| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Johan Manzambi | Knock | 19 Oct 2026 | 23 Oct 2026 | 4 | 1 |
 Aaron Wan-Bissaka | Hamstring Injury | 18 Oct 2026 | Current | 33 | 4 |
 Matteo Ruggeri | Hamstring Injury | 12 Oct 2026 | Current | 49 | 6 |
 Leon Goretzka | Fitness | 5 Oct 2026 | 11 Oct 2026 | 6 | 1 |
 Brian Madjo | Fitness | 30 Sept 2026 | 16 Oct 2026 | 16 | 3 |
 George Hemmings | Knee Problems | 23 Sept 2026 | 19 Oct 2026 | 26 | 2 |
 Marco Bizot | Back Problems | 16 Sept 2026 | 30 Sept 2026 | 14 | 2 |
 Alysson | Muscle Injury | 16 Sept 2026 | 30 Sept 2026 | 14 | 2 |
 Modou Kéba Cissé | Groin Problems | 14 Sept 2026 | 23 Oct 2026 | 39 | 7 |
 Ian Maatsen | Ankle Injury | 12 Sept 2026 | 21 Oct 2026 | 39 | 7 |
 Pau Torres | Thigh Problems | 12 Sept 2026 | 30 Sept 2026 | 18 | 3 |
| Leon Goretzka | Knee Problems | 7 Sept 2026 | 5 Oct 2026 | 28 | 5 |
 Matty Cash | Muscular Problems | 7 Sept 2026 | 14 Sept 2026 | 7 | 2 |
| Brian Madjo | Ankle Injury | 14 Aug 2026 | 30 Sept 2026 | 47 | 8 |
Unknown player | Muscle Strain | 1 Aug 2026 | 1 Sept 2026 | 31 | 6 |
 Amadou Onana | Cruciate Ligament Injury | 7 Jul 2026 | Current | 329 | 23 |
| Johan Manzambi | Knee Bruise | 6 Jul 2026 | 10 Sept 2026 | 66 | 12 |
 John McGinn | Muscle Fatigue | 1 May 2026 | 4 May 2026 | 3 | 1 |
| Amadou Onana | Calf Problems | 30 Apr 2026 | 18 May 2026 | 18 | 5 |
| Amadou Onana | Knee Problems | 24 Apr 2026 | 27 Apr 2026 | 3 | 1 |
| Pau Torres | Rest | 17 Apr 2026 | 20 Apr 2026 | 3 | 1 |
 Emiliano Martínez | Calf Problems | 11 Apr 2026 | 15 Apr 2026 | 4 | 1 |
| Alysson | Groin Injury | 10 Apr 2026 | 8 Jun 2026 | 59 | 11 |
Unknown player | Shoulder Injury | 1 Apr 2026 | 15 Apr 2026 | 14 | 2 |
 Victor Lindelöf | Rest | 20 Mar 2026 | 23 Mar 2026 | 3 | 1 |
| Matty Cash | Calf Problems | 11 Mar 2026 | 16 Mar 2026 | 5 | 2 |
| Alysson | Muscle Injury | 9 Mar 2026 | 10 Apr 2026 | 32 | 9 |
 Andrés García | Thigh Problems | 26 Feb 2026 | 9 Mar 2026 | 11 | 2 |
| Alysson | Knock | 13 Feb 2026 | 23 Feb 2026 | 10 | 3 |
| Matty Cash | Knee Problems | 8 Feb 2026 | 20 Feb 2026 | 12 | 2 |
Unknown player | Muscle Injury | 29 Jan 2026 | 6 Feb 2026 | 8 | 2 |
 Youri Tielemans | Ankle Injury | 25 Jan 2026 | 22 Mar 2026 | 56 | 12 |
| Andrés García | Thigh Problems | 23 Jan 2026 | 12 Feb 2026 | 20 | 6 |
| John McGinn | Knee Injury | 19 Jan 2026 | 10 Mar 2026 | 50 | 9 |
Unknown player | ILL | 16 Jan 2026 | 19 Jan 2026 | 3 | 1 |
 Boubacar Kamara | Knee Injury | 11 Jan 2026 | 1 Jul 2026 | 171 | 28 |
| Amadou Onana | Hamstring Injury | 31 Dec 2025 | 19 Jan 2026 | 19 | 3 |
 Harvey Elliott | ILL | 19 Dec 2025 | 28 Dec 2025 | 9 | 1 |
| Emiliano Martínez | Muscular Problems | 12 Dec 2025 | 15 Dec 2025 | 3 | 1 |
| Pau Torres | Calf Injury | 7 Dec 2025 | 9 Jan 2026 | 33 | 4 |
 Evann Guessand | Muscular Problems | 5 Dec 2025 | 8 Dec 2025 | 3 | 1 |
| Emiliano Martínez | Muscular Problems | 2 Dec 2025 | 4 Dec 2025 | 2 | 1 |
 Ross Barkley | Knee Injury | 2 Dec 2025 | 31 Jan 2026 | 60 | 14 |
| Amadou Onana | Muscle Injury | 15 Nov 2025 | 27 Nov 2025 | 12 | 1 |
 Tyrone Mings | Thigh Problems | 1 Nov 2025 | 16 Jan 2026 | 76 | 13 |
 Emiliano Buendía | Foot Injury | 27 Oct 2025 | 7 Nov 2025 | 11 | 2 |
| Emiliano Martínez | Knock | 1 Oct 2025 | 3 Oct 2025 | 2 | 1 |
| Tyrone Mings | Foot Injury | 29 Sept 2025 | 20 Oct 2025 | 21 | 3 |
Unknown player | ILL | 29 Sept 2025 | 6 Oct 2025 | 7 | 1 |
| Emiliano Martínez | Muscle Injury | 15 Sept 2025 | 26 Sept 2025 | 11 | 3 |
| Youri Tielemans | Calf Problems | 13 Sept 2025 | 6 Nov 2025 | 54 | 11 |
| Amadou Onana | Hamstring Injury | 24 Aug 2025 | 5 Oct 2025 | 42 | 7 |
| Boubacar Kamara | Hamstring Injury | 23 Aug 2025 | 16 Sept 2025 | 24 | 3 |
| Andrés García | Muscle Injury | 20 Jul 2025 | 1 Dec 2025 | 134 | 8 |
| Youri Tielemans | Calf Injury | 5 May 2025 | 20 May 2025 | 15 | 1 |
 Marcus Rashford | Hamstring Injury | 23 Apr 2025 | 23 May 2025 | 30 | 4 |
Unknown player | Injury | 26 Mar 2025 | 14 Apr 2025 | 19 | 3 |
| Emiliano Martínez | Injury | 7 Mar 2025 | 9 Mar 2025 | 2 | 0 |
 Donyell Malen | ILL | 26 Feb 2025 | 3 Mar 2025 | 5 | 1 |
| Matty Cash | Injury | 24 Feb 2025 | 3 Mar 2025 | 7 | 2 |
| Tyrone Mings | Knee Problems | 24 Feb 2025 | 3 Mar 2025 | 7 | 2 |
| Boubacar Kamara | Hamstring Injury | 15 Feb 2025 | 3 Mar 2025 | 16 | 6 |
Unknown player | Injury | 14 Feb 2025 | 20 Feb 2025 | 6 | 1 |
 Ezri Konsa | Hamstring Injury | 9 Feb 2025 | 22 Feb 2025 | 13 | 3 |
| Amadou Onana | Hamstring Injury | 3 Feb 2025 | 10 Mar 2025 | 35 | 4 |
Unknown player | Muscle Injury | 2 Feb 2025 | 14 Feb 2025 | 12 | 1 |
| Matty Cash | Muscle Injury | 30 Jan 2025 | 17 Feb 2025 | 18 | 5 |
| Tyrone Mings | Knee Injury | 26 Jan 2025 | 10 Feb 2025 | 15 | 1 |
| Amadou Onana | Hamstring Injury | 19 Jan 2025 | 31 Jan 2025 | 12 | 3 |
| Ross Barkley | Calf Injury | 10 Jan 2025 | 6 Apr 2025 | 86 | 10 |
| Emiliano Martínez | Injury | 9 Jan 2025 | 14 Jan 2025 | 5 | 1 |
| John McGinn | Hamstring Injury | 5 Jan 2025 | 25 Jan 2025 | 20 | 4 |
 Jaden Philogene | Knock | 3 Jan 2025 | 15 Jan 2025 | 12 | 2 |
 Diego Carlos | Foot Injury | 3 Jan 2025 | 19 Jan 2025 | 16 | 4 |
| Pau Torres | Metatarsal Fracture | 31 Dec 2024 | 3 Mar 2025 | 62 | 15 |
| Diego Carlos | Injury | 20 Dec 2024 | 22 Dec 2024 | 2 | 0 |
Unknown player | Doubtful | 14 Dec 2024 | 14 Dec 2024 | 0 | 1 |
Unknown player | Thigh Problems | 13 Dec 2024 | 15 Dec 2024 | 2 | 0 |
| Tyrone Mings | ILL | 13 Dec 2024 | 15 Dec 2024 | 2 | 0 |
| Ezri Konsa | Hip Problems | 22 Nov 2024 | 24 Nov 2024 | 2 | 0 |
| Boubacar Kamara | Thigh Problems | 22 Nov 2024 | 24 Nov 2024 | 2 | 0 |
 Jacob Ramsey | Hamstring Injury | 22 Nov 2024 | 27 Dec 2024 | 35 | 8 |
| Amadou Onana | Foot Injury | 22 Nov 2024 | 5 Dec 2024 | 13 | 3 |
| Matty Cash | Calf Injury | 5 Nov 2024 | 11 Nov 2024 | 6 | 2 |
| Ross Barkley | Injury | 3 Nov 2024 | 11 Nov 2024 | 8 | 3 |
| Jacob Ramsey | Muscle Injury | 5 Oct 2024 | 7 Oct 2024 | 2 | 0 |
| Amadou Onana | Hamstring Injury | 2 Oct 2024 | 17 Oct 2024 | 15 | 2 |
| John McGinn | Thigh Problems | 28 Sept 2024 | 7 Oct 2024 | 9 | 2 |
Unknown player | Hamstring Injury | 2 Sept 2024 | 17 Sept 2024 | 15 | 1 |
| Jaden Philogene | Knock | 30 Aug 2024 | 29 Sept 2024 | 30 | 5 |
| Diego Carlos | Injury | 30 Aug 2024 | 1 Sept 2024 | 2 | 0 |
| Matty Cash | Hamstring Injury | 24 Aug 2024 | 8 Oct 2024 | 45 | 6 |
 Morgan Rogers | Doubtful | 19 May 2024 | 19 May 2024 | 0 | 1 |
Unknown player | ILL | 18 May 2024 | 31 May 2024 | 13 | 1 |
| Youri Tielemans | Groin Injury | 15 May 2024 | 10 Jun 2024 | 26 | 1 |
 Nicolò Zaniolo | Metatarsal Fracture | 14 May 2024 | 3 Aug 2024 | 81 | — |
| Matty Cash | Calf Injury | 12 May 2024 | 12 Jun 2024 | 31 | 2 |
| Morgan Rogers | Hamstring Injury | 6 May 2024 | 1 Jun 2024 | 26 | 3 |
| Youri Tielemans | Groin Injury | 27 Apr 2024 | 8 May 2024 | 11 | 3 |
| Nicolò Zaniolo | Injury | 18 Apr 2024 | 30 Apr 2024 | 12 | 3 |
