| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Unknown player | Ankle Sprain | 19 Apr 2022 | 25 Apr 2022 | 6 | 1 |
 Unknown player | Ankle Problems | 14 Apr 2022 | 19 Apr 2022 | 5 | 1 |
| Unknown player | Muscle Fatigue | 9 Apr 2022 | 12 Apr 2022 | 3 | 1 |
| Unknown player | Muscle Fatigue | 9 Apr 2022 | 13 Apr 2022 | 4 | 1 |
 Unknown player | Muscle Fatigue | 9 Apr 2022 | 12 Apr 2022 | 3 | 1 |
 Unknown player | Knee Problems | 7 Apr 2022 | 25 Apr 2022 | 18 | 3 |
 Unknown player | Meniscus Injury | 4 Apr 2022 | 5 May 2022 | 31 | 6 |
 Alessio Romagnoli | Adductor Pain | 3 Apr 2022 | 21 Apr 2022 | 18 | 4 |
 Daniel Maldini | Fever | 18 Mar 2022 | 20 Mar 2022 | 2 | 0 |
 Unknown player | Adductor Injury | 5 Mar 2022 | 18 Mar 2022 | 13 | 2 |
| Alessio Romagnoli | Adductor Pain | 1 Mar 2022 | 10 Mar 2022 | 9 | 2 |
 Unknown player | Fitness | 12 Feb 2022 | 28 Feb 2022 | 16 | 3 |
 Matteo Gabbia | Heel Spur | 9 Feb 2022 | 15 Feb 2022 | 6 | 2 |
 Unknown player | Adductor Pain | 9 Feb 2022 | 12 Feb 2022 | 3 | 1 |
| Unknown player | Ankle Injury | 1 Feb 2022 | 7 Feb 2022 | 6 | 1 |
| Unknown player | Achilles Tendon Problems | 20 Jan 2022 | 7 Mar 2022 | 46 | 7 |
 Fikayo Tomori | Meniscus Injury | 13 Jan 2022 | 4 Feb 2022 | 22 | 3 |
| Unknown player | COVID 19 | 12 Jan 2022 | 16 Jan 2022 | 4 | 1 |
| Fikayo Tomori | COVID 19 | 5 Jan 2022 | 10 Jan 2022 | 5 | 1 |
| Alessio Romagnoli | COVID 19 | 5 Jan 2022 | 18 Jan 2022 | 13 | 3 |
| Unknown player | COVID 19 | 5 Jan 2022 | 14 Jan 2022 | 9 | 2 |
 Unknown player | COVID 19 | 3 Jan 2022 | 17 Jan 2022 | 14 | 3 |
 Unknown player | COVID 19 | 3 Jan 2022 | 13 Jan 2022 | 10 | 2 |
| Unknown player | Knee Problems | 20 Dec 2021 | 6 Jan 2022 | 17 | 1 |
 Unknown player | Fever | 15 Dec 2021 | 20 Dec 2021 | 5 | 0 |
 Pietro Pellegri | Adductor Injury | 5 Dec 2021 | 5 Feb 2022 | 62 | — |
 Unknown player | Hamstring Muscle Injury | 4 Dec 2021 | 1 Jan 2022 | 28 | 5 |
 Unknown player | Cruciate Ligament Tear | 1 Dec 2021 | 1 Jun 2022 | 182 | 19 |
| Unknown player | Inflammation | 1 Dec 2021 | 4 Dec 2021 | 3 | 1 |
 Olivier Giroud | Torn Muscle Fiber | 24 Nov 2021 | 17 Dec 2021 | 23 | 6 |
| Fikayo Tomori | Hip Problems | 19 Nov 2021 | 29 Nov 2021 | 10 | 2 |
| Unknown player | Torn Thigh Muscle | 17 Nov 2021 | 6 Jan 2022 | 50 | 9 |
| Unknown player | Calf Injury | 11 Nov 2021 | 6 Jan 2022 | 56 | 9 |
| Alessio Romagnoli | Adductor Injury | 6 Nov 2021 | 16 Nov 2021 | 10 | 1 |
| Unknown player | Ankle Problems | 2 Nov 2021 | 5 Nov 2021 | 3 | 1 |
| Pietro Pellegri | Bruise On Ankle | 30 Oct 2021 | 5 Nov 2021 | 6 | 2 |
| Unknown player | Torn Muscle Fiber | 23 Oct 2021 | 8 Dec 2021 | 46 | 10 |
| Unknown player | Ankle Injury | 23 Oct 2021 | 30 Oct 2021 | 7 | 2 |
 Franck Kessié | Flu | 22 Oct 2021 | 24 Oct 2021 | 2 | 0 |
| Pietro Pellegri | Inflammation | 21 Oct 2021 | 25 Oct 2021 | 4 | 1 |
| Unknown player | Ankle Injury | 16 Oct 2021 | 5 Nov 2021 | 20 | 6 |
 Brahim Díaz | COVID 19 | 15 Oct 2021 | 27 Oct 2021 | 12 | 3 |
 Unknown player | Fitness | 13 Oct 2021 | 22 Oct 2021 | 9 | 2 |
| Unknown player | COVID 19 | 13 Oct 2021 | 24 Oct 2021 | 11 | 2 |
 Mike Maignan | Wrist Injury | 12 Oct 2021 | 25 Nov 2021 | 44 | 8 |
 Junior Messias | Torn Muscle Fiber | 10 Oct 2021 | 11 Nov 2021 | 32 | 7 |
| Olivier Giroud | Back Injury | 2 Oct 2021 | 6 Oct 2021 | 4 | 1 |
| Unknown player | Meniscus Injury | 30 Sept 2021 | 4 Nov 2021 | 35 | 6 |
| Unknown player | Knee Bruise | 24 Sept 2021 | 27 Sept 2021 | 3 | 1 |
 Unknown player | Knee Surgery | 22 Sept 2021 | 14 Jan 2022 | 114 | 22 |
| Unknown player | Muscle Injury | 19 Sept 2021 | 30 Sept 2021 | 11 | 4 |
| Unknown player | Muscle Fatigue | 16 Sept 2021 | 23 Sept 2021 | 7 | 1 |
| Olivier Giroud | Lumbago | 16 Sept 2021 | 23 Sept 2021 | 7 | 1 |
| Unknown player | Achilles Tendon Irritation | 13 Sept 2021 | 14 Oct 2021 | 31 | 6 |
| Unknown player | Muscle Injury | 12 Sept 2021 | 17 Oct 2021 | 35 | 7 |
| Olivier Giroud | Quarantine | 11 Sept 2021 | 13 Sept 2021 | 2 | 0 |
| Unknown player | Knee Injury | 10 Sept 2021 | 22 Sept 2021 | 12 | 3 |
| Junior Messias | Fitness | 1 Sept 2021 | 30 Sept 2021 | 29 | 6 |
 Unknown player | Muscle Injury | 1 Sept 2021 | 15 Oct 2021 | 44 | 7 |
| Franck Kessié | Muscle Injury | 13 Aug 2021 | 10 Sept 2021 | 28 | 3 |
| Unknown player | Calf Problems | 21 May 2021 | 31 May 2021 | 10 | 1 |
| Matteo Gabbia | Muscle Injury | 16 May 2021 | 2 Jun 2021 | 17 | 2 |
 Sandro Tonali | Knee Injury | 10 May 2021 | 16 May 2021 | 6 | 1 |
| Unknown player | Knee Injury | 10 May 2021 | 13 Sept 2021 | 126 | 11 |
| Unknown player | Muscle Fatigue | 20 Apr 2021 | 26 Apr 2021 | 6 | 1 |
| Unknown player | Muscle Fatigue | 19 Apr 2021 | 3 May 2021 | 14 | 3 |
| Unknown player | Ankle Problems | 18 Apr 2021 | 25 Apr 2021 | 7 | 2 |
| Brahim Díaz | Injury | 31 Mar 2021 | 7 Apr 2021 | 7 | 1 |
| Unknown player | Meniscus Injury | 18 Mar 2021 | 22 Apr 2021 | 35 | 5 |
| Alessio Romagnoli | Calf Injury | 17 Mar 2021 | 12 Apr 2021 | 26 | 4 |
| Unknown player | Hip Flexor Problems | 17 Mar 2021 | 30 Mar 2021 | 13 | 2 |
| Unknown player | Muscle Injury | 14 Mar 2021 | 5 Apr 2021 | 22 | 4 |
| Unknown player | Stomach Flu | 11 Mar 2021 | 12 Mar 2021 | 1 | 0 |
| Unknown player | Pubic Bone Irritation | 11 Mar 2021 | 18 Mar 2021 | 7 | 2 |
| Alessio Romagnoli | Injury | 10 Mar 2021 | 15 Mar 2021 | 5 | 1 |
| Unknown player | Hip Flexor Problems | 6 Mar 2021 | 12 Mar 2021 | 6 | 1 |
| Unknown player | Shin Bruise | 3 Mar 2021 | 11 Mar 2021 | 8 | 2 |
 Hakan Çalhanoğlu | Muscle Injury | 28 Feb 2021 | 12 Mar 2021 | 12 | 3 |
| Unknown player | Adductor Injury | 25 Feb 2021 | 18 Mar 2021 | 21 | 6 |
| Unknown player | Muscle Injury | 18 Feb 2021 | 16 Mar 2021 | 26 | 8 |
| Unknown player | Patellar Tendon Problems | 12 Feb 2021 | 14 Feb 2021 | 2 | 0 |
| Daniel Maldini | Injury | 10 Feb 2021 | 1 May 2021 | 80 | 16 |
| Unknown player | Fever | 6 Feb 2021 | 8 Feb 2021 | 2 | 0 |
| Sandro Tonali | Bursitis | 5 Feb 2021 | 9 Feb 2021 | 4 | 1 |
| Hakan Çalhanoğlu | Quarantine | 29 Jan 2021 | 1 Feb 2021 | 3 | 1 |
| Brahim Díaz | Thigh Problems | 27 Jan 2021 | 20 Feb 2021 | 24 | 4 |
| Sandro Tonali | Injury | 26 Jan 2021 | 27 Jan 2021 | 1 | 0 |
| Unknown player | Hamstring Muscle Injury | 26 Jan 2021 | 11 Feb 2021 | 16 | 3 |
 Alexis Saelemaekers | Doubtful | 18 Jan 2021 | 18 Jan 2021 | 0 | 1 |
| Unknown player | Quarantine | 17 Jan 2021 | 21 Jan 2021 | 4 | 1 |
| Hakan Çalhanoğlu | COVID 19 | 17 Jan 2021 | 29 Jan 2021 | 12 | 3 |
| Unknown player | COVID 19 | 5 Jan 2021 | 19 Jan 2021 | 14 | 3 |
| Unknown player | COVID 19 | 5 Jan 2021 | 19 Jan 2021 | 14 | 3 |
| Unknown player | Doubtful | 23 Dec 2020 | 23 Dec 2020 | 0 | 1 |
| Alexis Saelemaekers | Hamstring Muscle Injury | 21 Dec 2020 | 14 Jan 2021 | 24 | 5 |
| Unknown player | Calf Injury | 17 Dec 2020 | 11 Jan 2021 | 25 | 5 |
| Unknown player | Foot Injury | 16 Dec 2020 | 21 Dec 2020 | 5 | 1 |
| Matteo Gabbia | Inner Ligament Injury | 13 Dec 2020 | 2 Feb 2021 | 51 | 12 |
| Unknown player | Hamstring Muscle Injury | 13 Dec 2020 | 27 Jan 2021 | 45 | 10 |
| Alexis Saelemaekers | Intestinal Virus | 10 Dec 2020 | 17 Dec 2020 | 7 | 2 |
