| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Ibrahim Maza | ILL | 15 Sept 2026 | Current | — | 0 |
 Guéla Doué | Fitness | 8 Sept 2026 | — | — | 1 |
 Eliesse Ben Seghir | Fitness | 3 Sept 2026 | 10 Sept 2026 | 7 | 1 |
| Guéla Doué | Knock | 1 Sept 2026 | 7 Sept 2026 | 6 | 1 |
 Nathan Tella | Back Problems | 29 Aug 2026 | Current | — | 3 |
 Martin Terrier | Knock | 25 Aug 2026 | 4 Sept 2026 | 10 | 1 |
 Arthur | Knock | 15 Aug 2026 | 28 Aug 2026 | 13 | 2 |
 Montrell Culbreath | Foot Injury | 9 Aug 2026 | Current | — | 6 |
 Robert Andrich | Muscular Problems | 8 Aug 2026 | 24 Aug 2026 | 16 | 4 |
 Kennet Eichhorn | ILL | 1 Aug 2026 | Current | — | 8 |
| Eliesse Ben Seghir | Hamstring Injury | 20 Jul 2026 | 2 Sept 2026 | 44 | 8 |
 Christian Kofane | Shoulder Injury | 10 May 2026 | 30 Jun 2026 | 51 | 1 |
| Nathan Tella | Muscular Problems | 9 May 2026 | 30 Jun 2026 | 52 | 2 |
 Mark Flekken | Muscular Problems | 25 Apr 2026 | 27 Apr 2026 | 2 | 1 |
 Lucas Vázquez | Knock | 23 Apr 2026 | 8 May 2026 | 15 | 2 |
| Christian Kofane | Hamstring Injury | 21 Apr 2026 | 27 Apr 2026 | 6 | 2 |
 Equi Fernández | Minor Knock | 18 Apr 2026 | 21 Apr 2026 | 3 | 1 |
 Jarell Quansah | Thigh Problems | 22 Mar 2026 | 14 Apr 2026 | 23 | 2 |
| Martin Terrier | Hamstring Injury | 22 Mar 2026 | 15 Jul 2026 | 115 | 8 |
| Eliesse Ben Seghir | Fitness | 16 Mar 2026 | 3 Apr 2026 | 18 | 2 |
 Patrik Schick | Muscular Problems | 4 Mar 2026 | 9 Mar 2026 | 5 | 2 |
| Arthur | Syndesmotic Ligament Tear | 1 Mar 2026 | 24 Apr 2026 | 54 | 10 |
| Lucas Vázquez | Calf Injury | 25 Feb 2026 | 10 Apr 2026 | 44 | 8 |
| Martin Terrier | Knock | 24 Feb 2026 | 27 Feb 2026 | 3 | 1 |
 Malik Tillman | Ankle Problems | 22 Feb 2026 | 3 Mar 2026 | 9 | 2 |
 Loïc Badé | Hamstring Injury | 22 Feb 2026 | 1 Apr 2026 | 38 | 8 |
 Tim Oermann | ILL | 7 Feb 2026 | 11 Feb 2026 | 4 | 1 |
| Ibrahim Maza | Knee Problems | 30 Jan 2026 | 10 Feb 2026 | 11 | 3 |
| Eliesse Ben Seghir | Ankle Injury | 18 Jan 2026 | 15 Mar 2026 | 56 | 15 |
| Mark Flekken | Cruciate Ligament Injury | 18 Jan 2026 | 18 Mar 2026 | 59 | 16 |
| Nathan Tella | Foot Injury | 18 Jan 2026 | 13 Mar 2026 | 54 | 14 |
 Axel Tape | Muscular Problems | 10 Jan 2026 | 19 Jan 2026 | 9 | 2 |
| Patrik Schick | Muscular Problems | 10 Jan 2026 | 12 Jan 2026 | 2 | 1 |
 Edmond Tapsoba | Muscle Injury | 7 Jan 2026 | 26 Jan 2026 | 19 | 4 |
 Exequiel Palacios | Fitness | 16 Dec 2025 | 23 Jan 2026 | 38 | 4 |
 Unknown player | Thigh Problems | 14 Dec 2025 | 5 Jan 2026 | 22 | 1 |
 Alejandro Grimaldo | Muscular Problems | 13 Dec 2025 | 31 Dec 2025 | 18 | 2 |
| Patrik Schick | Ankle Injury | 11 Dec 2025 | 18 Dec 2025 | 7 | 1 |
| Lucas Vázquez | Fitness | 9 Dec 2025 | 19 Dec 2025 | 10 | 2 |
| Alejandro Grimaldo | Knock | 6 Dec 2025 | 9 Dec 2025 | 3 | 1 |
 Janis Blaswich | Muscular Problems | 24 Nov 2025 | 8 Dec 2025 | 14 | 4 |
| Arthur | Back Problems | 19 Nov 2025 | 3 Dec 2025 | 14 | 3 |
| Axel Tape | Fitness | 19 Nov 2025 | 8 Dec 2025 | 19 | 5 |
| Equi Fernández | Cruciate Ligament Injury | 27 Oct 2025 | 11 Dec 2025 | 45 | 9 |
| Malik Tillman | Muscle Injury | 16 Oct 2025 | 3 Nov 2025 | 18 | 5 |
| Lucas Vázquez | Muscular Problems | 14 Oct 2025 | 8 Dec 2025 | 55 | 12 |
| Jarell Quansah | Patellar Tendon Irritation | 10 Oct 2025 | 23 Oct 2025 | 13 | 2 |
| Axel Tape | Hamstring Injury | 2 Oct 2025 | 18 Nov 2025 | 47 | 8 |
| Lucas Vázquez | Muscular Problems | 29 Sept 2025 | 2 Oct 2025 | 3 | 0 |
| Robert Andrich | Muscular Problems | 28 Sept 2025 | 2 Oct 2025 | 4 | 1 |
| Patrik Schick | Hamstring Injury | 28 Sept 2025 | 23 Oct 2025 | 25 | 4 |
| Exequiel Palacios | Adductor Injury | 13 Sept 2025 | 15 Dec 2025 | 93 | 19 |
| Nathan Tella | Knee Bruise | 13 Sept 2025 | 18 Nov 2025 | 66 | 12 |
| Arthur | ILL | 12 Sept 2025 | 15 Sept 2025 | 3 | 1 |
 Jeanuël Belocian | Fitness | 11 Sept 2025 | 15 Sept 2025 | 4 | 1 |
 Jonas Hofmann | Muscular Problems | 3 Sept 2025 | 19 Sept 2025 | 16 | 1 |
| Jonas Hofmann | Fitness | 28 Aug 2025 | 1 Sept 2025 | 4 | 1 |
| Exequiel Palacios | Muscle Injury | 6 Aug 2025 | 27 Aug 2025 | 21 | 3 |
| Jonas Hofmann | Muscle Injury | 1 Aug 2025 | 27 Aug 2025 | 26 | 4 |
| Malik Tillman | Calf Injury | 1 Aug 2025 | 27 Aug 2025 | 26 | 4 |
| Loïc Badé | Muscle Injury | 27 Jul 2025 | 25 Aug 2025 | 29 | 4 |
 Victor Boniface | ILL | 16 May 2025 | 19 May 2025 | 3 | 1 |
| Victor Boniface | Thigh Problems | 2 May 2025 | 8 May 2025 | 6 | 1 |
 Nordi Mukiele | Torn Muscle Fiber | 24 Apr 2025 | 1 Jun 2025 | 38 | 3 |
| Exequiel Palacios | Groin Problems | 1 Apr 2025 | 10 Apr 2025 | 9 | 2 |
 Mario Hermoso | Chest Injury | 11 Mar 2025 | 30 Jun 2025 | 111 | 11 |
| Edmond Tapsoba | Muscular Problems | 11 Mar 2025 | 3 Apr 2025 | 23 | 4 |
| Nathan Tella | Muscular Problems | 11 Mar 2025 | 31 Mar 2025 | 20 | 3 |
 Florian Wirtz | Inner Ligament Injury | 9 Mar 2025 | 7 Apr 2025 | 29 | 5 |
| Jonas Hofmann | ILL | 7 Mar 2025 | 10 Mar 2025 | 3 | 1 |
| Robert Andrich | ILL | 4 Mar 2025 | 10 Mar 2025 | 6 | 2 |
| Edmond Tapsoba | Knock | 1 Mar 2025 | 4 Mar 2025 | 3 | 1 |
| Nathan Tella | Hip Problems | 19 Feb 2025 | 28 Feb 2025 | 9 | 1 |
| Mario Hermoso | Stomach Flu | 15 Feb 2025 | 18 Feb 2025 | 3 | 1 |
 Unknown player | Injury | 3 Feb 2025 | 7 Apr 2025 | 63 | 6 |
 Amine Adli | Fitness | 30 Jan 2025 | 6 Feb 2025 | 7 | 1 |
| Martin Terrier | Achilles Tendon Rupture | 18 Jan 2025 | 13 Oct 2025 | 268 | 36 |
 Jonathan Tah | ILL | 14 Jan 2025 | 16 Jan 2025 | 2 | 1 |
| Jeanuël Belocian | Cruciate Ligament Tear | 6 Jan 2025 | 10 Sept 2025 | 247 | 25 |
| Victor Boniface | Fitness | 18 Dec 2024 | 20 Jan 2025 | 33 | 1 |
| Patrik Schick | Calf Problems | 4 Dec 2024 | 9 Dec 2024 | 5 | 1 |
| Martin Terrier | Forearm Fracture | 24 Nov 2024 | 2 Dec 2024 | 8 | 2 |
| Jonas Hofmann | Hamstring Injury | 22 Nov 2024 | 23 Dec 2024 | 31 | 8 |
| Victor Boniface | Hamstring Injury | 19 Nov 2024 | 18 Dec 2024 | 29 | 7 |
| Nordi Mukiele | Torn Muscle Fiber | 2 Nov 2024 | 27 Nov 2024 | 25 | 3 |
| Martin Terrier | Knock | 1 Nov 2024 | 11 Nov 2024 | 10 | 3 |
| Jeanuël Belocian | Ankle Injury | 25 Oct 2024 | 2 Dec 2024 | 38 | 8 |
| Amine Adli | Broken Fibula | 24 Oct 2024 | 30 Jan 2025 | 98 | 19 |
| Victor Boniface | Knock | 20 Oct 2024 | 24 Oct 2024 | 4 | 0 |
| Exequiel Palacios | Fitness | 5 Sept 2024 | 16 Sept 2024 | 11 | 1 |
 Lukas Hradecky | ILL | 27 Aug 2024 | 1 Sept 2024 | 5 | 1 |
| Exequiel Palacios | Knee Injury | 5 Aug 2024 | 5 Sept 2024 | 31 | 6 |
| Florian Wirtz | Bruise | 10 May 2024 | 16 May 2024 | 6 | 1 |
| Alejandro Grimaldo | Rest | 5 May 2024 | 6 May 2024 | 1 | 0 |
| Florian Wirtz | Bruise | 4 May 2024 | 8 May 2024 | 4 | 1 |
 Borja Iglesias | Muscular Problems | 13 Apr 2024 | 29 Apr 2024 | 16 | 4 |
 Adam Hlozek | Ankle Injury | 7 Apr 2024 | 29 Apr 2024 | 22 | 5 |
| Exequiel Palacios | Muscular Problems | 29 Mar 2024 | 1 Apr 2024 | 3 | 1 |
 Unknown player | Muscular Problems | 9 Mar 2024 | 11 Mar 2024 | 2 | 0 |
| Exequiel Palacios | Muscle Injury | 21 Jan 2024 | 27 Feb 2024 | 37 | 6 |
