| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
Unknown player | Cold | 25 Nov 2021 | 2 Dec 2021 | 7 | 1 |
 Chris Führich | COVID 19 | 25 Nov 2021 | 9 Dec 2021 | 14 | 2 |
 Silas | Fitness | 9 Nov 2021 | 23 Nov 2021 | 14 | 2 |
Unknown player | Cold | 5 Nov 2021 | 13 Nov 2021 | 8 | 2 |
| Chris Führich | Ankle Injury | 1 Nov 2021 | 25 Nov 2021 | 24 | 3 |
 Naouirou Ahamada | Achilles Tendon Problems | 1 Nov 2021 | 4 Dec 2021 | 33 | 4 |
 Marc Oliver Kempf | Hamstring Injury | 1 Nov 2021 | 2 Dec 2021 | 31 | 4 |
Unknown player | Torn Muscle Fiber | 28 Oct 2021 | 18 Nov 2021 | 21 | 3 |
 Florian Müller | Fitness | 26 Oct 2021 | 5 Nov 2021 | 10 | 2 |
 Atakan Karazor | Muscular Problems | 25 Oct 2021 | 28 Oct 2021 | 3 | 0 |
 Nikolas Nartey | Muscular Problems | 25 Oct 2021 | 28 Oct 2021 | 3 | 0 |
Unknown player | Fitness | 23 Oct 2021 | 3 Nov 2021 | 11 | 3 |
Unknown player | Pelvic Obliquity | 21 Oct 2021 | 19 Jan 2022 | 90 | 13 |
 Omar Marmoush | Foot Injury | 21 Oct 2021 | 23 Nov 2021 | 33 | 6 |
 Orel Mangala | COVID 19 | 15 Oct 2021 | 19 Oct 2021 | 4 | 1 |
| Florian Müller | COVID 19 | 11 Oct 2021 | 25 Oct 2021 | 14 | 1 |
Unknown player | Inner Knee Ligament Tear | 11 Oct 2021 | 30 Dec 2021 | 80 | 12 |
Unknown player | COVID 19 | 8 Oct 2021 | 22 Oct 2021 | 14 | 1 |
Unknown player | COVID 19 | 6 Oct 2021 | 20 Oct 2021 | 14 | 2 |
Unknown player | Fitness | 6 Oct 2021 | 5 Nov 2021 | 30 | 5 |
 Waldemar Anton | COVID 19 | 4 Oct 2021 | 25 Oct 2021 | 21 | 2 |
Unknown player | Muscular Problems | 20 Sept 2021 | 7 Oct 2021 | 17 | 2 |
| Chris Führich | Fitness | 13 Sept 2021 | 23 Sept 2021 | 10 | 1 |
Unknown player | Infection | 9 Sept 2021 | 7 Oct 2021 | 28 | 4 |
| Naouirou Ahamada | Fitness | 6 Sept 2021 | 23 Sept 2021 | 17 | 2 |
| Atakan Karazor | Doubtful | 28 Aug 2021 | 5 Jul 2023 | 676 | — |
| Nikolas Nartey | Fitness | 23 Aug 2021 | 9 Sept 2021 | 17 | 2 |
Unknown player | Shoulder Injury | 19 Aug 2021 | 3 Jan 2022 | 137 | 20 |
Unknown player | Fitness | 16 Aug 2021 | 26 Aug 2021 | 10 | 1 |
Unknown player | Knee Injury | 15 Aug 2021 | 30 Jun 2022 | 319 | 37 |
| Atakan Karazor | Muscular Problems | 12 Aug 2021 | 23 Aug 2021 | 11 | 2 |
Unknown player | Pelvic Contusion | 2 Aug 2021 | 9 Aug 2021 | 7 | 1 |
| Waldemar Anton | Cold | 2 Aug 2021 | 9 Aug 2021 | 7 | 1 |
Unknown player | COVID 19 | 29 Jul 2021 | 19 Aug 2021 | 21 | 3 |
Unknown player | COVID 19 | 29 Jul 2021 | 16 Aug 2021 | 18 | 3 |
| Nikolas Nartey | COVID 19 | 29 Jul 2021 | 23 Aug 2021 | 25 | 4 |
Unknown player | Bone Splintering | 24 Jul 2021 | 5 Nov 2021 | 104 | 15 |
| Chris Führich | Broken Collarbone | 22 Jul 2021 | 13 Sept 2021 | 53 | 7 |
| Naouirou Ahamada | Calf Injury | 19 Jul 2021 | 6 Sept 2021 | 49 | 7 |
| Orel Mangala | Torn Muscle Bundle | 14 Jul 2021 | 7 Sept 2021 | 55 | 8 |
Unknown player | Doubtful | 22 May 2021 | 5 Jul 2023 | 774 | — |
Unknown player | Adductor Pain | 10 May 2021 | 24 May 2021 | 14 | 2 |
 Gregor Kobel | Back Problems | 6 May 2021 | 13 May 2021 | 7 | 1 |
Unknown player | Inner Knee Ligament Tear | 6 May 2021 | 1 Jul 2021 | 56 | 3 |
Unknown player | Knee Problems | 3 May 2021 | 1 Jul 2021 | 59 | 3 |
Unknown player | Thigh Problems | 26 Apr 2021 | 10 May 2021 | 14 | 1 |
Unknown player | Fitness | 19 Apr 2021 | 26 Apr 2021 | 7 | 1 |
Unknown player | Quarantine | 19 Apr 2021 | 13 May 2021 | 24 | 3 |
 Borna Sosa | Capsular Injury | 15 Apr 2021 | 6 May 2021 | 21 | 3 |
Unknown player | Minor Knock | 8 Apr 2021 | 12 Apr 2021 | 4 | 1 |
Unknown player | Doubtful | 4 Apr 2021 | 5 Jul 2023 | 822 | 101 |
 Nico González | Torn Muscle Fiber | 29 Mar 2021 | 7 Jun 2021 | 70 | 8 |
| Silas | Cruciate Ligament Tear | 21 Mar 2021 | 8 Nov 2021 | 232 | 28 |
| Orel Mangala | Torn Muscle Fiber | 15 Mar 2021 | 1 Jul 2021 | 108 | 9 |
Unknown player | Calf Problems | 15 Mar 2021 | 29 Mar 2021 | 14 | 1 |
Unknown player | Syndesmosis Ligament Tear | 11 Mar 2021 | 18 Apr 2021 | 38 | 4 |
Unknown player | Fitness | 9 Mar 2021 | 18 Apr 2021 | 40 | 4 |
Unknown player | Fitness | 22 Feb 2021 | 1 Mar 2021 | 7 | 1 |
Unknown player | Hip Flexor Problems | 22 Feb 2021 | 9 Mar 2021 | 15 | 2 |
Unknown player | Broken Nose Bone | 10 Feb 2021 | 21 Feb 2021 | 11 | 1 |
| Nico González | Torn Muscle Fiber | 8 Feb 2021 | 15 Mar 2021 | 35 | 4 |
Unknown player | Fitness | 8 Feb 2021 | 14 Feb 2021 | 6 | 0 |
| Marc Oliver Kempf | Cold | 4 Feb 2021 | 18 Feb 2021 | 14 | 2 |
Unknown player | Muscular Problems | 4 Feb 2021 | 11 Feb 2021 | 7 | 1 |
Unknown player | Torn Muscle Fiber | 1 Feb 2021 | 15 Feb 2021 | 14 | 3 |
| Borna Sosa | Muscular Problems | 21 Jan 2021 | 28 Jan 2021 | 7 | 1 |
Unknown player | Muscular Problems | 21 Jan 2021 | 25 Jan 2021 | 4 | 1 |
Unknown player | Doubtful | 16 Jan 2021 | 16 Jan 2021 | 0 | 1 |
Unknown player | Fitness | 4 Jan 2021 | 13 Jan 2021 | 9 | 1 |
Unknown player | Flu | 28 Dec 2020 | 7 Jan 2021 | 10 | 1 |
| Silas | Rest | 22 Dec 2020 | 24 Dec 2020 | 2 | 0 |
Unknown player | Adductor Pain | 21 Dec 2020 | 31 Dec 2020 | 10 | 1 |
Unknown player | Metatarsal Fracture | 20 Dec 2020 | 5 Oct 2021 | 289 | 38 |
| Waldemar Anton | Doubtful | 15 Dec 2020 | 4 Jul 2023 | 931 | — |
| Atakan Karazor | Fitness | 14 Dec 2020 | 17 Dec 2020 | 3 | 1 |
Unknown player | Doubtful | 12 Dec 2020 | 4 Jul 2023 | 934 | — |
Unknown player | Fitness | 10 Dec 2020 | 14 Dec 2020 | 4 | 1 |
Unknown player | Doubtful | 6 Dec 2020 | 4 Jul 2023 | 940 | — |
| Atakan Karazor | Internal Ligament Strain | 30 Nov 2020 | 14 Dec 2020 | 14 | 2 |
Unknown player | Hip Injury | 26 Nov 2020 | 10 Dec 2020 | 14 | 2 |
| Nico González | Inner Knee Ligament Tear | 23 Nov 2020 | 10 Dec 2020 | 17 | 2 |
Unknown player | Doubtful | 21 Nov 2020 | 4 Jul 2023 | 955 | — |
Unknown player | Torn Muscle Fiber | 13 Nov 2020 | 28 Dec 2020 | 45 | 8 |
Unknown player | Inflammation Of Pubic Bone | 13 Nov 2020 | 7 Feb 2021 | 86 | 15 |
| Silas | Doubtful | 30 Oct 2020 | 4 Jul 2023 | 977 | — |
Unknown player | Knee Problems | 24 Oct 2020 | 2 Nov 2020 | 9 | 1 |
Unknown player | Doubtful | 17 Oct 2020 | 4 Jul 2023 | 990 | — |
| Nico González | Doubtful | 17 Oct 2020 | 4 Jul 2023 | 990 | — |
Unknown player | Bruise | 14 Oct 2020 | 21 Oct 2020 | 7 | 1 |
| Waldemar Anton | Outer Ligament Problems | 12 Oct 2020 | 26 Oct 2020 | 14 | 2 |
| Borna Sosa | Back Problems | 12 Oct 2020 | 29 Oct 2020 | 17 | 2 |
Unknown player | Knee Problems | 10 Oct 2020 | 21 Oct 2020 | 11 | 1 |
Unknown player | Meniscus Tear | 8 Oct 2020 | 23 Nov 2020 | 46 | 7 |
Unknown player | Fitness | 24 Sept 2020 | 12 Oct 2020 | 18 | 3 |
| Nico González | Torn Muscle Bundle | 7 Sept 2020 | 5 Oct 2020 | 28 | 4 |
Unknown player | Muscular Problems | 1 Sept 2020 | 15 Sept 2020 | 14 | 2 |
Unknown player | Groin Injury | 31 Aug 2020 | 5 Oct 2020 | 35 | 5 |
Unknown player | Syndesmosis Ligament Tear | 24 Aug 2020 | 12 Oct 2020 | 49 | 8 |
Unknown player | Elbow Injury | 22 Aug 2020 | 3 Jan 2021 | 134 | 21 |
Unknown player | Hip Injury | 17 Aug 2020 | 8 Mar 2021 | 203 | 33 |
