| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Ryan Sessegnon | Hamstring Injury | 17 Feb 2024 | 31 May 2024 | 104 | 15 |
 Pedro Porro | Injury | 16 Feb 2024 | 5 Mar 2024 | 18 | 2 |
 Fraser Forster | Ankle Injury | 16 Feb 2024 | 20 Aug 2024 | 186 | 15 |
 Destiny Udogie | Knee Injury | 11 Feb 2024 | 26 Feb 2024 | 15 | 1 |
| Ryan Sessegnon | Hamstring Injury | 13 Jan 2024 | 12 Feb 2024 | 30 | 5 |
 Ben Davies | Hamstring Injury | 12 Jan 2024 | 23 Jan 2024 | 11 | 1 |
 Dejan Kulusevski | ILL | 10 Jan 2024 | 16 Jan 2024 | 6 | 1 |
 Giovani Lo Celso | Muscle Injury | 6 Jan 2024 | 11 Feb 2024 | 36 | 4 |
 Eric Dier | Muscle Injury | 5 Jan 2024 | 11 Jan 2024 | 6 | 1 |
 Unknown player | Knee Injury | 1 Jan 2024 | 6 Feb 2024 | 36 | 4 |
 Unknown player | Knock | 26 Dec 2023 | 30 Dec 2023 | 4 | 1 |
 Cristian Romero | Hamstring Strain | 24 Dec 2023 | 12 Jan 2024 | 19 | 3 |
| Giovani Lo Celso | Injury | 14 Dec 2023 | 22 Dec 2023 | 8 | 1 |
| Eric Dier | Knock | 27 Nov 2023 | 24 Dec 2023 | 27 | 4 |
 Rodrigo Bentancur | Torn Ankle Ligaments | 27 Nov 2023 | 29 Dec 2023 | 32 | 6 |
 Unknown player | Ankle Injury | 24 Nov 2023 | 21 Dec 2023 | 27 | 5 |
 Pape Matar Sarr | Knock | 22 Nov 2023 | 7 Dec 2023 | 15 | 2 |
 Richarlison | Groin Surgery | 10 Nov 2023 | 3 Dec 2023 | 23 | 2 |
 James Maddison | Ankle Injury | 10 Nov 2023 | 23 Jan 2024 | 74 | 11 |
 Micky van de Ven | Hamstring Injury | 6 Nov 2023 | 1 Jan 2024 | 56 | 8 |
| Ben Davies | Knock | 27 Oct 2023 | 9 Nov 2023 | 13 | 2 |
| Destiny Udogie | Muscle Injury | 23 Oct 2023 | 4 Nov 2023 | 12 | 2 |
| Ben Davies | Knock | 22 Oct 2023 | 26 Oct 2023 | 4 | 1 |
 Unknown player | Meniscus Injury | 5 Oct 2023 | 7 Jul 2024 | 276 | 34 |
 Brennan Johnson | Doubtful | 30 Sept 2023 | 30 Sept 2023 | 0 | 1 |
| Brennan Johnson | Hamstring Injury | 28 Sept 2023 | 21 Oct 2023 | 23 | 1 |
 Unknown player | Cruciate Ligament Tear | 20 Sept 2023 | 28 Feb 2024 | 161 | 26 |
| Giovani Lo Celso | Hamstring Injury | 29 Aug 2023 | 5 Oct 2023 | 37 | 5 |
 Unknown player | Ankle Injury | 3 Aug 2023 | 15 May 2024 | 286 | 16 |
 Unknown player | Inflammation Of Pubic Bone | 2 Aug 2023 | 5 Oct 2023 | 64 | 10 |
 Unknown player | Knee Problems | 1 Aug 2023 | 29 Oct 2023 | 89 | 13 |
 Unknown player | Ankle Injury | 25 Jul 2023 | 27 Aug 2023 | 33 | 5 |
| Ryan Sessegnon | Surgery | 11 Jul 2023 | 4 Jan 2024 | 177 | 25 |
| Fraser Forster | Back Problems | 10 Jul 2023 | 27 Aug 2023 | 48 | 5 |
| Eric Dier | Groin Injury | 21 May 2023 | 30 Jun 2023 | 40 | 1 |
 Pierre-Emile Højbjerg | Bruise | 20 May 2023 | 7 Jun 2023 | 18 | 2 |
| Eric Dier | Knock | 7 May 2023 | 21 May 2023 | 14 | 1 |
 Unknown player | Thigh Problems | 24 Apr 2023 | 2 Oct 2023 | 161 | 6 |
 Unknown player | Knee Surgery | 25 Mar 2023 | 1 May 2023 | 37 | 5 |
| Ben Davies | Hamstring Injury | 18 Mar 2023 | 20 Apr 2023 | 33 | 4 |
| Rodrigo Bentancur | Cruciate Ligament Tear | 12 Feb 2023 | 24 Oct 2023 | 254 | 26 |
| Ryan Sessegnon | Hamstring Injury | 11 Feb 2023 | 30 Jun 2023 | 139 | 9 |
 Unknown player | Broken Ankle | 10 Feb 2023 | 1 May 2023 | 80 | 14 |
| Unknown player | Knee Injury | 6 Feb 2023 | 22 Mar 2023 | 44 | 9 |
| Pape Matar Sarr | Doubtful | 5 Feb 2023 | 5 Feb 2023 | 0 | 1 |
| Richarlison | Hamstring Injury | 9 Dec 2022 | 13 Jan 2023 | 35 | 6 |
| Rodrigo Bentancur | Adductor Pain | 3 Dec 2022 | 16 Jan 2023 | 44 | 6 |
 Unknown player | Facial Fracture | 2 Nov 2022 | 20 Nov 2022 | 18 | 3 |
| Cristian Romero | Hamstring Injury | 28 Oct 2022 | 19 Nov 2022 | 22 | 5 |
| Pierre-Emile Højbjerg | Dead Leg | 23 Oct 2022 | 28 Oct 2022 | 5 | 2 |
| Richarlison | Calf Injury | 15 Oct 2022 | 8 Nov 2022 | 24 | 5 |
| Unknown player | Knock | 10 Oct 2022 | 17 Oct 2022 | 7 | 2 |
| Dejan Kulusevski | Thigh Problems | 29 Sept 2022 | 5 Nov 2022 | 37 | 10 |
| Ben Davies | Knee Injury | 15 Sept 2022 | 3 Oct 2022 | 18 | 2 |
| Unknown player | Knock | 29 Aug 2022 | 12 Sept 2022 | 14 | 3 |
 Unknown player | Calf Injury | 29 Aug 2022 | 10 Oct 2022 | 42 | 8 |
| Rodrigo Bentancur | Head Injury | 28 Aug 2022 | 1 Sept 2022 | 4 | 1 |
 Unknown player | Pubalgia | 21 Aug 2022 | 27 Oct 2022 | 67 | 13 |
| Cristian Romero | Adductor Pain | 18 Aug 2022 | 2 Sept 2022 | 15 | 3 |
 Unknown player | Adductor Injury | 10 Aug 2022 | 18 Aug 2022 | 8 | 1 |
| Unknown player | Foot Injury | 18 Jul 2022 | 29 Aug 2022 | 42 | 5 |
| Cristian Romero | Hip Problems | 12 May 2022 | 26 May 2022 | 14 | 3 |
| Unknown player | Groin Problems | 30 Apr 2022 | 30 Jun 2022 | 61 | 5 |
 Unknown player | Internal Ligament Tear | 10 Apr 2022 | 10 Jul 2022 | 91 | 7 |
| Ryan Sessegnon | Hamstring Injury | 7 Mar 2022 | 7 Apr 2022 | 31 | 5 |
| Unknown player | Doubtful | 7 Mar 2022 | 6 Aug 2024 | 883 | — |
| Rodrigo Bentancur | Ankle Injury | 25 Feb 2022 | 4 Mar 2022 | 7 | 2 |
| Unknown player | Dead Leg | 24 Feb 2022 | 3 Mar 2022 | 7 | 2 |
| Unknown player | COVID 19 | 15 Feb 2022 | 22 Feb 2022 | 7 | 1 |
| Unknown player | Inflammation Of Pubic Bone | 5 Feb 2022 | 30 Jun 2022 | 145 | 20 |
| Unknown player | Knee Injury | 4 Feb 2022 | 30 Jun 2022 | 146 | 20 |
| Eric Dier | Thigh Problems | 4 Feb 2022 | 15 Feb 2022 | 11 | 3 |
| Unknown player | Hamstring Injury | 6 Jan 2022 | 3 Feb 2022 | 28 | 4 |
| Eric Dier | Thigh Problems | 3 Jan 2022 | 20 Jan 2022 | 17 | 3 |
 Unknown player | Calf Injury | 27 Dec 2021 | 16 Jan 2022 | 20 | 5 |
| Giovani Lo Celso | Shin Injury | 25 Dec 2021 | 30 Dec 2021 | 5 | 2 |
| Ryan Sessegnon | Muscle Injury | 21 Dec 2021 | 7 Jan 2022 | 17 | 5 |
| Unknown player | COVID 19 | 6 Dec 2021 | 23 Dec 2021 | 17 | 2 |
| Unknown player | Injury | 3 Dec 2021 | 13 Dec 2021 | 10 | 2 |
| Giovani Lo Celso | Knee Injury | 18 Nov 2021 | 15 Dec 2021 | 27 | 5 |
| Cristian Romero | Hamstring Injury | 17 Nov 2021 | 5 Feb 2022 | 80 | 15 |
| Unknown player | Hamstring Injury | 25 Oct 2021 | 18 Nov 2021 | 24 | 4 |
| Unknown player | Injury | 13 Oct 2021 | 26 Oct 2021 | 13 | 3 |
| Unknown player | Ankle Injury | 16 Sept 2021 | 23 Sept 2021 | 7 | 2 |
| Unknown player | Ankle Injury | 16 Sept 2021 | 11 Oct 2021 | 25 | 6 |
| Giovani Lo Celso | Quarantine | 9 Sept 2021 | 17 Sept 2021 | 8 | 1 |
| Cristian Romero | Quarantine | 9 Sept 2021 | 17 Sept 2021 | 8 | 1 |
 Unknown player | Quarantine | 9 Sept 2021 | 17 Sept 2021 | 8 | 1 |
| Unknown player | Ankle Injury | 7 Sept 2021 | 14 Sept 2021 | 7 | 1 |
| Unknown player | Calf Injury | 6 Sept 2021 | 20 Sept 2021 | 14 | 2 |
| Ryan Sessegnon | Bruise | 1 Sept 2021 | 14 Nov 2021 | 74 | 14 |
| Cristian Romero | Knee Injury | 20 Aug 2021 | 25 Aug 2021 | 5 | 1 |
 Unknown player | Ankle Injury | 19 Aug 2021 | 8 Sept 2021 | 20 | — |
 Joe Rodon | Injury | 16 Aug 2021 | 7 Sept 2021 | 22 | 4 |
| Unknown player | Knock | 8 Aug 2021 | 28 Aug 2021 | 20 | 5 |
 Unknown player | Groin Injury | 15 May 2021 | 18 May 2021 | 3 | 1 |
 Harry Kane | Ankle Injury | 16 Apr 2021 | 22 Apr 2021 | 6 | 1 |
| Unknown player | Muscle Injury | 1 Apr 2021 | 30 Apr 2021 | 29 | 5 |
| Ben Davies | Shin Injury | 22 Mar 2021 | 31 May 2021 | 70 | 10 |
| Unknown player | Hamstring Injury | 15 Mar 2021 | 5 Apr 2021 | 21 | 2 |
