| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
Unknown player | Muscular Problems | 9 Dec 2021 | 16 Dec 2021 | 7 | 1 |
 Donyell Malen | Virus | 9 Dec 2021 | 13 Dec 2021 | 4 | 1 |
 Manuel Akanji | Knee Surgery | 6 Dec 2021 | 10 Jan 2022 | 35 | 5 |
Unknown player | Concussion | 2 Dec 2021 | 9 Dec 2021 | 7 | 2 |
Unknown player | Torn Muscle Fiber | 29 Nov 2021 | 6 Jan 2022 | 38 | 5 |
 Giovanni Reyna | Fitness | 29 Nov 2021 | 24 Jan 2022 | 56 | 9 |
 Jude Bellingham | Knee Problems | 25 Nov 2021 | 1 Dec 2021 | 6 | 1 |
Unknown player | Muscular Problems | 22 Nov 2021 | 29 Nov 2021 | 7 | 2 |
 Thorgan Hazard | COVID 19 | 22 Nov 2021 | 9 Dec 2021 | 17 | 4 |
Unknown player | Inflammation | 11 Nov 2021 | 25 Nov 2021 | 14 | 1 |
 Marius Wolf | Hamstring Injury | 4 Nov 2021 | 25 Nov 2021 | 21 | 2 |
Unknown player | Hand Injury | 28 Oct 2021 | 20 Jan 2022 | 84 | 14 |
 Emre Can | Muscle Injury | 27 Oct 2021 | 17 Nov 2021 | 21 | 3 |
| Donyell Malen | Stomach Flu | 25 Oct 2021 | 28 Oct 2021 | 3 | 1 |
 Immanuel Pherai | Cold | 25 Oct 2021 | 1 Nov 2021 | 7 | 1 |
 Gregor Kobel | Minor Knock | 25 Oct 2021 | 28 Oct 2021 | 3 | 1 |
Unknown player | Torn Muscle Fiber | 22 Oct 2021 | 21 Nov 2021 | 30 | 5 |
 Thomas Meunier | Knock | 21 Oct 2021 | 25 Oct 2021 | 4 | 1 |
 Erling Haaland | Hip Flexor Problems | 21 Oct 2021 | 25 Nov 2021 | 35 | 6 |
Unknown player | Torn Muscle Fiber | 7 Oct 2021 | 8 Nov 2021 | 32 | 7 |
Unknown player | Muscle Injury | 7 Oct 2021 | 28 Oct 2021 | 21 | 4 |
Unknown player | Inner Ligament Stretch Of The Knee | 30 Sept 2021 | 18 Nov 2021 | 49 | 8 |
Unknown player | Knee Problems | 23 Sept 2021 | 27 Sept 2021 | 4 | 1 |
| Erling Haaland | Muscular Problems | 23 Sept 2021 | 11 Oct 2021 | 18 | 3 |
Unknown player | Muscle Injury | 16 Sept 2021 | 27 Sept 2021 | 11 | 2 |
Unknown player | Groin Problems | 11 Sept 2021 | 16 Sept 2021 | 5 | 1 |
| Giovanni Reyna | Muscle Injury | 6 Sept 2021 | 29 Nov 2021 | 84 | 16 |
Unknown player | Syndesmosis Ligament Tear | 6 Sept 2021 | 23 Sept 2021 | 17 | 3 |
Unknown player | Syndesmosis Ligament Tear | 5 Sept 2021 | 23 Jan 2022 | 140 | 15 |
 Steffen Tigges | Muscle Injury | 30 Aug 2021 | 7 Oct 2021 | 38 | 6 |
| Emre Can | Muscular Problems | 25 Aug 2021 | 30 Sept 2021 | 36 | 6 |
Unknown player | Muscle Injury | 22 Aug 2021 | 20 Sept 2021 | 29 | 3 |
Unknown player | Patellar Tendon Problems | 19 Aug 2021 | 9 Sept 2021 | 21 | 2 |
| Thorgan Hazard | Ankle Problems | 16 Aug 2021 | 13 Sept 2021 | 28 | 4 |
| Thomas Meunier | COVID 19 | 2 Aug 2021 | 19 Aug 2021 | 17 | 2 |
Unknown player | COVID 19 | 2 Aug 2021 | 19 Aug 2021 | 17 | 3 |
| Emre Can | Calf Problems | 27 Jul 2021 | 18 Aug 2021 | 22 | 3 |
| Marius Wolf | Torn Ankle Ligaments | 26 Jul 2021 | 12 Aug 2021 | 17 | 2 |
Unknown player | Calf Problems | 26 Jul 2021 | 19 Aug 2021 | 24 | 4 |
Unknown player | Patellar Tendon Problems | 1 Jul 2021 | 19 Aug 2021 | 49 | 6 |
Unknown player | Capsule Rupture | 10 May 2021 | 31 May 2021 | 21 | 3 |
| Erling Haaland | Minor Knock | 6 May 2021 | 10 May 2021 | 4 | 1 |
| Erling Haaland | Muscular Problems | 29 Apr 2021 | 3 May 2021 | 4 | 1 |
Unknown player | Cruciate Ligament Injury | 29 Apr 2021 | 9 May 2022 | 375 | 54 |
Unknown player | Cold | 20 Apr 2021 | 23 Apr 2021 | 3 | 1 |
Unknown player | Cruciate Ligament Injury | 1 Apr 2021 | 10 Jun 2021 | 70 | 12 |
 Dan-Axel Zagadou | Knee Surgery | 18 Mar 2021 | 30 Sept 2021 | 196 | 26 |
Unknown player | Bruise On Ankle | 14 Mar 2021 | 1 Apr 2021 | 18 | 1 |
Unknown player | Muscular Problems | 11 Mar 2021 | 22 Mar 2021 | 11 | 2 |
Unknown player | Muscle Injury | 4 Mar 2021 | 22 Mar 2021 | 18 | 4 |
| Giovanni Reyna | Muscular Problems | 4 Mar 2021 | 11 Mar 2021 | 7 | 2 |
Unknown player | Knock | 4 Mar 2021 | 8 Mar 2021 | 4 | 1 |
Unknown player | Torn Muscle Bundle | 3 Mar 2021 | 19 Apr 2021 | 47 | 8 |
Unknown player | Infection | 26 Feb 2021 | 28 Feb 2021 | 2 | 0 |
Unknown player | Cruciate Ligament Tear | 25 Feb 2021 | 25 Oct 2021 | 242 | — |
| Manuel Akanji | Torn Muscle Fiber | 19 Feb 2021 | 14 Mar 2021 | 23 | 5 |
Unknown player | Knee Problems | 1 Feb 2021 | 4 Feb 2021 | 3 | 1 |
Unknown player | Shoulder Injury | 29 Jan 2021 | 21 Feb 2021 | 23 | 5 |
| Thomas Meunier | Inflammation In The Knee | 28 Jan 2021 | 15 Feb 2021 | 18 | 4 |
| Jude Bellingham | Doubtful | 16 Jan 2021 | 16 Jan 2021 | 0 | 1 |
| Dan-Axel Zagadou | Torn Muscle Fiber | 14 Jan 2021 | 22 Feb 2021 | 39 | 9 |
| Giovanni Reyna | Infection | 14 Jan 2021 | 18 Jan 2021 | 4 | 1 |
 Axel Witsel | Achilles Tendon Rupture | 11 Jan 2021 | 14 Jun 2021 | 154 | 27 |
Unknown player | Doubtful | 9 Jan 2021 | 9 Jan 2021 | 0 | 1 |
| Jude Bellingham | Knock | 30 Dec 2020 | 10 Jan 2021 | 11 | 1 |
| Thorgan Hazard | Torn Muscle Fiber | 24 Dec 2020 | 22 Feb 2021 | 60 | 11 |
Unknown player | Minor Knock | 21 Dec 2020 | 24 Dec 2020 | 3 | 1 |
Unknown player | Knee Problems | 21 Dec 2020 | 7 Jan 2021 | 17 | 2 |
Unknown player | Doubtful | 18 Dec 2020 | 18 Dec 2020 | 0 | 1 |
| Thomas Meunier | Doubtful | 18 Dec 2020 | 18 Dec 2020 | 0 | 1 |
Unknown player | Muscular Problems | 17 Dec 2020 | 23 Dec 2020 | 6 | 1 |
Unknown player | Minor Knock | 17 Dec 2020 | 24 Dec 2020 | 7 | 2 |
Unknown player | Doubtful | 12 Dec 2020 | 12 Dec 2020 | 0 | 1 |
Unknown player | Doubtful | 12 Dec 2020 | 12 Dec 2020 | 0 | 1 |
| Manuel Akanji | Doubtful | 12 Dec 2020 | 12 Dec 2020 | 0 | 1 |
| Thorgan Hazard | Hamstring Strain | 10 Dec 2020 | 21 Dec 2020 | 11 | 3 |
Unknown player | Doubtful | 8 Dec 2020 | 8 Dec 2020 | 0 | 1 |
Unknown player | ILL | 7 Dec 2020 | 10 Dec 2020 | 3 | 1 |
Unknown player | Doubtful | 5 Dec 2020 | 5 Dec 2020 | 0 | 1 |
Unknown player | Muscular Problems | 3 Dec 2020 | 10 Dec 2020 | 7 | 2 |
Unknown player | Muscular Problems | 3 Dec 2020 | 10 Dec 2020 | 7 | 2 |
| Manuel Akanji | Knee Problems | 3 Dec 2020 | 9 Dec 2020 | 6 | 1 |
Unknown player | Doubtful | 2 Dec 2020 | 2 Dec 2020 | 0 | 1 |
| Emre Can | Muscular Problems | 30 Nov 2020 | 3 Dec 2020 | 3 | 0 |
| Thomas Meunier | Torn Muscle Fiber | 30 Nov 2020 | 17 Dec 2020 | 17 | 5 |
| Erling Haaland | Torn Muscle Fiber | 30 Nov 2020 | 28 Dec 2020 | 28 | 7 |
Unknown player | Muscle Strain | 26 Nov 2020 | 30 Nov 2020 | 4 | 1 |
Unknown player | COVID 19 | 23 Nov 2020 | 9 Dec 2020 | 16 | 4 |
Unknown player | Bruise | 20 Nov 2020 | 22 Nov 2020 | 2 | 0 |
Unknown player | Minor Knock | 2 Nov 2020 | 5 Nov 2020 | 3 | 0 |
| Erling Haaland | Knee Problems | 29 Oct 2020 | 2 Nov 2020 | 4 | 1 |
Unknown player | Hamstring Strain | 29 Oct 2020 | 5 Nov 2020 | 7 | 1 |
| Emre Can | COVID 19 | 23 Oct 2020 | 6 Nov 2020 | 14 | 4 |
Unknown player | Torn Muscle Fiber | 8 Oct 2020 | 1 Nov 2020 | 24 | 4 |
| Manuel Akanji | COVID 19 | 7 Oct 2020 | 21 Oct 2020 | 14 | 1 |
Unknown player | Infection | 29 Sept 2020 | 4 Oct 2020 | 5 | 1 |
Unknown player | Infection | 29 Sept 2020 | 4 Oct 2020 | 5 | 1 |
| Thorgan Hazard | Torn Muscle Fiber | 21 Sept 2020 | 22 Oct 2020 | 31 | 5 |
Unknown player | Foot Injury | 14 Sept 2020 | 18 Oct 2020 | 34 | 5 |
Unknown player | Muscle Strain | 14 Sept 2020 | 21 Sept 2020 | 7 | 2 |
