| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 William Osula | Knock | 23 Aug 2026 | Current | — | 6 |
 Dan Burn | Ankle Injury | 22 Aug 2026 | Current | — | 6 |
 Joelinton | Muscle Injury | 16 Aug 2026 | Current | — | 7 |
 Tino Livramento | Knee Injury | 16 Jun 2026 | Current | — | 13 |
 Sandro Tonali | Thigh Problems | 18 May 2026 | 1 Jun 2026 | 14 | 1 |
 Fabian Schär | Ankle Injury | 15 May 2026 | 1 Jun 2026 | 17 | 2 |
| Joelinton | Hamstring Injury | 15 May 2026 | 24 May 2026 | 9 | 1 |
 Lewis Miley | Broken Fibula | 5 May 2026 | 13 Jul 2026 | 69 | 3 |
| Tino Livramento | Thigh Problems | 18 Apr 2026 | 1 Jun 2026 | 44 | 6 |
 Anthony Gordon | Hip Injury | 17 Apr 2026 | 30 Apr 2026 | 13 | 2 |
| Fabian Schär | Surgery | 10 Apr 2026 | 11 May 2026 | 31 | 5 |
| Sandro Tonali | Groin Injury | 18 Mar 2026 | 25 Mar 2026 | 7 | 2 |
| Sandro Tonali | Virus | 11 Mar 2026 | 15 Mar 2026 | 4 | 1 |
 Nick Woltemade | ILL | 1 Mar 2026 | 6 Mar 2026 | 5 | 1 |
 Unknown player | Knee Surgery | 20 Feb 2026 | 29 Jun 2026 | 129 | 16 |
 Sven Botman | Back Problems | 17 Feb 2026 | 22 Feb 2026 | 5 | 1 |
 Bruno Guimarães | Hamstring Injury | 13 Feb 2026 | 16 Apr 2026 | 62 | 12 |
 Yoane Wissa | Bruised Knee | 12 Feb 2026 | 23 Feb 2026 | 11 | 3 |
| Lewis Miley | Dead Leg | 6 Feb 2026 | 5 Apr 2026 | 58 | 13 |
| Anthony Gordon | Thigh Problems | 6 Feb 2026 | 9 Feb 2026 | 3 | 1 |
| Joelinton | Groin Problems | 26 Jan 2026 | 17 Feb 2026 | 22 | 7 |
| Tino Livramento | Hamstring Injury | 11 Jan 2026 | 6 Mar 2026 | 54 | 17 |
| Fabian Schär | Broken Ankle | 8 Jan 2026 | 10 Apr 2026 | 92 | 21 |
 Anthony Elanga | Knock | 20 Dec 2025 | 14 Jan 2026 | 25 | 2 |
| Tino Livramento | Knee Injury | 18 Dec 2025 | 1 Jan 2026 | 14 | 3 |
| Dan Burn | Bruised Ribs | 15 Dec 2025 | 24 Jan 2026 | 40 | 10 |
| Sven Botman | Hamstring Injury | 28 Nov 2025 | 2 Jan 2026 | 35 | 9 |
 Nick Pope | Groin Injury | 28 Nov 2025 | 16 Dec 2025 | 18 | 5 |
| Unknown player | Knee Injury | 21 Nov 2025 | 20 Feb 2026 | 91 | 2 |
 Unknown player | Thigh Problems | 21 Nov 2025 | 4 Jan 2026 | 44 | 11 |
| Anthony Gordon | Hip Problems | 7 Nov 2025 | 24 Nov 2025 | 17 | 1 |
| William Osula | Ankle Injury | 3 Nov 2025 | 19 Jan 2026 | 77 | 2 |
| Unknown player | ILL | 31 Oct 2025 | 4 Nov 2025 | 4 | 1 |
 Lewis Hall | Hamstring Injury | 1 Oct 2025 | 2 Nov 2025 | 32 | 6 |
| Tino Livramento | Knee Injury | 28 Sept 2025 | 21 Nov 2025 | 54 | 10 |
 Unknown player | Thigh Problems | 23 Sept 2025 | 1 Dec 2025 | 69 | 14 |
| Fabian Schär | Head Injury | 19 Sept 2025 | 3 Oct 2025 | 14 | 4 |
 Jacob Ramsey | Ankle Injury | 1 Sept 2025 | 13 Oct 2025 | 42 | 7 |
| Joelinton | Thigh Problems | 29 Aug 2025 | 13 Sept 2025 | 15 | 1 |
| Unknown player | Knee Injury | 22 Aug 2025 | 28 Aug 2025 | 6 | 1 |
 Alexander Isak | Fitness | 10 Aug 2025 | 1 Sept 2025 | 22 | 3 |
 Joe Willock | Calf Injury | 31 Jul 2025 | 25 Aug 2025 | 25 | 4 |
 Matt Targett | Hamstring Injury | 21 Apr 2025 | 25 May 2025 | 34 | 5 |
| Joelinton | Knee Problems | 20 Apr 2025 | 23 May 2025 | 33 | 4 |
| Joe Willock | Concussion | 3 Apr 2025 | 15 Apr 2025 | 12 | 1 |
| Matt Targett | ILL | 1 Apr 2025 | 4 Apr 2025 | 3 | 1 |
| Anthony Gordon | Knock | 21 Mar 2025 | 14 Apr 2025 | 24 | 2 |
| Sven Botman | Knee Problems | 7 Mar 2025 | 23 Apr 2025 | 47 | 7 |
| Sven Botman | Knee Surgery | 5 Mar 2025 | Current | — | 89 |
| Lewis Hall | Ankle Surgery | 27 Feb 2025 | 2 Aug 2025 | 156 | 13 |
| Alexander Isak | Groin Injury | 25 Feb 2025 | 1 Mar 2025 | 4 | 1 |
| Anthony Gordon | Thigh Problems | 6 Feb 2025 | 10 Feb 2025 | 4 | 1 |
| Sven Botman | Broken Kneecap | 5 Feb 2025 | 6 Mar 2025 | 29 | 5 |
| Joelinton | Knee Injury | 2 Feb 2025 | 1 Mar 2025 | 27 | 5 |
 Unknown player | Ankle Injury | 16 Jan 2025 | 21 Apr 2025 | 95 | 12 |
| Fabian Schär | ILL | 14 Jan 2025 | 17 Jan 2025 | 3 | 1 |
 Harvey Barnes | Thigh Problems | 12 Jan 2025 | 14 Feb 2025 | 33 | 7 |
| Joe Willock | Muscle Injury | 11 Jan 2025 | 14 Jan 2025 | 3 | 1 |
| Alexander Isak | Hamstring Injury | 11 Jan 2025 | 14 Jan 2025 | 3 | 1 |
| Tino Livramento | ILL | 24 Dec 2024 | 29 Dec 2024 | 5 | 1 |
 Callum Wilson | Hamstring Injury | 7 Dec 2024 | 5 Feb 2025 | 60 | 13 |
| Nick Pope | Knee Injury | 7 Dec 2024 | 20 Jan 2025 | 44 | 11 |
| Unknown player | Broken Collarbone | 8 Nov 2024 | 13 Jan 2025 | 66 | 11 |
| Anthony Gordon | Groin Injury | 26 Oct 2024 | 30 Oct 2024 | 4 | 1 |
| Unknown player | Hamstring Injury | 14 Oct 2024 | 25 Nov 2024 | 42 | 5 |
 Martin Dúbravka | Knee Injury | 2 Oct 2024 | 30 Oct 2024 | 28 | 3 |
| Matt Targett | Skin Disease | 16 Sept 2024 | 4 Nov 2024 | 49 | 8 |
| Alexander Isak | Broken Toe | 15 Sept 2024 | 18 Oct 2024 | 33 | 5 |
| Joe Willock | Thigh Problems | 28 Aug 2024 | 11 Sept 2024 | 14 | 2 |
 Unknown player | Injury | 17 Aug 2024 | 18 Aug 2024 | 1 | 0 |
| Callum Wilson | Back Injury | 19 Jul 2024 | 25 Nov 2024 | 129 | 11 |
| Lewis Miley | Metatarsal Fracture | 2 Jul 2024 | 17 Oct 2024 | 107 | 11 |
| Anthony Gordon | Ankle Injury | 15 May 2024 | 27 May 2024 | 12 | 4 |
| Tino Livramento | Ankle Injury | 14 May 2024 | 27 May 2024 | 13 | 4 |
| Callum Wilson | ILL | 6 May 2024 | 17 May 2024 | 11 | 2 |
| Fabian Schär | Hamstring Injury | 27 Apr 2024 | 15 May 2024 | 18 | 3 |
| Joe Willock | Achilles Tendon Problems | 6 Apr 2024 | 20 May 2024 | 44 | 7 |
 Unknown player | Cruciate Ligament Injury | 30 Mar 2024 | 10 May 2025 | 406 | 23 |
 Unknown player | Knee Injury | 30 Mar 2024 | 3 May 2024 | 34 | 3 |
| Lewis Miley | Back Injury | 25 Mar 2024 | 20 May 2024 | 56 | 6 |
| Sven Botman | Cruciate Ligament Injury | 20 Mar 2024 | 13 Dec 2024 | 268 | 23 |
| Matt Targett | Achilles Tendon Problems | 18 Mar 2024 | 12 Aug 2024 | 147 | 12 |
| Tino Livramento | Ankle Injury | 11 Mar 2024 | 12 Apr 2024 | 32 | 5 |
| Harvey Barnes | Hamstring Injury | 2 Mar 2024 | 30 Mar 2024 | 28 | 3 |
| Unknown player | Calf Injury | 2 Mar 2024 | 10 May 2024 | 69 | 3 |
| Martin Dúbravka | ILL | 21 Feb 2024 | 26 Feb 2024 | 5 | 1 |
| Callum Wilson | Chest Injury | 11 Feb 2024 | 15 Apr 2024 | 64 | 10 |
| Alexander Isak | Groin Injury | 30 Jan 2024 | 23 Feb 2024 | 24 | 4 |
| Unknown player | ILL | 25 Jan 2024 | 30 Jan 2024 | 5 | 1 |
| Unknown player | Calf Injury | 22 Jan 2024 | 8 Feb 2024 | 17 | 3 |
| Tino Livramento | ILL | 12 Jan 2024 | 20 Jan 2024 | 8 | 1 |
| Joelinton | Groin Surgery | 6 Jan 2024 | 3 May 2024 | 118 | 24 |
| Unknown player | Groin Injury | 26 Dec 2023 | 5 Jan 2024 | 10 | 2 |
| Callum Wilson | Calf Injury | 26 Dec 2023 | 1 Feb 2024 | 37 | 6 |
| Unknown player | Injury | 23 Dec 2023 | 1 Jan 2024 | 9 | 2 |
| Joelinton | Hamstring Injury | 16 Dec 2023 | 25 Dec 2023 | 9 | 3 |
| Fabian Schär | Strain In The Thigh And Gluteal Muscles | 16 Dec 2023 | 22 Dec 2023 | 6 | 2 |
| Nick Pope | Shoulder Injury | 2 Dec 2023 | 2 May 2024 | 152 | 27 |
| Joe Willock | Achilles Tendon Problems | 24 Nov 2023 | 23 Feb 2024 | 91 | 18 |
 Sean Longstaff | Ankle Injury | 11 Nov 2023 | 8 Dec 2023 | 27 | 5 |
