 30 Sept 2021 | 10 | 2 |
Unknown player | Bruised Ribs | 14 Sept 2021 | 24 Sept 2021 | 10 | 3 |
| Christian Pulisic | Ankle Injury | 9 Sept 2021 | 31 Oct 2021 | 52 | 11 |
Unknown player | Groin Injury | 26 Aug 2021 | 16 Sept 2021 | 21 | 3 |
| Christian Pulisic | COVID 19 | 18 Aug 2021 | 30 Aug 2021 | 12 | 2 |
| Ruben Loftus-Cheek | Knock | 13 Aug 2021 | 20 Sept 2021 | 38 | 5 |
Unknown player | Shoulder Injury | 12 Aug 2021 | 17 Aug 2021 | 5 | 1 |
| Andreas Christensen | Cruciate Ligament Injury | 8 May 2021 | 22 May 2021 | 14 | 4 |
| Antonio Rüdiger | Facial Injury | 28 Apr 2021 | 3 May 2021 | 5 | 1 |
| Mateo Kovacic | Muscle Injury | 11 Apr 2021 | 14 May 2021 | 33 | 9 |
 Tammy Abraham | Ankle Injury | 21 Feb 2021 | 5 Apr 2021 | 43 | 8 |
Unknown player | Hamstring Strain | 8 Feb 2021 | 15 Feb 2021 | 7 | 1 |
Unknown player | Thigh Problems | 5 Feb 2021 | 7 Mar 2021 | 30 | 7 |
| Kai Havertz | Knock | 1 Feb 2021 | 20 Feb 2021 | 19 | 4 |
Unknown player | Hamstring Injury | 7 Jan 2021 | 1 Feb 2021 | 25 | 5 |
| Andreas Christensen | Knee Injury | 1 Jan 2021 | 16 Jan 2021 | 15 | 2 |
Unknown player | Rest | 28 Dec 2020 | 31 Dec 2020 | 3 | 1 |
| Reece James | Hamstring Strain | 24 Dec 2020 | 18 Jan 2021 | 25 | 5 |
| Reece James | Ankle Injury | 14 Dec 2020 | 28 Dec 2020 | 14 | 3 |
Unknown player | Hip Injury | 7 Dec 2020 | 2 Jan 2021 | 26 | 6 |
| Callum Hudson-Odoi | Hip Injury | 3 Dec 2020 | 21 Dec 2020 | 18 | 4 |
 Billy Gilmour | Doubtful | 2 Dec 2020 | 2 Dec 2020 | 0 | 1 |
