| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Junior Kroupi | Foot Injury | 29 Jul 2026 | Current | — | 9 |
 Julio Soler | Hamstring Injury | 10 Apr 2026 | 15 Jun 2026 | 66 | 7 |
 Tyler Adams | Hamstring Injury | 13 Mar 2026 | 1 Apr 2026 | 19 | 1 |
 Lewis Cook | Hamstring Injury | 20 Feb 2026 | 10 May 2026 | 79 | 5 |
 Marcus Tavernier | Hamstring Injury | 20 Jan 2026 | 23 Feb 2026 | 34 | 5 |
| Julio Soler | Hamstring Injury | 11 Jan 2026 | 6 Apr 2026 | 85 | 11 |
 David Brooks | Ankle Injury | 11 Jan 2026 | 2 Feb 2026 | 22 | 3 |
 Enes Ünal | Muscle Injury | 11 Jan 2026 | 21 Jan 2026 | 10 | 1 |
 Justin Kluivert | Knee Surgery | 4 Jan 2026 | 7 May 2026 | 123 | 12 |
 Will Dennis | Ankle Injury | 1 Jan 2026 | — | — | 30 |
| Lewis Cook | Neck Bruise | 29 Dec 2025 | 1 Jan 2026 | 3 | 1 |
 Ryan Christie | Knee Problems | 29 Dec 2025 | 16 Jan 2026 | 18 | 4 |
| Tyler Adams | Knee Medial Ligament Tear | 15 Dec 2025 | 16 Feb 2026 | 63 | 12 |
 Veljko Milosavljevic | Knee Injury | 3 Dec 2025 | 5 Jan 2026 | 33 | 13 |
| Ryan Christie | Knee Problems | 24 Nov 2025 | 19 Dec 2025 | 25 | 4 |
 Antoine Semenyo | ILL | 21 Nov 2025 | 24 Nov 2025 | 3 | 1 |
 Ben Gannon-Doak | Hamstring Injury | 18 Nov 2025 | 6 Mar 2026 | 108 | 16 |
| Justin Kluivert | Adductor Injury | 15 Nov 2025 | 24 Nov 2025 | 9 | 1 |
 Matai Akinmboni | Muscle Injury | 7 Nov 2025 | — | — | 39 |
| Enes Ünal | Rest | 31 Oct 2025 | 10 Nov 2025 | 10 | 2 |
 Evanilson | Calf Problems | 17 Oct 2025 | 31 Oct 2025 | 14 | 2 |
| David Brooks | Hamstring Injury | 15 Oct 2025 | 31 Oct 2025 | 16 | 2 |
| Lewis Cook | Shoulder Injury | 19 Sept 2025 | 29 Sept 2025 | 10 | 2 |
| Ryan Christie | Knock | 12 Sept 2025 | 15 Sept 2025 | 3 | 1 |
 Bafodé Diakité | Knock | 12 Sept 2025 | 15 Sept 2025 | 3 | 1 |
 Adam Smith | Thigh Problems | 30 Aug 2025 | 18 Oct 2025 | 49 | 5 |
| Lewis Cook | Knee Injury | 25 Jul 2025 | 13 Sept 2025 | 50 | 7 |
| Justin Kluivert | Calf Injury | 16 Jul 2025 | 23 Aug 2025 | 38 | 4 |
 Dango Ouattara | Adductor Pain | 5 May 2025 | 18 Aug 2025 | 105 | 2 |
| Ryan Christie | Groin Injury | 3 Apr 2025 | 23 Aug 2025 | 142 | 8 |
| Justin Kluivert | Injury | 1 Apr 2025 | 11 Apr 2025 | 10 | 2 |
| Marcus Tavernier | Foot Injury | 28 Mar 2025 | 11 Apr 2025 | 14 | 3 |
 Unknown player | Thigh Problems | 15 Mar 2025 | 21 Aug 2025 | 159 | 7 |
 Julián Araujo | Fitness | 3 Mar 2025 | 30 Mar 2025 | 27 | 2 |
| Ryan Christie | Groin Problems | 28 Feb 2025 | 3 Mar 2025 | 3 | 1 |
| Adam Smith | Calf Injury | 24 Feb 2025 | 28 Mar 2025 | 32 | 4 |
 James Hill | Hamstring Injury | 17 Jan 2025 | 20 Feb 2025 | 34 | 7 |
| Enes Ünal | Cruciate Ligament Tear | 8 Jan 2025 | 20 Oct 2025 | 285 | 33 |
| Evanilson | Broken Foot | 4 Jan 2025 | 20 Feb 2025 | 47 | 8 |
| Tyler Adams | Muscle Injury | 27 Dec 2024 | 30 Dec 2024 | 3 | 0 |
| Adam Smith | Hamstring Injury | 23 Dec 2024 | 24 Feb 2025 | 63 | 12 |
| Marcus Tavernier | Thigh Problems | 9 Dec 2024 | 24 Jan 2025 | 46 | 8 |
| Tyler Adams | Muscle Fatigue | 6 Dec 2024 | 9 Dec 2024 | 3 | 0 |
 Marcos Senesi | Hamstring Injury | 30 Nov 2024 | 1 Apr 2025 | 122 | 21 |
| Lewis Cook | Injury | 29 Nov 2024 | 2 Dec 2024 | 3 | 1 |
| Julián Araujo | Hamstring Injury | 10 Nov 2024 | 3 Mar 2025 | 113 | 18 |
| Dango Ouattara | Injury | 1 Nov 2024 | 11 Nov 2024 | 10 | 2 |
| Unknown player | Hamstring Injury | 25 Oct 2024 | 10 Feb 2025 | 108 | 18 |
 Kepa Arrizabalaga | Adductor Pain | 25 Oct 2024 | 4 Nov 2024 | 10 | 2 |
 Alex Scott | Meniscus Tear | 19 Oct 2024 | 10 Feb 2025 | 114 | 19 |
 Unknown player | ILL | 18 Oct 2024 | 31 Oct 2024 | 13 | 2 |
| Dango Ouattara | Ankle Injury | 7 Sept 2024 | 20 Sept 2024 | 13 | 1 |
| Unknown player | Back Problems | 23 Aug 2024 | 2 Sept 2024 | 10 | 3 |
| Marcos Senesi | Facial Injury | 10 Aug 2024 | 19 Aug 2024 | 9 | 2 |
| Tyler Adams | Back Injury | 15 Jul 2024 | 7 Oct 2024 | 84 | 11 |
| David Brooks | Fitness | 10 Jun 2024 | 27 Aug 2024 | 78 | 6 |
| Enes Ünal | Broken Toe | 31 May 2024 | 9 Sept 2024 | 101 | 0 |
 Romain Faivre | Ankle Injury | 11 May 2024 | 20 May 2024 | 9 | 1 |
| Romain Faivre | Dead Leg | 20 Apr 2024 | 3 Jun 2024 | 44 | 6 |
| Unknown player | Muscle Injury | 13 Apr 2024 | 20 May 2024 | 37 | 6 |
| Antoine Semenyo | Doubtful | 13 Apr 2024 | 13 Apr 2024 | 0 | 1 |
| Antoine Semenyo | Calf Problems | 10 Apr 2024 | 19 Apr 2024 | 9 | 1 |
| Marcus Tavernier | Hamstring Injury | 7 Apr 2024 | 5 May 2024 | 28 | 4 |
| Tyler Adams | Back Injury | 5 Apr 2024 | 5 May 2024 | 30 | 5 |
 Unknown player | ILL | 31 Mar 2024 | 30 Jun 2024 | 91 | 9 |
| Unknown player | Muscle Injury | 15 Mar 2024 | — | — | 110 |
| Marcos Senesi | Hamstring Injury | 3 Mar 2024 | 4 Apr 2024 | 32 | 5 |
 Lloyd Kelly | Hip Injury | 17 Feb 2024 | 18 Mar 2024 | 30 | 6 |
| Romain Faivre | ILL | 16 Feb 2024 | 23 Feb 2024 | 7 | 1 |
| James Hill | Ankle Injury | 25 Jan 2024 | 11 Mar 2024 | 46 | 9 |
 Max Aarons | Hamstring Injury | 22 Jan 2024 | 20 Mar 2024 | 58 | 10 |
| Dango Ouattara | Knock | 1 Jan 2024 | 22 Jan 2024 | 21 | 1 |
 Milos Kerkez | Knock | 20 Dec 2023 | 22 Jan 2024 | 33 | 5 |
 Hamed Traoré | Malaria | 4 Dec 2023 | 10 Jan 2024 | 37 | 6 |
| Lloyd Kelly | Muscle Injury | 1 Dec 2023 | 8 Jan 2024 | 38 | 7 |
| Max Aarons | Hamstring Injury | 12 Nov 2023 | 25 Dec 2023 | 43 | 5 |
 Unknown player | Ankle Injury | 27 Oct 2023 | 24 Nov 2023 | 28 | 4 |
| Unknown player | Muscle Injury | 28 Sept 2023 | 14 Oct 2023 | 16 | 2 |
| Tyler Adams | Hamstring Injury | 28 Sept 2023 | 4 Mar 2024 | 158 | 23 |
| Lloyd Kelly | Calf Injury | 23 Sept 2023 | 16 Oct 2023 | 23 | 4 |
| Lewis Cook | Doubtful | 19 Aug 2023 | 19 Aug 2023 | 0 | — |
 Unknown player | Doubtful | 12 Aug 2023 | 24 Aug 2023 | 12 | — |
| Adam Smith | Doubtful | 12 Aug 2023 | 24 Aug 2023 | 12 | — |
| Lloyd Kelly | Doubtful | 12 Aug 2023 | 24 Aug 2023 | 12 | — |
| Ryan Christie | Doubtful | 12 Aug 2023 | 24 Aug 2023 | 12 | — |
| Marcus Tavernier | Doubtful | 12 Aug 2023 | 24 Aug 2023 | 12 | — |
| Dango Ouattara | Ankle Injury | 6 Aug 2023 | 25 Sept 2023 | 50 | 6 |
| Alex Scott | Knee Injury | 1 Aug 2023 | 8 Oct 2023 | 68 | 12 |
| Antoine Semenyo | Doubtful | 20 May 2023 | 20 May 2023 | 0 | 1 |
| Unknown player | Thigh Problems | 28 Apr 2023 | 6 May 2023 | 8 | 1 |
| Marcus Tavernier | Hamstring Injury | 28 Apr 2023 | 28 Jun 2023 | 61 | 4 |
| Hamed Traoré | Foot Injury | 5 Apr 2023 | 5 Jun 2023 | 61 | 9 |
| Unknown player | Calf Injury | 12 Mar 2023 | — | — | — |
 Unknown player | Doubtful | 4 Mar 2023 | 4 Mar 2023 | 0 | 1 |
| Hamed Traoré | Foot Injury | 26 Feb 2023 | 12 Mar 2023 | 14 | 1 |
| Marcus Tavernier | Hamstring Injury | 24 Feb 2023 | 20 Mar 2023 | 24 | 4 |
 Ilya Zabarnyi | Ankle Injury | 10 Feb 2023 | 31 Mar 2023 | 49 | 6 |
| Lloyd Kelly | Ankle Injury | 25 Jan 2023 | 6 Mar 2023 | 40 | 5 |
| Lewis Cook | Knee Injury | 14 Jan 2023 | 1 Apr 2023 | 77 | 0 |
 Dominic Solanke | Knee Injury | 13 Jan 2023 | 6 Feb 2023 | 24 | 3 |
