| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Unknown player | Injury | 8 Feb 2021 | 12 Feb 2021 | 4 | 1 |
 Unknown player | Foot Injury | 7 Feb 2021 | 26 Feb 2021 | 19 | 6 |
 Harry Kane | Ankle Injury | 29 Jan 2021 | 5 Feb 2021 | 7 | 1 |
 Ben Davies | Doubtful | 28 Jan 2021 | 28 Jan 2021 | 0 | 1 |
 Unknown player | Muscle Injury | 26 Jan 2021 | 19 Feb 2021 | 24 | 6 |
 Unknown player | Tendon Irritation | 22 Jan 2021 | 9 Feb 2021 | 18 | 5 |
 Unknown player | Doubtful | 17 Jan 2021 | 17 Jan 2021 | 0 | 1 |
 Unknown player | Injury | 16 Jan 2021 | 26 Jan 2021 | 10 | 1 |
 Pierre-Emile Højbjerg | Doubtful | 13 Jan 2021 | 13 Jan 2021 | 0 | 1 |
| Unknown player | Injury | 8 Jan 2021 | 15 Jan 2021 | 7 | 2 |
 Unknown player | Doubtful | 2 Jan 2021 | 2 Jan 2021 | 0 | 1 |
| Unknown player | Calf Problems | 23 Dec 2020 | 12 Jan 2021 | 20 | 5 |
 Giovani Lo Celso | Hamstring Injury | 20 Dec 2020 | 14 Mar 2021 | 84 | 22 |
 Unknown player | Shoulder Injury | 15 Dec 2020 | 26 Dec 2020 | 11 | 3 |
| Unknown player | Knock | 12 Dec 2020 | 19 Dec 2020 | 7 | 2 |
| Unknown player | Knock | 7 Dec 2020 | 12 Dec 2020 | 5 | 1 |
 Unknown player | Doubtful | 6 Dec 2020 | 6 Dec 2020 | 0 | 1 |
 Unknown player | Doubtful | 6 Dec 2020 | 6 Dec 2020 | 0 | 1 |
| Harry Kane | Doubtful | 6 Dec 2020 | 6 Dec 2020 | 0 | 1 |
 Unknown player | Injury | 5 Dec 2020 | 8 Dec 2020 | 3 | 1 |
| Unknown player | Knock | 30 Nov 2020 | 5 Dec 2020 | 5 | 1 |
| Harry Kane | Injury | 30 Nov 2020 | 5 Dec 2020 | 5 | 1 |
 Unknown player | Knock | 30 Nov 2020 | 5 Dec 2020 | 5 | 1 |
| Unknown player | Knock | 22 Nov 2020 | 28 Nov 2020 | 6 | 1 |
| Giovani Lo Celso | Knock | 22 Nov 2020 | 28 Nov 2020 | 6 | 1 |
| Unknown player | Knock | 22 Nov 2020 | 28 Nov 2020 | 6 | 1 |
| Unknown player | Groin Injury | 21 Nov 2020 | 5 Dec 2020 | 14 | 4 |
| Unknown player | Doubtful | 21 Nov 2020 | 21 Nov 2020 | 0 | 1 |
 Harry Winks | Knock | 19 Nov 2020 | 25 Nov 2020 | 6 | 1 |
| Unknown player | COVID 19 | 16 Nov 2020 | 25 Nov 2020 | 9 | 1 |
| Unknown player | Doubtful | 8 Nov 2020 | 8 Nov 2020 | 0 | 1 |
| Unknown player | Knock | 6 Nov 2020 | 20 Nov 2020 | 14 | 1 |
 Unknown player | Calf Injury | 3 Nov 2020 | 26 Dec 2020 | 53 | 12 |
| Unknown player | Knock | 28 Oct 2020 | 31 Oct 2020 | 3 | 1 |
 Eric Dier | Doubtful | 26 Oct 2020 | 26 Oct 2020 | 0 | 1 |
| Unknown player | Doubtful | 18 Oct 2020 | 18 Oct 2020 | 0 | 1 |
| Eric Dier | Muscle Strain | 13 Oct 2020 | 25 Oct 2020 | 12 | 2 |
| Giovani Lo Celso | Muscle Injury | 2 Oct 2020 | 21 Oct 2020 | 19 | 2 |
| Unknown player | Thigh Problems | 30 Sept 2020 | 25 Nov 2020 | 56 | 10 |
 Unknown player | Doubtful | 29 Sept 2020 | 29 Sept 2020 | 0 | 1 |
 Unknown player | Hamstring Injury | 28 Sept 2020 | 5 Oct 2020 | 7 | 2 |
| Unknown player | Doubtful | 27 Sept 2020 | 27 Sept 2020 | 0 | 1 |
| Unknown player | Knock | 14 Sept 2020 | 19 Sept 2020 | 5 | 1 |
| Unknown player | Knee Problems | 9 Sept 2020 | 16 Oct 2020 | 37 | 4 |
| Unknown player | Ankle Sprain | 7 Sept 2020 | 25 Sept 2020 | 18 | 1 |
| Unknown player | Hamstring Strain | 22 Aug 2020 | 28 Sept 2020 | 37 | 8 |
| Giovani Lo Celso | Hamstring Strain | 22 Aug 2020 | 16 Sept 2020 | 25 | 5 |
| Unknown player | Knock | 13 Jul 2020 | 31 Jul 2020 | 18 | 3 |
| Unknown player | Muscle Injury | 3 Jul 2020 | 25 Jul 2020 | 22 | 5 |
| Unknown player | Back Problems | 15 Jun 2020 | 10 Jul 2020 | 25 | 4 |
 Troy Parrott | Appendicitis | 28 May 2020 | 11 Jul 2020 | 44 | — |
| Harry Kane | Fitness | 9 Mar 2020 | 1 Apr 2020 | 23 | 1 |
| Unknown player | Ankle Injury | 8 Mar 2020 | 31 May 2020 | 84 | 1 |
| Unknown player | Groin Injury | 23 Feb 2020 | 6 Mar 2020 | 12 | 2 |
| Unknown player | Broken Arm | 17 Feb 2020 | 30 Apr 2020 | 73 | 6 |
| Unknown player | Groin Injury | 3 Feb 2020 | 18 Feb 2020 | 15 | 2 |
| Giovani Lo Celso | Muscle Strain | 3 Feb 2020 | 15 Feb 2020 | 12 | 1 |
 Juan Foyth | Meniscus Injury | 26 Jan 2020 | 18 Jul 2020 | 174 | 16 |
| Harry Kane | Torn Thigh Muscle | 2 Jan 2020 | 9 Mar 2020 | 67 | 14 |
| Unknown player | Knee Surgery | 2 Jan 2020 | 20 Mar 2020 | 78 | 15 |
| Unknown player | Groin Injury | 1 Jan 2020 | 21 Jan 2020 | 20 | 5 |
| Harry Winks | Ankle Injury | 6 Dec 2019 | 14 Dec 2019 | 8 | 2 |
| Unknown player | Groin Injury | 6 Dec 2019 | 21 Dec 2019 | 15 | 3 |
| Ben Davies | Ankle Injury | 21 Nov 2019 | 10 Feb 2020 | 81 | 19 |
| Unknown player | Groin Injury | 19 Nov 2019 | 26 Nov 2019 | 7 | 1 |
 Unknown player | Hip Injury | 9 Nov 2019 | 4 Dec 2019 | 25 | 4 |
| Harry Kane | ILL | 1 Nov 2019 | 4 Nov 2019 | 3 | 0 |
 Unknown player | Muscle Injury | 31 Oct 2019 | 24 Nov 2019 | 24 | 3 |
| Unknown player | Hamstring Injury | 23 Oct 2019 | 25 Dec 2019 | 63 | 12 |
 Unknown player | Muscle Strain | 16 Oct 2019 | 21 Oct 2019 | 5 | 1 |
| Unknown player | Elbow Injury | 6 Oct 2019 | 18 Jan 2020 | 104 | 20 |
 Unknown player | Ankle Injury | 12 Sept 2019 | 17 Sept 2019 | 5 | 1 |
| Giovani Lo Celso | Hip Injury | 7 Sept 2019 | 20 Oct 2019 | 43 | 7 |
| Eric Dier | Hip Problems | 30 Aug 2019 | 12 Sept 2019 | 13 | 1 |
 Unknown player | Hamstring Strain | 26 Aug 2019 | 17 Sept 2019 | 22 | 2 |
| Unknown player | Hamstring Injury | 18 Aug 2019 | 12 Sept 2019 | 25 | 2 |
| Unknown player | Broken Arm | 17 Aug 2019 | 28 Aug 2019 | 11 | 2 |
| Ben Davies | Groin Injury | 8 Aug 2019 | 19 Aug 2019 | 11 | 2 |
| Unknown player | Hamstring Injury | 4 Aug 2019 | 31 Aug 2019 | 27 | 4 |
| Juan Foyth | Ankle Injury | 31 Jul 2019 | 22 Sept 2019 | 53 | 8 |
 Ryan Sessegnon | Hamstring Injury | 21 Jun 2019 | 2 Nov 2019 | 134 | 19 |
| Unknown player | Knock | 5 May 2019 | 31 May 2019 | 26 | 2 |
| Unknown player | Head Injury | 1 May 2019 | 31 May 2019 | 30 | 3 |
| Unknown player | Groin Injury | 19 Apr 2019 | 29 Apr 2019 | 10 | 3 |
| Unknown player | Muscle Injury | 18 Apr 2019 | 23 Apr 2019 | 5 | 1 |
| Harry Winks | Groin Surgery | 13 Apr 2019 | 31 May 2019 | 48 | 9 |
| Harry Kane | Cruciate Ligament Injury | 10 Apr 2019 | 31 May 2019 | 51 | 9 |
| Unknown player | Broken Hand | 10 Apr 2019 | 15 Apr 2019 | 5 | 1 |
 Unknown player | Concussion | 1 Apr 2019 | 9 Apr 2019 | 8 | 1 |
| Eric Dier | Hip Injury | 22 Mar 2019 | 20 Apr 2019 | 29 | 5 |
| Unknown player | Muscle Strain | 10 Mar 2019 | 11 May 2019 | 62 | 11 |
| Unknown player | Hamstring Injury | 9 Mar 2019 | 12 May 2019 | 64 | 12 |
 Unknown player | Strain In The Thigh And Gluteal Muscles | 3 Mar 2019 | 22 Mar 2019 | 19 | 2 |
| Harry Winks | Groin Injury | 1 Mar 2019 | 3 Apr 2019 | 33 | 4 |
| Unknown player | Hip Injury | 24 Feb 2019 | 1 Mar 2019 | 5 | 1 |
| Eric Dier | Virus | 3 Feb 2019 | 8 Mar 2019 | 33 | 6 |
| Unknown player | ILL | 1 Feb 2019 | 8 Feb 2019 | 7 | 1 |
 Unknown player | Foot Injury | 30 Jan 2019 | 19 Apr 2019 | 79 | 14 |
| Ben Davies | Groin Injury | 24 Jan 2019 | 25 Feb 2019 | 32 | 6 |
| Unknown player | Hamstring Strain | 20 Jan 2019 | 9 Mar 2019 | 48 | 11 |
