| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Nico González | Calf Injury | 23 Oct 2026 | Current | 24 | 2 |
 Zeki Çelik | Thigh Muscle Strain | 23 Oct 2026 | Current | 24 | 2 |
 Francisco Conceição | Shoulder Injury | 19 Oct 2026 | Current | 22 | 3 |
 Arkadiusz Milik | Injury | 10 Oct 2026 | Current | — | 6 |
| Francisco Conceição | Hamstring Injury | 27 Sept 2026 | — | — | 1 |
 Randal Kolo Muani | Broken Finger | 21 Sept 2026 | 5 Oct 2026 | 14 | 1 |
 Kamil Grabara | Cruciate Ligament Injury | 19 Sept 2026 | Current | 315 | 8 |
 Jérémie Boga | Hamstring Muscle Injury | 7 Sept 2026 | 16 Oct 2026 | 39 | 4 |
 Manuel Locatelli | Meniscus Injury | 7 Sept 2026 | Current | 122 | 10 |
 Juan Cabal | Thigh Problems | 2 Sept 2026 | 7 Oct 2026 | 35 | 5 |
 Pape Matar Sarr | Injury | 1 Sept 2026 | 10 Sept 2026 | 9 | 1 |
 Andrea Cambiaso | Ankle Sprain | 30 Aug 2026 | 30 Sept 2026 | 31 | 2 |
 Jeff Ekhator | Thigh Muscle Strain | 30 Aug 2026 | Current | 78 | 11 |
 Weston McKennie | Muscle Fatigue | 27 Aug 2026 | 15 Sept 2026 | 19 | 1 |
 Kenan Yıldız | Broken Foot | 24 Aug 2026 | Current | 93 | 12 |
 Federico Gatti | Ankle Problems | 18 Aug 2026 | 26 Aug 2026 | 8 | 1 |
| Jeff Ekhator | Muscular Problems | 19 Jul 2026 | 28 Aug 2026 | 40 | 6 |
 Khéphren Thuram | Knee Surgery | 13 Jul 2026 | 1 Jan 2027 | 172 | — |
| Arkadiusz Milik | Hamstring Muscle Injury | 15 Apr 2026 | 14 May 2026 | 29 | 4 |
| Juan Cabal | Adductor Injury | 10 Apr 2026 | 15 May 2026 | 35 | 5 |
Unknown player | Calf Problems | 7 Apr 2026 | 25 Apr 2026 | 18 | 2 |
 Mattia Perin | Calf Problems | 7 Apr 2026 | 24 Apr 2026 | 17 | 1 |
 Vasilije Adžić | Ankle Problems | 2 Apr 2026 | 24 Apr 2026 | 22 | 3 |
Unknown player | Rest | 7 Mar 2026 | — | — | 21 |
Unknown player | Rest | 6 Mar 2026 | 16 Mar 2026 | 10 | 1 |
 Bremer | Muscular Problems | 18 Feb 2026 | 24 Feb 2026 | 6 | 1 |
 Jonathan David | Adductor Pain | 16 Feb 2026 | 20 Feb 2026 | 4 | 1 |
 Emil Holm | Calf Muscle Tear | 15 Feb 2026 | 1 Apr 2026 | 45 | 6 |
| Khéphren Thuram | Bone Edema | 12 Feb 2026 | 16 Feb 2026 | 4 | 1 |
 Carlo Pinsoglio | Injury | 23 Jan 2026 | 27 Jan 2026 | 4 | 1 |
Unknown player | Muscular Problems | 15 Jan 2026 | 27 Jan 2026 | 12 | 3 |
Unknown player | Adductor Pain | 5 Jan 2026 | 10 Jan 2026 | 5 | 1 |
Unknown player | Broken Hand | 4 Jan 2026 | 31 Jan 2026 | 27 | 3 |
 Lloyd Kelly | Muscle Fatigue | 4 Jan 2026 | 10 Jan 2026 | 6 | 1 |
| Francisco Conceição | Muscle Fatigue | 4 Jan 2026 | 16 Jan 2026 | 12 | 1 |
| Arkadiusz Milik | Calf Injury | 1 Jan 2026 | 12 Mar 2026 | 70 | 4 |
| Francisco Conceição | Muscle Fatigue | 21 Dec 2025 | 1 Jan 2026 | 11 | 1 |
 Daniele Rugani | Calf Injury | 21 Dec 2025 | 17 Feb 2026 | 58 | 8 |
| Juan Cabal | Muscle Fatigue | 19 Dec 2025 | 2 Jan 2026 | 14 | 1 |
| Federico Gatti | Meniscus Injury | 3 Dec 2025 | 15 Jan 2026 | 43 | 8 |
| Mattia Perin | Muscle Fatigue | 1 Dec 2025 | 4 Dec 2025 | 3 | 1 |
Unknown player | Adductor Injury | 30 Nov 2025 | 5 Mar 2026 | 95 | 20 |
| Federico Gatti | Flu | 24 Nov 2025 | 28 Nov 2025 | 4 | 1 |
| Daniele Rugani | Muscular Problems | 18 Nov 2025 | 9 Dec 2025 | 21 | 5 |
| Kenan Yıldız | Knee Problems | 31 Oct 2025 | 3 Nov 2025 | 3 | 1 |
| Lloyd Kelly | Hamstring Injury | 31 Oct 2025 | 17 Nov 2025 | 17 | 3 |
| Khéphren Thuram | Calf Problems | 28 Oct 2025 | 30 Oct 2025 | 2 | 0 |
 Edon Zhegrova | Muscle Fatigue | 16 Oct 2025 | 20 Oct 2025 | 4 | 0 |
| Carlo Pinsoglio | Calf Muscle Tear | 15 Oct 2025 | 1 Jan 2026 | 78 | 8 |
| Bremer | Meniscus Injury | 13 Oct 2025 | 9 Dec 2025 | 57 | 9 |
| Juan Cabal | Hamstring Muscle Injury | 2 Oct 2025 | 21 Nov 2025 | 50 | 8 |
| Bremer | Muscular Problems | 28 Sept 2025 | 7 Oct 2025 | 9 | 2 |
| Khéphren Thuram | Calf Problems | 28 Sept 2025 | 4 Oct 2025 | 6 | 1 |
| Francisco Conceição | Injury | 26 Sept 2025 | 30 Sept 2025 | 4 | 1 |
Unknown player | Muscle Fatigue | 15 Sept 2025 | 22 Sept 2025 | 7 | 2 |
| Francisco Conceição | Muscular Problems | 8 Sept 2025 | 29 Sept 2025 | 21 | 1 |
| Edon Zhegrova | Fitness | 2 Sept 2025 | 15 Sept 2025 | 13 | 1 |
Unknown player | Muscle Fatigue | 15 Aug 2025 | 8 Sept 2025 | 24 | 3 |
 Fabio Miretti | Hamstring Injury | 14 Aug 2025 | 20 Oct 2025 | 67 | 4 |
| Arkadiusz Milik | Broken Tibia | 25 Jul 2025 | 18 Dec 2025 | 146 | 25 |
| Juan Cabal | Fitness | 15 Jul 2025 | 9 Sept 2025 | 56 | 5 |
 Nicolò Savona | Ankle Injury | 26 Jun 2025 | 1 Sept 2025 | 67 | 6 |
| Mattia Perin | Surgery | 26 May 2025 | 11 Sept 2025 | 108 | 4 |
| Andrea Cambiaso | Hamstring Injury | 4 May 2025 | 17 May 2025 | 13 | 2 |
| Lloyd Kelly | Hamstring Muscle Injury | 28 Apr 2025 | 13 May 2025 | 15 | 2 |
Unknown player | Stress Reaction Of The Bone | 23 Apr 2025 | 6 May 2025 | 13 | 2 |
 Teun Koopmeiners | Achilles Tendon Irritation | 14 Apr 2025 | 5 Jun 2025 | 52 | 5 |
 Samuel Mbangula | Stress Reaction Of The Bone | 8 Apr 2025 | 25 Apr 2025 | 17 | 2 |
| Mattia Perin | Muscular Problems | 5 Apr 2025 | 16 Apr 2025 | 11 | 2 |
| Federico Gatti | Broken Fibula | 29 Mar 2025 | 9 May 2025 | 41 | 5 |
| Arkadiusz Milik | Muscle Injury | 28 Mar 2025 | 25 Jun 2025 | 89 | 9 |
| Andrea Cambiaso | Injury | 16 Mar 2025 | 4 Apr 2025 | 19 | 2 |
| Francisco Conceição | Hamstring Muscle Injury | 2 Mar 2025 | 14 Mar 2025 | 12 | 2 |
 Douglas Luiz | Hamstring Muscle Injury | 23 Feb 2025 | 4 Apr 2025 | 40 | 6 |
| Nicolò Savona | Thigh Problems | 20 Feb 2025 | 11 Mar 2025 | 19 | 4 |
 Renato Veiga | Muscle Injury | 19 Feb 2025 | 7 Mar 2025 | 16 | 5 |
| Douglas Luiz | Muscle Fatigue | 13 Feb 2025 | 21 Feb 2025 | 8 | 2 |
 Pierre Kalulu | Muscle Injury | 29 Jan 2025 | 28 Feb 2025 | 30 | 4 |
Unknown player | Flu | 29 Jan 2025 | 30 Jan 2025 | 1 | — |
| Andrea Cambiaso | Ankle Problems | 28 Jan 2025 | 13 Feb 2025 | 16 | 4 |
Unknown player | Muscle Fatigue | 7 Jan 2025 | 15 Jan 2025 | 8 | 2 |
| Francisco Conceição | Stress Reaction Of The Bone | 3 Jan 2025 | 20 Jan 2025 | 17 | 2 |
| Arkadiusz Milik | Calf Injury | 1 Jan 2025 | 25 Mar 2025 | 83 | 7 |
Unknown player | Ankle Sprain | 20 Dec 2024 | 28 Dec 2024 | 8 | 1 |
| Douglas Luiz | Muscular Problems | 19 Dec 2024 | 27 Dec 2024 | 8 | 1 |
 Timothy Weah | Hamstring Injury | 18 Dec 2024 | 1 Jan 2025 | 14 | 2 |
| Douglas Luiz | Rest | 16 Dec 2024 | 18 Dec 2024 | 2 | 0 |
Unknown player | Muscle Fatigue | 12 Dec 2024 | 30 Dec 2024 | 18 | 3 |
| Andrea Cambiaso | Ankle Sprain | 7 Dec 2024 | 19 Dec 2024 | 12 | 2 |
Unknown player | ILL | 3 Dec 2024 | 25 Jan 2025 | 53 | 6 |
| Nicolò Savona | Adductor Pain | 27 Nov 2024 | 6 Dec 2024 | 9 | 2 |
| Weston McKennie | Muscle Fatigue | 24 Nov 2024 | 9 Dec 2024 | 15 | 1 |
Unknown player | Muscle Injury | 18 Nov 2024 | 4 Dec 2024 | 16 | 2 |
| Juan Cabal | Cruciate Ligament Injury | 12 Nov 2024 | 15 Jul 2025 | 245 | 35 |
| Vasilije Adžić | Injury | 3 Nov 2024 | 2 Dec 2024 | 29 | 2 |
| Douglas Luiz | Muscle Fatigue | 22 Oct 2024 | 9 Dec 2024 | 48 | 2 |
| Weston McKennie | Muscle Fatigue | 14 Oct 2024 | 20 Oct 2024 | 6 | 0 |
| Teun Koopmeiners | Rib Fracture | 6 Oct 2024 | 28 Oct 2024 | 22 | 3 |
| Bremer | Cruciate Ligament Tear | 3 Oct 2024 | 25 Jun 2025 | 265 | 38 |
| Nico González | Muscular Problems | 2 Oct 2024 | 13 Dec 2024 | 72 | 4 |
