| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Achraf Hakimi | Thigh Problems | 13 Sept 2026 | Current | — | 1 |
 Ousmane Dembélé | Rest | 26 Aug 2026 | 31 Aug 2026 | 5 | 1 |
 Nuno Mendes | Muscle Injury | 6 Jul 2026 | Current | — | 9 |
| Nuno Mendes | Dead Leg | 9 May 2026 | 18 May 2026 | 9 | 3 |
 Warren Zaïre-Emery | Back Injury | 9 May 2026 | 14 May 2026 | 5 | 2 |
 Willian Pacho | Dead Leg | 9 May 2026 | 18 May 2026 | 9 | 3 |
| Achraf Hakimi | Hamstring Injury | 29 Apr 2026 | 25 May 2026 | 26 | 5 |
 Lucas Chevalier | Hamstring Injury | 29 Apr 2026 | 18 May 2026 | 19 | 5 |
 Vitinha | Heel Injury | 20 Apr 2026 | 26 Apr 2026 | 6 | 2 |
 Martin James | Knee Injury | 18 Apr 2026 | 15 Jun 2026 | 58 | 10 |
| Nuno Mendes | Dead Leg | 15 Apr 2026 | 23 Apr 2026 | 8 | 2 |
 Senny Mayulu | Calf Injury | 22 Mar 2026 | 15 Apr 2026 | 24 | 3 |
 Bradley Barcola | Ankle Sprain | 18 Mar 2026 | 13 Apr 2026 | 26 | 3 |
 João Neves | Ankle Injury | 26 Feb 2026 | 7 Mar 2026 | 9 | 2 |
| Ousmane Dembélé | Calf Injury | 18 Feb 2026 | 1 Mar 2026 | 11 | 3 |
| Senny Mayulu | Calf Injury | 12 Feb 2026 | 1 Mar 2026 | 17 | 5 |
 Khvicha Kvaratskhelia | Ankle Sprain | 29 Jan 2026 | 5 Feb 2026 | 7 | 1 |
 Fabián Ruiz | Knee Injury | 21 Jan 2026 | 15 Apr 2026 | 84 | 16 |
| João Neves | Muscle Contusion | 15 Jan 2026 | 25 Jan 2026 | 10 | 3 |
 Unknown player | Ankle Injury | 21 Dec 2025 | 6 Jan 2026 | 16 | — |
 Quentin Ndjantou | Hamstring Injury | 21 Dec 2025 | 24 May 2026 | 154 | 30 |
 Matvey Safonov | Hand Injury | 18 Dec 2025 | 26 Jan 2026 | 39 | 7 |
 Kang-in Lee | Dead Leg | 18 Dec 2025 | 29 Jan 2026 | 42 | 7 |
| Senny Mayulu | Virus | 12 Dec 2025 | 15 Dec 2025 | 3 | 1 |
 Marquinhos | Muscle Fatigue | 11 Dec 2025 | 15 Dec 2025 | 4 | 1 |
| Ousmane Dembélé | ILL | 8 Dec 2025 | 15 Dec 2025 | 7 | 2 |
 Ilya Zabarnyi | ILL | 5 Dec 2025 | 7 Dec 2025 | 2 | 1 |
| Lucas Chevalier | Ankle Injury | 30 Nov 2025 | 11 Dec 2025 | 11 | 1 |
| Nuno Mendes | Dead Leg | 27 Nov 2025 | 8 Dec 2025 | 11 | 2 |
 Unknown player | Dead Leg | 26 Nov 2025 | 4 Dec 2025 | 8 | 2 |
| Ousmane Dembélé | Calf Injury | 5 Nov 2025 | 25 Nov 2025 | 20 | 2 |
| Achraf Hakimi | Ankle Sprain | 5 Nov 2025 | 27 Dec 2025 | 52 | 9 |
| Nuno Mendes | Knee Injury | 5 Nov 2025 | 19 Nov 2025 | 14 | 1 |
 Désiré Doué | Hamstring Injury | 30 Oct 2025 | 8 Dec 2025 | 39 | 9 |
| Kang-in Lee | ILL | 27 Oct 2025 | 30 Oct 2025 | 3 | 0 |
| Ousmane Dembélé | Fitness | 16 Oct 2025 | 19 Oct 2025 | 3 | 1 |
| Fabián Ruiz | Dead Leg | 2 Oct 2025 | 29 Oct 2025 | 27 | 4 |
| João Neves | Hamstring Injury | 2 Oct 2025 | 26 Oct 2025 | 24 | 3 |
| Khvicha Kvaratskhelia | Muscle Injury | 28 Sept 2025 | 8 Oct 2025 | 10 | 2 |
| Fabián Ruiz | Minor Knock | 26 Sept 2025 | 29 Sept 2025 | 3 | 1 |
| Marquinhos | Dead Leg | 26 Sept 2025 | 17 Oct 2025 | 21 | 3 |
| Bradley Barcola | Hamstring Injury | 20 Sept 2025 | 23 Sept 2025 | 3 | 0 |
| João Neves | Hamstring Injury | 18 Sept 2025 | 29 Sept 2025 | 11 | 2 |
 Lucas Beraldo | Ankle Sprain | 14 Sept 2025 | 20 Sept 2025 | 6 | 2 |
| Ousmane Dembélé | Hamstring Injury | 6 Sept 2025 | 15 Oct 2025 | 39 | 6 |
| Désiré Doué | Calf Injury | 6 Sept 2025 | 14 Oct 2025 | 38 | 5 |
| Khvicha Kvaratskhelia | Muscular Problems | 20 Aug 2025 | 27 Aug 2025 | 7 | 1 |
| Senny Mayulu | Adductor Injury | 11 Aug 2025 | 8 Sept 2025 | 28 | 4 |
| Ousmane Dembélé | Dead Leg | 6 Jun 2025 | 29 Jun 2025 | 23 | 4 |
| Bradley Barcola | Knee Injury | 6 Jun 2025 | 29 Jun 2025 | 23 | 3 |
| Ousmane Dembélé | Hamstring Injury | 30 Apr 2025 | 8 May 2025 | 8 | 2 |
| Willian Pacho | ILL | 18 Apr 2025 | 20 Apr 2025 | 2 | 1 |
| Kang-in Lee | Ankle Injury | 20 Mar 2025 | 6 Apr 2025 | 17 | 2 |
 Gonçalo Ramos | ILL | 15 Mar 2025 | 21 Mar 2025 | 6 | 1 |
| Senny Mayulu | Stomach Problems | 6 Feb 2025 | 8 Feb 2025 | 2 | 1 |
| João Neves | Knock | 30 Jan 2025 | 5 Feb 2025 | 6 | 1 |
| Warren Zaïre-Emery | Ankle Sprain | 29 Jan 2025 | 24 Feb 2025 | 26 | 7 |
| Ousmane Dembélé | ILL | 14 Jan 2025 | 19 Jan 2025 | 5 | 1 |
 Ibrahim Mbaye | Ankle Sprain | 11 Jan 2025 | 8 Feb 2025 | 28 | 8 |
| Marquinhos | Adductor Injury | 5 Jan 2025 | 26 Jan 2025 | 21 | 5 |
 Gianluigi Donnarumma | Facial Injury | 19 Dec 2024 | 3 Jan 2025 | 15 | 1 |
| Nuno Mendes | Hamstring Injury | 16 Dec 2024 | 20 Dec 2024 | 4 | 1 |
| Nuno Mendes | Ankle Sprain | 19 Nov 2024 | 23 Nov 2024 | 4 | 1 |
| Senny Mayulu | Calf Problems | 18 Nov 2024 | 12 Dec 2024 | 24 | 7 |
 Randal Kolo Muani | Ankle Injury | 19 Oct 2024 | 21 Oct 2024 | 2 | 1 |
| Vitinha | Ankle Injury | 25 Sept 2024 | 2 Oct 2024 | 7 | 2 |
| Désiré Doué | Ankle Injury | 25 Sept 2024 | 29 Sept 2024 | 4 | 1 |
| Nuno Mendes | Virus | 25 Sept 2024 | 29 Sept 2024 | 4 | 1 |
| Gianluigi Donnarumma | Hamstring Injury | 15 Sept 2024 | 28 Sept 2024 | 13 | 3 |
| Warren Zaïre-Emery | Calf Injury | 7 Sept 2024 | 16 Sept 2024 | 9 | 1 |
| Vitinha | Ankle Injury | 6 Sept 2024 | 17 Sept 2024 | 11 | 1 |
| Matvey Safonov | Virus | 31 Aug 2024 | 3 Sept 2024 | 3 | 1 |
| Nuno Mendes | Virus | 29 Aug 2024 | 3 Sept 2024 | 5 | 1 |
| Gonçalo Ramos | Ankle Injury | 16 Aug 2024 | 15 Nov 2024 | 91 | 15 |
| Ousmane Dembélé | Muscle Injury | 13 May 2024 | 21 May 2024 | 8 | 2 |
 Lucas Hernández | Cruciate Ligament Tear | 1 May 2024 | 1 Dec 2024 | 214 | 25 |
| Bradley Barcola | Muscle Injury | 23 Apr 2024 | 25 Apr 2024 | 2 | 1 |
| Lucas Hernández | Injury | 4 Apr 2024 | 10 Apr 2024 | 6 | 1 |
| Bradley Barcola | Hamstring Muscle Injury | 23 Mar 2024 | 7 Apr 2024 | 15 | 2 |
| Ousmane Dembélé | Ruptured Eardrum | 16 Mar 2024 | 20 Mar 2024 | 4 | 1 |
 Unknown player | Muscle Injury | 1 Mar 2024 | 28 Mar 2024 | 27 | 5 |
| Marquinhos | Achilles Tendon Contusion | 18 Feb 2024 | 4 Apr 2024 | 46 | 7 |
 Unknown player | Fitness | 14 Feb 2024 | 30 Jun 2024 | 137 | 21 |
| Randal Kolo Muani | Virus | 5 Feb 2024 | 8 Feb 2024 | 3 | 0 |
| Ousmane Dembélé | Dead Leg | 1 Feb 2024 | 8 Feb 2024 | 7 | 1 |
 Unknown player | Ankle Injury | 4 Jan 2024 | 27 Mar 2024 | 83 | 15 |
| Ousmane Dembélé | Groin Injury | 18 Dec 2023 | 8 Jan 2024 | 21 | 2 |
| Gonçalo Ramos | Flu | 11 Dec 2023 | 18 Dec 2023 | 7 | 2 |
| Fabián Ruiz | Shoulder Injury | 4 Dec 2023 | 25 Dec 2023 | 21 | 4 |
 Unknown player | Adductor Pain | 29 Nov 2023 | 10 Dec 2023 | 11 | 4 |
| Marquinhos | Hamstring Injury | 23 Nov 2023 | 3 Dec 2023 | 10 | 2 |
| Warren Zaïre-Emery | Ankle Sprain | 19 Nov 2023 | 6 Dec 2023 | 17 | 3 |
 Unknown player | Injury | 3 Nov 2023 | 20 Nov 2023 | 17 | 3 |
| Marquinhos | Adductor Pain | 28 Oct 2023 | 1 Nov 2023 | 4 | 1 |
 Unknown player | Lumbar Vertebra Problems | 24 Oct 2023 | 21 Dec 2023 | 58 | 11 |
| Warren Zaïre-Emery | Ankle Injury | 18 Oct 2023 | 24 Oct 2023 | 6 | 1 |
| Unknown player | Back Injury | 29 Sept 2023 | 4 Oct 2023 | 5 | 1 |
| Fabián Ruiz | Thigh Problems | 13 Sept 2023 | 21 Sept 2023 | 8 | 2 |
| Unknown player | Foot Injury | 9 Sept 2023 | 23 Nov 2023 | 75 | 12 |
| Randal Kolo Muani | Ankle Injury | 30 Aug 2023 | 11 Sept 2023 | 12 | 2 |
