| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Unknown player | COVID 19 | 25 Dec 2021 | 11 Jan 2022 | 17 | 2 |
 Unknown player | COVID 19 | 21 Dec 2021 | 29 Dec 2021 | 8 | 1 |
 Unknown player | Muscle Fatigue | 13 Dec 2021 | 20 Dec 2021 | 7 | 0 |
| Unknown player | Calf Problems | 13 Dec 2021 | 20 Dec 2021 | 7 | 0 |
 Stanislav Lobotka | Dead Leg | 4 Dec 2021 | 16 Dec 2021 | 12 | 3 |
 Unknown player | Hamstring Muscle Injury | 1 Dec 2021 | 2 Jan 2022 | 32 | 6 |
 Fabián Ruiz | Adductor Injury | 1 Dec 2021 | 8 Jan 2022 | 38 | 7 |
| Unknown player | Calf Problems | 1 Dec 2021 | 11 Dec 2021 | 10 | 3 |
 Unknown player | Stomach Flu | 30 Nov 2021 | 5 Dec 2021 | 5 | 1 |
 Unknown player | Flu | 26 Nov 2021 | 29 Nov 2021 | 3 | 0 |
 Unknown player | Knee Injury | 26 Nov 2021 | 3 Dec 2021 | 7 | — |
 Unknown player | Quarantine | 24 Nov 2021 | 25 Nov 2021 | 1 | 0 |
 Frank Anguissa | Adductor Injury | 22 Nov 2021 | 11 Dec 2021 | 19 | 5 |
| Unknown player | Knee Problems | 22 Nov 2021 | 26 Nov 2021 | 4 | 1 |
 Unknown player | Broken Cheekbone | 21 Nov 2021 | 14 Jan 2022 | 54 | 11 |
 Matteo Politano | COVID 19 | 20 Nov 2021 | 29 Nov 2021 | 9 | 2 |
 Alessandro Zanoli | COVID 19 | 20 Nov 2021 | 14 Dec 2021 | 24 | 7 |
| Unknown player | Fitness | 17 Nov 2021 | 22 Nov 2021 | 5 | 0 |
| Unknown player | Muscle Injury | 15 Nov 2021 | 29 Nov 2021 | 14 | 2 |
| Unknown player | COVID 19 | 12 Nov 2021 | 24 Nov 2021 | 12 | 1 |
 Unknown player | Stomach Flu | 7 Nov 2021 | 10 Nov 2021 | 3 | 1 |
| Fabián Ruiz | Adductor Pain | 3 Nov 2021 | 5 Nov 2021 | 2 | 0 |
| Unknown player | Muscle Fatigue | 30 Oct 2021 | 5 Nov 2021 | 6 | 1 |
| Unknown player | Calf Injury | 29 Oct 2021 | 5 Nov 2021 | 7 | 1 |
| Unknown player | Strain In The Thigh And Gluteal Muscles | 21 Oct 2021 | 16 Nov 2021 | 26 | 6 |
 Piotr Zielinski | Injury | 17 Oct 2021 | 22 Oct 2021 | 5 | 1 |
 Unknown player | Doubtful | 17 Oct 2021 | 5 Jul 2023 | 626 | — |
| Unknown player | Ankle Sprain | 15 Oct 2021 | 19 Oct 2021 | 4 | 1 |
 Unknown player | Muscle Strain | 8 Oct 2021 | 18 Nov 2021 | 41 | 7 |
| Unknown player | Hamstring Strain | 2 Oct 2021 | 2 Nov 2021 | 31 | 6 |
 Amir Rrahmani | Doubtful | 26 Sept 2021 | 5 Jul 2023 | 647 | — |
| Unknown player | Fitness | 21 Sept 2021 | 25 Sept 2021 | 4 | 1 |
| Unknown player | Muscle Fatigue | 12 Sept 2021 | 17 Sept 2021 | 5 | 0 |
 Unknown player | Fitness | 9 Sept 2021 | 25 Sept 2021 | 16 | 4 |
| Stanislav Lobotka | Muscle Injury | 8 Sept 2021 | 15 Oct 2021 | 37 | 7 |
| Unknown player | Fitness | 1 Sept 2021 | 27 Sept 2021 | 26 | 5 |
 Alex Meret | Lumbar Vertebra Fracture | 29 Aug 2021 | 19 Sept 2021 | 21 | 4 |
| Piotr Zielinski | Dead Leg | 23 Aug 2021 | 9 Sept 2021 | 17 | 2 |
| Unknown player | Doubtful | 22 Aug 2021 | 5 Jul 2023 | 682 | — |
| Unknown player | Knee Medial Ligament Tear | 25 Jul 2021 | 21 Sept 2021 | 58 | 9 |
| Unknown player | Shoulder Injury | 5 Jul 2021 | 8 Sept 2021 | 65 | 8 |
 Unknown player | Fitness | 20 May 2021 | 24 May 2021 | 4 | 0 |
| Unknown player | Hamstring Muscle Injury | 7 May 2021 | 28 May 2021 | 21 | — |
| Unknown player | Leg Injury | 4 May 2021 | 24 May 2021 | 20 | 3 |
| Stanislav Lobotka | Tonsillitis | 4 May 2021 | 19 May 2021 | 15 | 3 |
| Unknown player | COVID 19 | 4 May 2021 | 19 May 2021 | 15 | 3 |
| Stanislav Lobotka | Flu | 29 Apr 2021 | 4 May 2021 | 5 | 1 |
 Unknown player | Muscle Injury | 11 Apr 2021 | 6 May 2021 | 25 | 5 |
| Unknown player | Shin Bruise | 30 Mar 2021 | 5 Apr 2021 | 6 | 1 |
| Stanislav Lobotka | Tonsillitis | 17 Mar 2021 | 25 Mar 2021 | 8 | 1 |
 Giovanni Di Lorenzo | Doubtful | 14 Mar 2021 | 5 Jul 2023 | 843 | — |
| Unknown player | Doubtful | 14 Mar 2021 | 5 Jul 2023 | 843 | — |
| Unknown player | Doubtful | 14 Mar 2021 | 5 Jul 2023 | 843 | — |
| Unknown player | Fitness | 13 Mar 2021 | 15 Mar 2021 | 2 | 0 |
| Amir Rrahmani | Thigh Problems | 13 Mar 2021 | 31 Mar 2021 | 18 | 2 |
| Unknown player | Cruciate Ligament Tear | 7 Mar 2021 | 1 Sept 2021 | 178 | 21 |
| Unknown player | Doubtful | 3 Mar 2021 | 5 Jul 2023 | 854 | — |
| Unknown player | Doubtful | 25 Feb 2021 | 5 Jul 2023 | 860 | — |
| Unknown player | Head Injury | 22 Feb 2021 | 5 Mar 2021 | 11 | 3 |
| Matteo Politano | Doubtful | 21 Feb 2021 | 5 Jul 2023 | 864 | — |
| Unknown player | Thigh Problems | 16 Feb 2021 | 31 Mar 2021 | 43 | 8 |
| Unknown player | Hamstring Injury | 14 Feb 2021 | 15 Mar 2021 | 29 | 6 |
| Unknown player | Adductor Pain | 13 Feb 2021 | 26 Feb 2021 | 13 | 3 |
| Unknown player | Hamstring Injury | 11 Feb 2021 | 26 Feb 2021 | 15 | 3 |
 Unknown player | Calf Problems | 10 Feb 2021 | 26 Feb 2021 | 16 | 4 |
| Unknown player | Ankle Sprain | 7 Feb 2021 | 2 Mar 2021 | 23 | 6 |
| Fabián Ruiz | Fitness | 5 Feb 2021 | 7 Feb 2021 | 2 | 0 |
| Unknown player | COVID 19 | 5 Feb 2021 | 19 Feb 2021 | 14 | 3 |
| Unknown player | COVID 19 | 5 Feb 2021 | 19 Feb 2021 | 14 | 3 |
| Unknown player | Ankle Injury | 30 Jan 2021 | 23 Feb 2021 | 24 | 7 |
| Fabián Ruiz | COVID 19 | 16 Jan 2021 | 4 Feb 2021 | 19 | 5 |
| Unknown player | Doubtful | 10 Jan 2021 | 10 Jan 2021 | 0 | 1 |
| Unknown player | Muscle Strain | 10 Jan 2021 | 15 Jan 2021 | 5 | 2 |
| Unknown player | Bruised Back | 4 Jan 2021 | 9 Jan 2021 | 5 | 1 |
| Unknown player | Doubtful | 3 Jan 2021 | 3 Jan 2021 | 0 | 1 |
| Unknown player | COVID 19 | 1 Jan 2021 | 22 Jan 2021 | 21 | 6 |
| Unknown player | Calf Problems | 30 Dec 2020 | 25 Jan 2021 | 26 | 6 |
| Unknown player | Muscle Injury | 20 Dec 2020 | 9 Jan 2021 | 20 | 4 |
| Unknown player | Distortion Of The Ankle | 16 Dec 2020 | 11 Jan 2021 | 26 | 5 |
| Amir Rrahmani | Fitness | 11 Dec 2020 | 14 Dec 2020 | 3 | 0 |
| Amir Rrahmani | Quarantine | 10 Dec 2020 | 11 Dec 2020 | 1 | 0 |
| Fabián Ruiz | Doubtful | 6 Dec 2020 | 4 Jul 2023 | 940 | — |
| Unknown player | Knee Problems | 5 Dec 2020 | 11 Dec 2020 | 6 | 1 |
| Unknown player | Fitness | 3 Dec 2020 | 14 Dec 2020 | 11 | 3 |
| Amir Rrahmani | Fitness | 2 Dec 2020 | 7 Dec 2020 | 5 | 1 |
 Unknown player | Doubtful | 22 Nov 2020 | 4 Jul 2023 | 954 | — |
 Unknown player | Injury | 20 Nov 2020 | 8 Feb 2021 | 80 | — |
| Amir Rrahmani | COVID 19 | 18 Nov 2020 | 2 Dec 2020 | 14 | 3 |
| Unknown player | COVID 19 | 17 Nov 2020 | 2 Dec 2020 | 15 | 3 |
| Unknown player | Shoulder Injury | 14 Nov 2020 | 15 Jan 2021 | 62 | 14 |
| Unknown player | Hamstring Injury | 30 Oct 2020 | 3 Nov 2020 | 4 | 1 |
 Eljif Elmas | Doubtful | 29 Oct 2020 | 4 Jul 2023 | 978 | — |
| Piotr Zielinski | Doubtful | 29 Oct 2020 | 4 Jul 2023 | 978 | — |
| Eljif Elmas | Fitness | 24 Oct 2020 | 26 Oct 2020 | 2 | 0 |
| Piotr Zielinski | Fitness | 24 Oct 2020 | 26 Oct 2020 | 2 | 0 |
| Eljif Elmas | COVID 19 | 3 Oct 2020 | 23 Oct 2020 | 20 | 1 |
| Piotr Zielinski | COVID 19 | 1 Oct 2020 | 23 Oct 2020 | 22 | 1 |
 Unknown player | Doubtful | 27 Sept 2020 | 4 Jul 2023 | 1010 | — |
| Unknown player | Hamstring Muscle Injury | 27 Sept 2020 | 18 Oct 2020 | 21 | 1 |
| Unknown player | Doubtful | 27 Sept 2020 | 4 Jul 2023 | 1010 | — |
