| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Unknown player | Injury | 9 Jan 2022 | 18 Jan 2022 | 9 | 2 |
 Unknown player | COVID 19 | 31 Dec 2021 | 20 Jan 2022 | 20 | 4 |
 Unknown player | COVID 19 | 28 Dec 2021 | 7 Jan 2022 | 10 | 0 |
| Unknown player | Calf Problems | 21 Dec 2021 | 10 Feb 2022 | 51 | 7 |
 Unknown player | Injury | 20 Dec 2021 | 2 Feb 2022 | 44 | 6 |
 Unknown player | Injury | 17 Dec 2021 | 19 Jan 2022 | 33 | 6 |
 Unknown player | Injury | 17 Dec 2021 | 5 Jan 2022 | 19 | 2 |
 Unknown player | Fever | 4 Dec 2021 | 8 Dec 2021 | 4 | 1 |
 Unknown player | Hamstring Muscle Injury | 1 Dec 2021 | 9 Dec 2021 | 8 | 2 |
 Nicolò Rovella | Muscle Injury | 1 Dec 2021 | 9 Jan 2022 | 39 | 7 |
| Unknown player | Adductor Injury | 16 Nov 2021 | 9 Dec 2021 | 23 | 4 |
| Unknown player | Muscular Problems | 15 Nov 2021 | 9 Dec 2021 | 24 | 4 |
 Unknown player | Muscular Problems | 6 Nov 2021 | 4 Jan 2022 | 59 | 8 |
 Unknown player | Injury | 31 Oct 2021 | 9 Dec 2021 | 39 | 6 |
| Unknown player | Flu | 31 Oct 2021 | 3 Nov 2021 | 3 | 1 |
 Mohamed Fares | Muscle Injury | 23 Oct 2021 | 26 Dec 2021 | 64 | 11 |
 Unknown player | Muscular Problems | 15 Oct 2021 | 27 Nov 2021 | 43 | 6 |
 Unknown player | Adductor Injury | 14 Oct 2021 | 20 Nov 2021 | 37 | 5 |
 Unknown player | Muscle Strain | 9 Oct 2021 | 21 Jan 2022 | 104 | 17 |
| Unknown player | Muscular Problems | 2 Oct 2021 | 14 Oct 2021 | 12 | 1 |
| Unknown player | Muscular Problems | 30 Sept 2021 | 21 Nov 2021 | 52 | 6 |
| Unknown player | Adductor Injury | 27 Sept 2021 | 14 Oct 2021 | 17 | 1 |
 Unknown player | Shin Bruise | 27 Sept 2021 | 7 Oct 2021 | 10 | 1 |
| Unknown player | Injury | 20 Sept 2021 | 24 Sept 2021 | 4 | 1 |
| Unknown player | Muscle Fatigue | 17 Sept 2021 | 16 Oct 2021 | 29 | 4 |
 Unknown player | Muscle Fatigue | 17 Sept 2021 | 24 Sept 2021 | 7 | 2 |
| Unknown player | Injury | 11 Sept 2021 | 17 Sept 2021 | 6 | 1 |
| Unknown player | Muscle Fatigue | 10 Sept 2021 | 15 Oct 2021 | 35 | 5 |
 Unknown player | Knee Surgery | 27 Aug 2021 | 13 Dec 2021 | 108 | 17 |
| Unknown player | Calf Problems | 3 Aug 2021 | 13 Sept 2021 | 41 | 4 |
 Edoardo Goldaniga | Injury | 15 May 2021 | 22 May 2021 | 7 | 1 |
 Gianluca Scamacca | Muscle Fatigue | 12 May 2021 | 22 May 2021 | 10 | 2 |
| Unknown player | Injury | 12 May 2021 | 22 May 2021 | 10 | 2 |
 Unknown player | Lumbago | 11 May 2021 | 23 May 2021 | 12 | 2 |
 Unknown player | Injury | 9 May 2021 | 11 May 2021 | 2 | 1 |
| Unknown player | Muscle Injury | 7 May 2021 | 6 Jun 2021 | 30 | 4 |
| Unknown player | Calf Injury | 2 May 2021 | 21 May 2021 | 19 | 4 |
 Davide Zappacosta | Hamstring Muscle Injury | 14 Apr 2021 | 20 Apr 2021 | 6 | 1 |
| Unknown player | Knee Injury | 10 Apr 2021 | 18 Apr 2021 | 8 | 1 |
| Unknown player | Hamstring Injury | 11 Mar 2021 | 2 Apr 2021 | 22 | 2 |
 Mattia Perin | Muscular Problems | 7 Mar 2021 | 13 Mar 2021 | 6 | 1 |
 Unknown player | Muscular Problems | 5 Mar 2021 | 12 Mar 2021 | 7 | 1 |
| Nicolò Rovella | Ankle Problems | 2 Mar 2021 | 7 Mar 2021 | 5 | 1 |
 Luca Pellegrini | Thigh Problems | 22 Feb 2021 | 31 May 2021 | 98 | 15 |
 Unknown player | Muscle Fatigue | 4 Feb 2021 | 11 Feb 2021 | 7 | 1 |
 Unknown player | Muscle Fatigue | 3 Feb 2021 | 11 Feb 2021 | 8 | 1 |
 Unknown player | Muscle Fatigue | 2 Feb 2021 | 11 Feb 2021 | 9 | 1 |
 Alberto Paleari | Muscle Fatigue | 30 Jan 2021 | 6 Mar 2021 | 35 | 6 |
 Unknown player | Injury | 21 Jan 2021 | 28 Jan 2021 | 7 | 1 |
| Unknown player | Muscle Fatigue | 15 Jan 2021 | 22 Jan 2021 | 7 | 1 |
| Unknown player | Injury | 12 Jan 2021 | 6 Feb 2021 | 25 | 4 |
| Unknown player | Muscle Fatigue | 23 Dec 2020 | 16 Jan 2021 | 24 | 5 |
| Unknown player | Injury | 20 Dec 2020 | 5 Jan 2021 | 16 | 3 |
| Luca Pellegrini | Adductor Pain | 14 Dec 2020 | 1 Feb 2021 | 49 | 9 |
| Unknown player | Lumbago | 13 Dec 2020 | 19 Dec 2020 | 6 | 2 |
| Unknown player | Muscle Fatigue | 11 Dec 2020 | 15 Dec 2020 | 4 | 1 |
 Unknown player | Thigh Problems | 7 Dec 2020 | 8 Jan 2021 | 32 | 7 |
 Unknown player | Muscular Problems | 7 Dec 2020 | 27 Feb 2021 | 82 | 15 |
 Unknown player | Muscular Problems | 6 Dec 2020 | 28 Jan 2021 | 53 | 11 |
| Unknown player | Injury | 30 Nov 2020 | 1 Dec 2020 | 1 | 0 |
 Unknown player | Muscular Problems | 28 Nov 2020 | 12 Dec 2020 | 14 | 2 |
| Unknown player | Shoulder Injury | 22 Nov 2020 | 13 Mar 2021 | 111 | 21 |
| Mattia Perin | Hamstring Muscle Injury | 22 Nov 2020 | 13 Dec 2020 | 21 | 4 |
| Nicolò Rovella | Stomach Flu | 21 Nov 2020 | 25 Nov 2020 | 4 | 1 |
 Unknown player | Knee Injury | 15 Nov 2020 | 15 Mar 2021 | 120 | — |
| Unknown player | Hamstring Injury | 12 Nov 2020 | 25 Nov 2020 | 13 | 1 |
| Unknown player | Knee Problems | 9 Nov 2020 | 15 Dec 2020 | 36 | 5 |
| Unknown player | COVID 19 | 7 Nov 2020 | 17 Nov 2020 | 10 | 1 |
| Unknown player | Muscle Injury | 1 Nov 2020 | 2 Mar 2021 | 121 | 22 |
| Unknown player | Muscular Problems | 27 Oct 2020 | 16 Nov 2020 | 20 | 4 |
| Unknown player | Doubtful | 24 Oct 2020 | 24 Oct 2020 | 0 | 1 |
| Davide Zappacosta | Injury | 24 Oct 2020 | 19 Dec 2020 | 56 | 11 |
 Unknown player | COVID 19 | 19 Oct 2020 | 9 Nov 2020 | 21 | 5 |
 Unknown player | COVID 19 | 2 Oct 2020 | 28 Oct 2020 | 26 | 2 |
| Unknown player | COVID 19 | 30 Sept 2020 | 22 Oct 2020 | 22 | 1 |
| Davide Zappacosta | COVID 19 | 30 Sept 2020 | 22 Oct 2020 | 22 | 1 |
| Unknown player | COVID 19 | 30 Sept 2020 | 22 Oct 2020 | 22 | 1 |
| Unknown player | COVID 19 | 30 Sept 2020 | 20 Oct 2020 | 20 | 0 |
| Luca Pellegrini | COVID 19 | 28 Sept 2020 | 22 Oct 2020 | 24 | 1 |
 Unknown player | COVID 19 | 27 Sept 2020 | 14 Oct 2020 | 17 | 1 |
| Mattia Perin | COVID 19 | 26 Sept 2020 | 11 Oct 2020 | 15 | 1 |
| Unknown player | COVID 19 | 19 Sept 2020 | 22 Oct 2020 | 33 | 3 |
| Unknown player | COVID 19 | 16 Sept 2020 | 23 Oct 2020 | 37 | 3 |
 Unknown player | Injury | 16 Sept 2020 | 26 Oct 2020 | 40 | 4 |
| Unknown player | Injury | 1 Sept 2020 | 18 Oct 2020 | 47 | 5 |
| Unknown player | Injury | 1 Sept 2020 | 13 Nov 2020 | 73 | 11 |
 Unknown player | Muscle Injury | 20 Aug 2020 | 30 Sept 2020 | 41 | 5 |
| Unknown player | Thigh Problems | 20 Jul 2020 | 10 Aug 2020 | 21 | 4 |
| Unknown player | Injury | 17 Jul 2020 | 21 Jul 2020 | 4 | 1 |
| Unknown player | Muscular Problems | 7 Jul 2020 | 17 Jul 2020 | 10 | 2 |
| Unknown player | Hamstring Injury | 24 Jun 2020 | 13 Jul 2020 | 19 | 4 |
 Unknown player | Muscle Fatigue | 22 Jun 2020 | 26 Jun 2020 | 4 | 1 |
 Andrea Pinamonti | Flu | 22 Feb 2020 | 27 Feb 2020 | 5 | 1 |
 Unknown player | Cruciate Ligament Rupture | 16 Feb 2020 | 31 Aug 2020 | 197 | 14 |
 Unknown player | Flu | 14 Feb 2020 | 18 Feb 2020 | 4 | 1 |
 Unknown player | Hamstring Muscle Injury | 10 Feb 2020 | 20 Mar 2020 | 39 | 3 |
| Unknown player | Muscular Problems | 10 Feb 2020 | 20 Feb 2020 | 10 | 1 |
| Unknown player | Muscular Problems | 6 Feb 2020 | 13 Feb 2020 | 7 | 1 |
 Cristian Romero | Knee Injury | 3 Feb 2020 | 26 Feb 2020 | 23 | 3 |
 Unknown player | Inflammation | 31 Jan 2020 | 15 Mar 2020 | 44 | 5 |
