| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Unknown player | Knock | 1 Dec 2018 | 14 Dec 2018 | 13 | 3 |
 Unknown player | Knock | 13 Oct 2018 | 24 Nov 2018 | 42 | 5 |
 Unknown player | Foot Injury | 8 Sept 2018 | 20 Oct 2018 | 42 | 5 |
 Unknown player | Knock | 26 Aug 2018 | 15 Sept 2018 | 20 | 2 |
 Michael Keane | Skull Fracture | 25 Aug 2018 | 22 Sept 2018 | 28 | 4 |
 Unknown player | Knee Injury | 25 Aug 2018 | 16 Sept 2018 | 22 | 3 |
| Unknown player | Muscle Strain | 19 Aug 2018 | 31 Aug 2018 | 12 | 2 |
 Ademola Lookman | Groin Injury | 19 Aug 2018 | 31 Aug 2018 | 12 | 2 |
 Lucas Digne | Bruise | 13 Aug 2018 | 24 Aug 2018 | 11 | 1 |
 Unknown player | Knee Injury | 12 Aug 2018 | 11 Nov 2018 | 91 | 13 |
| Unknown player | Knock | 9 Aug 2018 | 24 Aug 2018 | 15 | 2 |
 Yerry Mina | Foot Injury | 30 Jul 2018 | 20 Oct 2018 | 82 | 13 |
 Unknown player | Bone Edema | 29 Jul 2018 | 20 Oct 2018 | 83 | 14 |
| Ademola Lookman | Hamstring Injury | 13 Jul 2018 | 17 Aug 2018 | 35 | 5 |
 Unknown player | Ankle Injury | 9 Jul 2018 | 22 Oct 2018 | 105 | 14 |
 Dominic Calvert-Lewin | Back Injury | 23 Apr 2018 | 30 Jun 2018 | 68 | 4 |
 Unknown player | Ankle Injury | 20 Mar 2018 | 13 May 2018 | 54 | 6 |
 Unknown player | Knee Injury | 11 Mar 2018 | 1 Jun 2018 | 82 | 8 |
| Unknown player | Doubtful | 3 Mar 2018 | 11 Sept 2024 | 2384 | — |
 Unknown player | Doubtful | 3 Mar 2018 | 11 Sept 2024 | 2384 | — |
| Unknown player | Hamstring Strain | 10 Feb 2018 | 3 Mar 2018 | 21 | 2 |
 Unknown player | Knee Injury | 10 Feb 2018 | 30 Oct 2018 | 262 | 28 |
 Unknown player | Tibia And Fibula Fracture | 20 Jan 2018 | 5 Jan 2019 | 350 | 43 |
| Unknown player | Toe Injury | 18 Nov 2017 | 26 Nov 2017 | 8 | 2 |
 Unknown player | Concussion | 2 Nov 2017 | 18 Nov 2017 | 16 | 2 |
| Unknown player | Hamstring Injury | 25 Oct 2017 | 14 Dec 2017 | 50 | 14 |
 Unknown player | Groin Injury | 23 Oct 2017 | 19 May 2018 | 208 | 34 |
| Unknown player | Thigh Problems | 22 Sept 2017 | 15 Oct 2017 | 23 | 3 |
| Michael Keane | Cut | 22 Sept 2017 | 30 Sept 2017 | 8 | 2 |
 Unknown player | Muscular Problems | 21 Sept 2017 | 24 Oct 2017 | 33 | 6 |
| Unknown player | Doubtful | 9 Sept 2017 | 11 Sept 2024 | 2559 | — |
 Unknown player | Foot Injury | 23 Aug 2017 | 7 Sept 2017 | 15 | 2 |
 Ross Barkley | Hamstring Injury | 14 Aug 2017 | 26 Dec 2017 | 134 | 28 |
 Unknown player | Heel Injury | 13 Aug 2017 | 24 Aug 2017 | 11 | 2 |
| Unknown player | Knee Injury | 26 Jul 2017 | 24 Oct 2017 | 90 | 18 |
| Unknown player | Knee Surgery | 17 Jul 2017 | 4 Feb 2018 | 202 | 41 |
| Unknown player | Meniscus Injury | 29 Mar 2017 | 17 Jul 2017 | 110 | 10 |
| Unknown player | Broken Leg | 27 Mar 2017 | 13 Jan 2018 | 292 | 48 |
| Unknown player | Hamstring Injury | 24 Mar 2017 | 30 Jun 2017 | 98 | 9 |
| Dominic Calvert-Lewin | Ankle Injury | 2 Jan 2017 | 25 Feb 2017 | 54 | 8 |
| Unknown player | Leg Injury | 19 Dec 2016 | 13 Jan 2017 | 25 | 5 |
| Unknown player | Hamstring Injury | 19 Dec 2016 | 7 Jan 2017 | 19 | 4 |
 Unknown player | Cruciate Ligament Tear | 5 Dec 2016 | 10 Dec 2017 | 370 | 57 |
| Unknown player | Foot Injury | 28 Oct 2016 | 2 Nov 2016 | 5 | 1 |
| Unknown player | Groin Injury | 23 Aug 2016 | 5 Oct 2016 | 43 | 7 |
| Unknown player | Ankle Injury | 11 Aug 2016 | 5 Sept 2016 | 25 | 4 |
 Unknown player | Cruciate Ligament Injury | 3 Aug 2016 | 18 Mar 2017 | 227 | 34 |
 Unknown player | Hamstring Injury | 30 Jul 2016 | 7 Jan 2017 | 161 | 25 |
| Unknown player | Hamstring Injury | 18 Apr 2016 | 16 May 2016 | 28 | 5 |
| Unknown player | Hamstring Injury | 10 Apr 2016 | 22 Apr 2016 | 12 | 3 |
| Unknown player | Hamstring Injury | 24 Jan 2016 | 5 Mar 2016 | 41 | 8 |
 Unknown player | Knee Surgery | 6 Nov 2015 | 8 Nov 2016 | 368 | 55 |
 Unknown player | Thigh Problems | 1 Nov 2015 | 9 Jan 2016 | 69 | 12 |
| Unknown player | Inner Knee Ligament Tear | 24 Oct 2015 | 31 Dec 2015 | 68 | 12 |
 John Stones | Knee Injury | 21 Sept 2015 | 15 Oct 2015 | 24 | 3 |
| Unknown player | Hamstring Strain | 14 Sept 2015 | 12 Oct 2015 | 28 | 4 |
| Unknown player | Thigh Problems | 12 Sept 2015 | 2 Nov 2015 | 51 | 8 |
 Unknown player | Ankle Injury | 29 Aug 2015 | 17 Oct 2015 | 49 | 6 |
| Unknown player | Internal Ligament Strain | 29 Aug 2015 | 19 Sept 2015 | 21 | 2 |
 Unknown player | Patellar Tendon Problems | 23 Aug 2015 | 7 Sept 2015 | 15 | 3 |
 Unknown player | Hamstring Injury | 11 Jul 2015 | 23 Aug 2015 | 43 | 4 |
| Unknown player | Metatarsal Fracture | 28 Apr 2015 | 1 Aug 2015 | 95 | 6 |
| Unknown player | Bruised Back | 3 Apr 2015 | 17 Apr 2015 | 14 | 2 |
 Unknown player | Thigh Problems | 22 Mar 2015 | 18 Apr 2015 | 27 | 3 |
| Unknown player | Hamstring Injury | 19 Feb 2015 | 27 Apr 2015 | 67 | 12 |
| Unknown player | Hamstring Injury | 28 Dec 2014 | 31 Jan 2015 | 34 | 6 |
 Unknown player | Hamstring Injury | 11 Dec 2014 | 1 Jan 2015 | 21 | 5 |
| Unknown player | Hamstring Injury | 9 Nov 2014 | 6 Dec 2014 | 27 | 5 |
 Unknown player | Ankle Injury | 9 Nov 2014 | 28 Nov 2014 | 19 | 2 |
 Unknown player | Shoulder Injury | 1 Nov 2014 | 10 Dec 2014 | 39 | 8 |
| John Stones | Ankle Injury | 6 Oct 2014 | 11 Dec 2014 | 66 | 11 |
| Unknown player | Hamstring Strain | 29 Sept 2014 | 16 Oct 2014 | 17 | 2 |
 Unknown player | Hamstring Injury | 27 Sept 2014 | 21 Nov 2014 | 55 | 9 |
| Unknown player | Concussion | 18 Sept 2014 | 2 Oct 2014 | 14 | 4 |
| Ross Barkley | Cruciate Ligament Injury | 18 Aug 2014 | 9 Oct 2014 | 52 | 9 |
| Unknown player | Groin Injury | 22 Apr 2014 | 22 May 2014 | 30 | 3 |
| Unknown player | Thigh Problems | 27 Feb 2014 | 7 Mar 2014 | 8 | 1 |
 Unknown player | Hamstring Injury | 21 Feb 2014 | 1 May 2014 | 69 | 12 |
| Unknown player | Torn Lateral Ankle Ligament | 28 Jan 2014 | 28 Feb 2014 | 31 | 5 |
| Unknown player | Dead Leg | 28 Jan 2014 | 28 Feb 2014 | 31 | 5 |
| Unknown player | Broken Leg | 26 Jan 2014 | 1 Sept 2014 | 218 | 21 |
| Unknown player | Minor Knock | 20 Jan 2014 | 30 Jan 2014 | 10 | 3 |
| Ross Barkley | Broken Toe | 6 Jan 2014 | 27 Jan 2014 | 21 | 3 |
| Unknown player | Thigh Problems | 27 Dec 2013 | 10 Jan 2014 | 14 | 3 |
 Unknown player | Hamstring Injury | 15 Dec 2013 | 1 Feb 2014 | 48 | 9 |
 Unknown player | Broken Leg | 24 Aug 2013 | 23 Jan 2014 | 152 | 28 |
| Unknown player | Hamstring Injury | 31 Jul 2013 | 23 Nov 2013 | 115 | 13 |
| Unknown player | Ankle Injury | 4 Mar 2013 | 29 Mar 2013 | 25 | 2 |
| Unknown player | Hamstring Injury | 21 Jan 2013 | 21 Feb 2013 | 31 | 6 |
| Unknown player | Hamstring Injury | 20 Dec 2012 | 7 Jan 2013 | 18 | 4 |
| Unknown player | Hamstring Injury | 9 Dec 2012 | 20 Jan 2013 | 42 | 8 |
| Unknown player | Hamstring Injury | 10 Nov 2012 | 30 Nov 2012 | 20 | 4 |
| Unknown player | Hamstring Strain | 19 Mar 2012 | 5 Apr 2012 | 17 | 4 |
 Unknown player | Tendon Rupture | 6 Feb 2012 | 1 Mar 2012 | 24 | 2 |
| Unknown player | Inner Knee Ligament Tear | 4 Jan 2012 | 2 Mar 2012 | 58 | 9 |
 Unknown player | Ankle Injury | 3 Mar 2011 | 4 Aug 2011 | 154 | 11 |
| Unknown player | Thigh Problems | 3 Jan 2011 | 10 Jan 2011 | 7 | 2 |
| Unknown player | Thigh Problems | 14 Oct 2010 | 18 Nov 2010 | 35 | 6 |
| Unknown player | Ankle Injury | 9 Sept 2010 | 6 Dec 2010 | 88 | 14 |
 Unknown player | Cruciate Ligament Tear | 27 Mar 2010 | 31 Dec 2010 | 279 | 28 |
