| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Matteo Gabbia | Ankle Problems | 1 Sept 2026 | 11 Sept 2026 | 10 | 1 |
 Unknown player | Hamstring Injury | 13 Aug 2026 | 24 Aug 2026 | 11 | 2 |
 Unknown player | Ankle Sprain | 6 Jul 2026 | 1 Sept 2026 | 57 | 1 |
 Christian Pulisic | Strain In The Thigh And Gluteal Muscles | 9 May 2026 | 16 May 2026 | 7 | 1 |
 David Odogu | Muscle Fatigue | 2 May 2026 | 7 May 2026 | 5 | 1 |
 Luka Modrić | Broken Cheekbone | 27 Apr 2026 | 15 May 2026 | 18 | 2 |
| Unknown player | Adductor Pain | 20 Mar 2026 | 3 Apr 2026 | 14 | 1 |
 Valeri Vladimirov | Injury | 14 Mar 2026 | 19 Apr 2026 | 36 | 4 |
| Unknown player | Rest | 14 Mar 2026 | 18 Mar 2026 | 4 | 1 |
| Matteo Gabbia | Inguinal Hernia | 3 Mar 2026 | 10 Apr 2026 | 38 | 3 |
 Ruben Loftus-Cheek | Broken Jaw | 23 Feb 2026 | 1 Apr 2026 | 37 | 4 |
| Matteo Gabbia | Thigh Problems | 22 Feb 2026 | 2 Mar 2026 | 8 | 2 |
 Alexis Saelemaekers | Adductor Pain | 26 Jan 2026 | 16 Feb 2026 | 21 | 1 |
| Christian Pulisic | Bursitis | 26 Jan 2026 | 11 Feb 2026 | 16 | 1 |
 Unknown player | Tendon Rupture | 26 Jan 2026 | 21 Apr 2026 | 85 | 11 |
 Strahinja Pavlović | Head Injury | 12 Jan 2026 | 17 Jan 2026 | 5 | 1 |
 Unknown player | Injury | 7 Jan 2026 | 19 Jan 2026 | 12 | — |
 Christopher Nkunku | Ankle Problems | 1 Jan 2026 | 9 Jan 2026 | 8 | 1 |
| Unknown player | Ankle Surgery | 18 Dec 2025 | 10 Mar 2026 | 82 | 12 |
| Matteo Gabbia | Knee Injury | 15 Dec 2025 | 1 Jan 2026 | 17 | 2 |
| Unknown player | Adductor Pain | 9 Dec 2025 | 29 Dec 2025 | 20 | 1 |
 Youssouf Fofana | Muscular Problems | 3 Dec 2025 | 18 Dec 2025 | 15 | 3 |
| Christian Pulisic | Muscular Problems | 26 Nov 2025 | 3 Dec 2025 | 7 | 1 |
 Zachary Athekame | Calf Problems | 22 Nov 2025 | 11 Dec 2025 | 19 | 4 |
| Unknown player | Bruise On Ankle | 28 Oct 2025 | 17 Dec 2025 | 50 | 8 |
 Unknown player | Injury | 20 Oct 2025 | 1 May 2026 | 193 | 29 |
| Ruben Loftus-Cheek | Muscle Fatigue | 18 Oct 2025 | 27 Oct 2025 | 9 | 2 |
| Christopher Nkunku | Foot Injury | 16 Oct 2025 | 22 Oct 2025 | 6 | 1 |
 Adrien Rabiot | Calf Injury | 16 Oct 2025 | 18 Nov 2025 | 33 | 5 |
| Christian Pulisic | Hamstring Muscle Injury | 15 Oct 2025 | 6 Nov 2025 | 22 | 4 |
 Pervis Estupiñán | Ankle Problems | 12 Oct 2025 | 31 Oct 2025 | 19 | 3 |
| Unknown player | Muscle Injury | 28 Sept 2025 | 18 Oct 2025 | 20 | 2 |
 Mike Maignan | Calf Problems | 15 Sept 2025 | 22 Sept 2025 | 7 | 1 |
 Ardon Jashari | Broken Fibula | 28 Aug 2025 | 31 Oct 2025 | 64 | 9 |
| Unknown player | Calf Injury | 18 Aug 2025 | 25 Sept 2025 | 38 | 2 |
 Lorenzo Torriani | Finger Injury | 14 Aug 2025 | 13 Sept 2025 | 30 | 3 |
 Unknown player | Stomach Flu | 17 May 2025 | 26 May 2025 | 9 | 2 |
 Samuel Chukwueze | Inflammation Of Pubic Bone | 15 May 2025 | 22 May 2025 | 7 | 1 |
 Unknown player | Thigh Problems | 15 May 2025 | 22 May 2025 | 7 | 1 |
| Youssouf Fofana | Foot Injury | 6 May 2025 | 12 May 2025 | 6 | 1 |
 Riccardo Sottil | Injury | 3 May 2025 | 16 May 2025 | 13 | 3 |
 Warren Bondo | Ankle Sprain | 2 May 2025 | 19 May 2025 | 17 | 3 |
 Tammy Abraham | Thigh Problems | 1 May 2025 | 7 May 2025 | 6 | 1 |
| Unknown player | Broken Arm | 8 Apr 2025 | 26 Apr 2025 | 18 | 1 |
| Unknown player | Bruise | 7 Apr 2025 | 16 Apr 2025 | 9 | 1 |
 Yunus Musah | Flu | 1 Apr 2025 | 4 Apr 2025 | 3 | 1 |
| Ruben Loftus-Cheek | Appendectomy | 29 Mar 2025 | 21 Apr 2025 | 23 | 4 |
| Unknown player | Hamstring Injury | 19 Feb 2025 | 28 Feb 2025 | 9 | 1 |
| Youssouf Fofana | Doubtful | 26 Jan 2025 | 26 Jan 2025 | 0 | 1 |
 Unknown player | Calf Injury | 22 Jan 2025 | 13 May 2025 | 111 | 14 |
 Unknown player | Injury | 20 Jan 2025 | 10 Feb 2025 | 21 | 3 |
 Álvaro Morata | Muscle Fatigue | 15 Jan 2025 | 21 Jan 2025 | 6 | 1 |
| Christian Pulisic | Muscle Fatigue | 14 Jan 2025 | 21 Jan 2025 | 7 | 2 |
 Malick Thiaw | Hamstring Muscle Injury | 14 Jan 2025 | 27 Jan 2025 | 13 | 3 |
 Unknown player | Ankle Sprain | 12 Jan 2025 | 13 Mar 2025 | 60 | 10 |
| Ruben Loftus-Cheek | Muscular Problems | 10 Jan 2025 | 15 Mar 2025 | 64 | 16 |
| Samuel Chukwueze | Hamstring Muscle Injury | 29 Dec 2024 | 24 Jan 2025 | 26 | 9 |
| Unknown player | Muscle Injury | 20 Dec 2024 | 4 Jan 2025 | 15 | 2 |
| Álvaro Morata | Tonsillitis | 19 Dec 2024 | 28 Dec 2024 | 9 | 1 |
 Noah Okafor | Calf Muscle Tear | 17 Dec 2024 | 21 Jan 2025 | 35 | 18 |
| Yunus Musah | Muscle Fatigue | 13 Dec 2024 | 1 Jan 2025 | 19 | 3 |
| Ruben Loftus-Cheek | Adductor Injury | 12 Dec 2024 | 3 Jan 2025 | 22 | 3 |
| Noah Okafor | Lumbago | 9 Dec 2024 | 14 Dec 2024 | 5 | 1 |
| Unknown player | Injury | 6 Dec 2024 | 6 Jan 2025 | 31 | 4 |
| Christian Pulisic | Calf Problems | 6 Dec 2024 | 1 Jan 2025 | 26 | 4 |
| Mike Maignan | Injury | 2 Dec 2024 | 4 Dec 2024 | 2 | 0 |
| Unknown player | Rest | 2 Dec 2024 | 5 Dec 2024 | 3 | 1 |
 Unknown player | Thigh Problems | 1 Dec 2024 | 16 Dec 2024 | 15 | 3 |
| Noah Okafor | Fever | 29 Nov 2024 | 2 Dec 2024 | 3 | 1 |
 Unknown player | Groin Surgery | 26 Nov 2024 | 26 Feb 2025 | 92 | 7 |
| Unknown player | Head Injury | 8 Nov 2024 | 25 Nov 2024 | 17 | 7 |
| Álvaro Morata | Head Injury | 7 Nov 2024 | 12 Nov 2024 | 5 | 1 |
| Matteo Gabbia | Muscular Problems | 27 Oct 2024 | 11 Nov 2024 | 15 | 4 |
 Unknown player | Calf Muscle Tear | 25 Oct 2024 | 3 Feb 2025 | 101 | 18 |
| Tammy Abraham | Shoulder Injury | 19 Oct 2024 | 1 Nov 2024 | 13 | 3 |
| Matteo Gabbia | Muscular Problems | 18 Oct 2024 | 21 Oct 2024 | 3 | 1 |
| Unknown player | Pubalgia | 2 Oct 2024 | 25 Nov 2024 | 54 | 1 |
 Unknown player | Calf Problems | 2 Oct 2024 | 23 Oct 2024 | 21 | 2 |
| Ruben Loftus-Cheek | Muscle Fatigue | 2 Oct 2024 | 16 Oct 2024 | 14 | 1 |
| Noah Okafor | Muscular Problems | 26 Sept 2024 | 2 Oct 2024 | 6 | 1 |
| Unknown player | Adductor Pain | 18 Sept 2024 | 28 Sept 2024 | 10 | 1 |
| Unknown player | Knock | 13 Sept 2024 | 17 Sept 2024 | 4 | 1 |
 Francesco Camarda | Muscle Fatigue | 1 Sept 2024 | 23 Sept 2024 | 22 | 3 |
| Malick Thiaw | Ankle Sprain | 30 Aug 2024 | 20 Sept 2024 | 21 | 3 |
 Unknown player | Calf Muscle Tear | 30 Aug 2024 | 24 Dec 2024 | 116 | 26 |
| Unknown player | Lumbago | 28 Aug 2024 | 4 Sept 2024 | 7 | 1 |
| Álvaro Morata | Muscle Injury | 18 Aug 2024 | 9 Sept 2024 | 22 | 2 |
| Youssouf Fofana | Fitness | 16 Aug 2024 | 18 Aug 2024 | 2 | 0 |
| Unknown player | Fitness | 16 Aug 2024 | 18 Aug 2024 | 2 | 0 |
 Unknown player | Cruciate Ligament Tear | 28 Jul 2024 | 6 Mar 2025 | 221 | 45 |
 Marco Sportiello | Hand Injury | 27 Jul 2024 | 14 Oct 2024 | 79 | 13 |
| Mike Maignan | Finger Injury | 23 May 2024 | 5 Jun 2024 | 13 | 2 |
| Unknown player | Flu | 17 May 2024 | 21 May 2024 | 4 | 1 |
| Samuel Chukwueze | Hamstring Muscle Injury | 17 May 2024 | 30 May 2024 | 13 | 1 |
| Ruben Loftus-Cheek | Hamstring Muscle Injury | 27 Apr 2024 | 22 May 2024 | 25 | 4 |
| Mike Maignan | Adductor Injury | 27 Apr 2024 | 17 May 2024 | 20 | 3 |
| Unknown player | Muscle Fatigue | 25 Apr 2024 | 6 May 2024 | 11 | 1 |
 Unknown player | Thigh Problems | 14 Apr 2024 | 25 May 2024 | 41 | 2 |
| Mike Maignan | Muscle Fatigue | 13 Apr 2024 | 15 Apr 2024 | 2 | 0 |
| Malick Thiaw | Heel Spur | 5 Apr 2024 | 10 Apr 2024 | 5 | 1 |
