| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Jamie Gittens | Shoulder Injury | 7 May 2023 | 18 Aug 2023 | 103 | 12 |
Unknown player | Knee Injury | 30 Apr 2023 | 19 Jun 2023 | 50 | 4 |
 Nico Schlotterbeck | Hamstring Injury | 23 Apr 2023 | 5 May 2023 | 12 | 1 |
Unknown player | Knee Injury | 21 Apr 2023 | 4 May 2023 | 13 | 2 |
 Thomas Meunier | Muscle Injury | 16 Apr 2023 | 29 May 2023 | 43 | 6 |
 Marius Wolf | ILL | 7 Apr 2023 | 12 Apr 2023 | 5 | 1 |
Unknown player | Knee Problems | 2 Apr 2023 | 7 Apr 2023 | 5 | 1 |
| Nico Schlotterbeck | Torn Muscle Fiber | 2 Apr 2023 | 20 Apr 2023 | 18 | 3 |
Unknown player | ILL | 31 Mar 2023 | 9 Apr 2023 | 9 | 1 |
| Thomas Meunier | Back Problems | 29 Mar 2023 | 6 Apr 2023 | 8 | 1 |
 Giovanni Reyna | Cold | 29 Mar 2023 | 2 Apr 2023 | 4 | 0 |
Unknown player | Stomach Flu | 16 Mar 2023 | 20 Mar 2023 | 4 | 1 |
| Jamie Gittens | Shoulder Injury | 16 Mar 2023 | 31 Mar 2023 | 15 | 1 |
 Gregor Kobel | Thigh Problems | 9 Mar 2023 | 29 Mar 2023 | 20 | 1 |
Unknown player | ILL | 9 Mar 2023 | 13 Mar 2023 | 4 | 1 |
Unknown player | Torn Muscle Fiber | 8 Mar 2023 | 29 Mar 2023 | 21 | 2 |
 Donyell Malen | Ankle Problems | 2 Mar 2023 | 4 Mar 2023 | 2 | 0 |
 Tom Rothe | Wrist Injury | 25 Feb 2023 | 6 Mar 2023 | 9 | 2 |
 Julian Ryerson | Eye Injury | 24 Feb 2023 | 28 Feb 2023 | 4 | 1 |
 Karim Adeyemi | Torn Muscle Fiber | 20 Feb 2023 | 30 Mar 2023 | 38 | 5 |
Unknown player | Fitness | 15 Feb 2023 | 29 May 2023 | 103 | 17 |
Unknown player | Syndesmosis Ligament Tear | 12 Feb 2023 | 30 Mar 2023 | 46 | 7 |
| Julian Ryerson | ILL | 3 Feb 2023 | 6 Feb 2023 | 3 | 1 |
Unknown player | Fitness | 24 Jan 2023 | 29 Apr 2023 | 95 | 15 |
 Emre Can | Muscular Problems | 20 Jan 2023 | 23 Jan 2023 | 3 | 0 |
Unknown player | ILL | 16 Jan 2023 | 26 Jan 2023 | 10 | 1 |
| Thomas Meunier | Torn Muscle Fiber | 12 Jan 2023 | 9 Feb 2023 | 28 | 4 |
Unknown player | Pelvic Injury | 12 Jan 2023 | 9 Feb 2023 | 28 | 4 |
 Julien Duranville | Partial Muscle Tear | 6 Dec 2022 | 19 May 2023 | 164 | 4 |
Unknown player | Inflammation In The Ankle Joint | 7 Nov 2022 | 2 Jan 2023 | 56 | 5 |
| Tom Rothe | Bone Sprain | 3 Nov 2022 | 2 Jan 2023 | 60 | 6 |
Unknown player | Muscular Problems | 24 Oct 2022 | 3 Nov 2022 | 10 | 2 |
 Justin Njinmah | ILL | 21 Oct 2022 | 27 Oct 2022 | 6 | 1 |
Unknown player | Knee Medial Ligament Tear | 21 Oct 2022 | 23 Jan 2023 | 94 | 7 |
| Thomas Meunier | Broken Cheekbone | 20 Oct 2022 | 17 Nov 2022 | 28 | 7 |
| Donyell Malen | Cold | 20 Oct 2022 | 24 Oct 2022 | 4 | 1 |
Unknown player | Ankle Problems | 17 Oct 2022 | 3 Nov 2022 | 17 | 4 |
| Marius Wolf | Infection | 13 Oct 2022 | 20 Oct 2022 | 7 | 1 |
Unknown player | Thigh Problems | 10 Oct 2022 | 17 Oct 2022 | 7 | 1 |
| Marius Wolf | Circulation Problems | 29 Sept 2022 | 6 Oct 2022 | 7 | 1 |
| Gregor Kobel | Back Problems | 29 Sept 2022 | 3 Oct 2022 | 4 | 1 |
Unknown player | Back Problems | 29 Sept 2022 | 24 Oct 2022 | 25 | 7 |
Unknown player | Cold | 29 Sept 2022 | 6 Oct 2022 | 7 | 1 |
| Giovanni Reyna | Injury | 29 Sept 2022 | 9 Oct 2022 | 10 | 1 |
Unknown player | Torn Lateral Ankle Ligament | 19 Sept 2022 | 13 Oct 2022 | 24 | 4 |
Unknown player | Thigh Problems | 15 Sept 2022 | 29 Sept 2022 | 14 | 1 |
Unknown player | Minor Knock | 12 Sept 2022 | 26 Sept 2022 | 14 | 2 |
 Thorgan Hazard | Thigh Problems | 8 Sept 2022 | 12 Sept 2022 | 4 | 1 |
| Gregor Kobel | Torn Muscle Fiber | 5 Sept 2022 | 29 Sept 2022 | 24 | 4 |
| Jamie Gittens | Shoulder Injury | 3 Sept 2022 | 28 Nov 2022 | 86 | 18 |
Unknown player | ILL | 1 Sept 2022 | 5 Sept 2022 | 4 | 1 |
Unknown player | Knee Surgery | 29 Aug 2022 | 15 Feb 2023 | 170 | 20 |
| Karim Adeyemi | Foot Injury | 29 Aug 2022 | 12 Sept 2022 | 14 | 3 |
Unknown player | Shoulder Injury | 22 Aug 2022 | 28 Nov 2022 | 98 | 0 |
| Giovanni Reyna | Muscular Problems | 22 Aug 2022 | 29 Aug 2022 | 7 | 1 |
| Donyell Malen | Torn Muscle Fiber | 18 Aug 2022 | 12 Sept 2022 | 25 | 5 |
| Giovanni Reyna | Muscular Problems | 8 Aug 2022 | 15 Aug 2022 | 7 | 1 |
| Karim Adeyemi | Toe Injury | 8 Aug 2022 | 22 Aug 2022 | 14 | 2 |
Unknown player | Muscle Injury | 1 Aug 2022 | 19 Aug 2022 | 18 | 3 |
Unknown player | Fitness | 25 Jul 2022 | 8 Aug 2022 | 14 | 3 |
Unknown player | Testicular Cancer | 18 Jul 2022 | 31 Dec 2022 | 166 | 29 |
| Giovanni Reyna | Fitness | 4 Jul 2022 | 1 Aug 2022 | 28 | 7 |
Unknown player | Knock | 12 May 2022 | 31 May 2022 | 19 | 1 |
Unknown player | Fitness | 9 May 2022 | 11 Aug 2022 | 94 | 9 |
| Gregor Kobel | Cruciate Ligament Injury | 21 Apr 2022 | 23 May 2022 | 32 | 5 |
 Axel Witsel | Infection | 21 Apr 2022 | 28 Apr 2022 | 7 | 2 |
| Thorgan Hazard | Back Problems | 14 Apr 2022 | 2 Jun 2022 | 49 | 6 |
Unknown player | Muscle Injury | 11 Apr 2022 | 30 Jun 2022 | 80 | 6 |
Unknown player | Muscular Problems | 11 Apr 2022 | 18 Apr 2022 | 7 | 1 |
Unknown player | Shoulder Injury | 11 Apr 2022 | 4 Jul 2022 | 84 | 6 |
| Giovanni Reyna | Muscle Injury | 11 Apr 2022 | 30 Jun 2022 | 80 | 1 |
| Donyell Malen | Injury | 7 Apr 2022 | 14 Jul 2022 | 98 | 9 |
Unknown player | Muscle Injury | 21 Mar 2022 | 18 Apr 2022 | 28 | 3 |
Unknown player | Muscle Injury | 21 Mar 2022 | 14 Apr 2022 | 24 | 2 |
 Immanuel Pherai | Foot Bruise | 19 Mar 2022 | 10 Apr 2022 | 22 | 2 |
Unknown player | Shoulder Injury | 13 Mar 2022 | 8 Aug 2022 | 148 | 15 |
 Steffen Tigges | Dislocation Fracture Of The Ankle Joint | 10 Mar 2022 | 30 Jun 2022 | 112 | 2 |
Unknown player | ILL | 7 Mar 2022 | 28 Mar 2022 | 21 | 3 |
Unknown player | COVID 19 | 7 Mar 2022 | 14 Mar 2022 | 7 | 0 |
Unknown player | COVID 19 | 7 Mar 2022 | 17 Mar 2022 | 10 | 1 |
Unknown player | Torn Muscle Fiber | 28 Feb 2022 | 31 Mar 2022 | 31 | 3 |
| Thomas Meunier | Tendon Rupture | 24 Feb 2022 | 12 May 2022 | 77 | 12 |
Unknown player | Minor Knock | 24 Feb 2022 | 7 Mar 2022 | 11 | 2 |
 Dan-Axel Zagadou | Torn Muscle Fiber | 21 Feb 2022 | 17 Mar 2022 | 24 | 3 |
| Giovanni Reyna | Hamstring Injury | 21 Feb 2022 | 7 Mar 2022 | 14 | 2 |
 Manuel Akanji | Torn Muscle Fiber | 18 Feb 2022 | 17 Mar 2022 | 27 | 4 |
| Thomas Meunier | Minor Knock | 10 Feb 2022 | 21 Feb 2022 | 11 | 3 |
| Giovanni Reyna | ILL | 10 Feb 2022 | 17 Feb 2022 | 7 | 1 |
Unknown player | Ankle Injury | 7 Feb 2022 | 14 Feb 2022 | 7 | 1 |
 Erling Haaland | Muscular Problems | 24 Jan 2022 | 7 Mar 2022 | 42 | 6 |
| Thomas Meunier | Muscular Problems | 20 Jan 2022 | 31 Jan 2022 | 11 | 1 |
| Emre Can | Muscle Injury | 17 Jan 2022 | 10 Feb 2022 | 24 | 3 |
Unknown player | Back Problems | 17 Jan 2022 | 20 Jan 2022 | 3 | 1 |
| Giovanni Reyna | Doubtful | 14 Jan 2022 | 14 Jan 2022 | 0 | 1 |
Unknown player | Calf Problems | 10 Jan 2022 | 17 Jan 2022 | 7 | 0 |
| Marius Wolf | COVID 19 | 3 Jan 2022 | 10 Jan 2022 | 7 | 1 |
| Dan-Axel Zagadou | COVID 19 | 30 Dec 2021 | 17 Jan 2022 | 18 | 2 |
Unknown player | Cold | 16 Dec 2021 | 20 Dec 2021 | 4 | 1 |
| Gregor Kobel | Cold | 16 Dec 2021 | 20 Dec 2021 | 4 | 1 |
| Donyell Malen | Doubtful | 11 Dec 2021 | 11 Dec 2021 | 0 | 1 |
