| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Rasmus Højlund | Hamstring Strain | 11 Nov 2023 | 27 Nov 2023 | 16 | 1 |
 Unknown player | Knee Injury | 11 Nov 2023 | 22 Dec 2023 | 41 | 5 |
 Unknown player | Hamstring Strain | 8 Nov 2023 | 5 Dec 2023 | 27 | 5 |
 Unknown player | Knock | 13 Oct 2023 | 4 Jan 2024 | 83 | 17 |
 Lisandro Martínez | Foot Injury | 21 Sept 2023 | 4 Jan 2024 | 105 | 22 |
 Aaron Wan-Bissaka | Hamstring Injury | 16 Sept 2023 | 30 Oct 2023 | 44 | 9 |
 Unknown player | Injury | 26 Aug 2023 | 22 Sept 2023 | 27 | 4 |
 Luke Shaw | Muscle Injury | 23 Aug 2023 | 23 Nov 2023 | 92 | 16 |
 Unknown player | Injury | 21 Aug 2023 | 20 Sept 2023 | 30 | 5 |
 Mason Mount | Injury | 19 Aug 2023 | 25 Sept 2023 | 37 | 6 |
 Harry Maguire | Injury | 18 Aug 2023 | 23 Aug 2023 | 5 | 1 |
 Tom Heaton | Calf Injury | 10 Aug 2023 | 17 Sept 2023 | 38 | 4 |
 Amad Diallo | Knee Injury | 3 Aug 2023 | 7 Dec 2023 | 126 | 23 |
| Rasmus Højlund | Back Injury | 1 Aug 2023 | 31 Aug 2023 | 30 | 6 |
 Kobbie Mainoo | Ankle Injury | 27 Jul 2023 | 22 Oct 2023 | 87 | 15 |
 Unknown player | Knee Injury | 1 Jul 2023 | 11 Nov 2024 | 499 | 82 |
 Marcus Rashford | Leg Injury | 11 May 2023 | 24 May 2023 | 13 | 2 |
 Marcel Sabitzer | Meniscus Injury | 10 May 2023 | 15 Jun 2023 | 36 | 5 |
| Harry Maguire | Injury | 22 Apr 2023 | 28 Apr 2023 | 6 | 2 |
| Marcel Sabitzer | Groin Problems | 16 Apr 2023 | 19 Apr 2023 | 3 | 1 |
| Unknown player | Foot Injury | 14 Apr 2023 | 8 May 2023 | 24 | 6 |
| Lisandro Martínez | Metatarsal Fracture | 14 Apr 2023 | 30 Jun 2023 | 77 | 12 |
 Scott McTominay | Injury | 9 Apr 2023 | 11 May 2023 | 32 | 9 |
| Marcus Rashford | Muscle Injury | 8 Apr 2023 | 19 Apr 2023 | 11 | 3 |
| Luke Shaw | Injury | 6 Apr 2023 | 19 Apr 2023 | 13 | 3 |
| Tom Heaton | Ankle Injury | 18 Mar 2023 | 17 May 2023 | 60 | 13 |
 Alejandro Garnacho | Ankle Injury | 13 Mar 2023 | 5 May 2023 | 53 | 11 |
| Marcel Sabitzer | Injury | 6 Mar 2023 | 14 Mar 2023 | 8 | 2 |
 Antony | Doubtful | 19 Feb 2023 | 19 Feb 2023 | 0 | 1 |
| Harry Maguire | Injury | 17 Feb 2023 | 21 Feb 2023 | 4 | 1 |
| Antony | Leg Injury | 5 Feb 2023 | 20 Feb 2023 | 15 | 3 |
 Unknown player | Hip Injury | 2 Feb 2023 | 8 Mar 2023 | 34 | 9 |
| Unknown player | Ankle Injury | 29 Jan 2023 | 6 Apr 2023 | 67 | 15 |
| Scott McTominay | Injury | 27 Jan 2023 | 18 Feb 2023 | 22 | 6 |
 Unknown player | Doubtful | 25 Jan 2023 | 22 Dec 2023 | 331 | 65 |
| Unknown player | Injury | 14 Jan 2023 | 30 Jan 2023 | 16 | 5 |
 Diogo Dalot | Hamstring Injury | 11 Jan 2023 | 2 Feb 2023 | 22 | 5 |
 Unknown player | Knee Collateral Ligament Strain | 3 Jan 2023 | 30 Jun 2023 | 178 | 38 |
| Unknown player | Depression | 26 Dec 2022 | 31 Jan 2023 | 36 | 10 |
| Diogo Dalot | Hamstring Injury | 11 Dec 2022 | 1 Jan 2023 | 21 | 3 |
 Unknown player | ILL | 9 Nov 2022 | 18 Nov 2022 | 9 | 2 |
| Unknown player | ILL | 1 Nov 2022 | 14 Nov 2022 | 13 | 3 |
| Antony | Injury | 28 Oct 2022 | 23 Nov 2022 | 26 | 5 |
| Unknown player | Leg Injury | 22 Oct 2022 | 14 Nov 2022 | 23 | 6 |
| Unknown player | Back Injury | 10 Oct 2022 | 31 Oct 2022 | 21 | 5 |
| Unknown player | Ankle Sprain | 3 Oct 2022 | 8 Oct 2022 | 5 | 1 |
| Harry Maguire | Hamstring Injury | 26 Sept 2022 | 25 Oct 2022 | 29 | 7 |
| Aaron Wan-Bissaka | Back Problems | 12 Sept 2022 | 25 Oct 2022 | 43 | 8 |
| Marcus Rashford | Muscle Injury | 4 Sept 2022 | 19 Sept 2022 | 15 | 3 |
| Unknown player | Shingles | 3 Sept 2022 | 24 Oct 2022 | 51 | 10 |
| Unknown player | Achilles Tendon Irritation | 23 Aug 2022 | 26 Sept 2022 | 34 | 5 |
 Victor Lindelöf | Back Problems | 7 Aug 2022 | 31 Aug 2022 | 24 | 4 |
| Unknown player | Hamstring Injury | 31 Jul 2022 | 18 Aug 2022 | 18 | 3 |
 Unknown player | Ankle Injury | 30 Jul 2022 | 31 Aug 2022 | 32 | 6 |
 Axel Tuanzebe | Injury | 13 Jul 2022 | 23 Jan 2023 | 194 | 36 |
 Unknown player | Injury | 8 Jul 2022 | 4 Dec 2022 | 149 | 27 |
 Unknown player | Hamstring Injury | 3 Jul 2022 | 1 Oct 2022 | 90 | 14 |
| Marcus Rashford | Bronchitis | 4 May 2022 | 19 May 2022 | 15 | 1 |
| Harry Maguire | Knee Problems | 26 Apr 2022 | 3 May 2022 | 7 | 1 |
| Unknown player | Tonsillitis | 26 Apr 2022 | 8 May 2022 | 12 | 2 |
 Unknown player | Calf Injury | 18 Apr 2022 | 23 May 2022 | 35 | 5 |
 Unknown player | Hip Flexor Problems | 9 Apr 2022 | 30 Apr 2022 | 21 | 5 |
| Scott McTominay | Foot Injury | 6 Apr 2022 | 18 Apr 2022 | 12 | 2 |
| Unknown player | Muscular Problems | 3 Apr 2022 | 21 Apr 2022 | 18 | 3 |
| Luke Shaw | Leg Injury | 2 Apr 2022 | 13 May 2022 | 41 | 2 |
 Unknown player | Calf Injury | 1 Apr 2022 | 30 Apr 2022 | 29 | 6 |
| Unknown player | Doubtful | 12 Mar 2022 | 6 Aug 2024 | 878 | — |
 Bruno Fernandes | ILL | 12 Mar 2022 | 14 Mar 2022 | 2 | 1 |
| Unknown player | Doubtful | 12 Mar 2022 | 6 Aug 2024 | 878 | — |
| Unknown player | Doubtful | 12 Mar 2022 | 6 Aug 2024 | 878 | — |
| Unknown player | Hip Flexor Problems | 3 Mar 2022 | 7 Mar 2022 | 4 | 0 |
| Luke Shaw | COVID 19 | 2 Mar 2022 | 16 Mar 2022 | 14 | 2 |
| Unknown player | COVID 19 | 1 Mar 2022 | 9 Mar 2022 | 8 | 1 |
| Scott McTominay | ILL | 22 Feb 2022 | 2 Mar 2022 | 8 | 2 |
| Unknown player | Abdominal Problems | 14 Feb 2022 | 18 Feb 2022 | 4 | 1 |
| Unknown player | Groin Problems | 11 Feb 2022 | 7 Mar 2022 | 24 | 5 |
 Nemanja Matić | Shin Injury | 10 Feb 2022 | 18 Feb 2022 | 8 | 2 |
| Bruno Fernandes | Doubtful | 8 Feb 2022 | 6 Aug 2024 | 910 | — |
| Unknown player | Doubtful | 8 Feb 2022 | 6 Aug 2024 | 910 | — |
| Victor Lindelöf | Doubtful | 8 Feb 2022 | 6 Aug 2024 | 910 | — |
| Unknown player | COVID 19 | 7 Feb 2022 | 14 Feb 2022 | 7 | 2 |
 Unknown player | Ankle Injury | 3 Feb 2022 | 16 Feb 2022 | 13 | 3 |
 Unknown player | COVID 19 | 3 Feb 2022 | 10 Feb 2022 | 7 | 2 |
| Victor Lindelöf | ILL | 31 Jan 2022 | 7 Feb 2022 | 7 | 1 |
| Unknown player | Doubtful | 22 Jan 2022 | 6 Aug 2024 | 927 | — |
| Scott McTominay | Doubtful | 22 Jan 2022 | 6 Aug 2024 | 927 | — |
| Luke Shaw | Hamstring Injury | 18 Jan 2022 | 31 Jan 2022 | 13 | 2 |
| Aaron Wan-Bissaka | ILL | 14 Jan 2022 | 23 Jan 2022 | 9 | 2 |
| Marcus Rashford | Dead Leg | 13 Jan 2022 | 17 Jan 2022 | 4 | 1 |
| Unknown player | Hip Flexor Problems | 10 Jan 2022 | 17 Jan 2022 | 7 | 2 |
| Harry Maguire | Chest Injury | 1 Jan 2022 | 14 Jan 2022 | 13 | 2 |
| Victor Lindelöf | COVID 19 | 26 Dec 2021 | 5 Jan 2022 | 10 | 3 |
| Nemanja Matić | ILL | 10 Dec 2021 | 17 Dec 2021 | 7 | 1 |
| Unknown player | Knee Injury | 4 Dec 2021 | 13 Dec 2021 | 9 | 3 |
| Nemanja Matić | Knock | 29 Nov 2021 | 4 Dec 2021 | 5 | 1 |
| Aaron Wan-Bissaka | Hand Injury | 29 Nov 2021 | 4 Dec 2021 | 5 | 1 |
| Luke Shaw | Head Injury | 20 Nov 2021 | 7 Dec 2021 | 17 | 5 |
 Unknown player | COVID 19 | 19 Nov 2021 | 27 Nov 2021 | 8 | 2 |
| Unknown player | Hamstring Injury | 8 Nov 2021 | 3 Feb 2022 | 87 | 14 |
| Unknown player | Tendon Irritation | 4 Nov 2021 | 22 Dec 2021 | 48 | 8 |
