| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Jérémy Doku | Calf Injury | 16 Aug 2026 | Current | 33 | 6 |
 Abdukodir Khusanov | Knock | 6 May 2026 | 11 May 2026 | 5 | 1 |
 Rodri | Groin Injury | 19 Apr 2026 | 15 May 2026 | 26 | 3 |
 John Stones | Calf Injury | 28 Mar 2026 | 17 Apr 2026 | 20 | 2 |
 Rúben Dias | Hamstring Injury | 18 Mar 2026 | 8 May 2026 | 51 | 7 |
 Savinho | Thigh Problems | 12 Mar 2026 | 15 Mar 2026 | 3 | 1 |
 Nico O'Reilly | Ankle Injury | 1 Mar 2026 | 6 Mar 2026 | 5 | 1 |
 Rico Lewis | Ankle Injury | 27 Feb 2026 | 16 Mar 2026 | 17 | 3 |
 Erling Haaland | Knock | 26 Feb 2026 | 1 Mar 2026 | 3 | 1 |
 Unknown player | Knock | 15 Feb 2026 | 5 Mar 2026 | 18 | 3 |
| Jérémy Doku | Calf Injury | 28 Jan 2026 | 23 Feb 2026 | 26 | 6 |
 Matheus Nunes | ILL | 16 Jan 2026 | 19 Jan 2026 | 3 | 1 |
 Nico González | Knock | 11 Jan 2026 | 27 Jan 2026 | 16 | 4 |
| Rúben Dias | Hamstring Injury | 4 Jan 2026 | 7 Feb 2026 | 34 | 12 |
 Josko Gvardiol | Broken Tibia | 4 Jan 2026 | 1 May 2026 | 117 | 26 |
| Nico González | Knock | 2 Jan 2026 | 5 Jan 2026 | 3 | 1 |
| Savinho | Thigh Problems | 2 Jan 2026 | 20 Feb 2026 | 49 | 17 |
 Oscar Bobb | Hamstring Injury | 17 Dec 2025 | 6 Feb 2026 | 51 | 11 |
| Jérémy Doku | Muscle Injury | 10 Dec 2025 | 28 Dec 2025 | 18 | 4 |
| John Stones | Thigh Problems | 5 Dec 2025 | 9 Feb 2026 | 66 | 17 |
| Rodri | Hamstring Injury | 4 Nov 2025 | 25 Dec 2025 | 51 | 2 |
 Mateo Kovacic | Ankle Injury | 27 Oct 2025 | 12 Mar 2026 | 136 | 33 |
| Rodri | Hamstring Injury | 5 Oct 2025 | 31 Oct 2025 | 26 | 5 |
 Unknown player | Fitness | 23 Sept 2025 | 13 Oct 2025 | 20 | 4 |
| Rodri | Knee Problems | 22 Sept 2025 | 29 Sept 2025 | 7 | 2 |
| Abdukodir Khusanov | Ankle Injury | 21 Sept 2025 | 12 Nov 2025 | 52 | 12 |
 Omar Marmoush | Knee Injury | 10 Sept 2025 | 13 Oct 2025 | 33 | 7 |
 Rayan Aït-Nouri | Ankle Injury | 1 Sept 2025 | 27 Oct 2025 | 56 | 8 |
| John Stones | Muscle Injury | 1 Sept 2025 | 15 Sept 2025 | 14 | 0 |
 Rayan Cherki | Thigh Problems | 30 Aug 2025 | 3 Oct 2025 | 34 | 10 |
 Phil Foden | Ankle Injury | 25 Aug 2025 | 12 Sept 2025 | 18 | 1 |
 Unknown player | ILL | 15 Aug 2025 | 23 Aug 2025 | 8 | 1 |
 Marcus Bettinelli | Knock | 11 Aug 2025 | 15 Sept 2025 | 35 | 3 |
| Savinho | Injury | 10 Aug 2025 | 8 Sept 2025 | 29 | 2 |
| Phil Foden | Ankle Injury | 4 Aug 2025 | 22 Aug 2025 | 18 | 2 |
| Rodri | Knee Problems | 4 Aug 2025 | 23 Aug 2025 | 19 | 2 |
| Josko Gvardiol | Injury | 1 Aug 2025 | 1 Sept 2025 | 31 | 3 |
 Claudio Echeverri | Ankle Injury | 21 Jul 2025 | 23 Aug 2025 | 33 | 2 |
| Claudio Echeverri | Muscle Injury | 24 Jun 2025 | 24 Jul 2025 | 30 | 2 |
| Mateo Kovacic | Achilles Tendon Problems | 2 Jun 2025 | 3 Oct 2025 | 123 | 14 |
| Rodri | Fitness | 1 May 2025 | 19 May 2025 | 18 | 3 |
| Unknown player | Hip Problems | 13 Apr 2025 | 25 Apr 2025 | 12 | 2 |
| Phil Foden | Ankle Injury | 7 Apr 2025 | 18 Apr 2025 | 11 | 1 |
| Erling Haaland | Ankle Injury | 31 Mar 2025 | 1 May 2025 | 31 | 7 |
| Unknown player | Abdominal Problems | 14 Mar 2025 | 30 Mar 2025 | 16 | 1 |
 Unknown player | Foot Surgery | 1 Mar 2025 | 19 May 2025 | 79 | 14 |
| Oscar Bobb | Fitness | 1 Mar 2025 | 30 Mar 2025 | 29 | 3 |
| John Stones | Hamstring Injury | 19 Feb 2025 | 23 May 2025 | 93 | 13 |
| Erling Haaland | Knee Problems | 16 Feb 2025 | 25 Feb 2025 | 9 | 2 |
| Unknown player | Muscle Stiffness | 13 Feb 2025 | 17 Feb 2025 | 4 | 1 |
| Rúben Dias | Muscle Stiffness | 13 Feb 2025 | 17 Feb 2025 | 4 | 1 |
 Manuel Akanji | Adductor Injury | 12 Feb 2025 | 13 Apr 2025 | 60 | 13 |
 Jack Grealish | Hip Injury | 11 Feb 2025 | 17 Feb 2025 | 6 | 2 |
 Unknown player | Injury | 3 Feb 2025 | 4 Aug 2025 | 182 | 11 |
| Unknown player | Injury | 1 Feb 2025 | 10 Feb 2025 | 9 | 2 |
| Jérémy Doku | Doubtful | 25 Jan 2025 | 25 Jan 2025 | 0 | 1 |
| Rúben Dias | Hip Injury | 24 Jan 2025 | 7 Feb 2025 | 14 | 3 |
| Jérémy Doku | Injury | 19 Jan 2025 | 11 Feb 2025 | 23 | 6 |
| Unknown player | Muscle Injury | 18 Jan 2025 | 11 Feb 2025 | 24 | 6 |
| John Stones | Foot Injury | 22 Dec 2024 | 20 Jan 2025 | 29 | 5 |
| Unknown player | Injury | 20 Dec 2024 | 10 Jan 2025 | 21 | 4 |
| Rúben Dias | Injury | 20 Dec 2024 | 18 Jan 2025 | 29 | 6 |
| Matheus Nunes | Injury | 20 Dec 2024 | 2 Jan 2025 | 13 | 3 |
| Manuel Akanji | Injury | 4 Dec 2024 | 20 Dec 2024 | 16 | 4 |
| Unknown player | Injury | 4 Dec 2024 | 20 Dec 2024 | 16 | 4 |
| Phil Foden | Injury | 1 Dec 2024 | 9 Dec 2024 | 8 | 3 |
| John Stones | Foot Injury | 23 Nov 2024 | 14 Dec 2024 | 21 | 6 |
| Mateo Kovacic | Injury | 18 Nov 2024 | 12 Dec 2024 | 24 | 5 |
| Jérémy Doku | Hamstring Injury | 3 Nov 2024 | 27 Nov 2024 | 24 | 3 |
| John Stones | Injury | 1 Nov 2024 | 18 Nov 2024 | 17 | 3 |
| Rúben Dias | Calf Injury | 30 Oct 2024 | 1 Dec 2024 | 32 | 6 |
| Rodri | Cruciate Ligament Tear | 23 Sept 2024 | 30 Apr 2025 | 219 | 47 |
 Kevin De Bruyne | Hamstring Muscle Injury | 18 Sept 2024 | 31 Oct 2024 | 43 | 9 |
| Unknown player | Hamstring Injury | 10 Sept 2024 | 14 Oct 2024 | 34 | 7 |
| Savinho | Knee Injury | 26 Aug 2024 | 12 Sept 2024 | 17 | 1 |
| Phil Foden | ILL | 21 Aug 2024 | 31 Aug 2024 | 10 | 1 |
| Oscar Bobb | Broken Leg | 14 Aug 2024 | 1 Mar 2025 | 199 | 1 |
| Rodri | Hamstring Injury | 14 Jul 2024 | 25 Aug 2024 | 42 | 6 |
| Unknown player | Eyebow Fracture | 14 May 2024 | 28 Jul 2024 | 75 | 4 |
| Rúben Dias | ILL | 26 Apr 2024 | 30 Apr 2024 | 4 | 1 |
| Phil Foden | ILL | 26 Apr 2024 | 30 Apr 2024 | 4 | 1 |
| Erling Haaland | Muscle Injury | 18 Apr 2024 | 26 Apr 2024 | 8 | 1 |
| Unknown player | Calf Injury | 31 Mar 2024 | 12 Apr 2024 | 12 | 4 |
 Unknown player | Hamstring Injury | 23 Mar 2024 | 12 Apr 2024 | 20 | 4 |
| Kevin De Bruyne | Groin Injury | 10 Mar 2024 | 18 Mar 2024 | 8 | 2 |
| Unknown player | Muscle Injury | 10 Mar 2024 | 5 Apr 2024 | 26 | 4 |
| Jérémy Doku | Minor Knock | 4 Mar 2024 | 8 Mar 2024 | 4 | 1 |
| Jack Grealish | Groin Injury | 28 Feb 2024 | 28 Mar 2024 | 29 | 4 |
| Jack Grealish | Groin Problems | 12 Feb 2024 | 22 Feb 2024 | 10 | 3 |
| Josko Gvardiol | Ankle Ligament Tear | 11 Feb 2024 | 4 Mar 2024 | 22 | 5 |
| Mateo Kovacic | Knee Injury | 8 Feb 2024 | 15 Feb 2024 | 7 | 2 |
| Manuel Akanji | Injury | 7 Jan 2024 | 31 Jan 2024 | 24 | 3 |
| John Stones | Ankle Injury | 28 Dec 2023 | 15 Jan 2024 | 18 | 3 |
| Rúben Dias | ILL | 25 Dec 2023 | 28 Dec 2023 | 3 | 1 |
| Kevin De Bruyne | Fitness | 18 Dec 2023 | 29 Dec 2023 | 11 | 3 |
| Erling Haaland | Stress Reaction Of The Bone | 9 Dec 2023 | 31 Jan 2024 | 53 | 10 |
| Jérémy Doku | Muscle Injury | 4 Dec 2023 | 5 Jan 2024 | 32 | 4 |
| Mateo Kovacic | Muscle Injury | 16 Nov 2023 | 1 Dec 2023 | 15 | 2 |
| Matheus Nunes | Muscle Injury | 14 Nov 2023 | 4 Dec 2023 | 20 | 3 |
 Sergio Gómez | Knock | 3 Nov 2023 | 13 Nov 2023 | 10 | 2 |
