| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
| Jamal Iddrissou | Muscle Injury | 27 Oct 2026 | — | — | 1 |
 Luis Henrique | Thigh Muscle Strain | 23 Oct 2026 | Current | 24 | 3 |
 Benjamin Pavard | Thigh Muscle Strain | 16 Oct 2026 | Current | 21 | 5 |
 Lautaro Martínez | Thigh Muscle Strain | 15 Oct 2026 | Current | 26 | 5 |
 Curtis Jones | Muscle Injury | 8 Oct 2026 | 2 Nov 2026 | 25 | 5 |
 Federico Dimarco | Knee Problems | 21 Sept 2026 | — | — | 1 |
| Federico Dimarco | Knee Problems | 21 Sept 2026 | — | — | 0 |
 John Stones | Thigh Muscle Strain | 15 Sept 2026 | 3 Nov 2026 | 49 | 3 |
 Hakan Çalhanoğlu | Adductor Injury | 13 Sept 2026 | 5 Oct 2026 | 22 | 1 |
| Jamal Iddrissou | Muscle Injury | 12 Sept 2026 | 22 Oct 2026 | 40 | 7 |
| Federico Dimarco | Knee Problems | 6 Sept 2026 | 11 Sept 2026 | 5 | 1 |
 Djed Spence | Fitness | 17 Aug 2026 | 5 Oct 2026 | 49 | 4 |
 Davide Frattesi | Adductor Pain | 22 May 2026 | 1 Jun 2026 | 10 | 1 |
 Pio Esposito | Bruised Back | 4 May 2026 | 11 May 2026 | 7 | 1 |
| Hakan Çalhanoğlu | Calf Muscle Tear | 27 Apr 2026 | 16 May 2026 | 19 | 2 |
| Luis Henrique | Adductor Injury | 22 Apr 2026 | 7 May 2026 | 15 | 2 |
Unknown player | Lung Contusion | 18 Apr 2026 | 24 Apr 2026 | 6 | 1 |
 Alessandro Bastoni | Ankle Problems | 15 Apr 2026 | 24 Apr 2026 | 9 | 1 |
| Lautaro Martínez | Calf Problems | 10 Apr 2026 | 25 Apr 2026 | 15 | 3 |
Unknown player | Injury | 3 Apr 2026 | — | — | 5 |
 Yann Bisseck | Muscle Injury | 2 Apr 2026 | 20 Apr 2026 | 18 | 3 |
 Henrikh Mkhitaryan | Muscle Injury | 16 Mar 2026 | 4 Apr 2026 | 19 | 1 |
| Alessandro Bastoni | Shin Bruise | 9 Mar 2026 | 25 Mar 2026 | 16 | — |
| Hakan Çalhanoğlu | Adductor Pain | 7 Mar 2026 | 17 Mar 2026 | 10 | 2 |
 Marcus Thuram | Flu | 6 Mar 2026 | 10 Mar 2026 | 4 | 1 |
 Ange-Yoan Bonny | Calf Problems | 1 Mar 2026 | 6 Mar 2026 | 5 | 1 |
| Lautaro Martínez | Calf Injury | 19 Feb 2026 | 1 Apr 2026 | 41 | 6 |
| Davide Frattesi | Stomach Flu | 16 Feb 2026 | 19 Feb 2026 | 3 | 0 |
| Hakan Çalhanoğlu | Muscle Fatigue | 15 Feb 2026 | 25 Feb 2026 | 10 | 1 |
 Matteo Darmian | Stomach Flu | 3 Feb 2026 | 7 Feb 2026 | 4 | 1 |
 Carlos Augusto | Muscle Fatigue | 30 Jan 2026 | 2 Feb 2026 | 3 | 0 |
 Nicolò Barella | Hamstring Injury | 27 Jan 2026 | 10 Feb 2026 | 14 | 4 |
| Hakan Çalhanoğlu | Calf Problems | 12 Jan 2026 | 10 Feb 2026 | 29 | 6 |
 Josep Martínez | Ankle Sprain | 8 Jan 2026 | 19 Jan 2026 | 11 | 3 |
| Davide Frattesi | Adductor Pain | 6 Jan 2026 | 10 Jan 2026 | 4 | 1 |
 Andy Diouf | Muscle Fatigue | 3 Jan 2026 | 9 Jan 2026 | 6 | 1 |
| Ange-Yoan Bonny | Sprain | 23 Dec 2025 | 5 Jan 2026 | 13 | 2 |
 Denzel Dumfries | Ankle Surgery | 16 Dec 2025 | 23 Feb 2026 | 69 | 16 |
Unknown player | Hamstring Muscle Injury | 10 Dec 2025 | 29 Dec 2025 | 19 | 3 |
| Hakan Çalhanoğlu | Adductor Injury | 10 Dec 2025 | 18 Dec 2025 | 8 | 1 |
| Yvan Maye | Foot Injury | 9 Dec 2025 | 23 Feb 2026 | 76 | 11 |
| Ange-Yoan Bonny | Flu | 29 Nov 2025 | 2 Dec 2025 | 3 | 1 |
| Denzel Dumfries | Ankle Problems | 13 Nov 2025 | 15 Dec 2025 | 32 | 5 |
Unknown player | Injury | 2 Nov 2025 | 29 Dec 2025 | 57 | 9 |
| Henrikh Mkhitaryan | Hamstring Injury | 26 Oct 2025 | 27 Nov 2025 | 32 | 5 |
Unknown player | Hamstring Injury | 24 Oct 2025 | 24 Jan 2026 | 92 | 6 |
 Raffaele Di Gennaro | Scaphoid Fracture | 15 Oct 2025 | 21 Jan 2026 | 98 | 21 |
| Matteo Darmian | Calf Problems | 15 Oct 2025 | 13 Jan 2026 | 90 | 7 |
| Marcus Thuram | Hamstring Muscle Injury | 1 Oct 2025 | 3 Nov 2025 | 33 | 7 |
| Matteo Darmian | Lumbago | 15 Sept 2025 | 20 Sept 2025 | 5 | 1 |
| Pio Esposito | Muscle Fatigue | 28 Jun 2025 | 6 Jul 2025 | 8 | 1 |
| Benjamin Pavard | Injury | 21 Jun 2025 | 10 Jul 2025 | 19 | 3 |
| Marcus Thuram | Muscle Fatigue | 18 Jun 2025 | 28 Jun 2025 | 10 | 2 |
| Denzel Dumfries | Muscle Fatigue | 15 Jun 2025 | 22 Jun 2025 | 7 | 0 |
| Davide Frattesi | Inguinal Hernia | 15 Jun 2025 | 10 Aug 2025 | 56 | 0 |
 Piotr Zielinski | Muscular Problems | 12 Jun 2025 | 8 Aug 2025 | 57 | 4 |
| Pio Esposito | Knee Problems | 2 Jun 2025 | 20 Jun 2025 | 18 | 0 |
| Yann Bisseck | Thigh Problems | 1 Jun 2025 | 8 Aug 2025 | 68 | 0 |
| Hakan Çalhanoğlu | Leg Injury | 31 May 2025 | 19 Jul 2025 | 49 | 1 |
| Piotr Zielinski | Ankle Problems | 22 May 2025 | 29 May 2025 | 7 | 1 |
| Benjamin Pavard | Muscle Fatigue | 22 May 2025 | 28 May 2025 | 6 | 1 |
| Lautaro Martínez | Muscle Fatigue | 9 May 2025 | 20 May 2025 | 11 | 2 |
| Davide Frattesi | Injury To Abdominal Muscles | 9 May 2025 | 20 May 2025 | 11 | 2 |
| Henrikh Mkhitaryan | Muscle Fatigue | 8 May 2025 | 14 May 2025 | 6 | 1 |
| Lautaro Martínez | Hamstring Injury | 30 Apr 2025 | 4 May 2025 | 4 | 1 |
| Benjamin Pavard | Ankle Sprain | 27 Apr 2025 | 14 May 2025 | 17 | 5 |
| Marcus Thuram | Adductor Pain | 18 Apr 2025 | 28 Apr 2025 | 10 | 2 |
Unknown player | Adductor Pain | 29 Mar 2025 | 10 Apr 2025 | 12 | 6 |
| Lautaro Martínez | Muscle Injury | 19 Mar 2025 | 3 Apr 2025 | 15 | 1 |
| Denzel Dumfries | Hamstring Muscle Injury | 16 Mar 2025 | 24 Apr 2025 | 39 | 4 |
Unknown player | Knee Problems | 11 Mar 2025 | 27 Mar 2025 | 16 | 2 |
| Piotr Zielinski | Calf Muscle Tear | 8 Mar 2025 | 24 Apr 2025 | 47 | 10 |
| Federico Dimarco | Hamstring Injury | 1 Mar 2025 | 25 Mar 2025 | 24 | 5 |
| Matteo Darmian | Hamstring Injury | 25 Feb 2025 | 18 Mar 2025 | 21 | 4 |
 Nicola Zalewski | Calf Injury | 24 Feb 2025 | 18 Mar 2025 | 22 | 2 |
| Carlos Augusto | Knock | 20 Feb 2025 | 8 Mar 2025 | 16 | 4 |
Unknown player | Broken Thumb | 19 Feb 2025 | 3 Mar 2025 | 12 | 6 |
| Marcus Thuram | Ankle Problems | 17 Feb 2025 | 26 Feb 2025 | 9 | 1 |
| Federico Dimarco | Flu | 9 Feb 2025 | 15 Feb 2025 | 6 | 1 |
Unknown player | Injury | 26 Jan 2025 | — | — | 101 |
Unknown player | Rest | 21 Jan 2025 | 31 Jan 2025 | 10 | 3 |
| Hakan Çalhanoğlu | Calf Problems | 13 Jan 2025 | 30 Jan 2025 | 17 | 4 |
| Henrikh Mkhitaryan | Adductor Pain | 9 Jan 2025 | 16 Jan 2025 | 7 | 1 |
| Yann Bisseck | Adductor Pain | 9 Jan 2025 | 23 Jan 2025 | 14 | 4 |
Unknown player | Calf Injury | 8 Jan 2025 | 7 Feb 2025 | 30 | 3 |
| Hakan Çalhanoğlu | Adductor Pain | 6 Jan 2025 | 13 Jan 2025 | 7 | 2 |
| Matteo Darmian | Bruised Knee | 21 Dec 2024 | 1 Jan 2025 | 11 | 2 |
| Nicolò Barella | Adductor Injury | 16 Dec 2024 | 23 Dec 2024 | 7 | 2 |
| Denzel Dumfries | Fever | 9 Dec 2024 | 11 Dec 2024 | 2 | 0 |
| Raffaele Di Gennaro | Finger Injury | 3 Dec 2024 | 1 Mar 2025 | 88 | 19 |
| Benjamin Pavard | Hamstring Muscle Injury | 27 Nov 2024 | 9 Jan 2025 | 43 | 4 |
Unknown player | Hamstring Strain | 23 Nov 2024 | 13 Jan 2025 | 51 | 2 |
| Lautaro Martínez | Fever | 22 Nov 2024 | 25 Nov 2024 | 3 | 1 |
Unknown player | Injury | 19 Nov 2024 | 14 Dec 2024 | 25 | 3 |
| Hakan Çalhanoğlu | Groin Injury | 16 Nov 2024 | 25 Nov 2024 | 9 | 1 |
Unknown player | Rest | 1 Nov 2024 | 4 Nov 2024 | 3 | 0 |
| Carlos Augusto | Hamstring Injury | 23 Oct 2024 | 18 Nov 2024 | 26 | 6 |
| Hakan Çalhanoğlu | Adductor Injury | 20 Oct 2024 | 1 Nov 2024 | 12 | 4 |
Unknown player | Hamstring Muscle Injury | 20 Oct 2024 | 1 Nov 2024 | 12 | 4 |
Unknown player | Knock | 18 Oct 2024 | 25 Oct 2024 | 7 | 2 |
