| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Unknown player | ILL | 2 Nov 2024 | 11 Nov 2024 | 9 | 2 |
 Carney Chukwuemeka | ILL | 2 Oct 2024 | 4 Oct 2024 | 2 | 0 |
 Enzo Fernández | ILL | 13 Sept 2024 | 15 Sept 2024 | 2 | 0 |
 Malo Gusto | Muscle Injury | 1 Sept 2024 | 22 Sept 2024 | 21 | 1 |
 Roméo Lavia | Hamstring Injury | 23 Aug 2024 | 15 Sept 2024 | 23 | 3 |
 Trevoh Chalobah | Abdominal Muscle Strain | 10 Aug 2024 | 27 Sept 2024 | 48 | 9 |
 Reece James | Hamstring Injury | 9 Aug 2024 | 14 Oct 2024 | 66 | 2 |
 Mykhaylo Mudryk | Concussion | 15 May 2024 | 20 May 2024 | 5 | 2 |
 Axel Disasi | Injury | 1 May 2024 | 5 May 2024 | 4 | 1 |
 Unknown player | Injury | 1 May 2024 | 5 May 2024 | 4 | 1 |
| Carney Chukwuemeka | Injury | 25 Apr 2024 | 18 May 2024 | 23 | 5 |
| Enzo Fernández | Groin Surgery | 25 Apr 2024 | 31 May 2024 | 36 | 6 |
 Unknown player | Injury | 25 Apr 2024 | 5 May 2024 | 10 | 2 |
 Cole Palmer | Cold | 22 Apr 2024 | 25 Apr 2024 | 3 | 1 |
| Malo Gusto | Injury | 22 Apr 2024 | 5 May 2024 | 13 | 3 |
 Ben Chilwell | Knee Problems | 22 Apr 2024 | 14 May 2024 | 22 | 5 |
| Axel Disasi | Injury | 13 Apr 2024 | 18 Apr 2024 | 5 | 1 |
| Enzo Fernández | Injury | 13 Apr 2024 | 18 Apr 2024 | 5 | 1 |
| Unknown player | ILL | 11 Apr 2024 | 16 Apr 2024 | 5 | 0 |
 Robert Sánchez | ILL | 9 Apr 2024 | 16 Apr 2024 | 7 | 0 |
| Malo Gusto | Rest | 7 Apr 2024 | 8 Apr 2024 | 1 | 0 |
| Ben Chilwell | ILL | 30 Mar 2024 | 5 Apr 2024 | 6 | 1 |
| Robert Sánchez | Injury | 27 Mar 2024 | 31 May 2024 | 65 | 1 |
| Ben Chilwell | Knee Problems | 27 Mar 2024 | 8 Apr 2024 | 12 | 1 |
| Carney Chukwuemeka | Knock | 25 Mar 2024 | 2 Apr 2024 | 8 | 1 |
| Ben Chilwell | Knee Problems | 7 Mar 2024 | 15 Mar 2024 | 8 | 1 |
 Levi Colwill | Toe Injury | 7 Mar 2024 | 5 May 2024 | 59 | 9 |
 Christopher Nkunku | Hamstring Injury | 26 Feb 2024 | 3 May 2024 | 67 | 11 |
| Unknown player | Injury | 13 Feb 2024 | 1 Mar 2024 | 17 | 3 |
| Carney Chukwuemeka | Ankle Injury | 13 Feb 2024 | 10 Mar 2024 | 26 | 4 |
 Benoît Badiashile | Groin Injury | 8 Feb 2024 | 13 Mar 2024 | 34 | 6 |
| Levi Colwill | Hamstring Injury | 26 Jan 2024 | 11 Feb 2024 | 16 | 4 |
| Malo Gusto | Muscle Injury | 20 Jan 2024 | 28 Jan 2024 | 8 | 2 |
| Trevoh Chalobah | Fitness | 10 Jan 2024 | 7 Feb 2024 | 28 | 5 |
| Christopher Nkunku | Hip Injury | 5 Jan 2024 | 28 Jan 2024 | 23 | 5 |
| Ben Chilwell | Fitness | 3 Jan 2024 | 8 Jan 2024 | 5 | 1 |
| Carney Chukwuemeka | Fitness | 1 Jan 2024 | 8 Jan 2024 | 7 | 1 |
| Benoît Badiashile | Muscle Fatigue | 28 Dec 2023 | 8 Jan 2024 | 11 | 1 |
| Roméo Lavia | Hamstring Injury | 28 Dec 2023 | 30 Jun 2024 | 185 | 28 |
 Unknown player | Hamstring Injury | 25 Dec 2023 | 6 May 2024 | 133 | 24 |
 Moisés Caicedo | Fever | 23 Dec 2023 | 25 Dec 2023 | 2 | 0 |
| Enzo Fernández | Injury | 19 Dec 2023 | 29 Dec 2023 | 10 | 3 |
 Marc Cucurella | Ankle Surgery | 15 Dec 2023 | 1 Mar 2024 | 77 | 17 |
| Robert Sánchez | Knee Injury | 11 Dec 2023 | 15 Feb 2024 | 66 | 7 |
| Reece James | Surgery | 11 Dec 2023 | 10 May 2024 | 151 | 29 |
 Noni Madueke | Injury | 5 Dec 2023 | 18 Dec 2023 | 13 | 3 |
| Unknown player | Hamstring Injury | 4 Dec 2023 | 23 Dec 2023 | 19 | 4 |
| Malo Gusto | Knee Injury | 14 Nov 2023 | 14 Dec 2023 | 30 | 4 |
| Roméo Lavia | Fitness | 13 Nov 2023 | 18 Dec 2023 | 35 | 5 |
| Christopher Nkunku | Fitness | 1 Nov 2023 | 14 Dec 2023 | 43 | 7 |
| Mykhaylo Mudryk | Muscle Strain | 27 Oct 2023 | 3 Nov 2023 | 7 | 2 |
| Cole Palmer | Doubtful | 21 Oct 2023 | 21 Oct 2023 | 0 | 1 |
 Unknown player | Knee Problems | 9 Oct 2023 | 8 Nov 2023 | 30 | 2 |
| Carney Chukwuemeka | Knee Injury | 9 Oct 2023 | 31 Dec 2023 | 83 | 13 |
| Ben Chilwell | Hamstring Injury | 27 Sept 2023 | 3 Jan 2024 | 98 | 17 |
| Benoît Badiashile | Fitness | 18 Sept 2023 | 19 Oct 2023 | 31 | 9 |
| Noni Madueke | Muscle Injury | 17 Sept 2023 | 25 Sept 2023 | 8 | 1 |
| Roméo Lavia | Ankle Injury | 17 Sept 2023 | 12 Nov 2023 | 56 | 5 |
| Moisés Caicedo | Knock | 14 Sept 2023 | 20 Sept 2023 | 6 | 1 |
| Mykhaylo Mudryk | Injury | 23 Aug 2023 | 31 Aug 2023 | 8 | 1 |
| Carney Chukwuemeka | Knee Injury | 21 Aug 2023 | 6 Oct 2023 | 46 | 6 |
| Reece James | Hamstring Injury | 13 Aug 2023 | 6 Oct 2023 | 54 | 10 |
| Christopher Nkunku | Knee Injury | 3 Aug 2023 | 20 Nov 2023 | 109 | 13 |
| Trevoh Chalobah | Thigh Problems | 1 Aug 2023 | 10 Jan 2024 | 162 | 26 |
 Wesley Fofana | Cruciate Ligament Tear | 17 Jul 2023 | 30 Jun 2024 | 349 | 56 |
| Benoît Badiashile | Groin Injury | 29 May 2023 | 17 Sept 2023 | 111 | 10 |
 Mateo Kovacic | Knock | 20 May 2023 | 27 May 2023 | 7 | 2 |
| Benoît Badiashile | Hamstring Injury | 19 May 2023 | 31 Aug 2023 | 104 | 3 |
 Unknown player | Groin Injury | 12 May 2023 | 29 May 2023 | 17 | 3 |
| Ben Chilwell | Hamstring Injury | 6 May 2023 | 3 Jun 2023 | 28 | 5 |
 Marcus Bettinelli | Injury | 27 Apr 2023 | 16 Oct 2023 | 172 | 21 |
 Mason Mount | Pelvic Injury | 25 Apr 2023 | 31 May 2023 | 36 | 7 |
| Reece James | Hamstring Injury | 25 Apr 2023 | 31 May 2023 | 36 | 7 |
| Marc Cucurella | Muscle Injury | 25 Apr 2023 | 2 Jun 2023 | 38 | 7 |
| Carney Chukwuemeka | Flu | 25 Apr 2023 | 27 Apr 2023 | 2 | 0 |
 Kai Havertz | Knee Injury | 24 Apr 2023 | 1 May 2023 | 7 | 1 |
| Carney Chukwuemeka | Doubtful | 15 Apr 2023 | 15 Apr 2023 | 0 | 1 |
 Ruben Loftus-Cheek | Knock | 14 Apr 2023 | 17 Apr 2023 | 3 | 1 |
 Unknown player | Hamstring Injury | 12 Apr 2023 | 20 May 2023 | 38 | 7 |
| Reece James | ILL | 9 Mar 2023 | 15 Mar 2023 | 6 | 1 |
| Unknown player | Hamstring Injury | 9 Mar 2023 | 2 Apr 2023 | 24 | 3 |
| Reece James | Hamstring Injury | 1 Mar 2023 | 5 Mar 2023 | 4 | 0 |
| Mason Mount | Pelvic Contusion | 28 Feb 2023 | 3 Apr 2023 | 34 | 7 |
| Unknown player | Cruciate Ligament Injury | 27 Feb 2023 | 10 Apr 2023 | 42 | 7 |
| Unknown player | Knee Injury | 26 Feb 2023 | 10 Apr 2023 | 43 | 8 |
| Trevoh Chalobah | Fitness | 25 Feb 2023 | 28 Feb 2023 | 3 | 1 |
| Unknown player | Fitness | 20 Feb 2023 | 12 Mar 2023 | 20 | 3 |
| Mateo Kovacic | ILL | 20 Feb 2023 | 27 Feb 2023 | 7 | 0 |
 Unknown player | Head Injury | 18 Feb 2023 | 10 Mar 2023 | 20 | 3 |
| Ruben Loftus-Cheek | Knock | 17 Feb 2023 | 19 Feb 2023 | 2 | 0 |
 Unknown player | Doubtful | 15 Feb 2023 | 15 Feb 2023 | 0 | 1 |
| Unknown player | Doubtful | 15 Feb 2023 | 22 Dec 2023 | 310 | 46 |
| Unknown player | Knee Problems | 9 Feb 2023 | 12 Feb 2023 | 3 | 0 |
| Ruben Loftus-Cheek | Knock | 1 Feb 2023 | 5 Feb 2023 | 4 | 1 |
| Mateo Kovacic | Calf Problems | 21 Jan 2023 | 4 Feb 2023 | 14 | 1 |
 Denis Zakaria | Hamstring Injury | 13 Jan 2023 | 13 Feb 2023 | 31 | 4 |
| Unknown player | Hamstring Injury | 5 Jan 2023 | 2 Feb 2023 | 28 | 5 |
 Unknown player | Shoulder Injury | 5 Jan 2023 | 16 Mar 2023 | 70 | 13 |
 Christian Pulisic | Knee Problems | 5 Jan 2023 | 5 Mar 2023 | 59 | 10 |
| Mason Mount | Knock | 5 Jan 2023 | 7 Jan 2023 | 2 | 1 |
