| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Unknown player | Heart Problems | 13 Jun 2021 | 30 Jan 2022 | 231 | — |
 Unknown player | Herniated Disc | 13 May 2021 | 20 Jun 2021 | 38 | 2 |
 Unknown player | Ankle Problems | 12 May 2021 | 23 May 2021 | 11 | 2 |
 Unknown player | Arthroscopy | 11 Apr 2021 | 21 May 2021 | 40 | 8 |
| Unknown player | Muscle Fatigue | 2 Apr 2021 | 12 May 2021 | 40 | 8 |
 Unknown player | Muscle Fatigue | 2 Apr 2021 | 11 Apr 2021 | 9 | 2 |
 Unknown player | COVID 19 | 14 Mar 2021 | 7 Apr 2021 | 24 | 2 |
| Unknown player | Knee Surgery | 12 Mar 2021 | 3 Apr 2021 | 22 | 1 |
 Unknown player | Muscle Fatigue | 20 Feb 2021 | 4 Mar 2021 | 12 | 2 |
| Unknown player | Knee Bruise | 5 Feb 2021 | 20 Feb 2021 | 15 | 3 |
| Unknown player | Collateral Ligament Injury | 6 Jan 2021 | 1 Feb 2021 | 26 | 7 |
| Unknown player | Adductor Pain | 14 Dec 2020 | 28 Dec 2020 | 14 | 3 |
| Unknown player | Thigh Problems | 5 Dec 2020 | 19 Dec 2020 | 14 | 4 |
 Nicolò Barella | Doubtful | 5 Dec 2020 | 5 Dec 2020 | 0 | 1 |
| Unknown player | Fitness | 4 Dec 2020 | 12 Dec 2020 | 8 | 2 |
 Unknown player | Muscle Fatigue | 28 Nov 2020 | 21 Dec 2020 | 23 | 6 |
 Andrea Pinamonti | Ankle Problems | 16 Nov 2020 | 16 Jan 2021 | 61 | 14 |
| Unknown player | COVID 19 | 15 Nov 2020 | 4 Dec 2020 | 19 | 4 |
 Unknown player | COVID 19 | 13 Nov 2020 | 30 Nov 2020 | 17 | 3 |
 Unknown player | Doubtful | 8 Nov 2020 | 8 Nov 2020 | 0 | 1 |
| Unknown player | Muscular Problems | 8 Nov 2020 | 11 Nov 2020 | 3 | 1 |
 Daniele Padelli | COVID 19 | 7 Nov 2020 | 2 Dec 2020 | 25 | 4 |
 Unknown player | Fever | 5 Nov 2020 | 12 Nov 2020 | 7 | 1 |
| Unknown player | Adductor Injury | 29 Oct 2020 | 6 Nov 2020 | 8 | 2 |
| Unknown player | Muscular Problems | 24 Oct 2020 | 24 Nov 2020 | 31 | 6 |
| Unknown player | Adductor Pain | 22 Oct 2020 | 2 Nov 2020 | 11 | 3 |
 Achraf Hakimi | Quarantine | 21 Oct 2020 | 23 Oct 2020 | 2 | 1 |
| Unknown player | Doubtful | 21 Oct 2020 | 21 Oct 2020 | 0 | 1 |
| Unknown player | Doubtful | 17 Oct 2020 | 17 Oct 2020 | 0 | 1 |
 Unknown player | COVID 19 | 11 Oct 2020 | 24 Oct 2020 | 13 | 2 |
 Ionuț Radu | COVID 19 | 9 Oct 2020 | 28 Oct 2020 | 19 | 3 |
| Unknown player | COVID 19 | 8 Oct 2020 | 18 Oct 2020 | 10 | 0 |
 Roberto Gagliardini | COVID 19 | 8 Oct 2020 | 28 Oct 2020 | 20 | 3 |
 Unknown player | COVID 19 | 7 Oct 2020 | 1 Nov 2020 | 25 | 4 |
 Alessandro Bastoni | COVID 19 | 7 Oct 2020 | 18 Oct 2020 | 11 | 0 |
| Unknown player | Inflammation | 29 Sept 2020 | 2 Oct 2020 | 3 | 1 |
 Unknown player | Knee Injury | 11 Jul 2020 | 25 Jan 2021 | 198 | 39 |
| Unknown player | Adductor Injury | 10 Jul 2020 | 18 Jul 2020 | 8 | 2 |
| Alessandro Bastoni | Knock | 8 Jul 2020 | 11 Jul 2020 | 3 | 1 |
| Nicolò Barella | Hamstring Injury | 4 Jul 2020 | 17 Jul 2020 | 13 | 3 |
| Unknown player | Calf Problems | 19 Jun 2020 | 4 Jul 2020 | 15 | 4 |
| Unknown player | Hamstring Muscle Injury | 19 Jun 2020 | 4 Aug 2020 | 46 | 13 |
| Unknown player | Meniscus Injury | 12 Jun 2020 | 4 Jul 2020 | 22 | 5 |
| Unknown player | Muscular Problems | 12 Jun 2020 | 20 Jun 2020 | 8 | 1 |
 Unknown player | Muscular Problems | 8 Jun 2020 | 19 Jun 2020 | 11 | 1 |
 Unknown player | Thigh Problems | 2 Mar 2020 | 16 Mar 2020 | 14 | 1 |
 Unknown player | Finger Injury | 17 Feb 2020 | 1 Mar 2020 | 13 | 2 |
| Unknown player | Foot Injury | 13 Feb 2020 | 31 Mar 2020 | 47 | 4 |
 Sebastiano Esposito | Thigh Problems | 11 Feb 2020 | 27 Feb 2020 | 16 | 3 |
| Alessandro Bastoni | Knock | 7 Feb 2020 | 10 Feb 2020 | 3 | 0 |
| Unknown player | Calf Problems | 27 Jan 2020 | 6 Feb 2020 | 10 | 2 |
| Unknown player | Ankle Sprain | 19 Jan 2020 | 1 Feb 2020 | 13 | 3 |
| Roberto Gagliardini | Bone Edema | 18 Jan 2020 | 29 Feb 2020 | 42 | 9 |
| Unknown player | Leg Injury | 1 Jan 2020 | 20 Jan 2020 | 19 | 3 |
 Unknown player | Lumbago | 11 Dec 2019 | 19 Dec 2019 | 8 | 1 |
| Nicolò Barella | Knee Injury | 24 Nov 2019 | 5 Jan 2020 | 42 | 6 |
| Unknown player | Adductor Injury | 10 Nov 2019 | 20 Dec 2019 | 40 | 6 |
 Matteo Politano | Ankle Injury | 6 Nov 2019 | 25 Nov 2019 | 19 | 2 |
| Roberto Gagliardini | Muscular Problems | 4 Nov 2019 | 26 Nov 2019 | 22 | 3 |
| Unknown player | Muscle Fatigue | 24 Oct 2019 | 31 Oct 2019 | 7 | 2 |
| Unknown player | Muscle Injury | 22 Oct 2019 | 31 Oct 2019 | 9 | 3 |
| Unknown player | Muscle Fatigue | 21 Oct 2019 | 28 Oct 2019 | 7 | 2 |
| Unknown player | Peroneus Tendon Injury | 13 Oct 2019 | 5 Jan 2020 | 84 | 14 |
| Unknown player | Broken Finger | 13 Oct 2019 | 4 Nov 2019 | 22 | 5 |
| Unknown player | Adductor Injury | 7 Oct 2019 | 1 Nov 2019 | 25 | 4 |
| Unknown player | Muscle Injury | 30 Sept 2019 | 6 Oct 2019 | 6 | 1 |
 Unknown player | Injury | 1 Sept 2019 | 14 Sept 2019 | 13 | 1 |
| Unknown player | Muscular Problems | 26 Aug 2019 | 1 Sept 2019 | 6 | 1 |
| Unknown player | Muscle Injury | 1 Aug 2019 | 30 Aug 2019 | 29 | 3 |
| Unknown player | Adductor Injury | 7 May 2019 | 24 May 2019 | 17 | 2 |
| Unknown player | Thigh Problems | 3 May 2019 | 10 May 2019 | 7 | 1 |
| Unknown player | Muscle Injury | 7 Apr 2019 | 24 Apr 2019 | 17 | 3 |
 Lautaro Martínez | Hamstring Injury | 27 Mar 2019 | 11 Apr 2019 | 15 | 3 |
| Unknown player | Muscle Injury | 20 Mar 2019 | 11 Apr 2019 | 22 | 3 |
 Unknown player | Broken Nose Bone | 10 Mar 2019 | 22 Mar 2019 | 12 | 3 |
| Unknown player | Calf Injury | 6 Mar 2019 | 31 Mar 2019 | 25 | 4 |
 Andrea Adorante | Cruciate Ligament Tear | 5 Mar 2019 | 22 Sept 2019 | 201 | — |
 Keita Baldé | Knock | 16 Feb 2019 | 7 Mar 2019 | 19 | 4 |
| Keita Baldé | Fitness | 3 Feb 2019 | 14 Feb 2019 | 11 | 2 |
| Unknown player | Injury | 30 Jan 2019 | 2 Feb 2019 | 3 | 1 |
 Unknown player | Knee Surgery | 20 Jan 2019 | 13 Nov 2019 | 297 | 45 |
| Keita Baldé | Hamstring Muscle Injury | 16 Jan 2019 | 2 Feb 2019 | 17 | 3 |
| Unknown player | Muscle Injury | 21 Dec 2018 | 27 Dec 2018 | 6 | 1 |
| Unknown player | Muscle Injury | 9 Dec 2018 | 17 Dec 2018 | 8 | 2 |
| Unknown player | Injury | 29 Nov 2018 | 10 Dec 2018 | 11 | 2 |
 Unknown player | Leg Injury | 22 Nov 2018 | 17 Dec 2018 | 25 | 6 |
| Unknown player | Injury | 18 Nov 2018 | 28 Nov 2018 | 10 | 1 |
| Unknown player | Injury | 21 Oct 2018 | 2 Nov 2018 | 12 | 3 |
| Unknown player | Muscular Problems | 6 Oct 2018 | 16 Oct 2018 | 10 | 1 |
| Unknown player | Ankle Injury | 24 Sept 2018 | 29 Sept 2018 | 5 | 1 |
| Unknown player | Knee Problems | 11 Sept 2018 | 4 Oct 2018 | 23 | 5 |
| Lautaro Martínez | Calf Problems | 5 Sept 2018 | 21 Sept 2018 | 16 | 2 |
 Unknown player | Doubtful | 1 Sept 2018 | 1 Sept 2018 | 0 | 1 |
 Unknown player | Muscular Problems | 31 Aug 2018 | 7 Sept 2018 | 7 | 1 |
| Unknown player | Injury | 18 Jul 2018 | 21 Aug 2018 | 34 | 7 |
 Unknown player | Injury | 18 Apr 2018 | 18 May 2018 | 30 | — |
| Roberto Gagliardini | Hamstring Injury | 17 Apr 2018 | 15 May 2018 | 28 | 5 |
| Unknown player | Adductor Pain | 6 Apr 2018 | 15 Apr 2018 | 9 | 1 |
| Unknown player | Hamstring Injury | 15 Mar 2018 | 2 Apr 2018 | 18 | 2 |
| Unknown player | Injury | 9 Mar 2018 | 6 Apr 2018 | 28 | — |
