| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
Unknown player | Hamstring Muscle Injury | 22 Oct 2022 | 7 Nov 2022 | 16 | 3 |
 Bremer | Hamstring Muscle Injury | 17 Oct 2022 | 5 Nov 2022 | 19 | 4 |
Unknown player | Hamstring Muscle Injury | 13 Oct 2022 | 3 Nov 2022 | 21 | 4 |
Unknown player | Hamstring Injury | 6 Oct 2022 | 26 Jan 2023 | 112 | 14 |
 Federico Chiesa | Cruciate Ligament Tear | 6 Oct 2022 | 1 Nov 2022 | 26 | 7 |
Unknown player | Thigh Problems | 14 Sept 2022 | 2 Oct 2022 | 18 | 2 |
 Adrien Rabiot | Calf Problems | 11 Sept 2022 | 27 Sept 2022 | 16 | 3 |
 Manuel Locatelli | Muscle Fatigue | 10 Sept 2022 | 2 Oct 2022 | 22 | 3 |
Unknown player | Knee Surgery | 5 Sept 2022 | 26 Jan 2023 | 143 | 11 |
| Adrien Rabiot | Thigh Problems | 2 Sept 2022 | 5 Sept 2022 | 3 | 1 |
Unknown player | Adductor Injury | 1 Sept 2022 | 12 Sept 2022 | 11 | 2 |
 Wojciech Szczesny | Ankle Sprain | 31 Aug 2022 | 18 Sept 2022 | 18 | 5 |
 Nicolò Fagioli | Muscular Problems | 26 Aug 2022 | 31 Aug 2022 | 5 | 1 |
Unknown player | Muscular Problems | 23 Aug 2022 | 2 Sept 2022 | 10 | 2 |
Unknown player | Adductor Injury | 15 Aug 2022 | 1 Sept 2022 | 17 | 3 |
Unknown player | Ankle Problems | 8 Aug 2022 | 16 Aug 2022 | 8 | 0 |
Unknown player | Broken Fibula | 31 Jul 2022 | 17 Dec 2022 | 139 | 11 |
| Wojciech Szczesny | Adductor Injury | 30 Jul 2022 | 26 Aug 2022 | 27 | 4 |
Unknown player | Meniscus Injury | 25 Jul 2022 | 12 Sept 2022 | 49 | 9 |
Unknown player | Minor Knock | 16 May 2022 | 26 May 2022 | 10 | 2 |
Unknown player | Injury | 15 May 2022 | 27 May 2022 | 12 | 1 |
 Denis Zakaria | Thigh Problems | 15 May 2022 | 21 May 2022 | 6 | 1 |
Unknown player | Muscular Problems | 11 May 2022 | 23 May 2022 | 12 | 3 |
Unknown player | Rest | 5 May 2022 | 9 May 2022 | 4 | 1 |
 Luca Pellegrini | Ankle Injury | 2 May 2022 | 12 May 2022 | 10 | 1 |
Unknown player | Muscle Fatigue | 25 Apr 2022 | 5 May 2022 | 10 | 2 |
Unknown player | Adductor Injury | 24 Apr 2022 | 5 May 2022 | 11 | 2 |
Unknown player | Ankle Sprain | 13 Apr 2022 | 30 Apr 2022 | 17 | 3 |
Unknown player | Injury | 8 Apr 2022 | 15 Apr 2022 | 7 | 1 |
| Manuel Locatelli | Inner Ligament Injury | 3 Apr 2022 | 10 May 2022 | 37 | 7 |
Unknown player | Injury | 1 Apr 2022 | 30 Apr 2022 | 29 | 5 |
Unknown player | Hamstring Muscle Injury | 17 Mar 2022 | 30 Apr 2022 | 44 | 6 |
| Manuel Locatelli | COVID 19 | 17 Mar 2022 | 24 Mar 2022 | 7 | 1 |
Unknown player | Calf Problems | 15 Mar 2022 | 21 Mar 2022 | 6 | 1 |
 Matías Soulé | Flu | 11 Mar 2022 | 14 Mar 2022 | 3 | 0 |
Unknown player | Knee Problems | 3 Mar 2022 | 10 Mar 2022 | 7 | 1 |
Unknown player | Calf Injury | 3 Mar 2022 | 27 Mar 2022 | 24 | 3 |
 Paulo Dybala | Hip Flexor Problems | 3 Mar 2022 | 17 Mar 2022 | 14 | 2 |
| Denis Zakaria | Adductor Injury | 26 Feb 2022 | 31 Mar 2022 | 33 | 2 |
Unknown player | Patellar Tendon Rupture | 24 Feb 2022 | 14 Feb 2023 | 355 | 48 |
Unknown player | Calf Injury | 23 Feb 2022 | 10 Mar 2022 | 15 | 3 |
 Weston McKennie | Metatarsal Fracture | 23 Feb 2022 | 21 May 2022 | 87 | 5 |
 Daniele Rugani | Hip Flexor Problems | 18 Feb 2022 | 5 Mar 2022 | 15 | 4 |
Unknown player | Calf Problems | 17 Feb 2022 | 21 Feb 2022 | 4 | 1 |
| Paulo Dybala | Thigh Problems | 17 Feb 2022 | 3 Mar 2022 | 14 | 3 |
Unknown player | Calf Injury | 6 Feb 2022 | 14 Mar 2022 | 36 | 9 |
 Federico Bernardeschi | Pubalgia | 3 Feb 2022 | 3 Mar 2022 | 28 | 6 |
Unknown player | COVID 19 | 31 Jan 2022 | 8 Feb 2022 | 8 | 1 |
 Koni De Winter | Shoulder Injury | 30 Jan 2022 | 15 Mar 2022 | 44 | 9 |
| Federico Bernardeschi | Muscular Problems | 17 Jan 2022 | 20 Jan 2022 | 3 | 1 |
Unknown player | Adductor Pain | 15 Jan 2022 | 17 Jan 2022 | 2 | 1 |
Unknown player | Muscular Problems | 13 Jan 2022 | 31 Jan 2022 | 18 | 3 |
Unknown player | COVID 19 | 10 Jan 2022 | 21 Jan 2022 | 11 | 2 |
| Federico Chiesa | Hamstring Muscle Injury | 10 Jan 2022 | 6 Oct 2022 | 269 | 26 |
Unknown player | Heart Problems | 9 Jan 2022 | 22 Feb 2022 | 44 | 7 |
Unknown player | Muscular Problems | 6 Jan 2022 | 11 Jan 2022 | 5 | 2 |
Unknown player | Muscular Problems | 3 Jan 2022 | 13 Jan 2022 | 10 | 2 |
| Luca Pellegrini | Flu | 3 Jan 2022 | 10 Jan 2022 | 7 | 1 |
Unknown player | COVID 19 | 1 Jan 2022 | 7 Jan 2022 | 6 | 0 |
 Carlo Pinsoglio | COVID 19 | 31 Dec 2021 | 9 Jan 2022 | 9 | 1 |
| Koni De Winter | COVID 19 | 29 Dec 2021 | 10 Jan 2022 | 12 | — |
Unknown player | Muscular Problems | 17 Dec 2021 | 26 Dec 2021 | 9 | 2 |
| Paulo Dybala | Muscular Problems | 9 Dec 2021 | 3 Jan 2022 | 25 | 3 |
 Dejan Kulusevski | Surgery | 7 Dec 2021 | 15 Dec 2021 | 8 | 2 |
| Federico Chiesa | Muscle Fatigue | 27 Nov 2021 | 26 Dec 2021 | 29 | 7 |
| Weston McKennie | Knee Problems | 27 Nov 2021 | 13 Dec 2021 | 16 | 5 |
Unknown player | Adductor Injury | 20 Nov 2021 | 10 Jan 2022 | 51 | 10 |
Unknown player | Muscular Problems | 19 Nov 2021 | 2 Jan 2022 | 44 | 9 |
| Federico Bernardeschi | Adductor Pain | 16 Nov 2021 | 26 Nov 2021 | 10 | 2 |
| Paulo Dybala | Muscle Fatigue | 11 Nov 2021 | 22 Nov 2021 | 11 | 1 |
Unknown player | Adductor Pain | 6 Nov 2021 | 26 Nov 2021 | 20 | 3 |
| Wojciech Szczesny | Bruised Ribs | 5 Nov 2021 | 7 Nov 2021 | 2 | 0 |
Unknown player | Muscular Problems | 5 Nov 2021 | 11 Nov 2021 | 6 | 1 |
| Federico Chiesa | Muscle Fatigue | 30 Oct 2021 | 1 Nov 2021 | 2 | 1 |
| Koni De Winter | ILL | 30 Oct 2021 | 1 Nov 2021 | 2 | 0 |
| Daniele Rugani | Stomach Flu | 30 Oct 2021 | 1 Nov 2021 | 2 | 1 |
Unknown player | Muscle Fatigue | 29 Oct 2021 | 2 Nov 2021 | 4 | 1 |
| Federico Chiesa | Injury | 28 Oct 2021 | 2 Nov 2021 | 5 | 1 |
Unknown player | Hamstring Muscle Injury | 28 Oct 2021 | 6 Dec 2021 | 39 | 7 |
| Federico Bernardeschi | Shoulder Injury | 24 Oct 2021 | 29 Oct 2021 | 5 | 2 |
| Adrien Rabiot | Quarantine | 23 Oct 2021 | 25 Oct 2021 | 2 | 0 |
 Moise Kean | Muscle Fatigue | 23 Oct 2021 | 9 Nov 2021 | 17 | 5 |
 Matthijs de Ligt | Adductor Pain | 14 Oct 2021 | 21 Oct 2021 | 7 | 1 |
| Adrien Rabiot | COVID 19 | 9 Oct 2021 | 22 Oct 2021 | 13 | 3 |
Unknown player | Muscular Problems | 28 Sept 2021 | 16 Oct 2021 | 18 | 3 |
| Paulo Dybala | Muscular Problems | 27 Sept 2021 | 25 Oct 2021 | 28 | 5 |
 Álvaro Morata | Torn Muscle Fiber | 26 Sept 2021 | 16 Oct 2021 | 20 | 4 |
| Adrien Rabiot | Ankle Problems | 23 Sept 2021 | 29 Sept 2021 | 6 | 1 |
Unknown player | Fever | 20 Sept 2021 | 23 Sept 2021 | 3 | 0 |
| Federico Chiesa | Hamstring Injury | 8 Sept 2021 | 17 Sept 2021 | 9 | 2 |
Unknown player | Arm Injury | 26 Aug 2021 | 30 Aug 2021 | 4 | 1 |
Unknown player | Muscular Problems | 24 Aug 2021 | 10 Sept 2021 | 17 | 1 |
Unknown player | Muscular Problems | 23 Aug 2021 | 30 Sept 2021 | 38 | 6 |
| Adrien Rabiot | Muscle Injury | 3 Aug 2021 | 27 Aug 2021 | 24 | 3 |
Unknown player | Surgery | 16 Jul 2021 | 1 Oct 2021 | 77 | 12 |
Unknown player | Muscular Problems | 11 May 2021 | 18 Sept 2021 | 130 | — |
| Koni De Winter | Bruise | 11 May 2021 | 25 May 2021 | 14 | — |
Unknown player | Pubalgia | 1 May 2021 | 11 May 2021 | 10 | 2 |
Unknown player | Hamstring Injury | 1 May 2021 | 18 May 2021 | 17 | 2 |
Unknown player | Cruciate Ligament Tear | 26 Apr 2021 | 4 Dec 2021 | 222 | 23 |
