| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Ousmane Dembélé | COVID 19 | 29 Dec 2021 | 5 Jan 2022 | 7 | 1 |
 Gavi | COVID 19 | 29 Dec 2021 | 7 Jan 2022 | 9 | 2 |
 Alejandro Balde | COVID 19 | 28 Dec 2021 | 7 Jan 2022 | 10 | — |
 Unknown player | COVID 19 | 28 Dec 2021 | 3 Jan 2022 | 6 | 0 |
 Unknown player | COVID 19 | 27 Dec 2021 | 3 Jan 2022 | 7 | 0 |
 Unknown player | Adductor Pain | 17 Dec 2021 | 28 Dec 2021 | 11 | 2 |
 Unknown player | Stomach Problems | 16 Dec 2021 | 27 Dec 2021 | 11 | 2 |
 Unknown player | Hamstring Injury | 9 Dec 2021 | 10 Jan 2022 | 32 | 5 |
| Unknown player | Hamstring Injury | 9 Dec 2021 | 16 Dec 2021 | 7 | 1 |
 Unknown player | Hamstring Injury | 22 Nov 2021 | 27 Apr 2022 | 156 | 22 |
 Ansu Fati | Hamstring Injury | 7 Nov 2021 | 11 Jan 2022 | 65 | 11 |
 Unknown player | Cold | 5 Nov 2021 | 8 Nov 2021 | 3 | 1 |
| Ousmane Dembélé | Hamstring Injury | 4 Nov 2021 | 22 Nov 2021 | 18 | 2 |
| Unknown player | Lumbago | 2 Nov 2021 | 22 Nov 2021 | 20 | 3 |
 Unknown player | Muscle Injury | 31 Oct 2021 | 14 Nov 2021 | 14 | 2 |
 Unknown player | Heart Problems | 31 Oct 2021 | 15 Dec 2021 | 45 | — |
| Unknown player | Muscle Injury | 28 Oct 2021 | 20 Nov 2021 | 23 | 3 |
| Ansu Fati | Knee Problems | 27 Oct 2021 | 1 Nov 2021 | 5 | 2 |
 Frenkie de Jong | Muscle Injury | 25 Oct 2021 | 1 Nov 2021 | 7 | 2 |
 Ronald Araujo | Hamstring Injury | 11 Oct 2021 | 1 Nov 2021 | 21 | 5 |
 Pedri | Hamstring Injury | 30 Sept 2021 | 10 Jan 2022 | 102 | 19 |
 Unknown player | Foot Injury | 25 Sept 2021 | 28 Oct 2021 | 33 | 4 |
| Unknown player | Stomach Flu | 25 Sept 2021 | 28 Sept 2021 | 3 | 1 |
| Alejandro Balde | Lumbago | 20 Sept 2021 | 14 Oct 2021 | 24 | 3 |
 Nico González | Knock | 18 Sept 2021 | 22 Sept 2021 | 4 | 1 |
| Pedri | Hamstring Injury | 16 Sept 2021 | 27 Sept 2021 | 11 | 2 |
| Unknown player | Muscle Injury | 15 Sept 2021 | 1 Oct 2021 | 16 | 4 |
| Ansu Fati | Fitness | 10 Sept 2021 | 24 Sept 2021 | 14 | 2 |
 Unknown player | Knee Injury | 30 Aug 2021 | 20 Jan 2022 | 143 | 25 |
| Unknown player | Calf Injury | 22 Aug 2021 | 14 Sept 2021 | 23 | 1 |
 Unknown player | Fitness | 8 Aug 2021 | 25 Aug 2021 | 17 | 3 |
| Unknown player | Calf Injury | 7 Aug 2021 | 16 Oct 2021 | 70 | 10 |
 Óscar Mingueza | Muscle Injury | 1 Aug 2021 | 24 Aug 2021 | 23 | 4 |
| Ousmane Dembélé | Knee Injury | 20 Jun 2021 | 1 Nov 2021 | 134 | 19 |
 Unknown player | Knee Surgery | 17 May 2021 | 28 Aug 2021 | 103 | 8 |
| Unknown player | Hamstring Injury | 12 May 2021 | 12 Jun 2021 | 31 | 2 |
 Unknown player | Muscular Problems | 24 Apr 2021 | 2 May 2021 | 8 | 1 |
| Ousmane Dembélé | Injury | 21 Apr 2021 | 23 Apr 2021 | 2 | 0 |
| Unknown player | Ankle Injury | 20 Apr 2021 | 4 May 2021 | 14 | 4 |
| Unknown player | Ankle Sprain | 22 Mar 2021 | 24 Apr 2021 | 33 | 4 |
| Unknown player | Knee Medial Ligament Tear | 4 Mar 2021 | 9 Apr 2021 | 36 | 5 |
 Unknown player | Ankle Injury | 26 Feb 2021 | 5 Mar 2021 | 7 | 2 |
| Ronald Araujo | Ankle Injury | 25 Feb 2021 | 15 Mar 2021 | 18 | 4 |
| Unknown player | Foot Injury | 9 Feb 2021 | 13 Feb 2021 | 4 | 1 |
| Unknown player | Hamstring Injury | 9 Feb 2021 | 16 Feb 2021 | 7 | 2 |
| Ronald Araujo | Ankle Sprain | 8 Feb 2021 | 1 Mar 2021 | 21 | 6 |
| Unknown player | Muscular Problems | 8 Feb 2021 | 13 Feb 2021 | 5 | 1 |
| Unknown player | Muscle Injury | 4 Feb 2021 | 8 Apr 2021 | 63 | 13 |
| Unknown player | Muscular Problems | 25 Jan 2021 | 2 Feb 2021 | 8 | 2 |
| Unknown player | Doubtful | 24 Jan 2021 | 24 Jan 2021 | 0 | 1 |
| Unknown player | Muscular Problems | 18 Jan 2021 | 23 Jan 2021 | 5 | 1 |
 Unknown player | Thigh Problems | 12 Jan 2021 | 15 Jan 2021 | 3 | 1 |
 Unknown player | Doubtful | 6 Jan 2021 | 6 Jan 2021 | 0 | 1 |
| Unknown player | Stomach Problems | 2 Jan 2021 | 5 Jan 2021 | 3 | 1 |
| Unknown player | Tear Of The Lateral Meniscus | 30 Dec 2020 | 7 Aug 2021 | 220 | 37 |
| Unknown player | Ankle Injury | 23 Dec 2020 | 1 Jan 2021 | 9 | 1 |
 Unknown player | Patellar Tendon Rupture | 13 Dec 2020 | 24 Jan 2022 | 407 | 67 |
 Unknown player | Hamstring Injury | 7 Dec 2020 | 27 Feb 2021 | 82 | 8 |
| Ousmane Dembélé | Hamstring Injury | 6 Dec 2020 | 28 Dec 2020 | 22 | 5 |
| Unknown player | COVID 19 | 1 Dec 2020 | 15 Dec 2020 | 14 | 4 |
| Unknown player | Rest | 1 Dec 2020 | 3 Dec 2020 | 2 | 0 |
 Unknown player | Doubtful | 29 Nov 2020 | 29 Nov 2020 | 0 | 1 |
| Unknown player | Knee Injury | 22 Nov 2020 | 16 Feb 2021 | 86 | 23 |
| Unknown player | Muscle Injury | 22 Nov 2020 | 30 Jan 2021 | 69 | 18 |
| Unknown player | Doubtful | 21 Nov 2020 | 21 Nov 2020 | 0 | 1 |
| Unknown player | Outer Ligament Problems | 14 Nov 2020 | 28 Nov 2020 | 14 | 2 |
| Ansu Fati | Meniscus Tear | 8 Nov 2020 | 9 Sept 2021 | 305 | 52 |
| Unknown player | Doubtful | 4 Nov 2020 | 4 Nov 2020 | 0 | 1 |
| Ronald Araujo | Muscle Injury | 29 Oct 2020 | 7 Dec 2020 | 39 | 7 |
| Unknown player | Hamstring Injury | 25 Oct 2020 | 20 Nov 2020 | 26 | 4 |
| Unknown player | Doubtful | 24 Oct 2020 | 24 Oct 2020 | 0 | 1 |
| Óscar Mingueza | Hamstring Injury | 23 Oct 2020 | 6 Nov 2020 | 14 | 1 |
 Junior Firpo | Doubtful | 17 Oct 2020 | 17 Oct 2020 | 0 | 1 |
| Unknown player | Doubtful | 17 Oct 2020 | 17 Oct 2020 | 0 | 1 |
| Unknown player | Muscle Injury | 5 Oct 2020 | 23 Oct 2020 | 18 | 2 |
| Junior Firpo | Muscle Injury | 30 Sept 2020 | 16 Oct 2020 | 16 | 2 |
| Unknown player | Muscle Injury | 20 Sept 2020 | 30 Sept 2020 | 10 | 1 |
 Unknown player | Muscular Problems | 14 Sept 2020 | 26 Oct 2020 | 42 | 8 |
| Unknown player | Knee Injury | 10 Sept 2020 | 8 Dec 2020 | 89 | 18 |
 Jean-Clair Todibo | Fitness | 10 Sept 2020 | 5 Oct 2020 | 25 | — |
| Unknown player | Knee Injury | 17 Aug 2020 | 3 Nov 2020 | 78 | 11 |
| Jean-Clair Todibo | COVID 19 | 14 Aug 2020 | 9 Sept 2020 | 26 | 1 |
| Unknown player | COVID 19 | 14 Aug 2020 | 9 Sept 2020 | 26 | 1 |
 Unknown player | Ankle Injury | 18 Jul 2020 | 25 Jul 2020 | 7 | 1 |
 Unknown player | Muscle Injury | 13 Jul 2020 | 3 Aug 2020 | 21 | 2 |
| Unknown player | Tonsillitis | 10 Jul 2020 | 15 Jul 2020 | 5 | 1 |
| Junior Firpo | Hip Problems | 4 Jul 2020 | 10 Jul 2020 | 6 | 2 |
| Unknown player | Knee Problems | 3 Jul 2020 | 9 Sept 2020 | 68 | 7 |
| Unknown player | Rib Fracture | 18 Jun 2020 | 29 Jun 2020 | 11 | 3 |
| Frenkie de Jong | Muscle Injury | 18 Jun 2020 | 13 Jul 2020 | 25 | 7 |
| Unknown player | Ankle Injury | 5 Mar 2020 | 16 Mar 2020 | 11 | 1 |
| Unknown player | Muscle Injury | 23 Feb 2020 | 23 Mar 2020 | 29 | 3 |
| Unknown player | Hamstring Injury | 16 Feb 2020 | 29 Feb 2020 | 13 | 2 |
| Ousmane Dembélé | Hamstring Injury | 4 Feb 2020 | 13 Aug 2020 | 191 | 19 |
 Unknown player | Knock | 1 Feb 2020 | 5 Feb 2020 | 4 | 1 |
 Unknown player | ILL | 24 Jan 2020 | 28 Jan 2020 | 4 | 1 |
| Unknown player | Ankle Sprain | 23 Jan 2020 | 14 Feb 2020 | 22 | 5 |
 Unknown player | Knee Surgery | 10 Jan 2020 | 7 Jun 2020 | 149 | 12 |
 Unknown player | Hamstring Injury | 3 Jan 2020 | 14 Jan 2020 | 11 | 1 |
| Unknown player | Knee Injury | 30 Dec 2019 | 10 Jan 2020 | 11 | 1 |
