| Player | Reason | From | Until | Days | Games missed |
|---|---|---|---|---|---|
 Unknown player | Broken Foot | 14 Dec 2021 | 6 Jan 2022 | 23 | 2 |
 Richarlison | Calf Injury | 12 Dec 2021 | 12 Jan 2022 | 31 | 4 |
 Unknown player | Knee Injury | 19 Nov 2021 | 30 Jun 2022 | 223 | 18 |
 Yerry Mina | Thigh Problems | 22 Oct 2021 | 30 Nov 2021 | 39 | 5 |
 Unknown player | Stress Reaction Of The Bone | 17 Oct 2021 | 28 Nov 2021 | 42 | 5 |
 Alex Iwobi | Calf Injury | 1 Oct 2021 | 13 Oct 2021 | 12 | 1 |
 Unknown player | Calf Injury | 21 Sept 2021 | 5 Dec 2021 | 75 | 10 |
 Unknown player | Hamstring Injury | 17 Sept 2021 | 15 Oct 2021 | 28 | 4 |
| Richarlison | Knee Injury | 13 Sept 2021 | 22 Oct 2021 | 39 | 6 |
 Jordan Pickford | Shoulder Injury | 13 Sept 2021 | 27 Sept 2021 | 14 | 4 |
 Dominic Calvert-Lewin | Broken Toe | 28 Aug 2021 | 31 Dec 2021 | 125 | 16 |
 Unknown player | Shoulder Injury | 27 Aug 2021 | 25 Oct 2021 | 59 | 8 |
 Unknown player | Quarantine | 12 Aug 2021 | 21 Sept 2021 | 40 | 6 |
 Moise Kean | Quarantine | 12 Aug 2021 | 19 Aug 2021 | 7 | 1 |
| Unknown player | Calf Injury | 1 May 2021 | 14 May 2021 | 13 | 2 |
 Unknown player | Inner Ligament Injury | 10 Apr 2021 | 30 Jun 2021 | 81 | 9 |
 Unknown player | Ankle Injury | 3 Apr 2021 | 4 Oct 2021 | 184 | 2 |
| Unknown player | Foot Injury | 4 Mar 2021 | 7 May 2021 | 64 | 9 |
| Unknown player | Calf Injury | 22 Feb 2021 | 1 Apr 2021 | 38 | 5 |
| Yerry Mina | Calf Injury | 18 Feb 2021 | 12 Mar 2021 | 22 | 4 |
| Dominic Calvert-Lewin | Hamstring Injury | 11 Feb 2021 | 19 Feb 2021 | 8 | 2 |
| Unknown player | Calf Injury | 7 Feb 2021 | 13 Feb 2021 | 6 | 1 |
| Jordan Pickford | Chest Injury | 28 Jan 2021 | 18 Feb 2021 | 21 | 5 |
 Niels Nkounkou | Hamstring Injury | 20 Jan 2021 | 3 Feb 2021 | 14 | 3 |
| Richarlison | Bruise | 2 Jan 2021 | 11 Jan 2021 | 9 | 1 |
| Dominic Calvert-Lewin | Muscle Injury | 2 Jan 2021 | 26 Jan 2021 | 24 | 3 |
| Richarlison | Head Injury | 25 Dec 2020 | 31 Dec 2020 | 6 | 1 |
 Unknown player | Muscle Injury | 17 Dec 2020 | 13 Feb 2021 | 58 | 12 |
| Unknown player | Hamstring Injury | 6 Dec 2020 | 3 Feb 2021 | 59 | 11 |
| Unknown player | Calf Injury | 6 Dec 2020 | 31 Dec 2020 | 25 | 5 |
 Lucas Digne | Ankle Injury | 26 Nov 2020 | 11 Jan 2021 | 46 | 9 |
| Unknown player | Muscle Injury | 8 Nov 2020 | 18 Dec 2020 | 40 | 5 |
| Unknown player | Doubtful | 7 Nov 2020 | 7 Nov 2020 | 0 | 1 |
 Unknown player | Doubtful | 7 Nov 2020 | 7 Nov 2020 | 0 | 1 |
| Unknown player | Doubtful | 7 Nov 2020 | 7 Nov 2020 | 0 | 1 |
 Unknown player | Knee Problems | 6 Nov 2020 | 10 Dec 2020 | 34 | 4 |
| Unknown player | Bruise | 2 Nov 2020 | 27 Nov 2020 | 25 | 2 |
| Unknown player | Bruise | 28 Oct 2020 | 4 Nov 2020 | 7 | 1 |
| Unknown player | Groin Injury | 26 Oct 2020 | 6 Nov 2020 | 11 | 1 |
| Unknown player | Hamstring Injury | 26 Oct 2020 | 6 Nov 2020 | 11 | 1 |
| Lucas Digne | Doubtful | 17 Oct 2020 | 17 Oct 2020 | 0 | 1 |
| Unknown player | Muscle Injury | 17 Oct 2020 | 5 Nov 2020 | 19 | 3 |
| Richarlison | Doubtful | 3 Oct 2020 | 3 Oct 2020 | 0 | 1 |
| Unknown player | Groin Injury | 2 Oct 2020 | 16 Oct 2020 | 14 | 1 |
| Unknown player | Ankle Injury | 2 Oct 2020 | 31 Oct 2020 | 29 | 3 |
| Unknown player | Bruise | 27 Sept 2020 | 16 Oct 2020 | 19 | 2 |
| Moise Kean | Knock | 27 Sept 2020 | 14 Oct 2020 | 17 | — |
 Unknown player | Ankle Injury | 18 Sept 2020 | 6 Nov 2020 | 49 | 8 |
 Jarrad Branthwaite | Ankle Injury | 16 Sept 2020 | 1 Nov 2020 | 46 | 8 |
| Moise Kean | Knee Injury | 17 Jul 2020 | 25 Jul 2020 | 8 | 1 |
| Yerry Mina | Muscle Injury | 13 Jul 2020 | 12 Sept 2020 | 61 | 5 |
| Unknown player | Calf Injury | 7 Jul 2020 | 15 Jul 2020 | 8 | 2 |
 Djibril Sidibé | Foot Injury | 21 Jun 2020 | 1 Jul 2020 | 10 | 2 |
 Unknown player | Abdominal Muscle Strain | 8 Jun 2020 | 8 Jul 2020 | 30 | 4 |
| Unknown player | Calf Injury | 2 Jun 2020 | 23 Sept 2020 | 113 | 14 |
| Yerry Mina | Muscle Injury | 2 Jun 2020 | 30 Jun 2020 | 28 | 2 |
| Unknown player | Achilles Tendon Rupture | 28 May 2020 | 2 Apr 2021 | 309 | 47 |
 Unknown player | Cruciate Ligament Injury | 2 Mar 2020 | 26 Oct 2020 | 238 | 21 |
| Unknown player | Hamstring Strain | 2 Mar 2020 | 14 Jun 2020 | 104 | 1 |
 Unknown player | Knee Injury | 24 Feb 2020 | 22 Aug 2020 | 180 | 12 |
| Unknown player | Knee Injury | 9 Feb 2020 | 28 Feb 2020 | 19 | 1 |
| Lucas Digne | Calf Injury | 9 Feb 2020 | 7 Mar 2020 | 27 | 2 |
| Unknown player | ILL | 30 Jan 2020 | 4 Feb 2020 | 5 | 1 |
 Michael Keane | Neck Injury | 17 Jan 2020 | 20 Jan 2020 | 3 | 1 |
 Unknown player | Groin Injury | 12 Jan 2020 | 31 Jan 2020 | 19 | 2 |
| Richarlison | Knee Injury | 12 Jan 2020 | 30 Jan 2020 | 18 | 2 |
 Unknown player | Knee Injury | 1 Jan 2020 | 4 Jan 2020 | 3 | 1 |
| Alex Iwobi | Hamstring Injury | 23 Dec 2019 | 27 Jan 2020 | 35 | 7 |
| Djibril Sidibé | Injury | 15 Dec 2019 | 18 Dec 2019 | 3 | 1 |
| Unknown player | Knock | 8 Dec 2019 | 20 Dec 2019 | 12 | 2 |
| Unknown player | Calf Injury | 8 Dec 2019 | 4 Jan 2020 | 27 | 6 |
| Unknown player | Calf Injury | 8 Dec 2019 | 25 Dec 2019 | 17 | 3 |
| Yerry Mina | Bruise | 6 Dec 2019 | 14 Dec 2019 | 8 | 1 |
| Unknown player | Knock | 24 Nov 2019 | 4 Dec 2019 | 10 | 1 |
| Unknown player | Hamstring Injury | 24 Nov 2019 | 14 Dec 2019 | 20 | 3 |
| Unknown player | Ankle Injury | 4 Nov 2019 | 21 Feb 2020 | 109 | 17 |
| Unknown player | Muscle Injury | 4 Nov 2019 | 20 Dec 2019 | 46 | 7 |
| Unknown player | Knee Injury | 27 Oct 2019 | 30 Nov 2019 | 34 | 4 |
| Yerry Mina | Knee Injury | 20 Oct 2019 | 2 Nov 2019 | 13 | 2 |
| Unknown player | Groin Injury | 18 Oct 2019 | 27 Oct 2019 | 9 | 1 |
| Unknown player | Muscle Injury | 6 Oct 2019 | 24 Oct 2019 | 18 | 1 |
| Unknown player | Head Injury | 29 Sept 2019 | 18 Oct 2019 | 19 | 1 |
| Unknown player | ILL | 26 Sept 2019 | 4 Oct 2019 | 8 | 1 |
| Unknown player | Bruised Ribs | 2 Sept 2019 | 4 Oct 2019 | 32 | 4 |
 Unknown player | Calf Injury | 18 Aug 2019 | 25 Sept 2019 | 38 | 5 |
| Unknown player | Hamstring Injury | 18 Aug 2019 | 3 Apr 2020 | 229 | 32 |
| Unknown player | Calf Injury | 3 Aug 2019 | 31 Aug 2019 | 28 | 5 |
| Unknown player | Groin Injury | 5 May 2019 | 31 May 2019 | 26 | 1 |
| Richarlison | Bruised Ribs | 5 May 2019 | 31 May 2019 | 26 | 1 |
| Dominic Calvert-Lewin | Bruise | 5 May 2019 | 31 May 2019 | 26 | 1 |
| Michael Keane | ILL | 31 Mar 2019 | 8 Apr 2019 | 8 | 0 |
| Yerry Mina | Hamstring Injury | 26 Mar 2019 | 12 May 2019 | 47 | 6 |
| Unknown player | Ankle Injury | 18 Mar 2019 | 20 Apr 2019 | 33 | 3 |
| Unknown player | ILL | 4 Mar 2019 | 16 Mar 2019 | 12 | 1 |
 Unknown player | Knock | 4 Mar 2019 | 29 Mar 2019 | 25 | 2 |
| Yerry Mina | Foot Injury | 27 Jan 2019 | 25 Feb 2019 | 29 | 4 |
 Unknown player | Groin Injury | 27 Jan 2019 | 5 Feb 2019 | 9 | 2 |
| Unknown player | Knock | 15 Jan 2019 | 25 Feb 2019 | 41 | 6 |
 Ademola Lookman | Ankle Injury | 20 Dec 2018 | 11 Jan 2019 | 22 | 5 |
| Unknown player | Groin Injury | 12 Dec 2018 | 25 Dec 2018 | 13 | 2 |
