| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 José María Giménez | Muscle Injury | 3 Apr 2022 | 29 Apr 2022 | 26 | 5 |
 Unknown player | Muscle Injury | 2 Apr 2022 | 29 Apr 2022 | 27 | 6 |
 Thomas Lemar | Muscle Injury | 9 Mar 2022 | 1 Apr 2022 | 23 | 3 |
 Unknown player | Muscle Injury | 7 Mar 2022 | 1 Apr 2022 | 25 | 3 |
 Mario Hermoso | Muscle Injury | 3 Mar 2022 | 14 Mar 2022 | 11 | 2 |
 Geoffrey Kondogbia | Muscle Injury | 28 Feb 2022 | 14 Mar 2022 | 14 | 2 |
 Koke | Muscle Injury | 22 Feb 2022 | 10 Mar 2022 | 16 | 3 |
| Thomas Lemar | COVID 19 | 18 Feb 2022 | 22 Feb 2022 | 4 | 1 |
 Matheus Cunha | Knee Injury | 17 Feb 2022 | 31 Mar 2022 | 42 | 7 |
 Benjamin Lecomte | COVID 19 | 17 Feb 2022 | 21 Feb 2022 | 4 | 1 |
| Mario Hermoso | COVID 19 | 16 Feb 2022 | 18 Feb 2022 | 2 | 1 |
 Unknown player | COVID 19 | 12 Feb 2022 | 18 Feb 2022 | 6 | 2 |
| José María Giménez | COVID 19 | 10 Feb 2022 | 15 Feb 2022 | 5 | 1 |
 Unknown player | Cruciate Ligament Injury | 7 Feb 2022 | 1 Apr 2022 | 53 | 9 |
| Geoffrey Kondogbia | Muscle Injury | 15 Jan 2022 | 11 Feb 2022 | 27 | 3 |
 Marcos Llorente | Muscle Injury | 15 Jan 2022 | 11 Feb 2022 | 27 | 3 |
 Unknown player | Muscle Injury | 6 Jan 2022 | 21 Feb 2022 | 46 | 9 |
| Unknown player | COVID 19 | 30 Dec 2021 | 6 Jan 2022 | 7 | 1 |
| Koke | COVID 19 | 30 Dec 2021 | 5 Jan 2022 | 6 | 1 |
| Unknown player | COVID 19 | 30 Dec 2021 | 7 Jan 2022 | 8 | 1 |
 Unknown player | COVID 19 | 30 Dec 2021 | 5 Jan 2022 | 6 | 1 |
| Marcos Llorente | Strain In The Thigh And Gluteal Muscles | 20 Dec 2021 | 3 Jan 2022 | 14 | 1 |
| Unknown player | Muscle Injury | 13 Dec 2021 | 6 Jan 2022 | 24 | 3 |
| Unknown player | Facial Fracture | 8 Dec 2021 | 31 Dec 2021 | 23 | 3 |
| José María Giménez | Muscle Injury | 6 Dec 2021 | 31 Dec 2021 | 25 | 4 |
 Unknown player | Muscle Injury | 5 Dec 2021 | 21 Jan 2022 | 47 | 9 |
| Unknown player | Muscle Injury | 3 Dec 2021 | 5 Dec 2021 | 2 | 0 |
 Unknown player | Lumbago | 27 Nov 2021 | 29 Nov 2021 | 2 | 0 |
| Unknown player | Muscle Injury | 18 Nov 2021 | 1 Dec 2021 | 13 | 3 |
 Unknown player | Shoulder Injury | 8 Nov 2021 | 10 Dec 2021 | 32 | 5 |
| Geoffrey Kondogbia | Muscle Injury | 28 Oct 2021 | 5 Nov 2021 | 8 | 3 |
| Thomas Lemar | Muscle Injury | 25 Oct 2021 | 20 Nov 2021 | 26 | 4 |
| Marcos Llorente | Muscle Injury | 24 Oct 2021 | 8 Nov 2021 | 15 | 4 |
| Marcos Llorente | Muscle Injury | 22 Oct 2021 | 13 Feb 2022 | 114 | — |
| Unknown player | Muscle Injury | 22 Oct 2021 | 24 Oct 2021 | 2 | 0 |
| Unknown player | Muscle Injury | 4 Oct 2021 | 25 Oct 2021 | 21 | 1 |
| Matheus Cunha | Muscle Injury | 1 Oct 2021 | 18 Oct 2021 | 17 | 1 |
| Geoffrey Kondogbia | Ankle Sprain | 19 Sept 2021 | 23 Sept 2021 | 4 | 1 |
| Koke | Muscle Injury | 17 Sept 2021 | 23 Sept 2021 | 6 | 2 |
| Thomas Lemar | Muscle Injury | 16 Sept 2021 | 28 Sept 2021 | 12 | 3 |
 Unknown player | Doubtful | 22 Aug 2021 | 22 Aug 2021 | 0 | 1 |
| Unknown player | Muscle Injury | 15 Aug 2021 | 11 Sept 2021 | 27 | 3 |
| Unknown player | Broken Ankle | 2 Jul 2021 | 11 Sept 2021 | 71 | 8 |
 Unknown player | Cruciate Ligament Injury | 20 Jun 2021 | 28 Aug 2021 | 69 | 7 |
| Thomas Lemar | Muscle Injury | 9 May 2021 | 3 Jun 2021 | 25 | 3 |
| Unknown player | Muscle Injury | 30 Apr 2021 | 3 May 2021 | 3 | 1 |
| Unknown player | Ankle Injury | 12 Apr 2021 | 23 Apr 2021 | 11 | 1 |
| Thomas Lemar | Muscle Injury | 11 Apr 2021 | 23 Apr 2021 | 12 | 2 |
 Unknown player | Muscle Injury | 7 Apr 2021 | 23 Apr 2021 | 16 | 2 |
| Unknown player | Ankle Injury | 30 Mar 2021 | 6 Apr 2021 | 7 | 1 |
 Unknown player | Fitness | 24 Mar 2021 | 12 Apr 2021 | 19 | 1 |
| José María Giménez | Muscular Problems | 21 Feb 2021 | 11 Mar 2021 | 18 | 3 |
| Unknown player | Foot Injury | 19 Feb 2021 | 3 Mar 2021 | 12 | 3 |
| José María Giménez | Muscle Injury | 11 Feb 2021 | 15 Feb 2021 | 4 | 1 |
| Thomas Lemar | COVID 19 | 8 Feb 2021 | 19 Feb 2021 | 11 | 3 |
| Unknown player | COVID 19 | 8 Feb 2021 | 27 Feb 2021 | 19 | 5 |
| Unknown player | COVID 19 | 4 Feb 2021 | 19 Feb 2021 | 15 | 3 |
| Unknown player | COVID 19 | 2 Feb 2021 | 16 Feb 2021 | 14 | 2 |
| Mario Hermoso | COVID 19 | 30 Jan 2021 | 12 Feb 2021 | 13 | 2 |
| Unknown player | COVID 19 | 30 Jan 2021 | 7 Feb 2021 | 8 | 1 |
| Unknown player | Doubtful | 24 Jan 2021 | 24 Jan 2021 | 0 | 1 |
| Mario Hermoso | Ankle Sprain | 15 Jan 2021 | 23 Jan 2021 | 8 | 1 |
| Unknown player | Knock | 20 Dec 2020 | 23 Dec 2020 | 3 | 0 |
| Unknown player | Muscle Injury | 13 Dec 2020 | 23 Jan 2021 | 41 | 8 |
| Unknown player | Knee Injury | 5 Dec 2020 | 7 Dec 2020 | 2 | 1 |
| Unknown player | Back Injury | 5 Dec 2020 | 8 Dec 2020 | 3 | 1 |
| José María Giménez | Thigh Problems | 2 Dec 2020 | 22 Dec 2020 | 20 | 5 |
 Unknown player | Doubtful | 1 Dec 2020 | 1 Dec 2020 | 0 | 1 |
 Unknown player | Leg Injury | 25 Nov 2020 | 13 Dec 2020 | 18 | 5 |
| Unknown player | Doubtful | 21 Nov 2020 | 21 Nov 2020 | 0 | 1 |
| Unknown player | Doubtful | 21 Nov 2020 | 21 Nov 2020 | 0 | 1 |
| Unknown player | COVID 19 | 19 Nov 2020 | 30 Nov 2020 | 11 | 3 |
 Manu Sánchez | Muscle Injury | 19 Nov 2020 | 1 Dec 2020 | 12 | 3 |
| Unknown player | COVID 19 | 18 Nov 2020 | 4 Dec 2020 | 16 | 4 |
| Unknown player | Hamstring Injury | 13 Nov 2020 | 30 Nov 2020 | 17 | 3 |
 Unknown player | Hamstring Injury | 3 Nov 2020 | 20 Nov 2020 | 17 | 2 |
| Unknown player | Knock | 30 Oct 2020 | 2 Nov 2020 | 3 | 1 |
| Unknown player | Doubtful | 27 Oct 2020 | 27 Oct 2020 | 0 | 1 |
| Unknown player | Muscle Injury | 25 Oct 2020 | 19 Nov 2020 | 25 | 4 |
| José María Giménez | Doubtful | 24 Oct 2020 | 24 Oct 2020 | 0 | 1 |
| Unknown player | Muscle Injury | 19 Oct 2020 | 8 Nov 2020 | 20 | 5 |
| Unknown player | Knock | 15 Oct 2020 | 18 Oct 2020 | 3 | 0 |
| José María Giménez | Muscular Problems | 6 Oct 2020 | 22 Oct 2020 | 16 | 1 |
| José María Giménez | COVID 19 | 21 Sept 2020 | 5 Oct 2020 | 14 | 3 |
| Unknown player | COVID 19 | 10 Aug 2020 | 22 Aug 2020 | 12 | 1 |
 Unknown player | Quarantine | 7 Aug 2020 | 21 Aug 2020 | 14 | 1 |
| José María Giménez | Ankle Injury | 8 Jul 2020 | 13 Jul 2020 | 5 | 1 |
| Unknown player | Ankle Injury | 4 Jul 2020 | 18 Jul 2020 | 14 | 3 |
| Mario Hermoso | Minor Knock | 2 Jul 2020 | 9 Jul 2020 | 7 | 2 |
| Unknown player | Knock | 2 Jul 2020 | 6 Jul 2020 | 4 | 1 |
| Mario Hermoso | Adductor Pain | 27 Jun 2020 | 30 Jun 2020 | 3 | 1 |
| Unknown player | Knock | 11 Jun 2020 | 16 Jun 2020 | 5 | 1 |
| Unknown player | Stomach Problems | 10 Jun 2020 | 26 Jun 2020 | 16 | 4 |
| Unknown player | Knee Injury | 3 Jun 2020 | 8 Dec 2020 | 188 | 27 |
| Unknown player | Muscle Injury | 5 Mar 2020 | 8 Mar 2020 | 3 | 0 |
| José María Giménez | Knee Problems | 29 Feb 2020 | 4 Mar 2020 | 4 | 1 |
| Thomas Lemar | Muscle Injury | 19 Feb 2020 | 9 Mar 2020 | 19 | 3 |
 Álvaro Morata | Muscle Injury | 2 Feb 2020 | 12 Feb 2020 | 10 | 1 |
| Unknown player | Adductor Pain | 1 Feb 2020 | 7 Mar 2020 | 35 | 6 |
| Unknown player | Leg Injury | 27 Jan 2020 | 21 Feb 2020 | 25 | 4 |
