| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Brian Brobbey | Muscle Injury | 9 Oct 2021 | 4 Nov 2021 | 26 | 5 |
 Willi Orbán | Flu | 1 Oct 2021 | 5 Oct 2021 | 4 | 1 |
 Tyler Adams | Muscular Problems | 24 Sept 2021 | 30 Sept 2021 | 6 | 2 |
 Dani Olmo | Torn Muscle Fiber | 16 Sept 2021 | 25 Oct 2021 | 39 | 8 |
 Angeliño | Muscle Injury | 19 Aug 2021 | 6 Sept 2021 | 18 | 2 |
 Alexander Sørloth | ILL | 12 Aug 2021 | 25 Aug 2021 | 13 | — |
 Unknown player | Capsular Injury | 9 Aug 2021 | 21 Feb 2022 | 196 | 33 |
 Benjamin Henrichs | Knee Problems | 3 Aug 2021 | 24 Aug 2021 | 21 | 3 |
 Yussuf Poulsen | Fitness | 2 Aug 2021 | 16 Aug 2021 | 14 | 1 |
 Unknown player | Cruciate Ligament Tear | 23 Jul 2021 | 26 Jan 2022 | 187 | 33 |
 Péter Gulácsi | Capsular Injury | 17 May 2021 | 24 May 2021 | 7 | 1 |
 Lazar Samardžić | Meniscus Tear | 6 May 2021 | 13 Jun 2021 | 38 | 4 |
 Christopher Nkunku | Back Problems | 3 May 2021 | 10 May 2021 | 7 | 1 |
| Tyler Adams | Back Problems | 3 May 2021 | 31 May 2021 | 28 | 4 |
 Marcel Sabitzer | Calf Problems | 17 Apr 2021 | 22 Apr 2021 | 5 | 1 |
| Yussuf Poulsen | Thigh Problems | 15 Apr 2021 | 26 Apr 2021 | 11 | 2 |
| Yussuf Poulsen | Muscle Injury | 5 Apr 2021 | 12 Apr 2021 | 7 | 1 |
| Unknown player | Quarantine | 22 Mar 2021 | 8 Apr 2021 | 17 | 1 |
 Dayot Upamecano | Muscle Injury | 15 Mar 2021 | 28 Mar 2021 | 13 | 1 |
| Angeliño | Muscle Injury | 25 Feb 2021 | 6 Apr 2021 | 40 | 7 |
| Benjamin Henrichs | Fitness | 2 Feb 2021 | 15 Feb 2021 | 13 | 3 |
 Justin Kluivert | Ankle Injury | 31 Jan 2021 | 9 Feb 2021 | 9 | 2 |
 Unknown player | Knee Injury | 27 Jan 2021 | 24 Feb 2021 | 28 | 6 |
| Yussuf Poulsen | Adductor Injury | 21 Jan 2021 | 25 Jan 2021 | 4 | 1 |
 Unknown player | Ankle Problems | 4 Jan 2021 | 12 Jan 2021 | 8 | 1 |
 Dominik Szoboszlai | Adductor Injury | 22 Dec 2020 | 1 Jul 2021 | 191 | 25 |
| Justin Kluivert | Calf Injury | 17 Dec 2020 | 11 Jan 2021 | 25 | 4 |
 Ibrahima Konaté | Ankle Injury | 17 Dec 2020 | 4 Feb 2021 | 49 | 8 |
| Christopher Nkunku | Ankle Problems | 10 Dec 2020 | 11 Jan 2021 | 32 | 6 |
| Lazar Samardžić | COVID 19 | 7 Dec 2020 | 20 Dec 2020 | 13 | 3 |
| Alexander Sørloth | Doubtful | 5 Dec 2020 | 5 Dec 2020 | 0 | 1 |
| Benjamin Henrichs | Patellar Tendon Problems | 26 Nov 2020 | 1 Feb 2021 | 67 | 14 |
 Hee-chan Hwang | COVID 19 | 18 Nov 2020 | 30 Dec 2020 | 42 | 10 |
| Unknown player | Adductor Injury | 9 Nov 2020 | 26 Nov 2020 | 17 | 2 |
| Benjamin Henrichs | Doubtful | 7 Nov 2020 | 7 Nov 2020 | 0 | 1 |
| Justin Kluivert | Doubtful | 7 Nov 2020 | 7 Nov 2020 | 0 | 1 |
| Dayot Upamecano | Torn Muscle Fiber | 5 Nov 2020 | 18 Nov 2020 | 13 | 1 |
| Unknown player | Muscular Problems | 29 Oct 2020 | 5 Nov 2020 | 7 | 1 |
| Tyler Adams | Doubtful | 28 Oct 2020 | 28 Oct 2020 | 0 | 1 |
 Nordi Mukiele | Torn Muscle Fiber | 25 Oct 2020 | 2 Nov 2020 | 8 | 2 |
| Tyler Adams | Inner Ligament Injury | 24 Oct 2020 | 25 Oct 2020 | 1 | 0 |
| Marcel Sabitzer | Doubtful | 20 Oct 2020 | 20 Oct 2020 | 0 | 1 |
| Ibrahima Konaté | Doubtful | 20 Oct 2020 | 20 Oct 2020 | 0 | 1 |
 Lukas Klostermann | Knee Surgery | 19 Oct 2020 | 21 Dec 2020 | 63 | 15 |
 Amadou Haidara | COVID 19 | 15 Oct 2020 | 29 Oct 2020 | 14 | 3 |
| Hee-chan Hwang | Doubtful | 3 Oct 2020 | 3 Oct 2020 | 0 | 1 |
| Yussuf Poulsen | Doubtful | 3 Oct 2020 | 3 Oct 2020 | 0 | 1 |
| Marcel Sabitzer | Torn Muscle Fiber | 24 Sept 2020 | 18 Oct 2020 | 24 | 2 |
 Konrad Laimer | Bone Edema | 27 Aug 2020 | 26 Apr 2021 | 242 | 42 |
| Ibrahima Konaté | Torn Muscle Fiber | 1 Jul 2020 | 15 Oct 2020 | 106 | 7 |
 Patrik Schick | Knee Problems | 22 Jun 2020 | 29 Jun 2020 | 7 | 1 |
| Marcel Sabitzer | Knee Injury | 22 Jun 2020 | 30 Jun 2020 | 8 | 1 |
 Ademola Lookman | Calf Injury | 20 Jun 2020 | 26 Jun 2020 | 6 | 1 |
| Konrad Laimer | Flu | 18 Jun 2020 | 22 Jun 2020 | 4 | 1 |
| Unknown player | Adductor Pain | 28 May 2020 | 3 Jun 2020 | 6 | 1 |
| Yussuf Poulsen | Ankle Injury | 25 May 2020 | 9 Jul 2020 | 45 | 7 |
| Ibrahima Konaté | Torn Muscle Fiber | 22 May 2020 | 5 Jun 2020 | 14 | 3 |
| Unknown player | Tonsillitis | 11 May 2020 | 17 May 2020 | 6 | 0 |
 Unknown player | Torn Knee Ligaments | 24 Apr 2020 | 15 Feb 2021 | 297 | 42 |
 Ethan Ampadu | Back Injury | 26 Feb 2020 | 28 Jun 2020 | 123 | 11 |
| Unknown player | Ankle Problems | 23 Feb 2020 | 20 Mar 2020 | 26 | 3 |
| Tyler Adams | Torn Muscle Fiber | 12 Feb 2020 | 24 Feb 2020 | 12 | 3 |
| Lukas Klostermann | Knee Problems | 23 Jan 2020 | 27 Jan 2020 | 4 | 1 |
| Unknown player | Fitness | 2 Jan 2020 | 21 Feb 2020 | 50 | 7 |
| Tyler Adams | Adductor Pain | 10 Dec 2019 | 20 Dec 2019 | 10 | 3 |
| Unknown player | Muscular Problems | 29 Nov 2019 | 2 Dec 2019 | 3 | 1 |
| Péter Gulácsi | Head Injury | 28 Nov 2019 | 5 Dec 2019 | 7 | 1 |
| Unknown player | Ankle Injury | 24 Nov 2019 | 1 Jan 2020 | 38 | 7 |
| Yussuf Poulsen | Adductor Pain | 21 Nov 2019 | 2 Dec 2019 | 11 | 3 |
| Unknown player | Adductor Pain | 21 Nov 2019 | 28 Nov 2019 | 7 | 1 |
| Nordi Mukiele | Torn Muscle Fiber | 10 Nov 2019 | 25 Nov 2019 | 15 | 1 |
 Unknown player | Fitness | 4 Nov 2019 | 28 Nov 2019 | 24 | 3 |
| Unknown player | Torn Muscle Fiber | 4 Nov 2019 | 21 Nov 2019 | 17 | 2 |
| Willi Orbán | Arthroscopy | 1 Nov 2019 | 11 May 2020 | 192 | 22 |
| Unknown player | Infection | 1 Nov 2019 | 7 Nov 2019 | 6 | 2 |
| Ademola Lookman | Back Problems | 27 Oct 2019 | 3 Nov 2019 | 7 | 1 |
| Unknown player | Tonsillitis | 24 Oct 2019 | 31 Oct 2019 | 7 | 1 |
| Unknown player | Back Problems | 17 Oct 2019 | 24 Oct 2019 | 7 | 1 |
| Ethan Ampadu | Concussion | 16 Oct 2019 | 25 Oct 2019 | 9 | 2 |
| Patrik Schick | Ankle Problems | 14 Oct 2019 | 18 Nov 2019 | 35 | 7 |
| Ibrahima Konaté | Torn Muscle Fiber | 3 Oct 2019 | 11 Mar 2020 | 160 | 26 |
| Unknown player | Hip Injury | 19 Sept 2019 | 30 Sept 2019 | 11 | 1 |
| Yussuf Poulsen | Rest | 19 Sept 2019 | 23 Sept 2019 | 4 | 1 |
| Patrik Schick | Ankle Problems | 16 Sept 2019 | 30 Sept 2019 | 14 | 3 |
| Tyler Adams | Fitness | 12 Sept 2019 | 19 Oct 2019 | 37 | 6 |
| Unknown player | Ankle Problems | 10 Sept 2019 | 14 Oct 2019 | 34 | 6 |
| Dayot Upamecano | Fitness | 27 Aug 2019 | 15 Sept 2019 | 19 | 1 |
 Unknown player | Fitness | 27 Aug 2019 | 31 Aug 2019 | 4 | 0 |
| Unknown player | Ankle Injury | 12 Aug 2019 | 26 Aug 2019 | 14 | 1 |
| Unknown player | Knee Injury | 8 Aug 2019 | 19 Aug 2019 | 11 | 1 |
| Unknown player | Ankle Injury | 1 Aug 2019 | 16 Aug 2019 | 15 | 2 |
| Dayot Upamecano | Knee Injury | 1 Aug 2019 | 26 Aug 2019 | 25 | 3 |
| Unknown player | Broken Leg | 17 Jun 2019 | 4 Nov 2019 | 140 | 26 |
| Tyler Adams | Adductor Pain | 12 Jun 2019 | 11 Sept 2019 | 91 | 8 |
 Unknown player | Thigh Problems | 22 Apr 2019 | 29 Apr 2019 | 7 | 2 |
 Emile Smith Rowe | Adductor Pain | 22 Apr 2019 | 13 May 2019 | 21 | 4 |
 Yvon Mvogo | Internal Ligament Strain | 7 Apr 2019 | 13 May 2019 | 36 | 6 |
| Yussuf Poulsen | Angina | 4 Apr 2019 | 15 Apr 2019 | 11 | 2 |
| Tyler Adams | Adductor Pain | 1 Apr 2019 | 12 May 2019 | 41 | 7 |
| Lukas Klostermann | Torn Muscle Fiber In The Adductor Area | 21 Mar 2019 | 4 Apr 2019 | 14 | 3 |
