| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Harry Kane | Torn Ankle Ligaments | 14 Jan 2019 | 23 Feb 2019 | 40 | 7 |
 Unknown player | Groin Injury | 13 Jan 2019 | 29 Jan 2019 | 16 | 4 |
 Unknown player | Knee Injury | 3 Jan 2019 | 24 Jan 2019 | 21 | 4 |
 Unknown player | Calf Injury | 27 Dec 2018 | 12 Jan 2019 | 16 | 4 |
 Unknown player | Hamstring Injury | 24 Dec 2018 | 28 Dec 2018 | 4 | 1 |
 Eric Dier | Appendectomy | 16 Dec 2018 | 20 Jan 2019 | 35 | 8 |
 Unknown player | Hamstring Injury | 12 Dec 2018 | 12 Jan 2019 | 31 | 8 |
 Unknown player | Groin Injury | 8 Dec 2018 | 12 Jan 2019 | 35 | 10 |
 Juan Foyth | Hamstring Injury | 6 Dec 2018 | 18 Dec 2018 | 12 | 3 |
| Unknown player | Muscle Strain | 29 Nov 2018 | 14 Dec 2018 | 15 | 4 |
 Unknown player | Knee Injury | 23 Nov 2018 | 27 Jan 2019 | 65 | 17 |
 Unknown player | Groin Injury | 10 Nov 2018 | 13 Dec 2018 | 33 | 7 |
 Unknown player | Hamstring Injury | 6 Nov 2018 | 26 Dec 2018 | 50 | 11 |
 Unknown player | Ankle Injury | 3 Nov 2018 | 13 Jan 2019 | 71 | 17 |
| Unknown player | Knee Injury | 1 Nov 2018 | 9 Nov 2018 | 8 | 2 |
| Eric Dier | Hamstring Strain | 29 Oct 2018 | 9 Nov 2018 | 11 | 4 |
| Unknown player | Hamstring Injury | 15 Oct 2018 | 23 Oct 2018 | 8 | 1 |
 Unknown player | Groin Injury | 6 Oct 2018 | 24 Nov 2018 | 49 | 8 |
| Unknown player | Hamstring Injury | 29 Sept 2018 | 22 Nov 2018 | 54 | 10 |
| Unknown player | Thigh Problems | 29 Sept 2018 | 20 Oct 2018 | 21 | 3 |
| Unknown player | Hamstring Injury | 28 Sept 2018 | 29 Oct 2018 | 31 | 5 |
| Unknown player | Thigh Problems | 26 Sept 2018 | 11 Oct 2018 | 15 | 4 |
 Unknown player | Abdominal Muscle Strain | 22 Sept 2018 | 20 Oct 2018 | 28 | 5 |
| Unknown player | Hamstring Injury | 8 Sept 2018 | 22 Sept 2018 | 14 | 2 |
| Unknown player | Hamstring Injury | 28 Aug 2018 | 26 Sept 2018 | 29 | 4 |
 Unknown player | Hamstring Strain | 28 Aug 2018 | 2 Oct 2018 | 35 | 6 |
| Unknown player | Hamstring Injury | 27 Aug 2018 | 14 Sept 2018 | 18 | 2 |
 Unknown player | Groin Injury | 2 Aug 2018 | 31 Aug 2018 | 29 | 4 |
| Unknown player | Bruise | 1 Aug 2018 | 17 Aug 2018 | 16 | 3 |
| Unknown player | Knee Problems | 29 Jul 2018 | 1 Sept 2018 | 34 | 6 |
| Unknown player | Knock | 26 Jul 2018 | 17 Aug 2018 | 22 | 5 |
| Juan Foyth | Hamstring Strain | 21 Jul 2018 | 26 Sept 2018 | 67 | 11 |
 Unknown player | Knee Injury | 14 Jul 2018 | 23 Aug 2018 | 40 | 6 |
 Unknown player | Foot Injury | 1 Jul 2018 | 1 Jan 2019 | 184 | 54 |
| Eric Dier | ILL | 7 May 2018 | 12 May 2018 | 5 | 1 |
 Unknown player | Hamstring Injury | 28 Mar 2018 | 28 Apr 2018 | 31 | 5 |
 Harry Winks | Ankle Injury | 20 Mar 2018 | 17 Aug 2018 | 150 | 14 |
| Harry Kane | Ankle Injury | 12 Mar 2018 | 1 Apr 2018 | 20 | 1 |
| Harry Winks | Ankle Injury | 5 Jan 2018 | 3 Feb 2018 | 29 | 5 |
| Unknown player | Knee Problems | 28 Dec 2017 | 30 Jan 2018 | 33 | 6 |
| Harry Winks | ILL | 25 Nov 2017 | 29 Nov 2017 | 4 | 1 |
| Unknown player | Hamstring Injury | 2 Nov 2017 | 15 Nov 2017 | 13 | 1 |
| Unknown player | Hip Flexor Problems | 2 Nov 2017 | 16 Nov 2017 | 14 | 1 |
 Unknown player | Hamstring Injury | 2 Nov 2017 | 11 Mar 2018 | 129 | 28 |
| Harry Kane | Hamstring Injury | 23 Oct 2017 | 30 Oct 2017 | 7 | 2 |
 Ben Davies | ILL | 9 Oct 2017 | 23 Oct 2017 | 14 | 2 |
| Unknown player | Bruise On Ankle | 19 Sept 2017 | 22 Oct 2017 | 33 | 6 |
| Unknown player | Doubtful | 9 Sept 2017 | 11 Sept 2024 | 2559 | — |
| Unknown player | Cartilage Damage | 21 Aug 2017 | 1 Jan 2018 | 133 | 26 |
| Unknown player | Ankle Injury | 5 Aug 2017 | 19 Aug 2017 | 14 | 2 |
 Unknown player | Foot Injury | 1 Aug 2017 | 16 Sept 2017 | 46 | 6 |
 Unknown player | Ankle Injury | 15 May 2017 | 1 Jun 2017 | 17 | 3 |
| Unknown player | Knee Injury | 13 Apr 2017 | 30 Apr 2017 | 17 | 3 |
| Harry Winks | Ankle Injury | 3 Apr 2017 | 1 Jun 2017 | 59 | 11 |
| Harry Kane | Ankle Injury | 13 Mar 2017 | 6 Apr 2017 | 24 | 2 |
| Unknown player | Knee Medial Ligament Tear | 30 Jan 2017 | 17 Oct 2017 | 260 | 37 |
| Unknown player | Ankle Injury | 14 Jan 2017 | 18 Feb 2017 | 35 | 7 |
| Unknown player | Ankle Injury | 1 Dec 2016 | 28 Dec 2016 | 27 | 5 |
| Ben Davies | Ankle Injury | 31 Oct 2016 | 12 Dec 2016 | 42 | 7 |
| Unknown player | Hip Injury | 24 Oct 2016 | 16 Nov 2017 | 388 | 62 |
| Unknown player | Knee Injury | 17 Oct 2016 | 1 Dec 2016 | 45 | 9 |
 Unknown player | Ankle Injury | 15 Oct 2016 | 31 Jan 2017 | 108 | 0 |
| Harry Kane | Ankle Injury | 19 Sept 2016 | 7 Nov 2016 | 49 | 10 |
| Eric Dier | Hamstring Injury | 18 Sept 2016 | 2 Oct 2016 | 14 | 4 |
| Unknown player | Injury | 18 Sept 2016 | 2 Oct 2016 | 14 | 4 |
| Unknown player | Hamstring Injury | 5 Sept 2016 | 3 Oct 2016 | 28 | 6 |
| Unknown player | Hamstring Injury | 15 Aug 2016 | 15 Sept 2016 | 31 | 3 |
 Unknown player | Hamstring Injury | 10 Aug 2016 | 20 Aug 2016 | 10 | 1 |
| Ben Davies | Head Injury | 17 Mar 2016 | 24 Mar 2016 | 7 | 2 |
 Nabil Bentaleb | Knee Surgery | 17 Mar 2016 | 16 May 2016 | 60 | 8 |
| Unknown player | Shoulder Injury | 15 Feb 2016 | 25 Feb 2016 | 10 | 2 |
| Unknown player | Knee Injury | 25 Jan 2016 | 14 Apr 2016 | 80 | 16 |
| Unknown player | Ankle Injury | 28 Dec 2015 | 11 Jan 2016 | 14 | 2 |
 Unknown player | Knee Injury | 11 Dec 2015 | 29 Apr 2016 | 140 | 28 |
 Unknown player | Hamstring Injury | 23 Oct 2015 | 1 Nov 2015 | 9 | 1 |
 Unknown player | Ankle Injury | 19 Oct 2015 | 7 Dec 2015 | 49 | 9 |
 Unknown player | Bruise | 16 Oct 2015 | 4 Nov 2015 | 19 | 4 |
 Unknown player | Foot Injury | 28 Sept 2015 | 5 Nov 2015 | 38 | 6 |
| Nabil Bentaleb | Ankle Injury | 10 Sept 2015 | 7 Dec 2015 | 88 | 17 |
 Unknown player | Ankle Injury | 6 Sept 2015 | 6 Feb 2016 | 153 | 30 |
| Unknown player | Ankle Sprain | 31 Aug 2015 | 17 Sept 2015 | 17 | 1 |
| Unknown player | Knee Injury | 21 Aug 2015 | 17 Sept 2015 | 27 | 3 |
| Ben Davies | Shoulder Injury | 27 Apr 2015 | 2 Jul 2015 | 66 | 4 |
| Unknown player | Hamstring Injury | 20 Apr 2015 | 4 May 2015 | 14 | 1 |
| Unknown player | Ankle Injury | 2 Apr 2015 | 25 May 2015 | 53 | 7 |
| Unknown player | Knee Injury | 23 Mar 2015 | 23 Apr 2015 | 31 | 3 |
| Unknown player | Calf Injury | 29 Dec 2014 | 22 Jan 2015 | 24 | 5 |
| Nabil Bentaleb | Ankle Injury | 16 Oct 2014 | 24 Nov 2014 | 39 | 7 |
| Unknown player | Groin Surgery | 1 Sept 2014 | 11 Dec 2014 | 101 | 19 |
 Unknown player | Cruciate Ligament Injury | 26 Apr 2014 | 5 Jul 2014 | 70 | 3 |
 Unknown player | Hamstring Injury | 4 Apr 2014 | 12 Apr 2014 | 8 | 1 |
| Unknown player | Ankle Sprain | 31 Mar 2014 | 17 Apr 2014 | 17 | 2 |
| Unknown player | Groin Injury | 17 Mar 2014 | 3 Jul 2014 | 108 | 9 |
 Unknown player | Leg Injury | 24 Feb 2014 | 19 Apr 2014 | 54 | 10 |
| Unknown player | Knee Injury | 24 Feb 2014 | 10 Mar 2014 | 14 | 3 |
| Unknown player | Hip Problems | 17 Feb 2014 | 3 Mar 2014 | 14 | 3 |
 Unknown player | Hamstring Strain | 8 Feb 2014 | 28 Feb 2014 | 20 | 4 |
 Unknown player | Back Injury | 30 Jan 2014 | 24 Mar 2014 | 53 | 12 |
| Unknown player | Back Problems | 9 Jan 2014 | 19 Jun 2014 | 161 | 22 |
 Unknown player | Ankle Injury | 30 Dec 2013 | 30 Jan 2014 | 31 | 4 |
