| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Mykhaylo Mudryk | Ankle Injury | 9 Sept 2026 | Current | 61 | 1 |
 James Maddison | Shoulder Injury | 23 Aug 2026 | Current | — | 4 |
 Dominic Solanke | Muscle Injury | 25 Apr 2026 | 19 May 2026 | 24 | 3 |
 Xavi Simons | Cruciate Ligament Tear | 25 Apr 2026 | Current | 301 | 17 |
 Destiny Udogie | Muscle Injury | 20 Apr 2026 | 30 Apr 2026 | 10 | 2 |
 Pape Matar Sarr | Shoulder Injury | 13 Apr 2026 | 1 May 2026 | 18 | 2 |
 Cristian Romero | Knee Injury | 12 Apr 2026 | 6 Jun 2026 | 55 | 7 |
 Guglielmo Vicario | Surgery | 23 Mar 2026 | 19 May 2026 | 57 | 5 |
 Unknown player | Muscle Injury | 14 Mar 2026 | 6 Apr 2026 | 23 | 3 |
 Conor Gallagher | ILL | 11 Mar 2026 | 16 Mar 2026 | 5 | 1 |
 Unknown player | Concussion | 10 Mar 2026 | 20 Mar 2026 | 10 | 3 |
 Radu Drăgușin | Injury | 2 Mar 2026 | 8 Mar 2026 | 6 | 1 |
 Djed Spence | Calf Problems | 23 Feb 2026 | 8 Mar 2026 | 13 | 2 |
 Wilson Odobert | Cruciate Ligament Tear | 10 Feb 2026 | Current | 291 | 27 |
| Destiny Udogie | Hamstring Injury | 7 Feb 2026 | 16 Mar 2026 | 37 | 6 |
 Kevin Danso | Toe Injury | 29 Jan 2026 | 23 Feb 2026 | 25 | 3 |
| Djed Spence | Calf Injury | 29 Jan 2026 | 9 Feb 2026 | 11 | 2 |
 Pedro Porro | Hamstring Injury | 25 Jan 2026 | 28 Feb 2026 | 34 | 5 |
 Micky van de Ven | Knock | 25 Jan 2026 | 31 Jan 2026 | 6 | 1 |
 Lucas Bergvall | Ankle Sprain | 21 Jan 2026 | 16 Mar 2026 | 54 | 10 |
 Ben Davies | Ankle Surgery | 19 Jan 2026 | 1 Jun 2026 | 133 | 20 |
| Unknown player | Knock | 15 Jan 2026 | 19 Jan 2026 | 4 | 1 |
 Richarlison | Hamstring Injury | 10 Jan 2026 | 21 Feb 2026 | 42 | 9 |
 Rodrigo Bentancur | Hamstring Injury | 8 Jan 2026 | 13 Apr 2026 | 95 | 15 |
 Mohammed Kudus | Hamstring Injury | 4 Jan 2026 | 29 Jun 2026 | 176 | 17 |
| Lucas Bergvall | Groin Injury | 28 Dec 2025 | 3 Jan 2026 | 6 | 2 |
| Destiny Udogie | Hamstring Injury | 3 Dec 2025 | 2 Jan 2026 | 30 | 5 |
 Unknown player | Fitness | 3 Dec 2025 | 27 Dec 2025 | 24 | 4 |
| Mohammed Kudus | Injury | 3 Nov 2025 | 21 Nov 2025 | 18 | 2 |
| Lucas Bergvall | Concussion | 1 Nov 2025 | 21 Nov 2025 | 20 | 3 |
 Archie Gray | Calf Injury | 28 Oct 2025 | 21 Nov 2025 | 24 | 4 |
| Cristian Romero | Adductor Injury | 19 Oct 2025 | 31 Oct 2025 | 12 | 4 |
| Destiny Udogie | Knee Injury | 18 Oct 2025 | 31 Oct 2025 | 13 | 4 |
| Ben Davies | Hamstring Injury | 17 Oct 2025 | 26 Nov 2025 | 40 | 7 |
 Randal Kolo Muani | Muscle Contusion | 20 Sept 2025 | 4 Nov 2025 | 45 | 10 |
| Dominic Solanke | Ankle Surgery | 24 Aug 2025 | 9 Jan 2026 | 138 | 15 |
| Unknown player | Knee Injury | 15 Aug 2025 | 23 Dec 2025 | 130 | 17 |
| James Maddison | Cruciate Ligament Tear | 3 Aug 2025 | 13 Apr 2026 | 253 | 48 |
 Unknown player | Groin Injury | 27 Jul 2025 | 4 Nov 2025 | 100 | 19 |
| Destiny Udogie | Knee Injury | 20 Jul 2025 | 30 Aug 2025 | 41 | 8 |
| Unknown player | Foot Injury | 6 Jul 2025 | 2 Dec 2025 | 149 | 24 |
 Unknown player | Calf Injury | 7 Jun 2025 | 30 Aug 2025 | 84 | 6 |
 Dejan Kulusevski | Knee Surgery | 12 May 2025 | 6 Sept 2026 | 482 | 29 |
| James Maddison | Knee Injury | 3 May 2025 | 23 Jun 2025 | 51 | 6 |
| Dominic Solanke | Thigh Problems | 2 May 2025 | 5 May 2025 | 3 | 0 |
| Lucas Bergvall | Ankle Injury | 30 Apr 2025 | 9 Jun 2025 | 40 | 7 |
 Unknown player | Foot Injury | 14 Apr 2025 | 9 May 2025 | 25 | 4 |
| Unknown player | Knock | 11 Apr 2025 | 14 Apr 2025 | 3 | 1 |
| Unknown player | Groin Surgery | 3 Apr 2025 | 30 Jun 2025 | 88 | 14 |
| Kevin Danso | Thigh Problems | 12 Mar 2025 | 14 Apr 2025 | 33 | 2 |
| Dejan Kulusevski | Foot Injury | 3 Mar 2025 | 10 Apr 2025 | 38 | 4 |
| Richarlison | Calf Injury | 6 Feb 2025 | 3 Apr 2025 | 56 | 6 |
| Micky van de Ven | Thigh Problems | 2 Feb 2025 | 5 Mar 2025 | 31 | 6 |
| Radu Drăgușin | Cruciate Ligament Tear | 30 Jan 2025 | 15 Dec 2025 | 319 | 49 |
| Djed Spence | Doubtful | 26 Jan 2025 | 26 Jan 2025 | 0 | 1 |
| James Maddison | Calf Injury | 25 Jan 2025 | 10 Feb 2025 | 16 | 1 |
 Unknown player | Injury | 23 Jan 2025 | 23 Jan 2025 | 0 | 0 |
 Antonín Kinský | Injury | 23 Jan 2025 | 23 Jan 2025 | 0 | 0 |
| Pape Matar Sarr | Knock | 21 Jan 2025 | 26 Jan 2025 | 5 | 0 |
| Djed Spence | Knock | 20 Jan 2025 | 1 Feb 2025 | 12 | 3 |
| Unknown player | Knock | 18 Jan 2025 | 25 Jan 2025 | 7 | 2 |
| Dominic Solanke | Knee Injury | 17 Jan 2025 | 2 Mar 2025 | 44 | 11 |
 Brennan Johnson | Calf Injury | 16 Jan 2025 | 13 Feb 2025 | 28 | 7 |
 Unknown player | Hamstring Injury | 13 Jan 2025 | 22 Feb 2025 | 40 | 9 |
| Rodrigo Bentancur | Concussion | 9 Jan 2025 | 22 Jan 2025 | 13 | 3 |
 Fraser Forster | ILL | 1 Jan 2025 | 17 Jan 2025 | 16 | 4 |
| Destiny Udogie | Hamstring Injury | 29 Dec 2024 | 10 Feb 2025 | 43 | 11 |
| Cristian Romero | Hamstring Injury | 8 Dec 2024 | 3 Mar 2025 | 85 | 21 |
| Micky van de Ven | Hamstring Injury | 8 Dec 2024 | 27 Jan 2025 | 50 | 13 |
| Ben Davies | Hamstring Injury | 5 Dec 2024 | 17 Jan 2025 | 43 | 12 |
| Dominic Solanke | ILL | 29 Nov 2024 | 2 Dec 2024 | 3 | 0 |
| Guglielmo Vicario | Ankle Surgery | 25 Nov 2024 | 10 Feb 2025 | 77 | 20 |
| Cristian Romero | Toe Injury | 22 Nov 2024 | 6 Dec 2024 | 14 | 3 |
 Mikey Moore | Doubtful | 10 Nov 2024 | 10 Nov 2024 | 0 | 1 |
| Mikey Moore | Virus | 6 Nov 2024 | 7 Jan 2025 | 62 | 14 |
| Unknown player | Hip Injury | 4 Nov 2024 | 9 Nov 2024 | 5 | 1 |
| Cristian Romero | Ankle Injury | 3 Nov 2024 | 8 Nov 2024 | 5 | 2 |
| Richarlison | Hamstring Injury | 3 Nov 2024 | 14 Jan 2025 | 72 | 17 |
| Micky van de Ven | Hamstring Injury | 30 Oct 2024 | 7 Dec 2024 | 38 | 8 |
| Wilson Odobert | Hamstring Injury | 27 Oct 2024 | 13 Feb 2025 | 109 | 27 |
| Djed Spence | Groin Injury | 21 Oct 2024 | 8 Nov 2024 | 18 | 4 |
| Unknown player | Thigh Problems | 21 Oct 2024 | 2 Nov 2024 | 12 | 3 |
| Unknown player | Hamstring Injury | 26 Sept 2024 | 19 Oct 2024 | 23 | 4 |
| Wilson Odobert | Hamstring Injury | 18 Sept 2024 | 23 Oct 2024 | 35 | 3 |
| Unknown player | Groin Problems | 10 Sept 2024 | 20 Sept 2024 | 10 | 2 |
| Micky van de Ven | Knee Injury | 29 Aug 2024 | 9 Sept 2024 | 11 | 1 |
| Richarlison | Injury | 27 Aug 2024 | 19 Oct 2024 | 53 | 5 |
| Dominic Solanke | Ankle Injury | 21 Aug 2024 | 9 Sept 2024 | 19 | 2 |
| Rodrigo Bentancur | Head Injury | 20 Aug 2024 | 31 Aug 2024 | 11 | 1 |
 Unknown player | Muscle Injury | 1 Aug 2024 | 25 Nov 2024 | 116 | 20 |
 Giovani Lo Celso | Knee Problems | 15 May 2024 | 20 May 2024 | 5 | 0 |
| Unknown player | Knee Injury | 13 May 2024 | 30 Jun 2024 | 48 | 3 |
| Richarlison | Hamstring Injury | 10 May 2024 | 14 Jul 2024 | 65 | 4 |
| Ben Davies | Calf Problems | 29 Apr 2024 | 27 Jul 2024 | 89 | 8 |
| Unknown player | Thigh Problems | 29 Apr 2024 | 30 Jun 2024 | 62 | 6 |
 Unknown player | Knock | 25 Apr 2024 | 30 Apr 2024 | 5 | 1 |
| Destiny Udogie | Hamstring Injury | 20 Apr 2024 | 5 Aug 2024 | 107 | 11 |
| Richarlison | Knee Injury | 5 Apr 2024 | 19 Apr 2024 | 14 | 2 |
| Micky van de Ven | Hamstring Injury | 10 Mar 2024 | 28 Mar 2024 | 18 | 2 |
| Richarlison | Knee Injury | 18 Feb 2024 | 11 Mar 2024 | 22 | 2 |
