| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Christian Nørgaard | Groin Injury | 20 Aug 2026 | Current | — | 5 |
 Jarrad Branthwaite | Hamstring Injury | 19 Apr 2026 | 31 May 2026 | 42 | 6 |
 Beto | Concussion | 19 Apr 2026 | 30 Apr 2026 | 11 | 2 |
| Jarrad Branthwaite | Injury | 13 Mar 2026 | 17 Mar 2026 | 4 | 1 |
 James Tarkowski | Injury | 13 Mar 2026 | 17 Mar 2026 | 4 | 1 |
 Carlos Alcaraz | Knock | 22 Feb 2026 | 17 Apr 2026 | 54 | 6 |
 Vitaliy Mykolenko | Knock | 30 Jan 2026 | 2 Feb 2026 | 3 | 1 |
 Jack Grealish | Foot Surgery | 19 Jan 2026 | 1 Jun 2026 | 133 | 16 |
 Tim Iroegbunam | Injury | 9 Jan 2026 | 27 Jan 2026 | 18 | 3 |
| Carlos Alcaraz | Knock | 29 Dec 2025 | 19 Jan 2026 | 21 | 4 |
 Michael Keane | ILL | 29 Dec 2025 | 31 Dec 2025 | 2 | 1 |
| Jack Grealish | ILL | 26 Dec 2025 | 28 Dec 2025 | 2 | 0 |
 Kiernan Dewsbury-Hall | Hamstring Injury | 13 Dec 2025 | 20 Jan 2026 | 38 | 8 |
| Michael Keane | Muscular Problems | 1 Dec 2025 | 5 Dec 2025 | 4 | 1 |
 Merlin Röhl | Inguinal Hernia | 17 Nov 2025 | 20 Dec 2025 | 33 | 5 |
 Nathan Patterson | Muscle Injury | 17 Oct 2025 | 6 Dec 2025 | 50 | 4 |
| Merlin Röhl | Hip Injury | 19 Sept 2025 | 6 Oct 2025 | 17 | 3 |
| Vitaliy Mykolenko | Injury | 3 Sept 2025 | 19 Sept 2025 | 16 | 1 |
| Jarrad Branthwaite | Hamstring Injury | 10 Aug 2025 | 19 Jan 2026 | 162 | 24 |
| Nathan Patterson | Muscle Injury | 1 Aug 2025 | 11 Sept 2025 | 41 | 6 |
| Vitaliy Mykolenko | Groin Injury | 1 Aug 2025 | 26 Aug 2025 | 25 | 4 |
| James Tarkowski | Hamstring Injury | 21 Apr 2025 | 14 Jul 2025 | 84 | 5 |
| Vitaliy Mykolenko | Knock | 4 Apr 2025 | 10 Apr 2025 | 6 | 1 |
 Unknown player | Groin Surgery | 16 Mar 2025 | 14 Aug 2025 | 151 | 9 |
 Iliman Ndiaye | Knee Injury | 12 Feb 2025 | 2 Apr 2025 | 49 | 5 |
| Nathan Patterson | Hamstring Injury | 3 Feb 2025 | 28 Feb 2025 | 25 | 5 |
| Vitaliy Mykolenko | Calf Stiffness | 3 Feb 2025 | 9 Feb 2025 | 6 | 0 |
 Dominic Calvert-Lewin | Hamstring Injury | 26 Jan 2025 | 5 May 2025 | 99 | 6 |
 Orel Mangala | Cruciate Ligament Tear | 26 Jan 2025 | 29 Nov 2025 | 307 | 40 |
 Unknown player | Ankle Injury | 10 Jan 2025 | 10 Mar 2025 | 59 | 9 |
| Dominic Calvert-Lewin | Ankle Injury | 5 Jan 2025 | 14 Jan 2025 | 9 | 1 |
 Unknown player | Hamstring Injury | 5 Jan 2025 | 26 Feb 2025 | 52 | 9 |
 Unknown player | Calf Injury | 30 Dec 2024 | 7 Mar 2025 | 67 | 11 |
| Iliman Ndiaye | Doubtful | 29 Dec 2024 | 29 Dec 2024 | 0 | 0 |
 Dwight McNeil | Knee Injury | 13 Dec 2024 | 2 Apr 2025 | 110 | 17 |
| Unknown player | Injury | 9 Nov 2024 | 25 Nov 2024 | 16 | 2 |
| Dwight McNeil | Knee Problems | 3 Nov 2024 | 17 Nov 2024 | 14 | 1 |
| Tim Iroegbunam | Ankle Injury | 18 Oct 2024 | 31 Jan 2025 | 105 | 16 |
 James Garner | Back Injury | 18 Oct 2024 | 24 Jan 2025 | 98 | 15 |
| Jarrad Branthwaite | Groin Injury | 3 Oct 2024 | 20 Oct 2024 | 17 | 1 |
| Vitaliy Mykolenko | Calf Stiffness | 28 Sept 2024 | 27 Oct 2024 | 29 | 3 |
| Vitaliy Mykolenko | ILL | 14 Sept 2024 | 27 Sept 2024 | 13 | 3 |
| Unknown player | Foot Injury | 7 Sept 2024 | 18 Oct 2024 | 41 | 5 |
| Unknown player | Achilles Tendon Problems | 29 Aug 2024 | 28 Nov 2024 | 91 | 6 |
| Unknown player | Foot Injury | 3 Aug 2024 | 28 Nov 2024 | 117 | 16 |
| Jarrad Branthwaite | Groin Surgery | 1 Aug 2024 | 30 Sept 2024 | 60 | 10 |
| Jarrad Branthwaite | Groin Injury | 18 Jul 2024 | 14 Sept 2024 | 58 | 9 |
| Dominic Calvert-Lewin | ILL | 25 Apr 2024 | 1 May 2024 | 6 | 1 |
| Vitaliy Mykolenko | Ankle Injury | 25 Apr 2024 | 4 Jun 2024 | 40 | 3 |
| Nathan Patterson | Thigh Problems | 15 Apr 2024 | 21 Sept 2024 | 159 | 6 |
| Vitaliy Mykolenko | Cold | 28 Mar 2024 | 1 Apr 2024 | 4 | 2 |
 Unknown player | Thigh Problems | 17 Dec 2023 | 12 Jan 2024 | 26 | 5 |
| Vitaliy Mykolenko | Groin Injury | 15 Dec 2023 | 22 Dec 2023 | 7 | 2 |
 Unknown player | Muscle Injury | 11 Dec 2023 | 25 Jan 2024 | 45 | 8 |
| Beto | Knee Injury | 23 Nov 2023 | 28 Nov 2023 | 5 | 1 |
 Amadou Onana | Calf Injury | 11 Nov 2023 | 8 Dec 2023 | 27 | 3 |
| Dominic Calvert-Lewin | Broken Cheekbone | 20 Aug 2023 | 14 Sept 2023 | 25 | 4 |
 Alex Iwobi | Hamstring Injury | 20 Aug 2023 | 15 Sept 2023 | 26 | 3 |
 Unknown player | Fitness | 13 Aug 2023 | 3 Dec 2023 | 112 | 15 |
| Dominic Calvert-Lewin | Fitness | 1 Aug 2023 | 18 Aug 2023 | 17 | 2 |
| Dwight McNeil | Ankle Injury | 29 Jul 2023 | 1 Sept 2023 | 34 | 6 |
 Unknown player | Hip Injury | 1 Jul 2023 | 21 Sept 2023 | 82 | 13 |
 Unknown player | Injury | 26 May 2023 | 15 Jul 2023 | 50 | 1 |
| Dominic Calvert-Lewin | Hamstring Injury | 20 May 2023 | 20 Jun 2023 | 31 | 8 |
| Vitaliy Mykolenko | Muscle Fatigue | 13 May 2023 | 5 Jun 2023 | 23 | 2 |
| Unknown player | Knee Injury | 1 May 2023 | 21 Nov 2023 | 204 | 5 |
 Unknown player | Adductor Injury | 30 Apr 2023 | 30 May 2023 | 30 | 5 |
| Amadou Onana | Leg Injury | 14 Apr 2023 | 24 Apr 2023 | 10 | 2 |
| Dominic Calvert-Lewin | Hamstring Injury | 4 Feb 2023 | 20 Apr 2023 | 75 | 6 |
 Anthony Gordon | ILL | 29 Dec 2022 | 4 Jan 2023 | 6 | 1 |
| James Garner | Back Injury | 12 Nov 2022 | 9 Feb 2023 | 89 | 10 |
| Dominic Calvert-Lewin | Hamstring Injury | 5 Nov 2022 | 28 Dec 2022 | 53 | 6 |
| Nathan Patterson | Ankle Injury | 21 Sept 2022 | 26 Oct 2022 | 35 | 5 |
 Unknown player | Knee Problems | 12 Sept 2022 | 20 Apr 2023 | 220 | 29 |
 Jordan Pickford | Thigh Problems | 9 Sept 2022 | 27 Sept 2022 | 18 | 1 |
 Unknown player | Knee Injury | 27 Aug 2022 | 16 Oct 2022 | 50 | 6 |
| Unknown player | Hamstring Injury | 13 Aug 2022 | 3 Oct 2022 | 51 | 8 |
 Yerry Mina | Ankle Injury | 6 Aug 2022 | 31 Oct 2022 | 86 | 9 |
| Unknown player | Broken Fibula | 6 Aug 2022 | 5 Nov 2022 | 91 | 14 |
| Dominic Calvert-Lewin | Knee Injury | 4 Aug 2022 | 3 Oct 2022 | 60 | 7 |
| Vitaliy Mykolenko | Doubtful | 11 May 2022 | 4 Aug 2024 | 816 | — |
| Yerry Mina | Doubtful | 11 May 2022 | 4 Aug 2024 | 816 | — |
| Unknown player | Doubtful | 11 May 2022 | 4 Aug 2024 | 816 | — |
 Unknown player | Thigh Problems | 21 Apr 2022 | 16 May 2022 | 25 | 4 |
| Dominic Calvert-Lewin | Hamstring Injury | 12 Apr 2022 | 30 Apr 2022 | 18 | 2 |
| Unknown player | Doubtful | 6 Apr 2022 | 6 Aug 2024 | 853 | — |
 Unknown player | Doubtful | 6 Apr 2022 | 6 Aug 2024 | 853 | — |
| Unknown player | Doubtful | 6 Apr 2022 | 6 Aug 2024 | 853 | — |
| Nathan Patterson | Ankle Surgery | 5 Apr 2022 | 6 Jun 2022 | 62 | 10 |
| Unknown player | Thigh Problems | 31 Mar 2022 | 11 Apr 2022 | 11 | 3 |
 Unknown player | Cruciate Ligament Injury | 20 Mar 2022 | 7 May 2023 | 413 | 55 |
 Unknown player | Torn Thigh Muscle | 10 Mar 2022 | 23 May 2022 | 74 | 2 |
| Vitaliy Mykolenko | Doubtful | 7 Mar 2022 | 6 Aug 2024 | 883 | — |
| Dominic Calvert-Lewin | Doubtful | 7 Mar 2022 | 6 Aug 2024 | 883 | — |
 Unknown player | ILL | 3 Mar 2022 | 8 Mar 2022 | 5 | 1 |
| Unknown player | Hip Injury | 8 Feb 2022 | 25 Feb 2022 | 17 | 3 |
| Yerry Mina | Hamstring Injury | 8 Feb 2022 | 11 Apr 2022 | 62 | 7 |
| Vitaliy Mykolenko | COVID 19 | 7 Feb 2022 | 16 Feb 2022 | 9 | 2 |
| Unknown player | Hamstring Injury | 21 Jan 2022 | 5 Apr 2022 | 74 | 12 |
| Unknown player | ILL | 15 Dec 2021 | 17 Dec 2021 | 2 | 0 |
