| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Unknown player | Lumbago | 13 Mar 2021 | 21 Mar 2021 | 8 | 1 |
 Unknown player | Thigh Problems | 11 Mar 2021 | 2 Apr 2021 | 22 | 2 |
 Unknown player | Thigh Problems | 8 Mar 2021 | 1 Apr 2021 | 24 | 3 |
 Unknown player | COVID 19 | 8 Mar 2021 | 28 Mar 2021 | 20 | 1 |
 Koni De Winter | Muscle Injury | 8 Mar 2021 | 23 Mar 2021 | 15 | — |
 Rodrigo Bentancur | COVID 19 | 4 Mar 2021 | 18 Mar 2021 | 14 | 3 |
 Matthijs de Ligt | Muscle Fatigue | 1 Mar 2021 | 11 Mar 2021 | 10 | 3 |
 Álvaro Morata | Virus | 26 Feb 2021 | 1 Mar 2021 | 3 | 1 |
 Unknown player | Calf Problems | 17 Feb 2021 | 9 Mar 2021 | 20 | 5 |
 Unknown player | Hamstring Muscle Injury | 14 Feb 2021 | 6 Mar 2021 | 20 | 4 |
 Unknown player | Calf Problems | 11 Feb 2021 | 14 Feb 2021 | 3 | 0 |
 Unknown player | Muscular Problems | 8 Feb 2021 | 4 Mar 2021 | 24 | 6 |
 Unknown player | Leg Injury | 7 Feb 2021 | 6 Mar 2021 | 27 | 6 |
 Nicolò Fagioli | ILL | 5 Feb 2021 | 11 Feb 2021 | 6 | 2 |
 Unknown player | Hamstring Strain | 5 Feb 2021 | 25 Feb 2021 | 20 | 0 |
| Unknown player | Muscular Problems | 1 Feb 2021 | 16 Feb 2021 | 15 | 4 |
 Federico Chiesa | Doubtful | 24 Jan 2021 | 24 Jan 2021 | 0 | 1 |
 Unknown player | Injury | 21 Jan 2021 | 26 Jan 2021 | 5 | — |
| Unknown player | Muscular Problems | 18 Jan 2021 | 21 Jan 2021 | 3 | 0 |
 Franco Israel | Broken Cheekbone | 14 Jan 2021 | 6 Apr 2021 | 82 | 14 |
 Unknown player | Inflammation In The Knee | 14 Jan 2021 | 11 Feb 2021 | 28 | 5 |
 Paulo Dybala | Inner Ligament Injury | 11 Jan 2021 | 1 Apr 2021 | 80 | 18 |
| Matthijs de Ligt | COVID 19 | 7 Jan 2021 | 25 Jan 2021 | 18 | 4 |
 Unknown player | Shoulder Injury | 6 Jan 2021 | 12 Jan 2021 | 6 | 1 |
| Unknown player | COVID 19 | 5 Jan 2021 | 20 Jan 2021 | 15 | 4 |
 Unknown player | COVID 19 | 4 Jan 2021 | 26 Jan 2021 | 22 | 6 |
| Álvaro Morata | Muscular Problems | 3 Jan 2021 | 9 Jan 2021 | 6 | 2 |
| Paulo Dybala | Doubtful | 22 Dec 2020 | 22 Dec 2020 | 0 | 1 |
| Paulo Dybala | Muscle Fatigue | 17 Dec 2020 | 21 Dec 2020 | 4 | 1 |
| Unknown player | Hamstring Injury | 16 Dec 2020 | 21 Dec 2020 | 5 | 2 |
| Unknown player | Muscle Injury | 3 Dec 2020 | 24 Dec 2020 | 21 | 6 |
| Unknown player | Muscular Problems | 1 Dec 2020 | 20 Dec 2020 | 19 | 5 |
 Unknown player | Broken Fibula | 27 Nov 2020 | 17 Apr 2021 | 141 | 23 |
| Unknown player | Calf Problems | 24 Nov 2020 | 7 Dec 2020 | 13 | 4 |
| Unknown player | Muscle Injury | 23 Nov 2020 | 30 Nov 2020 | 7 | 2 |
 Radu Drăgușin | Muscle Fatigue | 21 Nov 2020 | 27 Nov 2020 | 6 | 2 |
| Unknown player | Muscular Problems | 12 Nov 2020 | 26 Nov 2020 | 14 | 2 |
| Unknown player | Muscle Injury | 8 Nov 2020 | 29 Nov 2020 | 21 | 3 |
| Federico Chiesa | Ankle Problems | 8 Nov 2020 | 19 Nov 2020 | 11 | 1 |
| Unknown player | Muscle Injury | 5 Nov 2020 | 22 Nov 2020 | 17 | 1 |
| Unknown player | Doubtful | 20 Oct 2020 | 20 Oct 2020 | 0 | 1 |
| Unknown player | Muscular Problems | 20 Oct 2020 | 3 Nov 2020 | 14 | 4 |
 Weston McKennie | COVID 19 | 14 Oct 2020 | 24 Oct 2020 | 10 | 2 |
| Unknown player | Muscle Injury | 12 Oct 2020 | 19 Oct 2020 | 7 | 1 |
 Unknown player | COVID 19 | 12 Oct 2020 | 29 Oct 2020 | 17 | 3 |
| Unknown player | Hamstring Injury | 18 Sept 2020 | 17 Nov 2020 | 60 | 9 |
 Federico Bernardeschi | Muscle Injury | 2 Sept 2020 | 15 Oct 2020 | 43 | 3 |
| Matthijs de Ligt | Shoulder Injury | 10 Aug 2020 | 19 Nov 2020 | 101 | 10 |
| Paulo Dybala | Thigh Problems | 6 Aug 2020 | 24 Sept 2020 | 49 | 3 |
 Unknown player | Concussion | 27 Jul 2020 | 30 Jul 2020 | 3 | 1 |
| Matthijs de Ligt | Rest | 27 Jul 2020 | 3 Aug 2020 | 7 | 2 |
| Paulo Dybala | Thigh Problems | 27 Jul 2020 | 6 Aug 2020 | 10 | 2 |
 Unknown player | Adductor Injury | 24 Jul 2020 | 26 Aug 2020 | 33 | 4 |
 Unknown player | Back Problems | 22 Jul 2020 | 25 Jul 2020 | 3 | 1 |
| Unknown player | Calf Problems | 16 Jul 2020 | 30 Jul 2020 | 14 | 3 |
 Unknown player | Hamstring Muscle Injury | 22 Jun 2020 | 7 Sept 2020 | 77 | 13 |
| Unknown player | Inner Ligament Injury | 18 Jun 2020 | 5 Jul 2020 | 17 | 3 |
| Unknown player | Injury | 6 Jun 2020 | 15 Jun 2020 | 9 | 1 |
| Unknown player | Muscular Problems | 4 Jun 2020 | 25 Jun 2020 | 21 | 3 |
| Unknown player | Fitness | 1 Jun 2020 | 5 Jul 2020 | 34 | 5 |
| Unknown player | Lumbago | 19 Feb 2020 | 24 Feb 2020 | 5 | 1 |
 Unknown player | Adductor Pain | 17 Feb 2020 | 23 Feb 2020 | 6 | 0 |
| Unknown player | Hamstring Muscle Injury | 9 Feb 2020 | 29 Feb 2020 | 20 | 4 |
| Federico Bernardeschi | Calf Problems | 4 Feb 2020 | 18 Feb 2020 | 14 | 3 |
 Emre Can | Flu | 25 Jan 2020 | 1 Feb 2020 | 7 | 1 |
| Unknown player | Hamstring Strain | 23 Jan 2020 | 9 Feb 2020 | 17 | 2 |
| Unknown player | Adductor Injury | 13 Jan 2020 | 30 Jan 2020 | 17 | 4 |
| Unknown player | Cruciate Ligament Tear | 13 Jan 2020 | 13 Jul 2020 | 182 | 19 |
 Unknown player | Stress Reaction Of The Bone | 16 Dec 2019 | 20 Dec 2019 | 4 | 1 |
 Wojciech Szczesny | Muscular Problems | 14 Dec 2019 | 20 Dec 2019 | 6 | 2 |
| Rodrigo Bentancur | Knee Problems | 8 Dec 2019 | 13 Dec 2019 | 5 | 1 |
| Unknown player | Stress Reaction Of The Bone | 5 Dec 2019 | 14 Dec 2019 | 9 | 2 |
| Matthijs de Ligt | Shoulder Injury | 5 Dec 2019 | 16 Dec 2019 | 11 | 2 |
| Unknown player | Hamstring Injury | 24 Nov 2019 | 13 Dec 2019 | 19 | 4 |
 Adrien Rabiot | Adductor Pain | 20 Nov 2019 | 3 Dec 2019 | 13 | 3 |
| Unknown player | Adductor Pain | 17 Nov 2019 | 29 Nov 2019 | 12 | 2 |
| Matthijs de Ligt | Ankle Sprain | 4 Nov 2019 | 11 Nov 2019 | 7 | 1 |
 Unknown player | Stomach Flu | 1 Nov 2019 | 8 Nov 2019 | 7 | 2 |
| Unknown player | Head Injury | 27 Oct 2019 | 1 Nov 2019 | 5 | 1 |
| Unknown player | Muscular Problems | 27 Oct 2019 | 1 Nov 2019 | 5 | 1 |
 Unknown player | Knee Problems | 18 Oct 2019 | 2 Dec 2019 | 45 | 9 |
| Unknown player | Adductor Pain | 10 Oct 2019 | 30 Oct 2019 | 20 | 3 |
| Unknown player | Hamstring Muscle Injury | 25 Sept 2019 | 15 Oct 2019 | 20 | 3 |
| Unknown player | Adductor Pain | 23 Sept 2019 | 26 Sept 2019 | 3 | 1 |
| Unknown player | Muscle Injury | 15 Sept 2019 | 28 Oct 2019 | 43 | 9 |
| Unknown player | Hamstring Muscle Injury | 2 Sept 2019 | 24 Oct 2019 | 52 | 9 |
| Unknown player | Cruciate Ligament Tear | 30 Aug 2019 | 14 Feb 2020 | 168 | 31 |
| Unknown player | Lumbago | 28 Aug 2019 | 11 Sept 2019 | 14 | 1 |
| Unknown player | Bruise | 23 May 2019 | 2 Jun 2019 | 10 | 1 |
 João Cancelo | Nose Surgery | 20 May 2019 | 1 Jun 2019 | 12 | 1 |
 Moise Kean | Fever | 11 May 2019 | 14 May 2019 | 3 | 1 |
| Emre Can | Muscular Problems | 3 May 2019 | 9 May 2019 | 6 | 1 |
 Daniele Rugani | Inflammation | 3 May 2019 | 17 May 2019 | 14 | 2 |
| Unknown player | Hamstring Injury | 2 May 2019 | 11 May 2019 | 9 | 1 |
| Rodrigo Bentancur | Muscle Fatigue | 21 Apr 2019 | 9 May 2019 | 18 | 2 |
| Paulo Dybala | Knock | 18 Apr 2019 | 9 May 2019 | 21 | 3 |
 Mattia Perin | Shoulder Injury | 16 Apr 2019 | 18 Nov 2019 | 216 | 27 |
| Nicolò Fagioli | Heart Problems | 12 Apr 2019 | 13 May 2019 | 31 | — |
| Unknown player | Calf Injury | 11 Apr 2019 | 29 Jul 2019 | 109 | 10 |
 Unknown player | Calf Problems | 10 Apr 2019 | 14 Apr 2019 | 4 | 1 |
