| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
Unknown player | Heel Problems | 25 Feb 2022 | 5 Mar 2022 | 8 | 1 |
 Nicolò Zaniolo | Muscular Problems | 17 Feb 2022 | 22 Feb 2022 | 5 | 1 |
Unknown player | COVID 19 | 17 Feb 2022 | 26 Feb 2022 | 9 | 1 |
Unknown player | COVID 19 | 17 Feb 2022 | 23 Feb 2022 | 6 | 1 |
Unknown player | COVID 19 | 17 Feb 2022 | 24 Feb 2022 | 7 | 1 |
 Henrikh Mkhitaryan | COVID 19 | 17 Feb 2022 | 24 Feb 2022 | 7 | 1 |
 Stephan El Shaarawy | Calf Problems | 12 Feb 2022 | 22 Feb 2022 | 10 | 2 |
Unknown player | Collateral Ligament Injury | 8 Feb 2022 | 26 Feb 2022 | 18 | 3 |
 Lorenzo Pellegrini | Injury | 16 Jan 2022 | 4 Feb 2022 | 19 | 3 |
Unknown player | COVID 19 | 13 Jan 2022 | 20 Jan 2022 | 7 | 1 |
Unknown player | Injury | 12 Jan 2022 | 23 Jan 2022 | 11 | 2 |
| Stephan El Shaarawy | Muscle Fatigue | 8 Jan 2022 | 21 Jan 2022 | 13 | 2 |
| Nicolò Zaniolo | Injury | 8 Jan 2022 | 11 Jan 2022 | 3 | 1 |
Unknown player | COVID 19 | 3 Jan 2022 | 12 Jan 2022 | 9 | 2 |
 Borja Mayoral | COVID 19 | 2 Jan 2022 | 8 Jan 2022 | 6 | 1 |
Unknown player | Muscle Fatigue | 4 Dec 2021 | 18 Dec 2021 | 14 | 3 |
| Stephan El Shaarawy | Calf Muscle Tear | 1 Dec 2021 | 22 Dec 2021 | 21 | 5 |
Unknown player | COVID 19 | 30 Nov 2021 | 9 Dec 2021 | 9 | 2 |
| Lorenzo Pellegrini | Hamstring Injury | 28 Nov 2021 | 3 Jan 2022 | 36 | 7 |
 Bryan Cristante | COVID 19 | 20 Nov 2021 | 1 Dec 2021 | 11 | 3 |
 Gonzalo Villar | COVID 19 | 20 Nov 2021 | 3 Dec 2021 | 13 | 4 |
 Riccardo Calafiori | Muscular Problems | 6 Nov 2021 | 1 Dec 2021 | 25 | 4 |
Unknown player | Adductor Injury | 3 Nov 2021 | 26 Nov 2021 | 23 | 3 |
| Lorenzo Pellegrini | Inflammation In The Knee | 1 Nov 2021 | 7 Nov 2021 | 6 | 1 |
| Nicolò Zaniolo | Knee Injury | 17 Oct 2021 | 24 Oct 2021 | 7 | 2 |
Unknown player | Hamstring Injury | 5 Oct 2021 | 20 Nov 2021 | 46 | 7 |
Unknown player | Knee Injury | 15 Sept 2021 | 25 Sept 2021 | 10 | 3 |
Unknown player | Hamstring Injury | 17 Aug 2021 | 8 Sept 2021 | 22 | 4 |
| Gonzalo Villar | Knee Injury | 30 Jul 2021 | 20 Aug 2021 | 21 | 4 |
 Leonardo Spinazzola | Achilles Tendon Rupture | 5 Jul 2021 | 9 Apr 2022 | 278 | 53 |
| Lorenzo Pellegrini | Muscle Injury | 18 May 2021 | 1 Jun 2021 | 14 | 1 |
Unknown player | Lumbago | 14 May 2021 | 31 May 2021 | 17 | 2 |
Unknown player | Injury | 9 May 2021 | 23 May 2021 | 14 | 3 |
Unknown player | Muscular Problems | 6 May 2021 | 31 May 2021 | 25 | 5 |
| Gonzalo Villar | Adductor Pain | 2 May 2021 | 10 May 2021 | 8 | 2 |
Unknown player | Pubalgia | 30 Apr 2021 | 23 May 2021 | 23 | 5 |
Unknown player | Muscular Problems | 30 Apr 2021 | 11 May 2021 | 11 | 3 |
| Leonardo Spinazzola | Hamstring Muscle Injury | 29 Apr 2021 | 28 May 2021 | 29 | 7 |
| Stephan El Shaarawy | Injury | 29 Apr 2021 | 10 May 2021 | 11 | 3 |
Unknown player | Shoulder Injury | 29 Apr 2021 | 27 Aug 2021 | 120 | 18 |
Unknown player | Hamstring Muscle Injury | 29 Apr 2021 | 31 May 2021 | 32 | 7 |
Unknown player | Injury | 23 Apr 2021 | 28 Apr 2021 | 5 | 1 |
| Riccardo Calafiori | Hamstring Muscle Injury | 22 Apr 2021 | 31 May 2021 | 39 | 9 |
Unknown player | Hamstring Muscle Injury | 18 Apr 2021 | 3 May 2021 | 15 | 4 |
Unknown player | Ankle Injury | 16 Apr 2021 | 16 Jun 2021 | 61 | — |
| Leonardo Spinazzola | Thigh Problems | 8 Apr 2021 | 23 Apr 2021 | 15 | 4 |
| Stephan El Shaarawy | Hamstring Muscle Injury | 5 Apr 2021 | 23 Apr 2021 | 18 | 4 |
 Marash Kumbulla | Meniscus Tear | 26 Mar 2021 | 23 Apr 2021 | 28 | 5 |
Unknown player | Knee Problems | 12 Mar 2021 | 23 Apr 2021 | 42 | 8 |
| Henrikh Mkhitaryan | Calf Muscle Tear | 11 Mar 2021 | 9 Apr 2021 | 29 | 5 |
 Juan Jesus | COVID 19 | 10 Mar 2021 | 11 Apr 2021 | 32 | 6 |
Unknown player | Muscle Strain | 3 Mar 2021 | 2 Apr 2021 | 30 | 6 |
 Edin Džeko | Adductor Pain | 25 Feb 2021 | 10 Mar 2021 | 13 | 4 |
| Bryan Cristante | Lumbago | 18 Feb 2021 | 24 Feb 2021 | 6 | 2 |
Unknown player | Muscular Problems | 18 Feb 2021 | 10 Mar 2021 | 20 | 6 |
Unknown player | Muscle Injury | 17 Feb 2021 | 26 Feb 2021 | 9 | 2 |
| Marash Kumbulla | Muscle Fatigue | 13 Feb 2021 | 28 Feb 2021 | 15 | 4 |
| Riccardo Calafiori | Hamstring Muscle Injury | 13 Feb 2021 | 8 Mar 2021 | 23 | 6 |
 Bryan Reynolds | Fitness | 1 Feb 2021 | 1 Mar 2021 | 28 | 5 |
| Stephan El Shaarawy | Fitness | 1 Feb 2021 | 8 Feb 2021 | 7 | 1 |
Unknown player | Hamstring Muscle Injury | 31 Jan 2021 | 3 Mar 2021 | 31 | 7 |
Unknown player | Doubtful | 23 Jan 2021 | 23 Jan 2021 | 0 | 1 |
| Henrikh Mkhitaryan | Muscular Problems | 21 Jan 2021 | 29 Jan 2021 | 8 | 1 |
Unknown player | Muscular Problems | 21 Jan 2021 | 9 Feb 2021 | 19 | 3 |
| Edin Džeko | Bruise | 21 Jan 2021 | 28 Jan 2021 | 7 | 1 |
Unknown player | Tendon Irritation | 19 Jan 2021 | 22 Jan 2021 | 3 | 1 |
| Nicolò Zaniolo | COVID 19 | 18 Jan 2021 | 8 Feb 2021 | 21 | 3 |
Unknown player | Muscular Problems | 3 Jan 2021 | 18 Jan 2021 | 15 | 4 |
Unknown player | Knee Problems | 2 Jan 2021 | 12 Jan 2021 | 10 | 3 |
| Riccardo Calafiori | Hamstring Muscle Injury | 1 Jan 2021 | 27 Jan 2021 | 26 | 6 |
Unknown player | Hamstring Muscle Injury | 31 Dec 2020 | 13 Jan 2021 | 13 | 3 |
Unknown player | Hamstring Muscle Injury | 23 Dec 2020 | 25 Jan 2021 | 33 | 7 |
| Leonardo Spinazzola | Hamstring Muscle Injury | 20 Dec 2020 | 7 Jan 2021 | 18 | 3 |
Unknown player | Doubtful | 13 Dec 2020 | 13 Dec 2020 | 0 | 1 |
| Lorenzo Pellegrini | Bruise On Ankle | 6 Dec 2020 | 11 Dec 2020 | 5 | 1 |
 Gianluca Mancini | Muscular Problems | 30 Nov 2020 | 14 Dec 2020 | 14 | 4 |
Unknown player | Doubtful | 29 Nov 2020 | 29 Nov 2020 | 0 | 1 |
Unknown player | Muscular Problems | 29 Nov 2020 | 11 Dec 2020 | 12 | 3 |
Unknown player | Inflammation In The Knee | 24 Nov 2020 | 8 Dec 2020 | 14 | 4 |
Unknown player | Muscular Problems | 22 Nov 2020 | 28 Nov 2020 | 6 | 2 |
Unknown player | Food Poisoning | 18 Nov 2020 | 23 Nov 2020 | 5 | 0 |
| Marash Kumbulla | COVID 19 | 10 Nov 2020 | 30 Nov 2020 | 20 | 2 |
Unknown player | COVID 19 | 9 Nov 2020 | 30 Nov 2020 | 21 | 2 |
Unknown player | COVID 19 | 9 Nov 2020 | 30 Nov 2020 | 21 | 2 |
Unknown player | COVID 19 | 8 Nov 2020 | 11 Dec 2020 | 33 | — |
| Edin Džeko | COVID 19 | 6 Nov 2020 | 23 Nov 2020 | 17 | 1 |
Unknown player | Muscular Problems | 3 Nov 2020 | 18 Nov 2020 | 15 | 2 |
Unknown player | Hamstring Muscle Injury | 28 Oct 2020 | 17 Dec 2020 | 50 | 11 |
Unknown player | Tonsillitis | 25 Oct 2020 | 28 Oct 2020 | 3 | 1 |
| Riccardo Calafiori | COVID 19 | 17 Oct 2020 | 12 Nov 2020 | 26 | 7 |
Unknown player | COVID 19 | 12 Oct 2020 | 10 Nov 2020 | 29 | 7 |
Unknown player | Sprain | 7 Oct 2020 | 27 Oct 2020 | 20 | 2 |
Unknown player | Muscular Problems | 17 Sept 2020 | 19 Oct 2020 | 32 | 3 |
Unknown player | Ankle Sprain | 9 Sept 2020 | 23 Sept 2020 | 14 | 3 |
| Nicolò Zaniolo | Cruciate Ligament Tear | 7 Sept 2020 | 31 May 2021 | 266 | 53 |
Unknown player | Quarantine | 28 Aug 2020 | 20 Sept 2020 | 23 | 3 |
Unknown player | Surgery | 11 Aug 2020 | 30 Jan 2021 | 172 | 29 |
| Lorenzo Pellegrini | Nose Injury | 27 Jul 2020 | 4 Aug 2020 | 8 | 2 |
Unknown player | Calf Problems | 21 Jul 2020 | 27 Jul 2020 | 6 | 1 |
Unknown player | Adductor Pain | 20 Jul 2020 | 27 Jul 2020 | 7 | 1 |
