| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Christ Inao Oulaï | Muscular Problems | 6 Sept 2026 | 18 Sept 2026 | 12 | 1 |
 Rolando Mandragora | Injury | 14 Aug 2026 | 18 Aug 2026 | 4 | 1 |
 Álex Jiménez | Rest | 13 Aug 2026 | 15 Aug 2026 | 2 | 1 |
 Jacopo Fazzini | Flu | 21 May 2026 | 25 May 2026 | 4 | 1 |
 Fabiano Parisi | Cruciate Ligament Injury | 18 May 2026 | Current | 154 | 11 |
 Roberto Piccoli | Injury | 23 Apr 2026 | 5 May 2026 | 12 | 2 |
 Robin Gosens | Hamstring Injury | 21 Apr 2026 | 1 May 2026 | 10 | 1 |
 Marco Brescianini | Adductor Pain | 10 Apr 2026 | 19 Apr 2026 | 9 | 2 |
 Moise Kean | Shin Bruise | 7 Apr 2026 | 1 Jun 2026 | 55 | 1 |
 Dodô | Hamstring Injury | 28 Mar 2026 | 7 Apr 2026 | 10 | 1 |
| Fabiano Parisi | Foot Bruise | 23 Mar 2026 | 1 May 2026 | 39 | 1 |
| Rolando Mandragora | Calf Problems | 21 Mar 2026 | 7 Apr 2026 | 17 | 2 |
 Niccolò Fortini | Lumbago | 13 Mar 2026 | 8 May 2026 | 56 | 2 |
| Moise Kean | Shin Bruise | 3 Mar 2026 | 14 Mar 2026 | 11 | 2 |
 Luca Lezzerini | Hamstring Injury | 27 Feb 2026 | 2 Apr 2026 | 34 | 6 |
 Unknown player | Thigh Problems | 27 Feb 2026 | 11 Apr 2026 | 43 | 1 |
| Moise Kean | Rest | 18 Feb 2026 | 20 Feb 2026 | 2 | 0 |
| Dodô | Rest | 18 Feb 2026 | 20 Feb 2026 | 2 | 0 |
| Unknown player | Flu | 17 Feb 2026 | 21 Feb 2026 | 4 | 1 |
 David de Gea | Finger Injury | 15 Feb 2026 | 21 Feb 2026 | 6 | 1 |
 Albert Gudmundsson | Ankle Problems | 8 Feb 2026 | 22 Feb 2026 | 14 | 2 |
| Rolando Mandragora | Lumbago | 27 Jan 2026 | 29 Jan 2026 | 2 | 1 |
| Dodô | Thigh Problems | 27 Jan 2026 | 29 Jan 2026 | 2 | 1 |
| Fabiano Parisi | Hamstring Muscle Injury | 19 Jan 2026 | 29 Jan 2026 | 10 | 3 |
| Moise Kean | Ankle Problems | 16 Jan 2026 | 30 Jan 2026 | 14 | 1 |
 Unknown player | Injury | 10 Jan 2026 | 22 Jan 2026 | 12 | 2 |
 Edin Džeko | Foot Bruise | 5 Jan 2026 | 22 Jan 2026 | 17 | 2 |
 Unknown player | Muscle Injury | 19 Dec 2025 | 2 Jan 2026 | 14 | 1 |
 Nicolò Fagioli | Injury | 9 Dec 2025 | 14 Dec 2025 | 5 | 1 |
| Jacopo Fazzini | Injury | 30 Nov 2025 | 10 Jan 2026 | 41 | 3 |
| Dodô | Thigh Problems | 24 Nov 2025 | 29 Nov 2025 | 5 | 1 |
| Moise Kean | Shin Bruise | 7 Nov 2025 | 18 Nov 2025 | 11 | 1 |
| Robin Gosens | Hamstring Strain | 30 Oct 2025 | 26 Dec 2025 | 57 | 4 |
 Unknown player | Thigh Problems | 27 Oct 2025 | 30 Nov 2025 | 34 | 4 |
| Moise Kean | Rest | 22 Oct 2025 | 24 Oct 2025 | 2 | 0 |
| Robin Gosens | Flu | 22 Oct 2025 | 24 Oct 2025 | 2 | 0 |
 Amir Richardson | Lumbago | 18 Oct 2025 | 24 Oct 2025 | 6 | 1 |
 Simon Sohm | Heel Spur | 1 Oct 2025 | 14 Oct 2025 | 13 | 2 |
 Unknown player | Cruciate Ligament Injury | 24 Sept 2025 | 15 May 2026 | 233 | 19 |
| Albert Gudmundsson | Ankle Problems | 8 Sept 2025 | 18 Sept 2025 | 10 | 1 |
| Rolando Mandragora | Injury | 20 Aug 2025 | 22 Aug 2025 | 2 | 0 |
 Nicolò Zaniolo | Lumbago | 23 May 2025 | 31 May 2025 | 8 | 1 |
 Michael Folorunsho | Knee Problems | 23 May 2025 | 14 Jul 2025 | 52 | 1 |
| Albert Gudmundsson | Muscular Problems | 11 May 2025 | 16 May 2025 | 5 | 1 |
| Moise Kean | Muscular Problems | 11 May 2025 | 16 May 2025 | 5 | 1 |
 Danilo Cataldi | Muscular Problems | 1 May 2025 | 20 May 2025 | 19 | 5 |
| Dodô | Appendectomy | 25 Apr 2025 | 6 May 2025 | 11 | 3 |
| Robin Gosens | Knee Problems | 29 Mar 2025 | 15 Apr 2025 | 17 | 4 |
| Moise Kean | Head Injury | 23 Feb 2025 | 3 Mar 2025 | 8 | 2 |
| Albert Gudmundsson | Fracture | 19 Feb 2025 | 27 Feb 2025 | 8 | 6 |
| Michael Folorunsho | Thigh Problems | 17 Feb 2025 | 11 Mar 2025 | 22 | 4 |
 Andrea Colpani | Foot Injury | 16 Feb 2025 | 29 Apr 2025 | 72 | 6 |
 Unknown player | Ankle Problems | 4 Feb 2025 | 1 Mar 2025 | 25 | 5 |
 Pietro Comuzzo | Doubtful | 26 Jan 2025 | 26 Jan 2025 | 0 | 1 |
| Robin Gosens | Doubtful | 26 Jan 2025 | 26 Jan 2025 | 0 | 1 |
| Andrea Colpani | Bruise On Ankle | 24 Jan 2025 | 4 Feb 2025 | 11 | 2 |
| Unknown player | Muscle Fatigue | 13 Jan 2025 | 11 Feb 2025 | 29 | 2 |
| Danilo Cataldi | Muscle Fatigue | 10 Jan 2025 | 3 Feb 2025 | 24 | 3 |
| Danilo Cataldi | Bruise On Ankle | 9 Dec 2024 | 14 Dec 2024 | 5 | 1 |
 Marin Pongracic | Thigh Problems | 7 Dec 2024 | 22 Dec 2024 | 15 | 4 |
 Unknown player | Heart Problems | 1 Dec 2024 | 1 Jan 2026 | 396 | 61 |
 Cristiano Biraghi | Muscle Fatigue | 23 Nov 2024 | 27 Nov 2024 | 4 | 1 |
| Amir Richardson | Muscle Strain | 12 Nov 2024 | 2 Dec 2024 | 20 | 2 |
| Moise Kean | Rest | 6 Nov 2024 | 9 Nov 2024 | 3 | 1 |
| Danilo Cataldi | Injury | 28 Oct 2024 | 19 Nov 2024 | 22 | 4 |
| Moise Kean | Ankle Problems | 28 Oct 2024 | 1 Nov 2024 | 4 | 1 |
 Matías Moreno | Muscular Problems | 24 Oct 2024 | 28 Oct 2024 | 4 | 1 |
| Albert Gudmundsson | Hamstring Muscle Injury | 20 Oct 2024 | 30 Nov 2024 | 41 | 8 |
| Rolando Mandragora | Knee Injury | 3 Oct 2024 | 28 Oct 2024 | 25 | 4 |
| Marin Pongracic | Muscle Injury | 21 Sept 2024 | 2 Nov 2024 | 42 | 4 |
 Jonathan Ikoné | Muscle Fatigue | 23 Aug 2024 | 28 Aug 2024 | 5 | 1 |
| Albert Gudmundsson | Calf Problems | 20 Aug 2024 | 12 Sept 2024 | 23 | 4 |
| Jonathan Ikoné | Hip Injury | 11 May 2024 | 14 May 2024 | 3 | 0 |
 Unknown player | Lumbago | 9 May 2024 | 14 May 2024 | 5 | 0 |
 Unknown player | Ankle Problems | 7 May 2024 | 9 May 2024 | 2 | 0 |
 Riccardo Sottil | Broken Collarbone | 3 May 2024 | 10 Jun 2024 | 38 | 6 |
| Rolando Mandragora | Injury | 27 Apr 2024 | 1 May 2024 | 4 | 1 |
| Pietro Comuzzo | Fever | 20 Apr 2024 | 24 Apr 2024 | 4 | 1 |
 Nico González | Injury | 20 Apr 2024 | 24 Apr 2024 | 4 | 1 |
 M'Bala Nzola | Muscle Fatigue | 20 Apr 2024 | 30 Apr 2024 | 10 | 3 |
| Unknown player | Ankle Problems | 18 Apr 2024 | 23 Apr 2024 | 5 | 2 |
| Unknown player | Thigh Problems | 18 Apr 2024 | 23 Apr 2024 | 5 | 2 |
 Unknown player | Ankle Problems | 18 Apr 2024 | 24 Apr 2024 | 6 | 2 |
| Unknown player | Knock | 7 Apr 2024 | 12 Apr 2024 | 5 | 1 |
 Unknown player | Rest | 3 Apr 2024 | 4 Apr 2024 | 1 | 0 |
 Unknown player | Ankle Problems | 6 Mar 2024 | 10 Mar 2024 | 4 | 1 |
| Unknown player | Stomach Problems | 26 Feb 2024 | 10 Mar 2024 | 13 | 3 |
| Unknown player | Malaria | 20 Feb 2024 | 19 Mar 2024 | 28 | 5 |
| Fabiano Parisi | Tonsillitis | 10 Feb 2024 | 13 Feb 2024 | 3 | 1 |
| Unknown player | Muscle Fatigue | 1 Feb 2024 | 11 Feb 2024 | 10 | 1 |
 Oliver Christensen | Meniscus Injury | 31 Jan 2024 | 3 Apr 2024 | 63 | 9 |
| Dodô | Fitness | 25 Jan 2024 | 25 Feb 2024 | 31 | 5 |
| Riccardo Sottil | Thigh Problems | 30 Dec 2023 | 13 Jan 2024 | 14 | 2 |
| Unknown player | Flu | 21 Dec 2023 | 25 Dec 2023 | 4 | 1 |
| Pietro Comuzzo | Flu | 21 Dec 2023 | 26 Dec 2023 | 5 | 1 |
| Nico González | Hamstring Injury | 14 Dec 2023 | 17 Jan 2024 | 34 | 7 |
 Alfred Duncan | Flu | 14 Dec 2023 | 19 Dec 2023 | 5 | 1 |
| Unknown player | Foot Bruise | 13 Dec 2023 | 23 Dec 2023 | 10 | 1 |
| Unknown player | Adductor Pain | 13 Dec 2023 | 17 Dec 2023 | 4 | 1 |
| Riccardo Sottil | Muscle Fatigue | 13 Dec 2023 | 17 Dec 2023 | 4 | 1 |
