| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Kylian Mbappé | Muscle Injury | 25 Sept 2024 | 30 Sept 2024 | 5 | 0 |
 Unknown player | Thigh Problems | 22 Sept 2024 | 26 Sept 2024 | 4 | 1 |
 Brahim Díaz | Hamstring Injury | 14 Sept 2024 | 25 Oct 2024 | 41 | 9 |
 Jacobo Ramón | Muscle Injury | 6 Sept 2024 | 22 Sept 2024 | 16 | 3 |
 Aurélien Tchouaméni | Foot Injury | 2 Sept 2024 | 16 Sept 2024 | 14 | 1 |
 Dani Ceballos | Ankle Sprain | 2 Sept 2024 | 18 Oct 2024 | 46 | 6 |
 Jude Bellingham | Muscle Injury | 23 Aug 2024 | 15 Sept 2024 | 23 | 6 |
 Unknown player | Muscle Injury | 23 Aug 2024 | 13 Sept 2024 | 21 | 3 |
 Eduardo Camavinga | Knee Injury | 13 Aug 2024 | 26 Sept 2024 | 44 | 9 |
 Álvaro Rodríguez | Ankle Sprain | 1 Aug 2024 | 23 Sept 2024 | 53 | 6 |
| Aurélien Tchouaméni | Foot Injury | 8 May 2024 | 29 May 2024 | 21 | 5 |
 Rodrygo | Flu | 25 Apr 2024 | 28 Apr 2024 | 3 | 1 |
 Ferland Mendy | Muscle Fatigue | 22 Apr 2024 | 27 Apr 2024 | 5 | 1 |
 Thibaut Courtois | Meniscus Tear | 19 Mar 2024 | 28 Apr 2024 | 40 | 8 |
 Unknown player | Stomach Problems | 16 Mar 2024 | 21 Mar 2024 | 5 | 1 |
 Éder Militão | Fitness | 13 Mar 2024 | 30 Mar 2024 | 17 | 1 |
| Dani Ceballos | Injury | 12 Mar 2024 | 20 Mar 2024 | 8 | 1 |
| Unknown player | Ankle Injury | 23 Feb 2024 | 1 Mar 2024 | 7 | 1 |
| Jude Bellingham | Ankle Sprain | 10 Feb 2024 | 2 Mar 2024 | 21 | 4 |
 Unknown player | Muscular Problems | 5 Feb 2024 | 12 Feb 2024 | 7 | 1 |
 Antonio Rüdiger | Hamstring Injury | 2 Feb 2024 | 19 Feb 2024 | 17 | 1 |
 Lucas Vázquez | Hamstring Injury | 5 Jan 2024 | 19 Jan 2024 | 14 | 3 |
 Unknown player | Cruciate Ligament Tear | 18 Dec 2023 | 4 Jan 2025 | 383 | 31 |
| Ferland Mendy | Muscle Injury | 18 Dec 2023 | 7 Jan 2024 | 20 | 3 |
| Unknown player | Calf Injury | 3 Dec 2023 | 1 Jan 2024 | 29 | 4 |
 Luka Modrić | Thigh Problems | 26 Nov 2023 | 1 Dec 2023 | 5 | 2 |
 Vinicius Junior | Torn Thigh Muscle | 18 Nov 2023 | 1 Jan 2024 | 44 | 14 |
| Eduardo Camavinga | Torn Lateral Knee Ligament | 15 Nov 2023 | 4 Jan 2024 | 50 | 10 |
| Jude Bellingham | Shoulder Injury | 9 Nov 2023 | 26 Nov 2023 | 17 | 1 |
 Kepa Arrizabalaga | Adductor Injury | 8 Nov 2023 | 30 Nov 2023 | 22 | 3 |
 Arda Güler | Muscle Injury | 8 Nov 2023 | 31 Dec 2023 | 53 | 2 |
| Ferland Mendy | Injury | 29 Oct 2023 | 6 Nov 2023 | 8 | 1 |
| Aurélien Tchouaméni | Fatigue Fracture | 28 Oct 2023 | 14 Dec 2023 | 47 | 11 |
| Dani Ceballos | Muscle Strain | 19 Oct 2023 | 15 Nov 2023 | 27 | 6 |
| Unknown player | Adductor Pain | 27 Sept 2023 | 19 Oct 2023 | 22 | 3 |
| Arda Güler | Muscle Injury | 26 Sept 2023 | 29 Oct 2023 | 33 | 4 |
| Unknown player | Muscle Injury | 19 Sept 2023 | 26 Sept 2023 | 7 | 2 |
| Vinicius Junior | Hamstring Muscle Injury | 26 Aug 2023 | 26 Sept 2023 | 31 | 4 |
| Dani Ceballos | Doubtful | 19 Aug 2023 | 19 Aug 2023 | 0 | — |
| Éder Militão | Cruciate Ligament Tear | 13 Aug 2023 | 13 Mar 2024 | 213 | 38 |
| Dani Ceballos | Doubtful | 12 Aug 2023 | 12 Aug 2023 | 0 | — |
| Thibaut Courtois | Cruciate Ligament Tear | 10 Aug 2023 | 31 Mar 2024 | 234 | 41 |
| Ferland Mendy | Muscle Injury | 30 Jul 2023 | 20 Sept 2023 | 52 | 5 |
| Arda Güler | Meniscus Damage | 29 Jul 2023 | 26 Sept 2023 | 59 | 9 |
| Dani Ceballos | Hamstring Injury | 15 Jul 2023 | 31 Aug 2023 | 47 | 7 |
 Unknown player | Doubtful | 27 May 2023 | 27 May 2023 | 0 | 1 |
| Vinicius Junior | Doubtful | 27 May 2023 | 27 May 2023 | 0 | 1 |
| Vinicius Junior | Knee Problems | 24 May 2023 | 27 May 2023 | 3 | 1 |
 Mariano Díaz | Hamstring Injury | 20 May 2023 | 1 Jun 2023 | 12 | 3 |
| Unknown player | Rest | 12 May 2023 | 15 May 2023 | 3 | 1 |
| Rodrygo | Rest | 12 May 2023 | 15 May 2023 | 3 | 1 |
| Unknown player | Rest | 12 May 2023 | 15 May 2023 | 3 | 1 |
| Unknown player | Rest | 1 May 2023 | 3 May 2023 | 2 | 0 |
| Thibaut Courtois | Stomach Flu | 23 Apr 2023 | 26 Apr 2023 | 3 | 1 |
| Unknown player | Muscle Injury | 19 Apr 2023 | 6 May 2023 | 17 | 4 |
| Vinicius Junior | Muscle Strain | 13 Apr 2023 | 16 Apr 2023 | 3 | 1 |
| Antonio Rüdiger | Knee Problems | 22 Mar 2023 | 5 Apr 2023 | 14 | 1 |
| Ferland Mendy | Muscle Injury | 20 Mar 2023 | 11 May 2023 | 52 | 12 |
| Unknown player | Ankle Injury | 7 Mar 2023 | 13 Mar 2023 | 6 | 1 |
| Rodrygo | Left Hip Flexor Problems | 23 Feb 2023 | 1 Mar 2023 | 6 | 2 |
| Unknown player | Hamstring Injury | 22 Feb 2023 | 22 Mar 2023 | 28 | 6 |
| Aurélien Tchouaméni | Flu | 18 Feb 2023 | 20 Feb 2023 | 2 | 1 |
| Unknown player | Muscle Fatigue | 16 Feb 2023 | 20 Feb 2023 | 4 | 1 |
 Unknown player | Stomach Flu | 10 Feb 2023 | 20 Feb 2023 | 10 | 3 |
| Thibaut Courtois | Hamstring Injury | 6 Feb 2023 | 17 Feb 2023 | 11 | 3 |
 Unknown player | Patellar Tendon Irritation | 4 Feb 2023 | 17 Feb 2023 | 13 | 4 |
| Éder Militão | Muscle Injury | 3 Feb 2023 | 9 Feb 2023 | 6 | 1 |
| Unknown player | Muscle Fatigue | 3 Feb 2023 | 10 Feb 2023 | 7 | 2 |
| Ferland Mendy | Muscle Injury | 31 Jan 2023 | 12 Mar 2023 | 40 | 10 |
 Carlos Dotor | Muscle Injury | 22 Jan 2023 | 8 Mar 2023 | 45 | 6 |
| Unknown player | Ankle Injury | 21 Jan 2023 | 28 Jan 2023 | 7 | 2 |
| Unknown player | Muscle Injury | 16 Jan 2023 | 1 Feb 2023 | 16 | 4 |
| Lucas Vázquez | Ankle Injury | 12 Jan 2023 | 14 Feb 2023 | 33 | 9 |
| Aurélien Tchouaméni | Muscle Injury | 9 Jan 2023 | 1 Feb 2023 | 23 | 6 |
| Unknown player | Muscle Injury | 9 Jan 2023 | 3 Feb 2023 | 25 | 6 |
| Éder Militão | ILL | 29 Dec 2022 | 31 Dec 2022 | 2 | 1 |
| Antonio Rüdiger | Hip Injury | 5 Nov 2022 | 17 Nov 2022 | 12 | 2 |
| Unknown player | Muscular Problems | 4 Nov 2022 | 11 Nov 2022 | 7 | 1 |
| Aurélien Tchouaméni | Muscle Injury | 30 Oct 2022 | 4 Nov 2022 | 5 | 2 |
| Luka Modrić | Muscle Fatigue | 24 Oct 2022 | 29 Oct 2022 | 5 | 1 |
 Federico Valverde | Dead Leg | 23 Oct 2022 | 27 Oct 2022 | 4 | 1 |
| Unknown player | Muscle Fatigue | 21 Oct 2022 | 31 Oct 2022 | 10 | 2 |
| Unknown player | Minor Knock | 6 Oct 2022 | 10 Oct 2022 | 4 | 1 |
| Dani Ceballos | Knock | 6 Oct 2022 | 26 Oct 2022 | 20 | 5 |
| Thibaut Courtois | Sciatica Problems | 29 Sept 2022 | 17 Oct 2022 | 18 | 4 |
| Luka Modrić | Injury | 28 Sept 2022 | 6 Oct 2022 | 8 | 1 |
| Unknown player | Muscle Injury | 7 Sept 2022 | 29 Sept 2022 | 22 | 3 |
| Éder Militão | Hamstring Injury | 6 Sept 2022 | 16 Sept 2022 | 10 | 3 |
 Álvaro Odriozola | Muscle Injury | 1 Sept 2022 | 13 Sept 2022 | 12 | 3 |
| Unknown player | Injury | 27 Aug 2022 | 10 Sept 2022 | 14 | 3 |
| Unknown player | Flu | 18 Aug 2022 | 22 Aug 2022 | 4 | 1 |
| Unknown player | Ankle Sprain | 11 Aug 2022 | 17 Aug 2022 | 6 | 1 |
| Rodrygo | Muscle Fatigue | 9 Aug 2022 | 23 Aug 2022 | 14 | 3 |
| Unknown player | Knock | 10 May 2022 | 14 May 2022 | 4 | 1 |
 Unknown player | Minor Knock | 10 May 2022 | 14 May 2022 | 4 | 1 |
 Unknown player | Calf Problems | 7 May 2022 | 20 May 2022 | 13 | 3 |
| Unknown player | Adductor Pain | 5 May 2022 | 26 May 2022 | 21 | 4 |
| Dani Ceballos | Muscle Injury | 5 May 2022 | 14 May 2022 | 9 | 0 |
 Isco | Flu | 2 May 2022 | 19 May 2022 | 17 | 4 |
 Unknown player | Back Problems | 29 Apr 2022 | 19 May 2022 | 20 | 5 |
