| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Unknown player | Doubtful | 28 Aug 2021 | 28 Aug 2021 | 0 | 1 |
 Unknown player | Muscle Injury | 22 Aug 2021 | 6 Sept 2021 | 15 | 1 |
 Unknown player | Hamstring Injury | 8 Aug 2021 | 20 Oct 2021 | 73 | 11 |
 Unknown player | Knee Injury | 7 Aug 2021 | 1 Oct 2021 | 55 | 9 |
 Sergio Canales | Tendonitis | 19 May 2021 | 1 Jun 2021 | 13 | 1 |
 Paul Akouokou | Knock | 11 May 2021 | 1 Jun 2021 | 21 | 3 |
 Unknown player | Ankle Sprain | 28 Apr 2021 | 17 May 2021 | 19 | 3 |
 Unknown player | Knock | 22 Apr 2021 | 25 Apr 2021 | 3 | 0 |
 Borja Iglesias | Muscle Injury | 22 Feb 2021 | 3 Mar 2021 | 9 | 1 |
 Unknown player | Muscle Injury | 19 Feb 2021 | 3 Mar 2021 | 12 | 2 |
 Unknown player | Muscle Injury | 15 Feb 2021 | 23 Feb 2021 | 8 | 1 |
| Unknown player | COVID 19 | 28 Jan 2021 | 8 Feb 2021 | 11 | 2 |
 Guido Rodríguez | Muscular Problems | 22 Jan 2021 | 1 Feb 2021 | 10 | 2 |
 Aitor Ruibal | Ankle Problems | 20 Jan 2021 | 31 Jan 2021 | 11 | 3 |
 Unknown player | Muscle Injury | 18 Jan 2021 | 11 Feb 2021 | 24 | 6 |
 Unknown player | COVID 19 | 1 Jan 2021 | 12 Jan 2021 | 11 | 2 |
 Unknown player | Cruciate Ligament Tear | 1 Jan 2021 | 6 Jun 2021 | 156 | 26 |
| Unknown player | COVID 19 | 1 Jan 2021 | 14 Jan 2021 | 13 | 3 |
 Unknown player | COVID 19 | 1 Jan 2021 | 14 Jan 2021 | 13 | 3 |
| Unknown player | Muscle Injury | 30 Dec 2020 | 11 Jan 2021 | 12 | 2 |
| Unknown player | COVID 19 | 28 Dec 2020 | 8 Jan 2021 | 11 | 3 |
 Unknown player | Muscular Problems | 27 Dec 2020 | 11 Jan 2021 | 15 | 3 |
| Unknown player | Doubtful | 23 Dec 2020 | 23 Dec 2020 | 0 | 1 |
| Unknown player | Calf Problems | 21 Dec 2020 | 31 Dec 2020 | 10 | 2 |
| Unknown player | Doubtful | 20 Dec 2020 | 20 Dec 2020 | 0 | 1 |
 Unknown player | Doubtful | 20 Dec 2020 | 20 Dec 2020 | 0 | 1 |
 Marc Bartra | Heel Problems | 20 Dec 2020 | 15 Mar 2021 | 85 | 17 |
| Unknown player | Muscular Problems | 23 Nov 2020 | 14 Dec 2020 | 21 | 3 |
 Aïssa Mandi | COVID 19 | 22 Nov 2020 | 7 Dec 2020 | 15 | 2 |
| Sergio Canales | Muscle Injury | 17 Nov 2020 | 28 Dec 2020 | 41 | 7 |
| Unknown player | Muscular Problems | 5 Nov 2020 | 29 Nov 2020 | 24 | 2 |
| Marc Bartra | Doubtful | 1 Nov 2020 | 1 Nov 2020 | 0 | 1 |
| Aitor Ruibal | Doubtful | 1 Nov 2020 | 1 Nov 2020 | 0 | 1 |
| Unknown player | Sore Muscles | 19 Oct 2020 | 19 Nov 2020 | 31 | 3 |
 Unknown player | Knee Bruise | 4 Oct 2020 | 31 Oct 2020 | 27 | 2 |
| Unknown player | Quarantine | 28 Sept 2020 | 20 Oct 2020 | 22 | 3 |
| Unknown player | Doubtful | 26 Sept 2020 | 26 Sept 2020 | 0 | 1 |
 Juanmi | Doubtful | 26 Sept 2020 | 26 Sept 2020 | 0 | 1 |
| Unknown player | Knee Problems | 25 Sept 2020 | 15 Oct 2020 | 20 | 3 |
| Unknown player | Ankle Sprain | 1 Sept 2020 | 27 Oct 2020 | 56 | 9 |
 Unknown player | Cruciate Ligament Tear | 24 Aug 2020 | 8 Apr 2021 | 227 | 36 |
| Unknown player | Hamstring Injury | 17 Jul 2020 | 24 Jul 2020 | 7 | 1 |
| Unknown player | Muscle Injury | 16 Jun 2020 | 30 Jun 2020 | 14 | 3 |
| Unknown player | ILL | 14 Jun 2020 | 24 Jun 2020 | 10 | 2 |
| Unknown player | ILL | 14 Jun 2020 | 20 Jun 2020 | 6 | 1 |
 Unknown player | Calf Injury | 1 Jun 2020 | 27 Jun 2020 | 26 | 4 |
| Unknown player | Muscular Problems | 24 Feb 2020 | 24 May 2020 | 90 | 2 |
| Guido Rodríguez | Muscular Problems | 18 Feb 2020 | 24 Feb 2020 | 6 | 1 |
| Unknown player | Abdominal Muscle Strain | 12 Feb 2020 | 1 May 2020 | 79 | 4 |
 Alfonso Pedraza | Achilles Tendon Problems | 2 Feb 2020 | 5 Mar 2020 | 32 | 5 |
| Unknown player | Muscle Injury | 27 Jan 2020 | 13 Feb 2020 | 17 | 2 |
| Unknown player | Muscular Problems | 7 Dec 2019 | 14 Dec 2019 | 7 | 1 |
| Alfonso Pedraza | Muscle Injury | 5 Dec 2019 | 25 Jan 2020 | 51 | 8 |
| Unknown player | Muscular Problems | 27 Nov 2019 | 4 Dec 2019 | 7 | 1 |
| Unknown player | Foot Injury | 24 Nov 2019 | 18 Dec 2019 | 24 | 3 |
| Marc Bartra | Muscle Injury | 21 Nov 2019 | 28 Nov 2019 | 7 | 1 |
| Unknown player | Muscle Injury | 20 Nov 2019 | 4 Dec 2019 | 14 | 2 |
| Alfonso Pedraza | Knee Injury | 30 Oct 2019 | 20 Nov 2019 | 21 | 3 |
| Unknown player | Muscle Injury | 29 Oct 2019 | 6 Dec 2019 | 38 | 5 |
| Unknown player | Hamstring Injury | 24 Oct 2019 | 21 Nov 2019 | 28 | 4 |
| Unknown player | Muscle Injury | 3 Oct 2019 | 6 Feb 2020 | 126 | 18 |
| Juanmi | Foot Injury | 23 Sept 2019 | 20 Jun 2020 | 271 | 27 |
| Unknown player | Muscular Problems | 21 Sept 2019 | 3 Oct 2019 | 12 | 2 |
| Unknown player | Muscle Injury | 18 Sept 2019 | 24 Oct 2019 | 36 | 5 |
 Unknown player | Muscle Injury | 18 Sept 2019 | 18 Nov 2019 | 61 | 9 |
| Unknown player | Groin Injury | 26 Aug 2019 | 23 Sept 2019 | 28 | 3 |
| Borja Iglesias | Ankle Sprain | 19 Aug 2019 | 29 Aug 2019 | 10 | 1 |
| Sergio Canales | Knock | 16 Aug 2019 | 21 Aug 2019 | 5 | 1 |
 Unknown player | Foot Injury | 2 May 2019 | 2 Jun 2019 | 31 | 4 |
| Sergio Canales | Ankle Sprain | 30 Apr 2019 | 30 May 2019 | 30 | 4 |
| Unknown player | Broken Nose Bone | 16 Apr 2019 | 11 May 2019 | 25 | 4 |
| Sergio Canales | Ankle Sprain | 14 Apr 2019 | 23 Apr 2019 | 9 | 1 |
| Unknown player | Muscle Injury | 4 Mar 2019 | 25 Mar 2019 | 21 | 2 |
 Unknown player | Muscle Injury | 22 Feb 2019 | 27 Feb 2019 | 5 | 1 |
 Junior Firpo | Muscle Injury | 15 Feb 2019 | 6 Apr 2019 | 50 | 9 |
| Unknown player | Muscular Problems | 11 Feb 2019 | 23 Feb 2019 | 12 | 3 |
| Marc Bartra | Muscle Injury | 8 Feb 2019 | 16 Feb 2019 | 8 | 2 |
| Unknown player | Hamstring Injury | 31 Jan 2019 | 6 Feb 2019 | 6 | 1 |
| Unknown player | Hamstring Injury | 28 Jan 2019 | 28 Feb 2019 | 31 | 8 |
| Unknown player | Muscle Injury | 23 Jan 2019 | 29 Jan 2019 | 6 | 2 |
| Unknown player | Flu | 22 Jan 2019 | 29 Jan 2019 | 7 | 2 |
| Unknown player | Torn Muscle Fiber | 25 Dec 2018 | 25 Jan 2019 | 31 | — |
| Unknown player | Shoulder Injury | 23 Dec 2018 | 18 Jan 2019 | 26 | 3 |
| Junior Firpo | Hamstring Injury | 17 Dec 2018 | 2 Feb 2019 | 47 | 9 |
| Unknown player | Torn Muscle Fiber | 3 Dec 2018 | 3 Jan 2019 | 31 | 5 |
| Unknown player | Knee Injury | 12 Nov 2018 | 29 Nov 2018 | 17 | 1 |
| Unknown player | Muscle Tear | 22 Oct 2018 | 22 Nov 2018 | 31 | 6 |
| Unknown player | Muscle Injury | 16 Oct 2018 | 23 Oct 2018 | 7 | 1 |
| Unknown player | Muscle Injury | 11 Oct 2018 | 1 Nov 2018 | 21 | 3 |
| Unknown player | Hamstring Injury | 8 Oct 2018 | 31 Oct 2018 | 23 | 3 |
| Unknown player | Leg Injury | 11 Sept 2018 | 28 Sept 2018 | 17 | 3 |
 Giovani Lo Celso | Rest | 26 Aug 2018 | 3 Sept 2018 | 8 | 1 |
| Unknown player | Muscle Injury | 13 May 2018 | 3 Jun 2018 | 21 | 1 |
| Junior Firpo | Cruciate Ligament Injury | 6 May 2018 | 6 Jun 2018 | 31 | 2 |
| Unknown player | Muscular Problems | 3 May 2018 | 10 May 2018 | 7 | 1 |
| Unknown player | Foot Bruise | 20 Apr 2018 | 27 Apr 2018 | 7 | 1 |
 Unknown player | Inflammation Of Pubic Bone | 3 Apr 2018 | 3 Jun 2018 | 61 | 8 |
| Unknown player | Muscular Problems | 13 Mar 2018 | 30 Mar 2018 | 17 | 1 |
| Unknown player | Knee Bruise | 7 Mar 2018 | 31 Mar 2018 | 24 | 2 |
| Unknown player | Muscle Injury | 19 Feb 2018 | 17 Mar 2018 | 26 | 4 |
