| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
Unknown player | Fitness | 16 Aug 2024 | 18 Aug 2024 | 2 | 0 |
Unknown player | Cruciate Ligament Tear | 28 Jul 2024 | 6 Mar 2025 | 221 | 45 |
 Marco Sportiello | Hand Injury | 27 Jul 2024 | 14 Oct 2024 | 79 | 13 |
 Mike Maignan | Finger Injury | 23 May 2024 | 5 Jun 2024 | 13 | 2 |
Unknown player | Flu | 17 May 2024 | 21 May 2024 | 4 | 1 |
 Samuel Chukwueze | Hamstring Muscle Injury | 17 May 2024 | 30 May 2024 | 13 | 1 |
 Ruben Loftus-Cheek | Hamstring Muscle Injury | 27 Apr 2024 | 22 May 2024 | 25 | 4 |
| Mike Maignan | Adductor Injury | 27 Apr 2024 | 17 May 2024 | 20 | 3 |
Unknown player | Muscle Fatigue | 25 Apr 2024 | 6 May 2024 | 11 | 1 |
Unknown player | Thigh Problems | 14 Apr 2024 | 25 May 2024 | 41 | 2 |
| Mike Maignan | Muscle Fatigue | 13 Apr 2024 | 15 Apr 2024 | 2 | 0 |
 Malick Thiaw | Heel Spur | 5 Apr 2024 | 10 Apr 2024 | 5 | 1 |
Unknown player | Meniscus Injury | 28 Mar 2024 | 7 Oct 2024 | 193 | — |
Unknown player | Muscle Injury | 23 Mar 2024 | 6 Apr 2024 | 14 | 1 |
 Pierre Kalulu | Collateral Ligament Injury | 17 Mar 2024 | 30 Apr 2024 | 44 | 8 |
Unknown player | Injury | 16 Mar 2024 | 10 May 2024 | 55 | 9 |
 Alejandro Jiménez Sánchez | Muscle Injury | 12 Mar 2024 | 30 Apr 2024 | 49 | — |
Unknown player | Fitness | 15 Feb 2024 | 29 Feb 2024 | 14 | 4 |
Ignazio Abate | Injury | 15 Feb 2024 | 15 Feb 2024 | 0 | — |
Unknown player | Adductor Injury | 11 Feb 2024 | 25 Feb 2024 | 14 | 4 |
Unknown player | Surgery | 2 Feb 2024 | 10 Feb 2024 | 8 | 1 |
Unknown player | Doubtful | 27 Jan 2024 | 27 Jan 2024 | 0 | 1 |
Unknown player | Adductor Pain | 19 Jan 2024 | 1 Feb 2024 | 13 | 2 |
Unknown player | Adductor Injury | 7 Jan 2024 | 18 Jan 2024 | 11 | 3 |
Unknown player | Back Problems | 1 Jan 2024 | 11 Jan 2024 | 10 | 3 |
 Yunus Musah | Muscular Problems | 27 Dec 2023 | 6 Jan 2024 | 10 | 2 |
 Fikayo Tomori | Hamstring Muscle Injury | 23 Dec 2023 | 26 Feb 2024 | 65 | 12 |
 Tommaso Pobega | Hamstring Injury | 17 Dec 2023 | 29 Apr 2024 | 134 | 25 |
 Noah Okafor | Injury | 17 Dec 2023 | 11 Jan 2024 | 25 | 8 |
| Yunus Musah | Muscle Fatigue | 16 Dec 2023 | 29 Dec 2023 | 13 | 1 |
| Malick Thiaw | Hamstring Muscle Injury | 28 Nov 2023 | 14 Feb 2024 | 78 | 13 |
| Noah Okafor | Hamstring Muscle Injury | 21 Nov 2023 | 13 Dec 2023 | 22 | 4 |
Unknown player | Hamstring Muscle Injury | 11 Nov 2023 | 12 Dec 2023 | 31 | 2 |
 Christian Pulisic | Contracture | 7 Nov 2023 | 20 Nov 2023 | 13 | 1 |
Unknown player | Bruise On Ankle | 4 Nov 2023 | 7 Nov 2023 | 3 | 1 |
| Christian Pulisic | Thigh Problems | 29 Oct 2023 | 7 Nov 2023 | 9 | 1 |
Unknown player | Ankle Sprain | 29 Oct 2023 | 13 Jan 2024 | 76 | 5 |
| Pierre Kalulu | Torn Thigh Muscle | 29 Oct 2023 | 25 Feb 2024 | 119 | 23 |
Unknown player | Muscle Fatigue | 28 Oct 2023 | 14 Dec 2023 | 47 | 7 |
| Noah Okafor | Muscle Fatigue | 24 Oct 2023 | 29 Oct 2023 | 5 | 1 |
 Davide Bartesaghi | Ankle Problems | 21 Oct 2023 | 24 Oct 2023 | 3 | — |
| Marco Sportiello | Muscular Problems | 19 Oct 2023 | 15 Jan 2024 | 88 | 11 |
| Samuel Chukwueze | Hamstring Muscle Injury | 16 Oct 2023 | 6 Nov 2023 | 21 | 6 |
Unknown player | Muscle Fatigue | 6 Oct 2023 | 12 Oct 2023 | 6 | 1 |
| Ruben Loftus-Cheek | Adductor Injury | 30 Sept 2023 | 31 Oct 2023 | 31 | 3 |
Unknown player | Injury | 26 Sept 2023 | 29 Sept 2023 | 3 | 1 |
Unknown player | Muscle Injury | 24 Sept 2023 | 19 Oct 2023 | 25 | 4 |
Unknown player | Muscle Fatigue | 22 Sept 2023 | 25 Sept 2023 | 3 | 1 |
Unknown player | Muscle Fatigue | 22 Sept 2023 | 25 Sept 2023 | 3 | 1 |
| Mike Maignan | Thigh Problems | 19 Sept 2023 | 29 Sept 2023 | 10 | 3 |
| Pierre Kalulu | Muscle Injury | 13 Sept 2023 | 19 Oct 2023 | 36 | 7 |
Unknown player | Ankle Surgery | 18 Aug 2023 | 15 Feb 2024 | 181 | 32 |
 Alexis Saelemaekers | Ankle Injury | 3 Aug 2023 | 22 Sept 2023 | 50 | 8 |
Unknown player | Doubtful | 4 Jun 2023 | 4 Jun 2023 | 0 | 1 |
Unknown player | Inflammation Of Pubic Bone | 19 May 2023 | 25 May 2023 | 6 | 1 |
Unknown player | Adductor Pain | 19 May 2023 | 25 May 2023 | 6 | 1 |
Unknown player | Ankle Injury | 19 May 2023 | 25 Jun 2023 | 37 | 3 |
Unknown player | Injury | 18 May 2023 | 26 May 2023 | 8 | 1 |
 Junior Messias | Adductor Pain | 12 May 2023 | 16 May 2023 | 4 | 1 |
Unknown player | Knee Problems | 12 May 2023 | 16 May 2023 | 4 | 1 |
Unknown player | Knee Surgery | 10 May 2023 | 30 Nov 2023 | 204 | 29 |
Unknown player | Adductor Pain | 6 May 2023 | 15 May 2023 | 9 | 3 |
Unknown player | Muscular Problems | 5 May 2023 | 16 May 2023 | 11 | 1 |
Unknown player | Fever | 29 Apr 2023 | 2 May 2023 | 3 | 1 |
Unknown player | Calf Injury | 23 Apr 2023 | 30 Jun 2023 | 68 | 8 |
| Tommaso Pobega | Rib Fracture | 22 Apr 2023 | 5 May 2023 | 13 | 3 |
 Olivier Giroud | Calf Problems | 20 Apr 2023 | 27 Apr 2023 | 7 | 0 |
Unknown player | Rest | 14 Apr 2023 | 17 Apr 2023 | 3 | 1 |
Unknown player | Hamstring Injury | 26 Mar 2023 | 22 Apr 2023 | 27 | 5 |
| Pierre Kalulu | Calf Injury | 26 Mar 2023 | 10 Apr 2023 | 15 | 2 |
Unknown player | Flu | 17 Mar 2023 | 21 Mar 2023 | 4 | 1 |
Unknown player | Fitness | 15 Mar 2023 | 21 Mar 2023 | 6 | 1 |
| Junior Messias | Hamstring Muscle Injury | 8 Mar 2023 | 6 Apr 2023 | 29 | 5 |
 Brahim Díaz | Knee Injury | 3 Mar 2023 | 6 Mar 2023 | 3 | 1 |
 Matteo Gabbia | Fever | 3 Mar 2023 | 6 Mar 2023 | 3 | 1 |
Unknown player | Fitness | 20 Feb 2023 | 27 Feb 2023 | 7 | 0 |
Unknown player | Hip Problems | 16 Feb 2023 | 1 Mar 2023 | 13 | 2 |
Unknown player | Calf Problems | 10 Feb 2023 | 27 Feb 2023 | 17 | 3 |
Unknown player | Hamstring Muscle Injury | 30 Jan 2023 | 1 Mar 2023 | 30 | 5 |
Unknown player | Muscular Problems | 28 Jan 2023 | 6 Feb 2023 | 9 | 1 |
| Fikayo Tomori | Hip Injury | 24 Jan 2023 | 17 Feb 2023 | 24 | 4 |
Unknown player | Muscle Fatigue | 23 Jan 2023 | 27 Jan 2023 | 4 | 1 |
Unknown player | Injury | 3 Jan 2023 | 12 Jan 2023 | 9 | 2 |
Unknown player | Muscle Fatigue | 3 Jan 2023 | 23 Jan 2023 | 20 | 5 |
Unknown player | Acromioclavicular Joint Dislocation | 30 Dec 2022 | 28 Jan 2023 | 29 | 7 |
Unknown player | Adductor Injury | 30 Dec 2022 | 16 Jan 2023 | 17 | 3 |
Unknown player | Hamstring Injury | 18 Dec 2022 | 13 Jan 2023 | 26 | 4 |
Unknown player | Muscular Problems | 26 Nov 2022 | 12 Jan 2023 | 47 | 3 |
| Matteo Gabbia | Injury | 12 Nov 2022 | 24 Nov 2022 | 12 | 1 |
| Junior Messias | Muscle Fatigue | 11 Nov 2022 | 9 Jan 2023 | 59 | 5 |
Unknown player | Injury | 4 Nov 2022 | 10 Nov 2022 | 6 | 2 |
Unknown player | Muscle Fatigue | 22 Oct 2022 | 26 Oct 2022 | 4 | 1 |
| Mike Maignan | Calf Muscle Tear | 19 Oct 2022 | 24 Feb 2023 | 128 | 21 |
Unknown player | Injury | 11 Oct 2022 | 21 Oct 2022 | 10 | 2 |
 Charles De Ketelaere | Muscle Injury | 10 Oct 2022 | 20 Oct 2022 | 10 | 1 |
Unknown player | Hamstring Muscle Injury | 1 Oct 2022 | 20 Oct 2022 | 19 | 5 |
| Junior Messias | Muscular Problems | 30 Sept 2022 | 9 Oct 2022 | 9 | 2 |
| Alexis Saelemaekers | Inner Knee Ligament Tear | 29 Sept 2022 | 12 Dec 2022 | 74 | 15 |
Unknown player | Hamstring Muscle Injury | 29 Sept 2022 | 2 Jan 2023 | 95 | 15 |
| Mike Maignan | Calf Injury | 22 Sept 2022 | 19 Oct 2022 | 27 | 6 |
